KEGG   ENZYME: 1.1.1.178
Entry
EC 1.1.1.178                Enzyme                                 
Name
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:R04203]
Reaction(KEGG)
R04203
Substrate
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:C04405];
NAD+ [CPD:C00003]
Product
2-methylacetoacetyl-CoA [CPD:C03344];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
History
EC 1.1.1.178 created 1981
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Genes
HSA3028(HSD17B10)
PTR465649(HSD17B10)
PPS100971848(HSD17B10)
GGO101130538(HSD17B10)
PON100459385(HSD17B10)
PPYG129024985(HSD17B10)
NLE100594310(HSD17B10)
HMH116811708(HSD17B10)
SSYN129476088(HSD17B10)
MCC700018(HSD17B10)
MCF102123916(HSD17B10)
MTHB126946552
MNI105493784(HSD17B10)
CSAB103232017(HSD17B10)
CATY105576369(HSD17B10)
PANU101012016(HSD17B10)
TGE112616408(HSD17B10)
MLEU105532263(HSD17B10)
RRO104663370(HSD17B10)
RBB108520302(HSD17B10)
TFN117078288(HSD17B10) 117091873
PTEH111531744(HSD17B10)
CANG105514907(HSD17B10)
CJC100402832(HSD17B10)
SBQ101039788(HSD17B10)
CIMI108295447(HSD17B10)
ANAN105734476(HSD17B10)
CSYR103253700(HSD17B10)
MMUR105861240
LCAT123628032(HSD17B10) 123635438
PCOQ105823442(HSD17B10)
OGA100940377(HSD17B10)
MMU15108(Hsd17b10)
MCAL110286767(Hsd17b10)
MPAH110313838(Hsd17b10)
RNO63864(Hsd17b10)
MCOC116089853(Hsd17b10)
ANU117694035(Hsd17b10)
MUN110540816(Hsd17b10)
CGE100757689(Hsd17b10)
MAUA101837486(Hsd17b10)
PROB127217690(Hsd17b10) 127231134
PLEU114683399 114702840(Hsd17b10)
MORG121443092 121445568(Hsd17b10)
MFOT126494035
AAMP119804867(Hsd17b10) 119819446
NGI103747316(Hsd17b10)
HGL101712281(Hsd17b10)
CPOC100718814(Hsd17b10)
CCAN109702046(Hsd17b10)
DORD106000637(Hsd17b10)
DSP122112017(Hsd17b10)
PLOP125344092(Hsd17b10)
NCAR124972561
MMMA107159874(Hsd17b10)
OCU100342235
OPI101529823(HSD17B10)
TUP102491700(HSD17B10)
GVR103592126(HSD17B10)
CFA480930(HSD17B10)
CLUD112673073(HSD17B10)
VVP112911953(HSD17B10)
VLG121482238(HSD17B10)
NPO129518320(HSD17B10)
AML100483379(HSD17B10)
UMR103675231(HSD17B10)
UAH113247518(HSD17B10)
UAR123793530(HSD17B10)
ELK111139811
LLV125092362
MPUF101693030(HSD17B10)
MNP132007269(HSD17B10)
MLK131822124(HSD17B10)
NVS122894392 122896272(HSD17B10) 122916941
ORO101369544(HSD17B10)
EJU114200638(HSD17B10)
ZCA113931211(HSD17B10)
MLX117998525(HSD17B10)
NSU110588558(HSD17B10)
LWW102733441(HSD17B10)
FCA101090672(HSD17B10)
PYU121024801(HSD17B10)
PCOO112870930(HSD17B10)
PBG122477514(HSD17B10)
PVIV125157292(HSD17B10)
LRUF124522283
PTG102956982(HSD17B10)
PPAD109260276(HSD17B10)
PUC125931707
AJU106985377
HHV120222963(HSD17B10)
BTA281809(HSD17B10)
BOM102284367(HSD17B10)
BIU109555307(HSD17B10)
BBUB102403269(HSD17B10)
BBIS105000965(HSD17B10)
CHX102182021(HSD17B10)
OAS101119880(HSD17B10)
BTAX128070049(HSD17B10)
ODA120851531 120854550 120860174 120882164(HSD17B10)
CCAD122434299(HSD17B10)
MBEZ129564227(HSD17B10)
SSC100524293(HSD17B10)
CFR102504376(HSD17B10) 102511542
CBAI105081500(HSD17B10)
CDK105096695(HSD17B10)
