Homo sapiens (human): 4217
Help
Entry
4217 CDS
T01001
Symbol
MAP3K5, ASK1, MAPKKK5, MEKK5
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 5
KO
K04426
mitogen-activated protein kinase kinase kinase 5 [EC:
2.7.11.25
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa04010
MAPK signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04141
Protein processing in endoplasmic reticulum
hsa04210
Apoptosis
hsa04530
Tight junction
hsa04668
TNF signaling pathway
hsa04714
Thermogenesis
hsa04722
Neurotrophin signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06211
Other MAPK signaling (cancer)
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06466
Pathways of neurodegeneration
nt06524
Apoptosis
nt06534
Unfolded protein response
Element
N01013
IRE1a-JNK signaling pathway
N01014
Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway
N01056
FAS-JNK signaling pathway
N01057
Mutation-inactivated DJ1 to FAS-JNK signaling patwhay
N01407
Metals to JNK signaling pathway
N01417
Paraquat to FAS-JNK signaling pathway
Drug target
Selonsertib:
D10988
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
4217 (MAP3K5)
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
4217 (MAP3K5)
04071 Sphingolipid signaling pathway
4217 (MAP3K5)
09150 Organismal Systems
09156 Nervous system
04722 Neurotrophin signaling pathway
4217 (MAP3K5)
09159 Environmental adaptation
04714 Thermogenesis
4217 (MAP3K5)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
4217 (MAP3K5)
09164 Neurodegenerative disease
05010 Alzheimer disease
4217 (MAP3K5)
05012 Parkinson disease
4217 (MAP3K5)
05014 Amyotrophic lateral sclerosis
4217 (MAP3K5)
05016 Huntington disease
4217 (MAP3K5)
05017 Spinocerebellar ataxia
4217 (MAP3K5)
05022 Pathways of neurodegeneration - multiple diseases
4217 (MAP3K5)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
4217 (MAP3K5)
05418 Fluid shear stress and atherosclerosis
4217 (MAP3K5)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
4217 (MAP3K5)
04932 Non-alcoholic fatty liver disease
4217 (MAP3K5)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
4217 (MAP3K5)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
4217 (MAP3K5)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.25 mitogen-activated protein kinase kinase kinase
4217 (MAP3K5)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: STE group
STE11 family
4217 (MAP3K5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MAP3K_TRAF_bd
Pkinase
HisK-N-like
PK_Tyr_Ser-Thr
ASK_PH
TPR-S
DRHyd-ASK
FPP
Kinase-like
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
4217
NCBI-ProteinID:
NP_005914
OMIM:
602448
HGNC:
6857
Ensembl:
ENSG00000197442
UniProt:
Q99683
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:complement(136557046..136793091)
Genome browser
AA seq
1374 aa
AA seq
DB search
MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI
PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP
KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK
VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE
QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV
RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN
GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
NT seq
4125 nt
NT seq
+upstream
nt +downstream
nt
atgagcacggaggcggacgagggcatcactttctctgtgccacccttcgccccctcgggc
ttctgcaccatccccgagggcggcatctgcaggaggggaggagcggcggcggtgggcgag
ggcgaggagcaccagctgccaccgccgccgccgggcagcttctggaacgtggagagcgcc
gctgcccctggcatcggttgtccggcggccacctcctcgagcagtgccacccgaggccgg
ggcagctctgttggcgggggcagccgacggaccacggtggcatatgtgatcaacgaagcg
agccaagggcaactggtggtggccgagagcgaggccctgcagagcttgcgggaggcgtgc
gagacagtgggcgccaccctggaaaccctgcattttgggaaactcgactttggagaaacc
accgtgctggaccgcttttacaatgcagatattgcggtggtggagatgagcgatgccttc
