Homo sapiens (human): 5602
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Entry
5602 CDS
T01001
Gene name
MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Definition
(RefSeq) mitogen-activated protein kinase 10
KO
K04440
mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:
2.7.11.24
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04014
Ras signaling pathway
hsa04024
cAMP signaling pathway
hsa04068
FoxO signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04137
Mitophagy - animal
hsa04140
Autophagy - animal
hsa04141
Protein processing in endoplasmic reticulum
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04217
Necroptosis
hsa04310
Wnt signaling pathway
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04530
Tight junction
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04723
Retrograde endocannabinoid signaling
hsa04728
Dopaminergic synapse
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04910
Insulin signaling pathway
hsa04912
GnRH signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04917
Prolactin signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04926
Relaxin signaling pathway
hsa04930
Type II diabetes mellitus
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05162
Measles
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05231
Choline metabolism in cancer
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06110
MAPK signaling (viruses and bacteria)
nt06121
TLR signaling (viruses and bacteria)
nt06123
TNF signaling (viruses and bacteria)
nt06124
Chemokine signaling (viruses)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus type 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06211
Other MAPK signaling
nt06223
TNF signaling
nt06224
CXCR signaling
nt06263
Hepatocellular carcinoma
nt06412
Unfolded protein response (UPR) signaling
nt06414
Apoptosis
nt06416
TNF signaling
nt06419
Microtubule-based transport
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
Element
N00178
KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00188
IL1-IL1R-JNK signaling pathway
N00189
KSHV K15 to JNK signaling pathway
N00438
TLR2/4-MAPK signaling pathway
N00446
TNF-JNK signaling pathway
N00447
HIV Vpr/Tat to TNF-JNK signaling pathway
N00503
HTLV-1 Tax to TNF-JNK signaling pathway
N00542
EGF-EGFR-RAS-JNK signaling pathway
N00543
HBV HBx to JNK signaling pathway
N00551
HBV HBs to TLR2/4-MAPK signaling pathway
N00930
Escherichia NleD to TNF-JNK signaling pathway
N00979
Mutation-caused aberrant Htt to anterograde axonal transport
N00992
Mutation-caused aberrant Htt to TNF-JNK signaling pathway
N01013
IRE1a-JNK signaling pathway
N01014
Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway
N01056
FAS-JNK signaling pathway
N01057
Mutation-inactivated DJ1 to FAS-JNK signaling patwhay
Disease
H01813
Lennox-Gastaut syndrome
Drug target
Tanzisertib:
D10168
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
5602 (MAPK10)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5602 (MAPK10)
04012 ErbB signaling pathway
5602 (MAPK10)
04014 Ras signaling pathway
5602 (MAPK10)
04310 Wnt signaling pathway
5602 (MAPK10)
04668 TNF signaling pathway
5602 (MAPK10)
04068 FoxO signaling pathway
5602 (MAPK10)
04071 Sphingolipid signaling pathway
5602 (MAPK10)
04024 cAMP signaling pathway
5602 (MAPK10)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
5602 (MAPK10)
04137 Mitophagy - animal
5602 (MAPK10)
09143 Cell growth and death
04210 Apoptosis
5602 (MAPK10)
04215 Apoptosis - multiple species
5602 (MAPK10)
04217 Necroptosis
5602 (MAPK10)
09144 Cellular community - eukaryotes
04510 Focal adhesion
5602 (MAPK10)
04530 Tight junction
5602 (MAPK10)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
5602 (MAPK10)
04621 NOD-like receptor signaling pathway
5602 (MAPK10)
04622 RIG-I-like receptor signaling pathway
5602 (MAPK10)
04625 C-type lectin receptor signaling pathway
5602 (MAPK10)
04660 T cell receptor signaling pathway
5602 (MAPK10)
04658 Th1 and Th2 cell differentiation
5602 (MAPK10)
04659 Th17 cell differentiation
5602 (MAPK10)
04657 IL-17 signaling pathway
5602 (MAPK10)
04664 Fc epsilon RI signaling pathway
5602 (MAPK10)
09152 Endocrine system
04910 Insulin signaling pathway
5602 (MAPK10)
04920 Adipocytokine signaling pathway
5602 (MAPK10)
04912 GnRH signaling pathway
5602 (MAPK10)
04914 Progesterone-mediated oocyte maturation
5602 (MAPK10)
04917 Prolactin signaling pathway
5602 (MAPK10)
04926 Relaxin signaling pathway
5602 (MAPK10)
04935 Growth hormone synthesis, secretion and action
5602 (MAPK10)
09156 Nervous system
