Entry
Name
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:
R04203 ]
Reaction(KEGG)
Substrate
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:
C04405 ];
NAD+ [CPD:
C00003 ]
Product
Comment
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
History
EC 1.1.1.178 created 1981
Pathway
ec00280 Valine, leucine and isoleucine degradation
ec01110 Biosynthesis of secondary metabolites
Orthology
K08683 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Genes
PPYG : 129024985(HSD17B10)
SSYN : 129476088(HSD17B10)
CSAB : 103232017(HSD17B10)
CATY : 105576369(HSD17B10)
PANU : 101012016(HSD17B10)
MLEU : 105532263(HSD17B10)
TFN : 117078288(HSD17B10) 117091873
PTEH : 111531744(HSD17B10)
CANG : 105514907(HSD17B10)
CIMI : 108295447(HSD17B10)
ANAN : 105734476(HSD17B10)
CSYR : 103253700(HSD17B10)
LCAT : 123628032(HSD17B10) 123635438
PCOQ : 105823442(HSD17B10)
MCAL : 110286767(Hsd17b10)
MPAH : 110313838(Hsd17b10)
MCOC : 116089853(Hsd17b10)
MAUA : 101837486(Hsd17b10)
PROB : 127217690(Hsd17b10) 127231134
PLEU : 114683399 114702840(Hsd17b10)
MORG : 121443092 121445568(Hsd17b10)
AAMP : 119804867(Hsd17b10) 119819446
CPOC : 100718814(Hsd17b10)
CCAN : 109702046(Hsd17b10)
DORD : 106000637(Hsd17b10)
PLOP : 125344092(Hsd17b10)
MMMA : 107159874(Hsd17b10)
CLUD : 112673073(HSD17B10)
MPUF : 101693030(HSD17B10)
NVS : 122894392 122896272(HSD17B10) 122916941
PCOO : 112870930(HSD17B10)
PVIV : 125157292(HSD17B10)
PPAD : 109260276(HSD17B10)
BBUB : 102403269(HSD17B10)
BBIS : 105000965(HSD17B10)
BTAX : 128070049(HSD17B10)
ODA : 120851531 120854550 120860174 120882164(HSD17B10)
CCAD : 122434299(HSD17B10)
MBEZ : 129564227(HSD17B10)
CFR : 102504376(HSD17B10) 102511542
CBAI : 105081500(HSD17B10)
BACU : 103010500(HSD17B10)
BMUS : 118889266(HSD17B10)
PCAD : 102982939(HSD17B10)
PSIU : 116747313(HSD17B10)
NASI : 112408416(HSD17B10)
MMYO : 118653717(HSD17B10) 118659315
MDT : 132224076(HSD17B10) 132226464
PKL : 118706130 118706176 118714042(HSD17B10)
EFUS : 103294936 103301347(HSD17B10)
SHON : 118978337(HSD17B10)
PDIC : 114505044(HSD17B10)
PHAS : 123814830(HSD17B10)
PPAM : 129064545(HSD17B10) 129075737
PALE : 102882756(HSD17B10)
PGIG : 120593567(HSD17B10)
SARA : 101554831(HSD17B10)
SETR : 125999256(HSD17B10)
ETF : 101643918 101654022(HSD17B10)
DNM : 101437023 101443695(HSD17B10)
PCOC : 116240178(HSD17B10)
NMEL : 110391433(HSD17B10)
ACYG : 136787508(HSD17B10)
PMOA : 120503076(HSD17B10)
PRUF : 121362366(HSD17B10)
PMAJ : 107199346(HSD17B10)
CBRC : 103617130(HSD17B10)
MMEA : 130586734(HSD17B10)
SHAB : 115603483(HSD17B10)
ACHC : 115338221(HSD17B10)
PGUU : 104460485(HSD17B10)
CUCA : 104067759(HSD17B10)
AROW : 112972653(HSD17B10)
CCAY : 125628021(HSD17B10)
CPIC : 101946623(HSD17B10)
CABI : 116818886(HSD17B10)
ASAO : 132767863(HSD17B10)
SUND : 121922707(HSD17B10)
PMUR : 107284213(HSD17B10)
CTIG : 120311302(HSD17B10)
PGUT : 117675536(HSD17B10)
APRI : 131192205(HSD17B10)
PTEX : 113443230(HSD17B10)
PMUA : 114588150(HSD17B10)
PRAF : 128404927(HSD17B10) 128406171
XLA : 108699982(hsd17b10.S) 446903(hsd17b10.L)
RTEM : 120913022(HSD17B10)
BBUF : 121009152(HSD17B10)
BGAR : 122946398(HSD17B10)
SANH : 107656989 107672063(hsd17b10)
CAUA : 113069104(hsd17b10) 113094765
CGIB : 127944159 128011065
PTET : 122329266(hsd17b10)
LROH : 127155270(hsd17b10)
PPRM : 120463755(hsd17b10)
MAMB : 125260492(hsd17b10)
CERY : 137009352(hsd17b10)
MASI : 127419442 127420442
TROS : 130544981(hsd17b10)
MANU : 129431225(hsd17b10)
PHYP : 113530295(hsd17b10)
SMEO : 124398597(hsd17b10)
AMEX : 103024621(hsd17b10)
CMAO : 118822580(hsd17b10)
CHAR : 105894129(hsd17b10)
TBEN : 117483467(hsd17b10) 117483479 117483535
CGOB : 115011423(hsd17b10)
PGEO : 117449563(hsd17b10)
GACU : 117562352(hsd17b10)
EMAC : 134871417(hsd17b10)
PLEP : 121947111(hsd17b10)
SLUC : 116059325(hsd17b10)
ECRA : 117948109(hsd17b10)
PFLV : 114559071(hsd17b10)
PPUG : 119223392(hsd17b10)
CLUM : 117733173(hsd17b10) 117733856
