Entry
Name
long-chain-3-hydroxyacyl-CoA dehydrogenase;
beta-hydroxyacyl-CoA dehydrogenase;
long-chain 3-hydroxyacyl coenzyme A dehydrogenase;
3-hydroxyacyl-CoA dehydrogenase;
LCHAD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
a long-chain (S)-3-hydroxyacyl-CoA + NAD+ = a long-chain 3-oxoacyl-CoA + NADH + H+ [RN:
R01778 ]
Reaction(KEGG)
Substrate
long-chain (S)-3-hydroxyacyl-CoA;
NAD+ [CPD:
C00003 ]
Product
long-chain 3-oxoacyl-CoA;
NADH [CPD:
C00004 ];
H+ [CPD:
C00080 ]
Comment
This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).
History
EC 1.1.1.211 created 1986
Pathway
Orthology
K07515 enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
K10527 enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
Genes
PPS : 100973698 100978217(HADHA)
NLE : 100593214 100593233(HADHA)
HMH : 116461684 116480441(HADHA)
SSYN : 129467997(HADHA) 129483408
ANAN : 105706957(HADHA) 105709061
OGA : 100956476(HADHA) 100959271
MORG : 121439589 121439637
TUP : 102471941(HADHA) 102478660
PBRV : 138149109(HADHA) 138151200
ACYG : 106048383 136790573
PMUR : 107291031(HADHA) 107300505
XLA : 108717268(hadha.L) 444044(hadha.S)
DRE : 553401(hadhaa) 793834(hadhab)
SRX : 107721447 107741851 107752738
SANH : 107666258 107679805 107691000 107697212
SGH : 107550361 107593272 107594700 107600864
CCAR : 109061322 109113061 109113066
CAUA : 113060497 113075076 113117304
CGIB : 127933597 127938398 127976195
PTET : 122324594(hadhaa) 122362014(hadhab)
LROH : 127179432(hadhab) 127182941(hadhaa)
OMC : 131523450(hadhab) 131526914(hadhaa)
PPRM : 120460162(hadhaa) 120476495(hadhab)
RKG : 130080259(hadhab) 130103211(hadhaa)
MAMB : 125269353(hadhab) 125278517(hadhaa)
CIDE : 127498262 127502128
CERY : 137006404(hadhab) 137018605(hadhaa)
MASI : 127416366 127455035
TROS : 130560178(hadhab) 130566310(hadhaa)
TDW : 130434668(hadhaa) 130437285(hadhab)
MANU : 129417841(hadhab) 129429768(hadhaa)
IPU : 100304971(hadhab) 108257474(hadhaa)
IFU : 128612244(hadhab) 128618654(hadhaa)
PHYP : 113529090 113538951
TFD : 113658631(hadhaa) 113659508(hadhab)
TVC : 132852655(hadhab) 132855051(hadhaa)
TRN : 134319837(hadhaa) 134325601(hadhab)
AMEX : 103035446(hadhab) 103046024(hadhaa)
CMAO : 118815199(hadhaa) 118824197(hadhab)
EEE : 113586544 113586545 113591046(hadha)
CHAR : 105898013(hadhab) 105907306(hadhaa)
SPIL : 134067280(hadhab) 134098518(hadhaa)
ELY : 117267492(hadhab) 117271127(hadhaa)
EFO : 125896959(hadhaa) 125901249(hadhab)
PLEP : 121953563(hadhab) 121955566(hadhaa)
SLUC : 116057562(hadhab) 116066337(hadhaa)
PFLV : 114547202 114573387
CUD : 121521089(hadhaa) 121526460(hadhab)
SPUL : 138585099(hadhaa) 138591001(hadhab)
LMIX : 132984755(hadhaa) 132992768(hadhab)
OAU : 116310316(hadhab) 116311176(hadhaa)
CTUL : 119788761 119792796
AOCE : 111569588 111589017
SBIA : 133496650(hadhaa) 133513355(hadhab)
PEE : 133413150(hadhab) 133416888(hadhaa)
PTAO : 133468555(hadhaa) 133487742(hadhab)
BPEC : 110156324 110175061
SASA : 106603767 106611334(ECHA)
STRU : 115162017 115172268
OTW : 112256902 112261537(hadhab)
OMY : 110497612(hadhab) 110505842
OGO : 124001829(hadhab) 124046680
OKE : 118362866(hadhab) 118378687
SALP : 112068050 112071018
CCLU : 121539559(hadhab) 121544655
PKI : 111851531(hadha) 111857967
PSPA : 121315588 121317462
DME : Dmel_CG4389(Mtpalpha)
DSI : Dsimw501_GD22351(Dsim_GD22351)
AALB : 109401379 109432898
BPHI : 137921904(Mtpalpha)
HHAL : 106692538(Mtpalpha)
PCLA : 123757303(Mtpalpha)
PTEP : 107437387 107437388
CEL : CELE_C29F3.1(ech-1.1) CELE_T08B2.7(ech-1.2)
DPOL : 127861852 127862733
MFOO : 137975053 137984681
ATH : AT3G06860(MFP2) AT4G29010(AIM1)