04728 Dopaminergic synapse
5602 (MAPK10)
04723 Retrograde endocannabinoid signaling
5602 (MAPK10)
04722 Neurotrophin signaling pathway
5602 (MAPK10)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
5602 (MAPK10)
09158 Development and regeneration
04380 Osteoclast differentiation
5602 (MAPK10)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5602 (MAPK10)
05231 Choline metabolism in cancer
5602 (MAPK10)
09162 Cancer: specific types
05210 Colorectal cancer
5602 (MAPK10)
05212 Pancreatic cancer
5602 (MAPK10)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
5602 (MAPK10)
05170 Human immunodeficiency virus 1 infection
5602 (MAPK10)
05161 Hepatitis B
5602 (MAPK10)
05171 Coronavirus disease - COVID-19
5602 (MAPK10)
05162 Measles
5602 (MAPK10)
05167 Kaposi sarcoma-associated herpesvirus infection
5602 (MAPK10)
05169 Epstein-Barr virus infection
5602 (MAPK10)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
5602 (MAPK10)
05130 Pathogenic Escherichia coli infection
5602 (MAPK10)
05132 Salmonella infection
5602 (MAPK10)
05131 Shigellosis
5602 (MAPK10)
05135 Yersinia infection
5602 (MAPK10)
05133 Pertussis
5602 (MAPK10)
05152 Tuberculosis
5602 (MAPK10)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
5602 (MAPK10)
05142 Chagas disease
5602 (MAPK10)
09164 Neurodegenerative disease
05010 Alzheimer disease
5602 (MAPK10)
05012 Parkinson disease
5602 (MAPK10)
05016 Huntington disease
5602 (MAPK10)
05017 Spinocerebellar ataxia
5602 (MAPK10)
05020 Prion disease
5602 (MAPK10)
05022 Pathways of neurodegeneration - multiple diseases
5602 (MAPK10)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5602 (MAPK10)
05418 Fluid shear stress and atherosclerosis
5602 (MAPK10)
05415 Diabetic cardiomyopathy
5602 (MAPK10)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
5602 (MAPK10)
04932 Non-alcoholic fatty liver disease
5602 (MAPK10)
04931 Insulin resistance
5602 (MAPK10)
04933 AGE-RAGE signaling pathway in diabetic complications
5602 (MAPK10)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
5602 (MAPK10)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
5602 (MAPK10)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
5602 (MAPK10)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
5602 (MAPK10)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kdo
Kinase-like
RIO1
APH
FTA2
Motif
Other DBs
NCBI-GeneID:
5602
NCBI-ProteinID:
NP_001304996
OMIM:
602897
HGNC:
6872
Ensembl:
ENSG00000109339
Vega:
OTTHUMG00000130604
Pharos:
P53779
(Tchem)
UniProt:
P53779
A0A286YF97
LinkDB
All DBs
Structure
PDB:
3OY1
6EMH
4WHZ
6EQ9
4W4W
2B1P
4X21
4H39
4KKH
3DA6
2ZDT
4W4V
4Y46
4Y5H
4H3B
6EKD
4Z9L
3TTJ
2O0U
4KKE
3TTI
3OXI
3G9L
3FI3
1PMN
4U79
3FV8
3FI2
4W4Y
1JNK
4KKG
3RTP
3KVX
3G90
2WAJ
2R9S
2P33
2OK1
3PTG
2O2U
2ZDU
1PMV
3V6R
4W4X
1PMU
2EXC
3G9N
3V6S
4H36
3CGO
3CGF
Thumbnails
Position
4q21.3
AA seq
464 aa
AA seq
DB search
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDMWSVGCIMGEMIKGAVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
NT seq
1395 nt
NT seq
+upstream
nt +downstream
nt
atgagcctccatttcttatactactgcagtgaaccaacattggatgtgaaaattgccttt
tgtcagggattcgataaacaagtggatgtgtcatatattgccaaacattacaacatgagc
aaaagcaaagttgacaaccagttctacagtgtggaagtgggagactcaaccttcacagtt
ctcaagcgctaccagaatctaaagcctattggctctggggctcagggcatagtttgtgcc
gcgtatgatgctgtccttgacagaaatgtggccattaagaagctcagcagaccctttcag
aaccaaacacatgccaagagagcgtaccgggagctggtcctcatgaagtgtgtgaaccat
aaaaacattattagtttattaaatgtcttcacaccccagaaaacgctggaggagttccaa
gatgtttacttagtaatggaactgatggatgccaacttatgtcaagtgattcagatggaa
ttagaccatgagcgaatgtcttacctgctgtaccaaatgttgtgtggcattaagcacctc
cattctgctggaattattcacagggatttaaaaccaagtaacattgtagtcaagtctgat
tgcacattgaaaatcctggactttggactggccaggacagcaggcacaagcttcatgatg
actccatatgtggtgacacgttattacagagcccctgaggtcatcctggggatgggctac
aaggagaacgttgacatgtggtcagtagggtgcatcatgggagaaatgataaaaggtgca
gtgctgtttcctggcactgatcatattgaccagtggaataaggtaattgaacaactagga
acaccatgtccagaattcatgaagaaattgcaacccacagtaagaaactatgtggagaat
cggcccaagtatgcgggactcaccttccccaaactcttcccagattccctcttcccagcg
gactccgagcacaataaactcaaagccagccaagccagggacttgttgtcaaagatgcta
gtgattgacccagcaaaaagaatatcagtggacgacgccttacagcatccctacatcaac
gtctggtatgacccagccgaagtggaggcgcctccacctcagatatatgacaagcagttg
gatgaaagagaacacacaattgaagaatggaaagaacttatctacaaggaagtaatgaat
tcagaagaaaagactaaaaatggtgtagtaaaaggacagccttctccttcaggtgcagca
gtgaacagcagtgagagtctccctccatcctcgtctgtcaatgacatctcctccatgtcc
accgaccagaccctggcatctgacactgacagcagcctggaagcctcggcaggacccctg
ggttgttgcaggtga
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integrated database retrieval system
