KEGG ORTHOLOGY: K05854

ORTHOLOGY: K05854

Entry

K05854                      KO

Symbol

LYN

Name

tyrosine-protein kinase Lyn [EC:2.7.10.2]

Pathway

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04611

Platelet activation

map04662

B cell receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04666

Fc gamma R-mediated phagocytosis

map04730

Long-term depression

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05203

Viral carcinogenesis

map05417

Lipid and atherosclerosis

Disease

H02672

Systemic autoinflammatory disease with vasculitis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05854  LYN; tyrosine-protein kinase Lyn
   04662 B cell receptor signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04664 Fc epsilon RI signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04666 Fc gamma R-mediated phagocytosis
    K05854  LYN; tyrosine-protein kinase Lyn
   04062 Chemokine signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
  09156 Nervous system
   04730 Long-term depression
    K05854  LYN; tyrosine-protein kinase Lyn
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05854  LYN; tyrosine-protein kinase Lyn
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05854  LYN; tyrosine-protein kinase Lyn
   05169 Epstein-Barr virus infection
    K05854  LYN; tyrosine-protein kinase Lyn
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05854  LYN; tyrosine-protein kinase Lyn
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05854  LYN; tyrosine-protein kinase Lyn
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05854  LYN; tyrosine-protein kinase Lyn
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05854  LYN; tyrosine-protein kinase Lyn
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05854  LYN; tyrosine-protein kinase Lyn
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SRC family
   K05854  LYN; tyrosine-protein kinase Lyn
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K05854  LYN; tyrosine-protein kinase Lyn

Other DBs

GO:	0004715 0004716

Genes

HSA:

4067(LYN)

PTR:	472771(LYN)

PPS:	100996017(LYN)

GGO:	101145340(LYN)

PON:	100447326(LYN)

NLE:	100593961(LYN)

HMH:	116813281(LYN)

MCC:	698553(LYN)

MCF:	102118154(LYN)

MTHB:

126961723

MNI:	105482277(LYN)

CSAB:

103236819(LYN)

CATY:

105592167(LYN)

PANU:

101025874(LYN)

TGE:	112630297(LYN)

MLEU:

105552072(LYN)

RRO:	104661780(LYN)

RBB:	108521691(LYN)

TFN:	117079186(LYN)

PTEH:

111524867(LYN)

CANG:

105508677(LYN)

CJC:	100390096(LYN)

SBQ:	101036887(LYN)

CIMI:

108306729(LYN)

CSYR:

103259066(LYN)

MMUR:

105876398(LYN)

LCAT:

123644610(LYN)

PCOQ:

105824094(LYN)

OGA:	100951050(LYN)

MMU:	17096(Lyn)

MPAH:

110338916(Lyn)

RNO:	81515(Lyn)

MCOC:

116088122(Lyn)

ANU:	117698663(Lyn)

MUN:	110541812(Lyn)

CGE:	100754828(Lyn)

MAUA:

101823786(Lyn)

PROB:

127231840(Lyn)

PLEU:

114710233(Lyn)

MORG:

121451525(Lyn)

MFOT:

126515585

AAMP:

119826164(Lyn)

NGI:	103734185(Lyn)

HGL:	101696753(Lyn)

CPOC:

100714653(Lyn)

CCAN:

109696666(Lyn)

DORD:

105980494(Lyn)

DSP:	122121929(Lyn)

PLOP:

125360983(Lyn)

NCAR:

124985502

MMMA:

107142398(Lyn)

OCU:

100340056

OPI:	101531240(LYN)

TUP:	102493585(LYN)

GVR:

103597005

CFA:	477886(LYN)

CLUD:

112678466(LYN)

VVP:	112929497(LYN)

VLG:	121498834(LYN)

NPO:	129505366(LYN)

AML:	100479606(LYN)

UMR:	103677438(LYN)

UAH:	113268089(LYN)