VPC102531602(HSD17B10)
BACU103010500(HSD17B10)
BMUS118889266(HSD17B10)
LVE103085758(HSD17B10)
OOR101287041(HSD17B10)
DLE111170779(HSD17B10)
PCAD102982939(HSD17B10)
PSIU116747313(HSD17B10)
NASI112408416(HSD17B10)
ECB100060335(HSD17B10)
EPZ103542953(HSD17B10)
EAI106822166(HSD17B10)
MYB102241897
MYD102751672(HSD17B10)
MMYO118653717(HSD17B10) 118659315
MLF102417112(HSD17B10)
MDT132224076(HSD17B10) 132226464
PKL118706130 118706176 118714042(HSD17B10)
EFUS103294936 103301347(HSD17B10)
MNA107542354(HSD17B10)
DRO112322468(HSD17B10)
SHON118978337(HSD17B10)
AJM119055505(HSD17B10)
PDIC114505044(HSD17B10)
PHAS123814830(HSD17B10)
MMF118635833(HSD17B10)
PPAM129064545(HSD17B10) 129075737
HAI109396389(HSD17B10)
RFQ117021353(HSD17B10)
PALE102882756(HSD17B10)
PGIG120593567(HSD17B10)
PVP105307806(HSD17B10)
RAY107506614(HSD17B10)
MJV108393376(HSD17B10)
TOD119246140(HSD17B10)
SARA101554831(HSD17B10)
SETR125999256(HSD17B10)
LAV100676457(HSD17B10)
TMU101360197
ETF101643918 101654022(HSD17B10)
DNM101437023 101443695(HSD17B10)
MDO100019657(HSD17B10)
GAS123253957(HSD17B10)
SHR100918332(HSD17B10)
AFZ127542698
PCW110201063(HSD17B10)
TVP118832785(HSD17B10)
OAA100081790(HSD17B10)
GGA425758(HSD17B10)
PCOC116240178(HSD17B10)
MGP100540780(HSD17B10)
NMEL110391433(HSD17B10)
ACYG136787508(HSD17B10)
LSR110482653(HSD17B10)
PMOA120503076(HSD17B10)
OTC121340067(HSD17B10)
PRUF121362366(HSD17B10)
OMA130262830(HSD17B10)
PHI102108549(HSD17B10)
PMAJ107199346(HSD17B10)
CCW120412192(HSD17B10)
CBRC103617130(HSD17B10)
ZLE135460324(HSD17B10)
SVG106864400(HSD17B8)
MMEA130586734(HSD17B10)
HRT120748218(HSD17B10)
FPG101922240(HSD17B10)
FCH102045831(HSD17B10)
SHAB115603483(HSD17B10)
ACHC115338221(HSD17B10)
HLE104834323(HSD17B10)
AGEN126035190
PGUU104460485(HSD17B10)
CUCA104067759(HSD17B10)
CVF104291634(HSD17B10)
AROW112972653(HSD17B10)
NPD112946761(HSD17B10)
DNE112985485(HSD17B10)
ASN102377997(HSD17B10)
AMJ102559608(HSD17B10)
CMY102935413(HSD17B10)
CCAY125628021(HSD17B10)
DCC119847007(HSD17B10)
CPIC101946623(HSD17B10)
CABI116818886(HSD17B10)
MRV120388542(HSD17B10)
ACS100566347(hsd17b10)
ASAO132767863(HSD17B10)
PVT110089193(HSD17B10)
SUND121922707(HSD17B10)
PBI103051793(HSD17B10)
PMUR107284213(HSD17B10)
CTIG120311302(HSD17B10)
PGUT117675536(HSD17B10)
APRI131192205(HSD17B10)
PTEX113443230(HSD17B10)
NSS113417676(HSD17B10)
VKO123030114(HSD17B10)
PMUA114588150(HSD17B10)
PRAF128404927(HSD17B10) 128406171
ZVI118097678(HSD17B10)
HCG128344203(HSD17B10)
GJA107117365(HSD17B10)
EMC129346280(HSD17B10)
XLA108699982(hsd17b10.S) 446903(hsd17b10.L)
XTR549265(hsd17b10)
NPR108797529(HSD17B10)
RTEM120913022(HSD17B10)
BBUF121009152(HSD17B10)
BGAR122946398(HSD17B10)
MUO115463597(HSD17B10)
GSH117349060(HSD17B10)
DRE450078(hsd17b10)
SRX107737644 107741341
SANH107656989 107672063(hsd17b10)
SGH107560905 107562460
CAUA113069104(hsd17b10) 113094765
CGIB127944159 128011065
PTET122329266(hsd17b10)
LROH127155270(hsd17b10)
OMC131532057(hsd17b10)
PPRM120463755(hsd17b10)
RKG130081712(hsd17b10)
