KEGG   NETWORK: N01057
Entry
N01057                      Network                                

Name
Mutation-inactivated DJ1 to FAS-JNK signaling patwhay
Definition
DJ1* // (DAXX+ASK1) -> JNK
  Expanded
11315v1 // (1616+4217) -> (5599,5601,5602)
Class
nt06414 Apoptosis
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
11315  PARK7; Parkinsonism associated deglycase
1616  DAXX; death domain associated protein
4217  MAP3K5; mitogen-activated protein kinase kinase kinase 5
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
Variant
11315v1 (DJ1*)  PARK7 mutation
Reference
  Authors
Oh SE, Mouradian MM
  Title
Regulation of Signal Transduction by DJ-1.
  Journal
Adv Exp Med Biol 1037:97-131 (2017)
DOI:10.1007/978-981-10-6583-5_8
Reference
  Authors
Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM
  Title
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.
  Journal
Proc Natl Acad Sci U S A 102:9691-6 (2005)
DOI:10.1073/pnas.0409635102
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