UAR:	123786722(LYN)

ELK:

111155370

LLV:

125096997

MPUF:

101680128(LYN)

MNP:	132014023(LYN)

MLK:	131826820(LYN)

NVS:	122904587(LYN)

ORO:	101383639(LYN)

EJU:	114220924(LYN)

ZCA:	113913209(LYN)

MLX:	118014834(LYN)

NSU:	110579039(LYN)

LWW:	102748833(LYN)

FCA:	101096633(LYN)

PYU:	121038252(LYN)

PCOO:

112859429(LYN)

PBG:	122495424(LYN)

PVIV:

125156741(LYN)

LRUF:

124507653

PTG:	102957150(LYN)

PPAD:

109250302(LYN)

PUC:

125924861

AJU:

106982528

HHV:	120222462(LYN)

BTA:	534996(LYN)

BOM:	102276698(LYN)

BIU:	109568555(LYN)

BBUB:

102394691(LYN)

BBIS:

104987876(LYN)

CHX:	102184639(LYN)

OAS:	100302103(LYN)

BTAX:

128059059(LYN)

ODA:	120878587(LYN)

CCAD:

122451060(LYN)

MBEZ:

129559856(LYN)

SSC:	100152890(LYN)

CFR:	102515625(LYN)

CBAI:

105081485(LYN)

CDK:	105097055(LYN)

VPC:	102545554(LYN)

BACU:

103001606(LYN)

BMUS:

118883303(LYN)

LVE:	103074440(LYN)

OOR:	101280666(LYN)

DLE:	111165865(LYN)

PCAD:

102984630(LYN)

PSIU:

116742719(LYN)

NASI:

112398227(LYN)

ECB:	100053129(LYN)

EPZ:	103552502(LYN)

EAI:	106841654(LYN)

MYB:	102262917(LYN)

MYD:	102755397(LYN)

MMYO:

118670849(LYN)

MLF:	102429660(LYN)

PKL:	118718271(LYN)

EFUS:

103287627(LYN)

MNA:	107533160(LYN)

DRO:	112315403(LYN)

SHON:

118974987(LYN)

AJM:	119051466(LYN)

PDIC:

114514669(LYN)

PHAS:

123833051(LYN)

MMF:	118631367(LYN)

PPAM:

129077477(LYN)

HAI:	109394449(LYN)

RFQ:	117033683(LYN)

PALE:

102880204(LYN)

PGIG:

120607236(LYN)

PVP:	105291403(LYN)

RAY:	107500716(LYN)

MJV:

108396202

TOD:	119241288(LYN)

SARA:

101544577(LYN)

SETR:

126020443(LYN)

LAV:	100673903(LYN)

TMU:

101353037

ETF:	101662820(LYN)

DNM:	101429842(LYN)

MDO:	100616821(LYN)

GAS:	123238979(LYN)

SHR:	100929196(LYN)

AFZ:

127543855

PCW:	110221373(LYN)

OAA:	100079507(LYN)

GGA:	421127(LYN)

PCOC:

116242212(LYN)

MGP:	100550537(LYN)

CJO:	107310194(LYN)

TPAI:

128090698(LYN)

LMUT:

125691036(LYN)

NMEL:

110393410(LYN)

APLA:

101803881(LYN)

ACYG:

106039045(LYN)

CATA:

118251211(LYN)

AFUL:

116486610(LYN)

TGU:	100230728(LYN)

LSR:	110484761(LYN)

SCAN:

103812340(LYN)

PMOA:

120499280(LYN)

OTC:	121340169(LYN)

PRUF:

121356860(LYN)

GFR:	102032206(LYN)

FAB:	101812689(LYN)

OMA:	130249528(LYN)

PHI:	102103954(LYN)

PMAJ:

107200243(LYN)

CCAE:

111924719(LYN)

CCW:	104690380(LYN)

CBRC:

103625501(LYN)