MAMB125260492(hsd17b10)
CIDE127505258
CERY137009352(hsd17b10)
MASI127419442 127420442
TROS130544981(hsd17b10)
TDW130409300(hsd17b10)
MANU129431225(hsd17b10)
IPU100528090(hsd17b10)
IFU128619628(hsd17b10)
PHYP113530295(hsd17b10)
SMEO124398597(hsd17b10)
TFD113642024(hsd17b10)
TVC132862612(hsd17b10)
TRN134333511(hsd17b10)
AMEX103024621(hsd17b10)
CMAO118822580(hsd17b10)
EEE113575440(hsd17b10)
CHAR105894129(hsd17b10)
TFS130529577(hsd17b10)
TNGGSTEN00023338G001
LCO104928358(hsd17b10)
TBEN117483467(hsd17b10) 117483479 117483535
CGOB115011423(hsd17b10)
PGEO117449563(hsd17b10)
GACU117562352(hsd17b10)
EMAC134871417(hsd17b10)
ELY117258246(hsd17b10)
EFO125891170(hsd17b10)
PLEP121947111(hsd17b10)
SLUC116059325(hsd17b10)
ECRA117948109(hsd17b10)
ESP116692997(hsd17b10)
PFLV114559071(hsd17b10)
GAT120829460(hsd17b10)
PPUG119223392(hsd17b10)
AFB129100181(hsd17b10)
CLUM117733173(hsd17b10) 117733856
PSWI130199841(hsd17b10)
MSAM119905089(hsd17b10)
SCHU122882575(hsd17b10)
CUD121517639(hsd17b10)
ALAT119022692(hsd17b10)
MZE101486814(hsd17b10)
ONL100708936(hsd17b10)
OAU116309184(hsd17b10)
OLA101170516(hsd17b10)
OML112159416(hsd17b10)
CSAI133456220(hsd17b10)
XMA102219644(hsd17b10) 111608152
XCO114141158(hsd17b10)
XHE116717817(hsd17b10) 116717849 116720286
PRET103467892(hsd17b10)
PFOR103130892(hsd17b10)
PLAI106960803(hsd17b10)
PMEI106932965(hsd17b10)
GAF122835328(hsd17b10)
PPRL129377107(hsd17b10)
CVG107088734(hsd17b10)
CTUL119799317(hsd17b10)
GMU124877059(hsd17b10)
NFU107390369(hsd17b10)
KMR108230534(hsd17b10)
ALIM106511017(hsd17b10)
NWH119416676(hsd17b10)
MCEP125023683(hsd17b10)
CSEM103385214(hsd17b10)
POV109646243(hsd17b10)
SSEN122761722(hsd17b10)
HHIP117765000(hsd17b10)
HSP118111521(hsd17b10)
PPLT128441855(hsd17b10)
SMAU118316978(hsd17b10)
LCF108875474
SDU111235061(hsd17b10)
SLAL111644152(hsd17b10)
XGL120803441(hsd17b10)
HCQ109523116(hsd17b10)
SSCV125989420
SBIA133505115(hsd17b10)
PEE133396423(hsd17b10)
PTAO133477268(hsd17b10)
BPEC110175804(hsd17b10)
MALB109951871(hsd17b10)
BSPL114859022(hsd17b10)
SJO128357055(hsd17b10)
SASA100196585(hsd17b10)
STRU115168753(hsd17b10)
OTW112221480(hsd17b10)
OMY110492729(hsd17b10)
OGO124045434(hsd17b10)
ONE115126100
OKI109885832(hsd17b10)
OKE118360242
SALP112075320(hsd17b10)
SNH120037698(hsd17b10)
CCLU121546823(hsd17b10)
ELS105013512(hsd17b10)
SFM108918316(hsd17b10)
PKI111857098(hsd17b10)
AANG118207783(hsd17b10)
PSPA121305366(hsd17b10)
PSEX120542716(hsd17b10)
LCM102359593(HSD17B10)
RTP109920085(hsd17b10)
CPLA122542360(hsd17b10)
HOC132809036(hsd17b10)
PMRN116952231(HSD17B10)
LRJ133355481 133355602
BFO118415771
BBEL109477394
CIN100180343
SCLV120327902 120331757
SPU579135
LPIC129257317 129257335
APLC110974895
ARUN117302867
AJC117115542
SKO100374978
DMEDmel_CG7113(scu)
DER6550269
DSE6614820
DSIDsimw501_GD17383(Dsim_GD17383)
DYADyak_GE17707
DAN6502128
DSR110184295
DPO4814601
DPE6599292
DMN108156573
DWI6648649
DGR6565878
DMODmoj_GI14682
DAZ108619639
DNV108657245
DHE111602401
DVI6633483
CCAT101454723
BOD106615670
