KEGG   ENZYME: 1.1.1.181
Entry
EC 1.1.1.181                Enzyme                                 
Name
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase;
3beta-hydroxy-Delta5-C27-steroid oxidoreductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase
Reaction(IUBMB)
cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+ [RN:R04263]
Reaction(KEGG)
R04263 > R08721 R08723 R08724 R08728;
(other) R04264
Substrate
cholest-5-ene-3beta,7alpha-diol [CPD:C03594];
NAD+ [CPD:C00003]
Product
7alpha-hydroxycholest-4-en-3-one [CPD:C05455];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Highly specific for 3beta,7alpha-dihydroxy-C27-steroids with Delta5-double bond.
History
EC 1.1.1.181 created 1983
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K12408  cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
Genes
HSA80270(HSD3B7)
PTR454059(HSD3B7)
PPS100986476(HSD3B7)
GGO101148659(HSD3B7)
PON100460204(HSD3B7)
NLE105739386(HSD3B7)
MCC714136(HSD3B7)
MCF102133533(HSD3B7)
CSAB103231160(HSD3B7)
CATY105599353(HSD3B7)
PANU101021257(HSD3B7)
TGE112614268(HSD3B7)
RRO104661560(HSD3B7)
RBB108530070(HSD3B7)
TFN117087679(HSD3B7)
PTEH111525721(HSD3B7)
CJC100385140(HSD3B7)
SBQ101043229(HSD3B7)
CSYR103264404(HSD3B7)
MMUR105871052(HSD3B7)
LCAT123632704(HSD3B7)
OGA100946229(HSD3B7)
MMU101502(Hsd3b7)
MCAL110297828(Hsd3b7)
MPAH110330448(Hsd3b7)
RNO246211(Hsd3b7)
MCOC116103032(Hsd3b7)
MUN110559773 110559776
CGE100754260(Hsd3b7)
MAUA101825788(Hsd3b7)
PLEU114704388(Hsd3b7)
MORG121457535(Hsd3b7)
AAMP119823498(Hsd3b7)
NGI103726335(Hsd3b7)
HGL101708818(Hsd3b7)
CPOC100716211(Hsd3b7)
CCAN109682434(Hsd3b7)
DORD105982011(Hsd3b7)
DSP122096312(Hsd3b7)
NCAR124970052
OCU100353878(HSD3B7)
OPI101519930(HSD3B7)
TUP102492683(HSD3B7)
CFA489917(HSD3B7)
VVP112929257(HSD3B7)
VLG121487213(HSD3B7)
AML100482450(HSD3B7)
UMR103657879(HSD3B7)
UAH113267710(HSD3B7)
UAR123784668(HSD3B7)
ELK111162271
LLV125091092
MPUF101679450(HSD3B7)
ORO101377282(HSD3B7)
EJU114214457(HSD3B7)
ZCA113933095(HSD3B7)
MLX117999574(HSD3B7)
FCA101090824(HSD3B7)
PYU121022171(HSD3B7)
PBG122471426(HSD3B7)
PTG102962469(HSD3B7)
PPAD109259009(HSD3B7)
AJU106979112(HSD3B7)
HHV120242217(HSD3B7)
BTA540229(HSD3B7)
BOM102274613(HSD3B7)
BIU109578512(HSD3B7)
BBUB102400601(HSD3B7)
CHX102170750(HSD3B7)
OAS101105716(HSD3B7)
ODA120877566(HSD3B7)
CCAD122432973(HSD3B7)
SSC100525281(HSD3B7)
CFR102516280(HSD3B7)
CBAI105082785(HSD3B7)
CDK105102720(HSD3B7)
VPC102546134(HSD3B7)
BACU102999563(HSD3B7)
LVE103079291(HSD3B7)
OOR101283577(HSD3B7)
DLE111182125(HSD3B7)
PCAD102980635(HSD3B7)
PSIU116740100(HSD3B7)
ECB100063491(HSD3B7)
EPZ103547271(HSD3B7)
EAI106831895(HSD3B7)
MYB102253555(HSD3B7)
MYD102773587(HSD3B7)
MMYO118656656(HSD3B7)
MLF102442201(HSD3B7)
MNA107540817(HSD3B7)
PKL118704851(HSD3B7)
HAI109374191(HSD3B7)
DRO112304886(HSD3B7)
AJM119041140(HSD3B7)
PDIC114496623(HSD3B7)
PHAS123825535(HSD3B7)
MMF118642750(HSD3B7)
RFQ117019890(HSD3B7)
PALE102884924(HSD3B7)
PGIG120620064(HSD3B7)
PVP105304516(HSD3B7)
RAY107503987(HSD3B7)
MJV108385489(HSD3B7)
TOD119241717(HSD3B7)
SARA101548248(HSD3B7)
LAV100660226(HSD3B7)
TMU101357159
DNM111760808(HSD3B7)
MDO100018964(HSD3B7)
GAS123233539(HSD3B7)
SHR100929800(HSD3B7)
PCW110223144(HSD3B7)
OAA100086824(HSD3B7)
GGA417505(HSD3B7)
PCOC116228166(HSD3B7)
MGP100542495 104917028
CJO107322719
NMEL110391731 110407811
APLA101794290
ACYG106041408
AFUL116497401
TGU115497474(HSD3B7)
LSR110480029 110484390(HSD3B7)
SCAN103820251(HSD3B7)
PMOA120507755
OTC121344781 121345888
PRUF121361860
GFR102044144
FAB101816782(HSD3B7)
PHI102108187
CCW104691231
ETL114056717
ZAB102073947(HSD3B7)
FPG101910304
CLV102094713(HSD3B7)
EGZ104131788
NNI104016146(HSD3B7)
PLET104625408
ACUN113487249
TALA104357633