PSWI : 130199841(hsd17b10)
MSAM : 119905089(hsd17b10)
SCHU : 122882575(hsd17b10)
ALAT : 119022692(hsd17b10)
CSAI : 133456220(hsd17b10)
XMA : 102219644(hsd17b10) 111608152
XHE : 116717817(hsd17b10) 116717849 116720286
PRET : 103467892(hsd17b10)
PFOR : 103130892(hsd17b10)
PLAI : 106960803(hsd17b10)
PMEI : 106932965(hsd17b10)
PPRL : 129377107(hsd17b10)
CTUL : 119799317(hsd17b10)
ALIM : 106511017(hsd17b10)
MCEP : 125023683(hsd17b10)
CSEM : 103385214(hsd17b10)
SSEN : 122761722(hsd17b10)
HHIP : 117765000(hsd17b10)
PPLT : 128441855(hsd17b10)
SMAU : 118316978(hsd17b10)
SLAL : 111644152(hsd17b10)
SBIA : 133505115(hsd17b10)
PTAO : 133477268(hsd17b10)
BPEC : 110175804(hsd17b10)
MALB : 109951871(hsd17b10)
BSPL : 114859022(hsd17b10)
SASA : 100196585(hsd17b10)
STRU : 115168753(hsd17b10)
SALP : 112075320(hsd17b10)
CCLU : 121546823(hsd17b10)
AANG : 118207783(hsd17b10)
PSPA : 121305366(hsd17b10)
PSEX : 120542716(hsd17b10)
CPLA : 122542360(hsd17b10)
PMRN : 116952231(HSD17B10)
SCLV : 120327902 120331757
LPIC : 129257317 129257335
DSI : Dsimw501_GD17383(Dsim_GD17383)
AALB : 109427471 109427473 109427541 115253538 115253659 115269370
ASUA : 134207157 134213392
CQU : CpipJ_CPIJ014285 CpipJ_CPIJ014286
CPII : 120420167 120420202
CNS : 116340896 116341640 116347922 116347923 116348465 116348677 116352597
BCOO : 119077639 119083641
ALAB : 122710550 122711460
AFLR : 100867464 100871693
BBIF : 117206297 117207552 117207654
BVAN : 117153343 117156912
BTER : 100642257 100652075 100652169
BAFF : 126917491 126917492 126917494 126922587
BPYO : 122569073 122569811 122572480 122572547
BPAS : 132907124 132916712
MGEN : 117223643 117223858
NMEA : 116425158 116425159 116425336
CGIG : 122395028 122399651
ACEP : 105623752 105623755
PFUC : 122524227 122525451 122525452
VCRB : 124430227 124430228
TPRE : 106653412 106653557
CGLO : 123267606 123270676
DAM : 107042858 107047511 107047998
AGIF : 122853371 122855531 122855533 122856582
CINS : 118071768 118073789
VCAN : 122406472 122417374
DPA : 109539142 109542618 109543344 109546870
SOY : 115885943 115885955 115888479
AGRG : 126735339 126739758 126743681
CSET : 123312088 123321083
BMAN : 114239449 114246883
MSEX : 115440509 115442905
DPL : KGM_206141 KGM_207362
BANY : 112048026 112053858
MCIX : 123664193 123668706
PMAC : 106719897 106721132
PPOT : 106103284 106104281
PRAP : 110993036 111000559
PNAP : 125053857 125062863
CCRC : 123700762 123705454
LSIN : 126975470 126978561
AAGE : 121735759 121738572
TNL : 113494026 113499310 113499443
SLIU : 111348796 111360581
ATRA : 106133934 106134451
LGLY : 125230288 125241063
CFEL : 113381984 113382094 113382095
TPAL : 117650272 117651916
SGRE : 126339020 126339036
HAME : 121875227 121875315
DPTE : 113791783 113798578
DFR : 124490400 124498538 124499261
CSCU : 111628029 111640538
CVS : 136980625 136982669(scu)
PTEP : 107443400 107443407 107444042 107444043
ABRU : 129963812 129964069 129964070
UDV : 129217412 129217414 129217417
SDM : 118183746 118187370 118193954 118193955 118193956
PMEO : 129583335 129583377 129584270 129584271 129586187 129589768 129589791 129589810 129589832 129592188 129598566
CBR : CBG_06017(Cbr-ard-1)
CRQ : GCK72_014065 GCK72_014228
BMY : BM_BM3137(Bma-ard-1.1) BM_BM3231(Bma-ard-1.2)
LOA : LOAG_02590 LOAG_02591
LGI : LOTGIDRAFT_130767 LOTGIDRAFT_130874
CRG : 105337727 105349048 117682061
CANU : 128157694 128159502 128161110
CVN : 111106365 111108694 111109578 111109751
MAEA : 128217246 128228617
ATEN : 116304314 116304315
SPIS : 111326563 111327200
TAD : TRIADDRAFT_22420 TRIADDRAFT_51183
ABP : AGABI1DRAFT119037(AGABI1DRAFT_119037)
MRR : Moror_1115 Moror_1116
WSE : WALSEDRAFT_66965 WALSEDRAFT_66966
TET : TTHERM_00085280 TTHERM_00085290 TTHERM_00085300 TTHERM_00085310
BLAC : 94348758(CCR75_005002)
» show all
Taxonomy
Reference
Authors
Conrad RS, Massey LK, Sokatch JR.
Title
D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.178
LinkDB
All DBs