KEGG   PATHWAY: prd03410
Entry
prd03410                    Pathway                                

Name
Base excision repair - Pradoshia sp. D12
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
prd03410  Base excision repair
prd03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Pradoshia sp. D12 [GN:prd]
Gene
F7984_15120  mutM; DNA-formamidopyrimidine glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
F7984_06505  Fpg/Nei family DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
F7984_11325  nth; endonuclease III [KO:K10773] [EC:4.2.99.18]
F7984_02415  DNA-3-methyladenine glycosylase 2 family protein [KO:K01247] [EC:3.2.2.21]
F7984_10290  mismatch-specific DNA-glycosylase [KO:K03649] [EC:3.2.2.28]
F7984_18310  uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
F7984_03055  mutY; A/G-specific adenine glycosylase [KO:K03575] [EC:3.2.2.31]
F7984_09940  xth; exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
F7984_13710  deoxyribonuclease IV [KO:K01151] [EC:3.1.21.2]
F7984_15125  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
F7984_14230  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
F7984_01925  ligA; NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
F7984_03780  hypothetical protein [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
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