ETL:	114060207(LYN)

ZAB:	102070927(LYN)

ACHL:

103802396(LYN)

SVG:	106851269(LYN)

MMEA:

130573848(LYN)

HRT:	120755563(LYN)

FPG:	101914020(LYN)

FCH:	102048730(LYN)

CLV:	102084226(LYN)

EGZ:	104127723(LYN)

NNI:	104019751(LYN)

PLET:

104614756

PCAO:

104039443

ACUN:

113477137(LYN)

TALA:

104355933(LYN)

PADL:

103923663(LYN)

AFOR:

103907204(LYN)

ACHC:

115340485(LYN)

HALD:

104316638

HLE:	104841345(LYN)

AGEN:

126049376

GCL:

127013818

CCRI:

104154544(LYN)

CSTI:

104550544(LYN)

CMAC:

104473783(LYN)

MUI:	104534127(LYN)

BREG:

104629122

FGA:	104070860(LYN)

LDI:	104354879(LYN)

MNB:	103770585(LYN)

OHA:	104332296(LYN)

NNT:	104402638(LYN)

SHAB:

115606875(LYN)

DPUB:

104303486(LYN)

PGUU:

104461014(LYN)

ACAR:

104517692

CPEA:

104396894(LYN)

AVIT:

104280619(LYN)

CVF:	104293291(LYN)

RTD:	128905374(LYN)

CUCA:

104067671(LYN)

TEO:	104375539(LYN)

BRHI:

104496627(LYN)

AAM:	106494468(LYN)

AROW:

112973089(LYN)

NPD:	112956596(LYN)

TGT:	104575776(LYN)

DNE:	112981685(LYN)

SCAM:

104143187(LYN)

ASN:	102383816(LYN)

AMJ:	102566940(LYN)

CPOO:

109318811(LYN)

GGN:	109304675(LYN)

PSS:	102462919(LYN)

CMY:	102931818(LYN)

CCAY:

125632466(LYN)

DCC:	119850919(LYN)

CPIC:

101950325(LYN)

TST:	117873498(LYN)

CABI:

116834646(LYN)

MRV:	120397873(LYN)

ACS:	100554372(lyn)

ASAO:

132774848(LYN)

PVT:	110089695(LYN)

SUND:

121928264(LYN)

PBI:

103061071

PMUR:

107284322(LYN)

CTIG:

120311662(LYN)

TSR:	106540519(LYN)

PGUT:

117672810(LYN)

APRI:

131194417(LYN)

PTEX:

113440031(LYN)

NSS:	113430002(LYN)

VKO:	123020359(LYN)

PMUA:

114600595(LYN)

PRAF:

128417445(LYN)

ZVI:	118089967(LYN)

HCG:	128324645(LYN)

GJA:	107113876(LYN)

STOW:

125439224(LYN)

EMC:	129333139(LYN)

XLA:	108695301(lyn.S) 373649(lyn.L)

XTR:	549989(lyn)

NPR:	108789967(LYN)

RTEM:

120941007(LYN)

BBUF:

121001061(LYN) 121007450

BGAR:

122938101(LYN)

MUO:	115477572(LYN)

GSH:	117355303(LYN)

DRE:	447804(lyn)

SRX:	107714826 107728263 107729007(lyn)

SANH:

107674289

SGH:	107584583 107602520

CCAR:

109067019 109067021

CAUA:

113045558 113080576 113117495

CGIB:

127951334 128029302

PTET:

122360194(lyn)

LROH:

127176796(lyn)

PPRM:

120482173(lyn)

RKG:	130089355(lyn)

MAMB:

125251681(lyn)

CIDE:

127521887

MASI:

127427255 127440464 127442366 127454133

TROS:

130554326(lyn) 130559306

TDW:	130415753(lyn) 130417987

MANU:

129442185(lyn) 129453027

IPU:	108267808 108280443(lyn)

IFU:	128609883 128623945(lyn)

