KEGG   Pan troglodytes (chimpanzee): 737245
Entry
737245            CDS       T01005                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr01521  EGFR tyrosine kinase inhibitor resistance
ptr01522  Endocrine resistance
ptr04010  MAPK signaling pathway
ptr04012  ErbB signaling pathway
ptr04014  Ras signaling pathway
ptr04062  Chemokine signaling pathway
ptr04068  FoxO signaling pathway
ptr04072  Phospholipase D signaling pathway
ptr04150  mTOR signaling pathway
ptr04151  PI3K-Akt signaling pathway
ptr04380  Osteoclast differentiation
ptr04510  Focal adhesion
ptr04540  Gap junction
ptr04550  Signaling pathways regulating pluripotency of stem cells
ptr04630  JAK-STAT signaling pathway
ptr04650  Natural killer cell mediated cytotoxicity
ptr04660  T cell receptor signaling pathway
ptr04662  B cell receptor signaling pathway
ptr04664  Fc epsilon RI signaling pathway
ptr04714  Thermogenesis
ptr04722  Neurotrophin signaling pathway
ptr04910  Insulin signaling pathway
ptr04912  GnRH signaling pathway
ptr04915  Estrogen signaling pathway
ptr04917  Prolactin signaling pathway
ptr04926  Relaxin signaling pathway
ptr04935  Growth hormone synthesis, secretion and action
ptr05034  Alcoholism
ptr05160  Hepatitis C
ptr05161  Hepatitis B
ptr05163  Human cytomegalovirus infection
ptr05165  Human papillomavirus infection
ptr05200  Pathways in cancer
ptr05203  Viral carcinogenesis
ptr05205  Proteoglycans in cancer
ptr05206  MicroRNAs in cancer
ptr05210  Colorectal cancer
ptr05211  Renal cell carcinoma
ptr05213  Endometrial cancer
ptr05214  Glioma
ptr05215  Prostate cancer
ptr05220  Chronic myeloid leukemia
ptr05221  Acute myeloid leukemia
ptr05223  Non-small cell lung cancer
ptr05224  Breast cancer
ptr05225  Hepatocellular carcinoma
ptr05226  Gastric cancer
ptr05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ptr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    737245 (GRB2)
   04012 ErbB signaling pathway
    737245 (GRB2)
   04014 Ras signaling pathway
    737245 (GRB2)
   04630 JAK-STAT signaling pathway
    737245 (GRB2)
   04068 FoxO signaling pathway
    737245 (GRB2)
   04072 Phospholipase D signaling pathway
    737245 (GRB2)
   04151 PI3K-Akt signaling pathway
    737245 (GRB2)
   04150 mTOR signaling pathway
    737245 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    737245 (GRB2)
   04540 Gap junction
    737245 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    737245 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    737245 (GRB2)
   04660 T cell receptor signaling pathway
    737245 (GRB2)
   04662 B cell receptor signaling pathway
    737245 (GRB2)
   04664 Fc epsilon RI signaling pathway
    737245 (GRB2)
   04062 Chemokine signaling pathway
    737245 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    737245 (GRB2)
   04912 GnRH signaling pathway
    737245 (GRB2)
   04915 Estrogen signaling pathway
    737245 (GRB2)
   04917 Prolactin signaling pathway
    737245 (GRB2)
   04926 Relaxin signaling pathway
    737245 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    737245 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    737245 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    737245 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    737245 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    737245 (GRB2)
   05206 MicroRNAs in cancer
    737245 (GRB2)
   05205 Proteoglycans in cancer
    737245 (GRB2)
   05203 Viral carcinogenesis
    737245 (GRB2)
   05231 Choline metabolism in cancer
    737245 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    737245 (GRB2)
   05225 Hepatocellular carcinoma
    737245 (GRB2)
   05226 Gastric cancer
    737245 (GRB2)
   05214 Glioma
    737245 (GRB2)
   05221 Acute myeloid leukemia
    737245 (GRB2)
   05220 Chronic myeloid leukemia
    737245 (GRB2)
   05211 Renal cell carcinoma
    737245 (GRB2)
   05215 Prostate cancer
    737245 (GRB2)
   05213 Endometrial cancer
    737245 (GRB2)
   05224 Breast cancer
    737245 (GRB2)
   05223 Non-small cell lung cancer
    737245 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    737245 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    737245 (GRB2)
   05160 Hepatitis C
    737245 (GRB2)
   05163 Human cytomegalovirus infection
    737245 (GRB2)
   05165 Human papillomavirus infection
    737245 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    737245 (GRB2)
   01522 Endocrine resistance
    737245 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptr04131]
    737245 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:ptr04990]
    737245 (GRB2)
Membrane trafficking [BR:ptr04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    737245 (GRB2)
Domain-containing proteins not elsewhere classified [BR:ptr04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   737245 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 737245
NCBI-ProteinID: NP_001233546
Ensembl: ENSPTRG00000009642
VGNC: 14183
UniProt: A0A6D2Y3A5 G2HGD2
LinkDB
Position
17
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaacgaagaatgtgatcagaactggtacaaggcagag
cttaatggaaaagacggcttcattcccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagtgagagcgctcctggggacttctccctctctgtcaag
tttggaaacgatgtgcagcacttcaaggtgctccgagatggagccgggaagtacttcctc
tgggtggtgaagttcaattctttgaatgagctggtggattatcacagatctacatctgtc
tccagaaaccagcagatattcctgcgggacatagaacaggtgccacagcagccgacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggcttccgccgggga
gattttatccatgtcatggataactcagaccccaactggtggaaaggagcttgccacggg
cagaccggcatgtttccccgcaattatgtcacccccgtgaaccggaacgtctaa

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