KEGG   REACTION: R00074
Entry
R00074                      Reaction                               

Name
2-aminophenol:oxygen oxidoreductase (dimerizing)
Definition
4 2-Aminophenol + 3 Oxygen <=> 2 2-Aminophenoxazin-3-one + 6 H2O
Equation
4 C01987 + 3 C00007 <=> 2 C02161 + 6 C00001
Comment
multi-step reaction (see R08762+R08763)
Reaction class
RC00767  C01987_C02161
RC02319  C01987_C02161
Enzyme
Pathway
rn00380  Tryptophan metabolism
rn01100  Metabolic pathways
Orthology
K20204  grixazone synthase / o-aminophenol oxidase [EC:1.10.3.15 1.10.3.4]
K20219  o-aminophenol oxidase [EC:1.10.3.4]
Reference
1  [PMID:14298835]
  Authors
NAIR PM, VINING LC.
  Title
ESOPHENOXAZINE SYNTHASE APOENZYME FROM PYCNOPORUS COCCINEUS.
  Journal
Biochim Biophys Acta 96:318-27 (1965)
DOI:10.1016/0005-2787(65)90594-0
Reference
2  [PMID:4166439]
  Authors
Subba Rao PV, Vaidyanathan CS.
  Title
Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.
  Journal
Arch Biochem Biophys 118:388-94 (1967)
DOI:10.1016/0003-9861(67)90365-7
Reference
3  [PMID:16282322]
  Authors
Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S.
  Title
A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.
  Journal
J Biol Chem 281:824-33 (2006)
DOI:10.1074/jbc.M505806200
Other DBs
RHEA: 40966
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