PHYP:

113540120 113543069

SMEO:

124387324 124402923(lyn)

TFD:	113640329(lyn) 113657552

TVC:	132848143(lyn) 132848471

AMEX:

103026730 103046993

CMAO:

118796958(lyn) 118826647

EEE:	113571979 113579313

CHAR:

105894736 105900514(lyn) 116224366

TRU:

101072875

TFS:	130539278(lyn)

TNG:	GSTEN00032670G001

LCO:

104929874

NCC:

104963253

TBEN:

117488798(lyn)

CGOB:

115022351

PGEO:

117462722(lyn)

GACU:

117557313

EMAC:

134865866(lyn)

ELY:	117271400(lyn)

EFO:	125902210(lyn)

PLEP:

121951069(lyn)

SLUC:

116042005(lyn)

ECRA:

117954545(lyn)

ESP:

116699179

PFLV:

114564997

GAT:	120815604(lyn)

PPUG:

119209838(lyn)

AFB:	129094092(lyn)

CLUM:

117746196(lyn)

PSWI:

130198082(lyn)

MSAM:

119902531(lyn)

SCHU:

122886572(lyn)

CUD:	121519992(lyn)

ALAT:

119011557(lyn)

MZE:

101477890

ONL:

100711419

OAU:	116313154(lyn)

OLA:

101167902

OML:	112147318(lyn)

CSAI:

133453005(lyn)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122841534(lyn)

PPRL:

129361758(lyn)

CVG:

107091676

CTUL:

119793363(lyn)

GMU:	124869865(lyn)

NFU:

107384206

KMR:	108238651(lyn)

ALIM:

106514931

NWH:	119414478(lyn)

AOCE:

111580728

MCEP:

125011267(lyn)

POV:

109637092

SSEN:

122766440(lyn)

HHIP:

117778259(lyn)

HSP:	118118086(lyn)

SMAU:

118310754(lyn)

LCF:

108883973

SDU:

111239118

SLAL:

111653435

XGL:	120799019(lyn)

HCQ:

109515497

SBIA:

133511120(lyn)

PEE:	133411520(lyn)

PTAO:

133488588(lyn)

BPEC:

110170453

MALB:

109962671

BSPL:

114844557(lyn)

SJO:	128368614(lyn)

SASA:

100196779(lyn) 106569254

STRU:

115157025 115169751

OTW:	112226929 112260483

OMY:	110508715 110530332

OGO:	124009795 124041848

ONE:	115103073 115114431

OKI:	109871713 109874862

OKE:	118394668 118402095(lyn)

SALP:

111956320 111979672

SNH:	120020021 120055886

CCLU:

121535234(lyn) 121580934

ELS:	105022707(lyn)

SFM:	108929639(lyn) 108937715

PKI:	111847231 111852531

AANG:

118225568 118234134(lyn)

LOC:	102692416(lyn)

PSPA:

121313441(lyn) 121314381

ARUT:

117394326 117400239(lyn)

LCM:	102360998(LYN)

CMK:	103177046(lyn)

RTP:	109918542(lyn)

CPLA:

122549104(lyn)

HOC:	132814249(lyn)

LERI:

129696289(lyn)

MNZ:

135198504

PVUL:

126831351

BGT:

106064330

GAE:	121369795 121373058

HRF:	124114471 124114473

MCAF:

127736788

MMER:

123524562 123524563 123524566 123524572 123528263 123538741

RPHI:

132713706 132722752 132732437 132734790

» show all

Reference

PMID:3561390

Authors

Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, Toyoshima K

Title

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

Journal

Mol Cell Biol 7:237-43 (1987)
DOI:10.1128/MCB.7.1.237

Sequence

[hsa:4067]

Reference

PMID:10748115

Authors

Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB

Title

Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.

Journal

J Biol Chem 275:16174-82 (2000)
DOI:10.1074/jbc.M909044199

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