BDR105227468
RZE108371357 108376016
AOQ129238945
TDA119670822
MDE101893864
SCAC106081076
LCQ111678909
LSQ119606776
GFS119638479
ECOE129947661
CLON129613368
HIS119646612
AGA1272787
ACOZ120949516
AARA120897970
AMER121591078
ASTE118506790
AFUN125775105
AMOU128299231
AALI118457824
AAG5571801 5571804
AALB109427471 109427473 109427541 115253538 115253659 115269370
ASUA134207157 134213392
CQUCpipJ_CPIJ014285 CpipJ_CPIJ014286
CPII120420167 120420202
CNS116340896 116341640 116347922 116347923 116348465 116348677 116352597
BCOO119077639 119083641
AME725274 726590
ALAB122710550 122711460
ADR102670881 102673042
AFLR100867464 100871693
BIM100744954 100745932
BBIF117206297 117207552 117207654
BVK117233088 117236101
BVAN117153343 117156912
BTER100642257 100652075 100652169
BAFF126917491 126917492 126917494 126922587
BPYO122569073 122569811 122572480 122572547
BPAS132907124 132916712
FVI122535016 122535905
CCAL108632372
OBB114872622 114881413
OLG117607659 117609087
MGEN117223643 117223858
NMEA116425158 116425159 116425336
CGIG122395028 122399651
SOC105205705 120356835
MPHA105840130
AEC105144619 105147099
ACEP105623752 105623755
PBAR105431577
VEM105565701
HST105184127
DQU106748723
CFO105248305
FEX115245137
LHU105674362(scu)
PGC109854144
OBO105283150
PCF106789194 106791582
PFUC122524227 122525451 122525452
VPS122634700 122634701
VCRB124430227 124430228
VVE124954848 124954849
NVI100114736
CSOL105363298
TPRE106653412 106653557
LHT122499182
LBD127281908
MDL103575367 103575716
CGLO123267606 123270676
FAS105264291
DAM107042858 107047511 107047998
AGIF122853371 122855531 122855533 122856582
CINS118071768 118073789
VCAN122406472 122417374
CCIN107263357
DSM124404017
NPT124211958
NFB124174619
NLO107224820
NVG124297908
AROA105689327
TCA660648
DPA109539142 109542618 109543344 109546870
SOY115885943 115885955 115888479
AGRG126735339 126739758 126743681
ATD109596271
CSET123312088 123321083
AGB108916550
LDC111508946
DVV126890896
NVL108566047
DCOR135793403(scu)
APLN108742099
PPYR116180131
OTU111425860
BMOR101744555 732961
BMAN114239449 114246883
MSEX115440509 115442905
DPLKGM_206141 KGM_207362
BANY112048026 112053858
MJU123876904 123880125
NIQ126776519 126780464
VCD124538772 124543010
MCIX123664193 123668706
PMAC106719897 106721132
PPOT106103284 106104281
PXU106113640 106116574
PRAP110993036 111000559
PBX123710398 123718779
PNAP125053857 125062863
ZCE119828938 119835635
CCRC123700762 123705454
LSIN126975470 126978561
AAGE121735759 121738572
HAW110371359 110373884
HZE124640969 124645237
TNL113494026 113499310 113499443
SLIU111348796 111360581
OFU114354109 114357052
ATRA106133934 106134451
GMW113518793 113520360
PXY105381601 105382604
PGW126379862 126380374
LGLY125230288 125241063
CFEL113381984 113382094 113382095
CCRN123294859
API100164493
DNX107170240
AGS114131679
RMD113550064
ACOO126834724
DVT126906157
BTAB109040424
DCI103511570
CLEC106672202
HHAL106685955(scu)
NLU111049763
HVI124359640
PHUPhum_PHUM489260
FOC113210867 113214822