PADL103912915
AAM106497335
AROW112964983
DNE112987319
ASN102370034(HSD3B7) 106722879
AMJ102574351(HSD3B7) 106737280 109282929
CPOO109317014(HSD3B7)
GGN109293492(HSD3B7)
PSS102456594 102460382(HSD3B7)
CMY102936770(HSD3B7)
CPIC101936626(HSD3B7) 101940872
TST117867713(HSD3B7)
CABI116815503(HSD3B7) 116825890
MRV120387391 120404364(HSD3B7)
ACS100555869(hsd3b7)
PVT110086394(HSD3B7)
SUND121933324(HSD3B7)
PBI103058949(HSD3B7)
PMUR107292629(HSD3B7) 107299717
TSR106551431(HSD3B7)
PGUT117666834(HSD3B7)
VKO123019578(HSD3B7)
PMUA114582844(HSD3B7)
ZVI118094494(HSD3B7)
GJA107106647(HSD3B7)
STOW125444560(HSD3B7)
XLA108707682(XB986526.L) 431878(hsd3b7.L) 444015(hsd3b7.S)
XTR100145626(hsd3b7) 100494546
NPR108799016(HSD3B7) 108801722
RTEM120927622 120927623 120943009(HSD3B7)
BBUF120994736 121008362(HSD3B7)
BGAR122922779 122944985(HSD3B7)
DRE327462(hsd3b7)
SRX107729456 107737759
SANH107658501 107689649
SGH107554123 107582995
CCAR109054761 109062276
CAUA113045547 113047170
PPRM120489365(hsd3b7)
MAMB125277596(hsd3b7)
IPU108280431(hsd3b7)
PHYP113528615(hsd3b7)
SMEO124396624(hsd3b7)
TFD113663313(hsd3b7)
AMEX103040338(hsd3b7)
EEE113580883(hsd3b7)
TRU101071654(hsd3b7)
TNGGSTEN00027807G001
LCO104930228(hsd3b7)
NCC104943711(hsd3b7)
CGOB115012252(hsd3b7)
ELY117267829(hsd3b7)
PLEP121957203(hsd3b7)
SLUC116063863(hsd3b7)
ECRA117958586(hsd3b7)
PFLV114570398(hsd3b7)
GAT120827550(hsd3b7)
PPUG119220852(hsd3b7)
MSAM119893648(hsd3b7)
CUD121503546(hsd3b7)
ALAT119014449(hsd3b7)
MZE101470315 112434760
ONL100534450(hsd3b7)
OAU116328746(hsd3b7)
OLA101172816 105356506
OML112146871(hsd3b7)
XMA102234415(hsd3b7)
XCO114160223(hsd3b7)
XHE116735972(hsd3b7)
PRET103468932(hsd3b7)
PFOR103133119(hsd3b7) 103145017
PLAI106961105(hsd3b7)
PMEI106910445 106910446
GAF122821674(hsd3b7)
CVG107084829(hsd3b7)
CTUL119783323(hsd3b7)
GMU124863582 124863676
NFU107378516(hsd3b7)
KMR108237684(hsd3b7)
ALIM106529541(hsd3b7)
NWH119421346(hsd3b7)
AOCE111588900(hsd3b7)
CSEM103392669(hsd3b7)
POV109634345(hsd3b7)
SSEN122769725(hsd3b7)
HHIP117766843(hsd3b7)
HSP118123877(hsd3b7)
LCF108880630(hsd3b7)
SDU111217691(hsd3b7)
SLAL111660593(hsd3b7)
XGL120786651(hsd3b7)
HCQ109509468 109531629(hsd3b7)
BPEC110167779 110173349
MALB109963199(hsd3b7)
BSPL114860955(hsd3b7)
SASA106601563 106601564(hsd3b7)
OTW112258965(hsd3b7) 112259032
OMY110486682(hsd3b7) 110538636
OGO123999794 124015305(hsd3b7)
ONE115110771 115110772
SALP111981354 111981355
SNH120034511 120040521
ELS105012969(hsd3b7)
SFM108919183(hsd3b7) 108922563
PKI111833123(hsd3b7) 111854084
AANG118216705 118221781
LOC102689987(hsd3b7) 102690188
PSPA121305159(hsd3b7)
ARUT117398296(hsd3b7)
LCM102350807(HSD3B7) 102356171
BFO118404685 118427027 118427492 118427590 118428002
BBEL109464333 109465785 109476736
SKO100377099
ISCIscW_ISCW007164 IscW_ISCW007167
RSAN119391546
TSPTsp_09898
PCAN112562244
BGT106059220
HRF124140222 124140223 124140224
HRJ124260824
CRG117687540
MMER123534051
LAK106170818
SPIS111322118
VCNVOLCADRAFT_86632
SREPTSG_08303
 » show all
Reference
1  [PMID:6937465]
  Authors
Wikvall K.
  Title
Purification and properties of a 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase from rabbit liver microsomes.
  Journal
J Biol Chem 256:3376-80 (1981)
Reference
2  [PMID:11067870]
  Authors
Schwarz M, Wright AC, Davis DL, Nazer H, Bjorkhem I, Russell DW
  Title
The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.
  Journal
J Clin Invest 106:1175-84 (2000)
DOI:10.1172/JCI10902
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.181
IUBMB Enzyme Nomenclature: 1.1.1.181
ExPASy - ENZYME nomenclature database: 1.1.1.181
BRENDA, the Enzyme Database: 1.1.1.181
CAS: 56626-16-5
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