CSAT : 104717299 104721975 104728084 104730438 104744862 104764393
EUS : EUTSA_v10020152mg EUTSA_v10024533mg
BRP : 103834740 103849627 103853925 103859186 103861864 103870717
BNA : 106346097 106348746 106349686 106361183 106375554 106388929 106389027 106389792 106398246 106401486 106409243 106415581 125590726
BOE : 106295945 106303780 106304818 106312132 106327577 106335788
RSZ : 108813782 108822759 108841906 108848805 108856939 108862021 130496946 130508094
THJ : 104802693 104814713 104818910
CIC : CICLE_v10004429mg CICLE_v10007590mg
PVY : 116116793 116135578 116135612
MINC : 123200342 123206803 123211856 123221025 123221562
TCC : 18587944 18588574 18588575 18603530 18613590
GRA : 105774094 105777302 105786587 105792895 105798859
GHI : 107891859 107896697 107901248 107916181 107930826 107932835 107932954 107939487 121206665 121230435
GAB : 108456773 108469496 108484106 108486224 108489585
HSYR : 120127442 120127451 120144839 120152600 120156218 120173517 120189677 120211802
DZI : 111279702 111283515 111284788 111284789 111292937 111299112
EGR : 104415161 104428598 104436741 104439158 120286185
RARG : 115727789 115740609 115751746
GMX : 100170754 100777319 100780325 100798079 100813542
GSJ : 114368875 114393637 114394062 114418553 114420030
PVU : 137806776 137806778 137838082
VRA : 106766980 106768824 106773786
VAR : 108342169 108342180 108345899
VUN : 114175727 114175728 114182034
VUM : 124837766 124837770 124839251 124839256
CCAJ : 109800067 109807955 109809413
APRC : 113846185 113867124
MTR : 11419352 11435682 25488097
TPRA : 123882103 123883176 123883178 123883358
CAM : 101492255 101492731 101509552
PSAT : 127073182 127073286 127116760
VVO : 131595216 131631389 131631437 131636678 131637337
LJA : 130711589 130723131 130738974
ADU : 107463971 107483586 107490282
AIP : 107636178 107638698 107644391
AHF : 112703784 112723093 112741727 112751218 112796415 112802129
LANG : 109330029 109340259 109343445 109358341
PCIN : 129309106 129320051
QSA : O6P43_003578 O6P43_004013 O6P43_004015 O6P43_007910 O6P43_015519 O6P43_021768
AANS : 126784910 126790602
PMUM : 103323034 103340979
PAVI : 110750295 110771278
PDUL : 117631689 117634291
MDM : 103400486 103403739 103418149 103452890
MSYL : 126594136 126594144 126596801 126602458 126607901
PXB : 103943676 103960685 103962984
MNT : 21384821 21386066 21386067 21390618
CSAV : 115702146 115722169
CSV : 101209359 101210295 101218899
CMO : 103497841 103497849 103497860
BHJ : 120067271 120067869 120079743
MCHA : 111009683 111009902 111024216
CMAX : 111493808 111494319 111494685 111499076
CMOS : 111436752 111436753 111450378 111460069
CPEP : 111778622 111779036 111798022 111805343 111806463 111806496
MEAN : 126668007 126668924
HBR : 110631424 110633034 110636151 110661083
MESC : 110603692 110611094 110611736
POP : 18101815 7475903 7476291
PEU : 105110534 105115105 105142449
PALZ : 118032861 118036960 118051653
PNZ : 133674342 133682850 133697181
JRE : 108986842 108987297 108987298 108994835 108997856
CILL : 122300415 122300416 122304953 122308273 122318671 122318683
CAVE : 132165340 132166952 132167069 132180078
AGLU : 133857054 133880614 133880632 133880664 133880671 133880679 133880687 133880695 133880710
TWL : 119996085 120000391 120005871 120015532
SLY : 101248790 101252256 101258102 101259939 101263592
SPEN : 107007255 107007290 107023510 107026420 107027206 107027328 107028200
SOT : 102579434 102586729 102586890 102587081 102587367 102596014 102605537
SSTN : 125841791 125853782 125861844 125861910 125872449 125876862
SDUL : 129879807 129883708 129884977 129889439 129893455 129899109 129904956
CANN : 107839143 107841025 107850556 107855140 107879966