TPAL117650272 117651916
ZNE110836005
CSEC111867521
SGRE126339020 126339036
BROR134534165
IEL124162942
FCD110856173
DPXDAPPUDRAFT_299789
DMK116919773
DPZ124341893
PVM113800367
PJA122266448
PCHN125039767
PMOO119586202
HAME121875227 121875315
PCLA123757213
CQD128697141 128697161
PTRU123503647
ESN126988545
MNZ135200777
HAZT108672063
EAF111700268
LSM121119093
TCF131884743
PPOI119089544
ISC8051190
DSV119461856
RSAN119395709
RMP119174103
VDE111246771
VJA111261356
TUT107360644
DPTE113791783 113798578
DFR124490400 124498538 124499261
CSCU111628029 111640538
CVS136980625 136982669(scu)
PTEP107443400 107443407 107444042 107444043
ABRU129963812 129964069 129964070
UDV129217412 129217414 129217417
SDM118183746 118187370 118193954 118193955 118193956
LPOL106462667
PMEO129583335 129583377 129584270 129584271 129586187 129589768 129589791 129589810 129589832 129592188 129598566
CELCELE_F01G4.2(ard-1)
CBRCBG_06017(Cbr-ard-1)
CRQGCK72_014065 GCK72_014228
NAINECAME_03624
BMYBM_BM3137(Bma-ard-1.1) BM_BM3231(Bma-ard-1.2)
LOALOAG_02590 LOAG_02591
HROHELRODRAFT_62336
LGILOTGIDRAFT_130767 LOTGIDRAFT_130874
PVUL126828734
PCAN112572112
BGT106056571
GAE121367959
HRF124136333
HRJ124253271
CRG105337727 105349048 117682061
CANU128157694 128159502 128161110
CVN111106365 111108694 111109578 111109751
OED125655895 125656946
MYI110451007
PMAX117330948
MCAF127700854
MMER123529183
RPHI132755698
DPOL127869198
MAEA128217246 128228617
OBI106870550
OSN115209392
LJP135471157
LAK106166979
SMMSmp_151030
SHXMS3_00007148
OVIT265_14188
EGLEGR_00218
LLON135491141
NVE5516466 5516467
EPA110234807 110234808
ATEN116304314 116304315
AMIL114960870
PDAM113677917
SPIS111326563 111327200
DGT114530007
XEN124447390
HMG100210676
HSY130654996
RES135686412
TADTRIADDRAFT_22420 TRIADDRAFT_51183
AQU100642054
SSLSS1G_12339
BFUBCIN_05g06820
MBEMBM_06971
PSCOLY89DRAFT_690741
GLZGLAREA_10926
HIRHETIRDRAFT_410926
PSQPUNSTDRAFT_54939
GTRGLOTRDRAFT_128483
ABPAGABI1DRAFT119037(AGABI1DRAFT_119037)
MRRMoror_1115 Moror_1116
WSEWALSEDRAFT_66965 WALSEDRAFT_66966
MBRMONBRDRAFT_35161
SREPTSG_09481
TETTTHERM_00085280 TTHERM_00085290 TTHERM_00085300 TTHERM_00085310
FCYFRACYDRAFT_229426
TPSTHAPS_263178(HCD1)
PIFPITG_05542
PSOJPHYSODRAFT_284787
BLAC94348758(CCR75_005002)
SPARSPRG_04958
MLQASQ50_13255
AMAAamad1_20275
AMADI636_19425
AMAII635_20265
AMAGI533_19160
ALNAS19_06730
ADIB5T_03344
AXEP40_15700
APACS7S_05705
GPBHDN1F_11030(hadH2)
VIGBKP57_16440
VPNA21D_02478(fabG_5)
SALEEPH95_16455
SLPSlip_1987
PBROHOP40_05980
 » show all
Reference
1  [PMID:4150713]
  Authors
Conrad RS, Massey LK, Sokatch JR.
  Title
D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida.
  Journal
J Bacteriol 118:103-11 (1974)
DOI:10.1128/JB.118.1.103-111.1974
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.178
IUBMB Enzyme Nomenclature: 1.1.1.178
ExPASy - ENZYME nomenclature database: 1.1.1.178
BRENDA, the Enzyme Database: 1.1.1.178
CAS: 52227-66-4
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