cggcagccgtccttgttttaccaccttggggtgagagaaagtttcagcatggccaacaac
atcatcctctactgtgatactaactcggactctctgcagtcactgaaggaaataatttgc
cagaagaatactatgtgcactgggaactacacctttgttccttacatgataactccacat
aacaaagtctactgctgtgacagcagcttcatgaaggggttgacagagctcatgcaaccg
aacttcgagctgcttcttggacccatctgcttacctcttgtggatcgttttattcaactt
ttgaaggtggcacaagcaagttctagccagtacttccgggaatctatactcaatgacatc
aggaaagctcgtaatttatacactggtaaagaattggcagctgagttggcaagaattcgg
cagcgagtagataatatcgaagtcttgacagcagatattgtcataaatctgttactttcc
tacagagatatccaggactatgattctattgtgaagctggtagagactttagaaaaactg
ccaacctttgatttggcctcccatcaccatgtgaagtttcattatgcatttgcactgaat
aggagaaatctccctggtgacagagcaaaagctcttgatattatgattcccatggtgcaa
agcgaaggacaagttgcttcagatatgtattgcctagttggtcgaatctacaaagatatg
tttttggactctaatttcacggacactgaaagcagagaccatggagcttcttggttcaaa
aaggcatttgaatctgagccaacactacagtcaggaattaattatgcggtcctcctcctg
gcagctggacaccagtttgaatcttcctttgagctccggaaagttggggtgaagctaagt
agtcttcttggtaaaaagggaaacttggaaaaactccagagctactgggaagttggattt
tttctgggggccagcgtcctagccaatgaccacatgagagtcattcaagcatctgaaaag
ctttttaaactgaagacaccagcatggtacctcaagtctattgtagagacaattttaata
tataagcattttgtgaaactgaccacagaacagcctgtggccaagcaagaacttgtggac
ttttggatggatttcctggtcgaggccacaaagacagatgttactgtggttaggtttcca
gtattaatattagaaccaaccaaaatctatcaaccttcttatttgtctatcaacaatgaa
gttgaggaaaagacaatctctatttggcacgtgcttcctgatgacaagaaaggtatacat
gagtggaattttagtgcctcttctgtcaggggagtgagtatttctaaatttgaagaaaga
tgctgctttctttatgtgcttcacaattctgatgatttccaaatctatttctgtacagaa
cttcattgtaaaaagttttttgagatggtgaacaccattaccgaagagaaggggagaagc
acagaggaaggagactgtgaaagtgacttgctggagtatgactatgaatatgatgaaaat
ggtgacagagtcgttttaggaaaaggcacttatgggatagtctacgcaggtcgggacttg
agcaaccaagtcagaattgctattaaggaaatcccagagagagacagcagatactctcag
cccctgcatgaagaaatagcattgcataaacacctgaagcacaaaaatattgtccagtat
ctgggctctttcagtgagaatggtttcattaaaatcttcatggagcaggtccctggagga
agtctttctgctctccttcgttccaaatggggtccattaaaagacaatgagcaaacaatt
ggcttttatacaaagcaaatactggaaggattaaaatatctccatgacaatcagatagtt
caccgggacataaagggtgacaatgtgttgattaatacctacagtggtgttctcaagatc
tctgacttcggaacatcaaagaggcttgctggcataaacccctgtactgaaacttttact
ggtaccctccagtatatggcaccagaaataatagataaaggaccaagaggctacggaaaa
gcagcagacatctggtctctgggctgtacaatcattgaaatggccacaggaaaaccccca
ttttatgaactgggagaaccacaagcagctatgttcaaggtgggaatgtttaaagtccac
cctgagatcccagagtccatgtctgcagaggccaaggcattcatactgaaatgttttgaa
ccagatcctgacaagagagcctgtgctaacgacttgcttgttgatgagtttttaaaagtt
tcaagcaaaaagaaaaagacacaacctaagctttcagctctttcagctggatcaaatgaa
tatctcaggagtatatccttgccggtacctgtgctggtggaggacaccagcagcagcagt
gagtacggctcagtttcacccgacacggagttgaaagtggaccccttctctttcaaaaca
agagccaagtcctgcggagaaagagatgtcaagggaattcggacactctttttgggcatt
ccagatgagaattttgaagatcacagtgctcctccttcccctgaagaaaaagattctgga
ttcttcatgctgaggaaggacagtgagaggcgagctacccttcacaggatcctgacggaa
gaccaagacaaaattgtgagaaacctaatggaatctttagctcagggggctgaagaaccg
aaactaaaatgggaacacatcacaaccctcattgcaagcctcagagaatttgtgagatcc
actgaccgaaaaatcatagccaccacactgtcaaagctgaaactggagctggacttcgac
agccatggcattagccaagtccaggtggtactctttggttttcaagatgctgtcaataaa
gttcttcggaatcataacatcaagccgcactggatgtttgccttagacagtatcattcgg
aaggcggtacagacagccattaccatcctggttccagaactaaggccacatttcagcctt
gcatctgagagtgatactgctgatcaagaagacttggatgtagaagatgaccatgaggaa
cagccttcaaatcaaactgtccgaagacctcaggctgtcattgaagatgctgtggctacc
tcaggcgtgagcacgctcagttctactgtgtctcatgattcccagagtgctcaccggtca
ctgaatgtacagcttggaaggatgaaaatagaaaccaatagattactggaagaattggtt
cggaaagagaaagaattacaagcactccttcatcgagctattgaagaaaaagaccaagaa
attaaacacctgaagcttaagtcccaacccatagaaattcctgaattgcctgtatttcat
ctaaattcttctggcacaaatactgaagattctgaacttaccgactggctgagagtgaat
ggagctgatgaagacactataagccggtttttggctgaagattatacactattggatgtt
ctctactatgttacacgtgatgacttaaaatgcttgagactaaggggagggatgctgtgc
acactgtggaaggctatcattgactttcgaaacaaacagacttga
DBGET
integrated database retrieval system
