KEGG   ENZYME: 1.1.1.149
Entry
EC 1.1.1.149                Enzyme                                 
Name
20alpha-hydroxysteroid dehydrogenase;
20alpha-hydroxy steroid dehydrogenase;
20alpha-HSD;
20alpha-HSDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Reaction(IUBMB)
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ [RN:R03325]
Reaction(KEGG)
R03325;
(other) R02207 R02209 R08958 R08959
Substrate
17alpha,20alpha-dihydroxypregn-4-en-3-one [CPD:C04518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
17alpha-hydroxyprogesterone [CPD:C01176];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).
History
EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K05295  20alpha-hydroxysteroid dehydrogenase
Genes
HSA1645(AKR1C1)
PTR100607996
PPS100986729
GGO101146324 115936027
PON100171658(AKR1C1) 100189776
NLE100605934
MCC711198(AKR1C1) 711360(AKR1C2)
MCF101865536(AKR1C1) 102141103
CSAB103237807 103237808
CATY105587685 105587688
PANU101023297
TGE112631308 112631309
RRO104678924 104678925
RBB108532991 108532992
TFN117083548 117083560 117087703 117087714
CJC100404656(AKR1C1)
SBQ101042532
MMU105349(Akr1c18)
MCAL110308710
MPAH110315750
RNO171516(Akr1c3) 307092(Akr1c1)
MUN110540933 110542801
CGE100768666 100770100
PLEU114708030
NGI103725895
HGL101716553
CPOC100722094 100724342 100724620
CCAN109680485
DORD105980417
DSP122113030
OCU100348607(PGER1) 100352716
OPI101525116 101525279 101526245 118759111
ECB100070570
EPZ103540778
EAI106827244
DNM101433871 101435315
GAS123247018 123248678
BBEL109473367
HAME121859286
 » show all
Reference
1  [PMID:4382486]
  Authors
Shikita M, Inano H, Tamaoki B.
  Title
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
  Journal
Biochemistry 6:1760-4 (1967)
DOI:10.1021/bi00858a026
Reference
2  [PMID:6935192]
  Authors
Strickler RC, Tobias B, Covey DF
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J Biol Chem 256:316-21 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.149
IUBMB Enzyme Nomenclature: 1.1.1.149
ExPASy - ENZYME nomenclature database: 1.1.1.149
BRENDA, the Enzyme Database: 1.1.1.149
CAS: 9040-08-8
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