KEGG   NETWORK: N00127Help
Entry
N00127                      Network                                

Name
PRCC-TFE3 fusion to transcriptional activation
Definition
PRCC-TFE3 => CDKN1A
  Expanded
7030v1 => 1026
Class
nt06240 Transcription
nt06264 Renal cell carcinoma
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00021  Renal cell carcinoma
Gene
7030  TFE3; transcription factor binding to IGHM enhancer 3
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
Variant
7030v1  PRCC-TFE3 fusion
Reference
  Authors
Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG
  Title
The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
  Journal
Exp Cell Res 315:2399-409 (2009)
DOI:10.1016/j.yexcr.2009.04.022
Reference
  Authors
Muller-Hocker J, Babaryka G, Schmid I, Jung A
  Title
Overexpression of cyclin D1, D3, and p21 in an infantile renal carcinoma with Xp11.2 TFE3-gene fusion.
  Journal
Pathol Res Pract 204:589-97 (2008)
DOI:10.1016/j.prp.2008.01.010
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