LBB : 132603400 132604518 132605583 132628753 132635645 132635647 132636798
NTA : 107766180 107770112 107781819 107786400 107794207 107797268 107798726 107805198 107824491 107825779 107828149(NtMFP) 107831676
NSY : 104217699 104220198 104221368 104235287 104248918
NTO : 104091880 104098969 104102803 104114113 104115085
NAU : 109214987 109218338 109226540 109234185 109241281
INI : 109148091 109175130 109178676 109178711 109179559 109191370
ITR : 115999262 116006198 116007123 116007124 116016572 116031040
SIND : 105156885 105162083 105165214
OEU : 111372764 111396583 111407897
EGT : 105952502 105961081 105962940 105966448
SSPL : 121747970 121751668 121769224 121771471 121798565 121804796
SMIL : 130988330 130995376 131020988
SHIS : 125187853 125192268 125203706 125208198
APAN : 127239597 127259360 127266457
HAN : 110886914 110893751 110899786 110899789 110928562 110930717
ECAD : 122595274 122599142 122599397
LSV : 111883753 111892781 111895467 111908713
CCAV : 112500142 112500143 112501883 112504620
DCR : 108199406 108199516 108202825 108203297
CSIN : 114279320 114292590 114292755
RVL : 131315057 131317647 131324521 131324929
AEW : 130756577 130764192 130772488 130785250
CQI : 110690998 110707499 110707751 110735020
ATRI : 130814976 130824610 130825926
MING : 122070826 122076058 122082607 122091877
TSS : 122656041 122658061 122671461
PSOM : 113300558 113303947 113303948 113317859 113337926 113338071 113348892
OSA : 4326503 4328997(MFP) 4337848 4338541
DOSA : Os01g0348600 Os02g0274100 Os05g0155000 Os05g0362100
OBR : 102700056 102715892 102721898
OGL : 127761428 127773505 127774116 127785171
BDI : 100826280 100827794 100842445
ATS : 109733511 109739968 109751016 109760663 109773312
TDC : 119266989 119267061 119274876 119276751 119279323 119315323 119325551 119326624 119340544 119367575
TAES : 123053285 123060164 123060238 123068651 123068742 123077174 123077243 123113610 123129514 123132309 123136357 123143868 123180564 123181767 123191683
TUA : 125514708 125515736 125528060 125530317 125542670 125542752
LPER : 127295720 127317334 127327153 127349247
LRD : 124646493 124681498 124685883 124692136 124692151 124696462 124706732 124707737
SBI : 110433383 8059103 8061917
ZMA : 100281695 100285945 103628476 103630229 103654691
MFLO : 136449960 136452145 136466989 136467006 136476157 136512412 136512435 136516534
SITA : 101757736 101758148 101774575 101777462
SVS : 117849540 117856473 117856696 117856783
PVIR : 120655368 120665743 120672320 120697632 120698970 120706866
PHAI : 112874622 112874630 112886630 112895946
PAUA : 133901050 133911825 133918778 133918779 133922291 133928754
PDA : 103696074 103703626 103715010 103721688 120106977 120107306
EGU : 105040837 105045176 105048300 105052538
MUS : 135584452 135605272 135608155 135617212
ZOF : 121967422 121973865 121977160 121977161 121989400 121998348 122025893 122043213 122047737
DCT : 110091912 110091914 110095175 110104403 110112426
PEQ : 110020962 110025557 110025559 110026758 110035965
AOF : 109824930 109831419 109831837 109848615
MSIN : 131225562 131225563 131231197 131257096
ACAK : 137945381 137950454 137958533
NCOL : 116261219 116262432
ATR : 18426634 18426635 18430263
CJF : 131028197 131034059 131046571
SMO : SELMODRAFT_168461 SELMODRAFT_176615 SELMODRAFT_176660 SELMODRAFT_439712
PPP : 112278701 112282516 112284966
FCY : FRACYDRAFT_183437(ECH_HADH2)
BLAC : 94344761(CCR75_000985)
EHX : EMIHUDRAFT_239062 EMIHUDRAFT_436024 EMIHUDRAFT_442209
» show all
Taxonomy
Reference
Authors
El-Fakhri M, Middleton B
Title
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.211
LinkDB
All DBs