KEGG   REACTION: R04203
Entry
R04203                      Reaction                               
Name
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Definition
(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
Equation
C04405 + C00003 <=> C03344 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00525  C03344_C04405
Enzyme
1.1.1.35        1.1.1.178
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
    1.1.1.178
     R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylacetoacetyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
Other DBs
RHEA: 13284
LinkDB

DBGET integrated database retrieval system