KEGG   ENZYME: 1.1.1.211
Entry
EC 1.1.1.211                Enzyme                                 
Name
long-chain-3-hydroxyacyl-CoA dehydrogenase;
beta-hydroxyacyl-CoA dehydrogenase;
long-chain 3-hydroxyacyl coenzyme A dehydrogenase;
3-hydroxyacyl-CoA dehydrogenase;
LCHAD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
a long-chain (S)-3-hydroxyacyl-CoA + NAD+ = a long-chain 3-oxoacyl-CoA + NADH + H+ [RN:R01778]
Reaction(KEGG)
Substrate
long-chain (S)-3-hydroxyacyl-CoA;
NAD+ [CPD:C00003]
Product
long-chain 3-oxoacyl-CoA;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).
History
EC 1.1.1.211 created 1986
Pathway
ec00062  Fatty acid elongation
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Orthology
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
Genes
HSA3030(HADHA)
PTR459079(HADHA)
PPS100973698 100978217(HADHA)
GGO101143053(HADHA)
PON100172963(HADHA)
NLE100593214 100593233(HADHA)
MCC695975(HADHA)
MCF102142372(HADHA)
MTHB126933649
CSAB103220642(HADHA)
CATY105578503(HADHA)
PANU101014815(HADHA)
TGE112637000(HADHA)
RRO104677892(HADHA)
RBB108532679(HADHA)
TFN117062602(HADHA)
PTEH111554430(HADHA)
CJC100390439(HADHA)
SBQ101047074(HADHA)
CSYR103272350(HADHA)
MMUR105884363(HADHA)
LCAT123636688(HADHA)
OGA100956476(HADHA) 100959271
MMU97212(Hadha)
MCAL110294690(Hadha)
MPAH110324206(Hadha)
RNO170670(Hadha)
MCOC116080906(Hadha)
MUN110547680(Hadha)
CGE100757947(Hadha)
MAUA101836365(Hadha)
PLEU114696488(Hadha)
MORG121439589 121439637
MFOT126490728
AAMP119806471(Hadha)
NGI103735655(Hadha)
HGL101724137(Hadha)
CPOC100723555(Hadha)
CCAN109685831(Hadha)
DORD105983591(Hadha)
DSP122122455(Hadha)
NCAR124963689
OCU100355022(HADHA)
OPI101531960(HADHA)
TUP102471941(HADHA) 102478660
CFA100856745(HADHA)
CLUD112664671(HADHA)
VVP112908532(HADHA)
VLG121490718(HADHA)
AML100469654(HADHA)
UMR103671672(HADHA)
UAH113270772(HADHA)
UAR123799939(HADHA)
ELK111154088
LLV125108850
MPUF101690570(HADHA)
ORO101364854(HADHA)
EJU114205821(HADHA)
ZCA113938677(HADHA)
MLX118007670(HADHA)
NSU110587297(HADHA)
FCA101084701(HADHA)
PYU121044215(HADHA)
PBG122497372(HADHA)
LRUF124503524
PTG102966470(HADHA)
PPAD109267284(HADHA)
AJU106967830(HADHA)
HHV120235789(HADHA)
BTA281810(HADHA)
BOM102287426(HADHA)
BIU109566315(HADHA)
BBUB102398211(HADHA)
CHX102189046(HADHA)
OAS100192316(HADHA)
ODA120851587(HADHA)
CCAD122441976(HADHA)
SSC397012(HADHA)
CFR102516648(HADHA)
CBAI105063860(HADHA)
CDK105098509(HADHA)
VPC102539775(HADHA)
BACU103001885(HADHA)
LVE103086620(HADHA)
OOR101286957(HADHA)
DLE111174988(HADHA)
PCAD102996843(HADHA)
PSIU116764788(HADHA)
ECB100071381(HADHA)
EPZ103546462(HADHA)
EAI106840921(HADHA)
MYB102263028(HADHA)
MYD102751724(HADHA)
MMYO118669207(HADHA)
MLF102421232 102423317
MNA107534200(HADHA)
PKL118717224(HADHA)
HAI109383051(HADHA)
DRO112297764(HADHA)
SHON119001366(HADHA)
AJM119050402(HADHA)
PDIC114500082(HADHA)
PHAS123822436(HADHA)
MMF118630828(HADHA)
RFQ117033224(HADHA)
PALE102889313(HADHA)
PGIG120621876(HADHA)
PVP105289756(HADHA)
RAY107498535(HADHA)
MJV108392159(HADHA)
TOD119259491(HADHA)
SARA101542790(HADHA)
LAV100675857(HADHA)
TMU101353485
DNM101445364(HADHA)
MDO100030776(HADHA)
GAS123237091(HADHA)
SHR100928252(HADHA)
PCW110206510(HADHA)
OAA100077524(HADHA)
GGA395929(HADHA)
PCOC116230687(HADHA)
MGP100548080(HADHA)
CJO107312378(HADHA)
NMEL110397114(HADHA)
ACYG106048383(HADHA)
AFUL116487940(HADHA)
LSR110478445(HADHA)
SCAN103824695(HADHA)
PMOA120502645(HADHA)
OTC121336465(HADHA)
PRUF121358327(HADHA)
GFR102032411(HADHA)
FAB101815112(HADHA)
PHI102103703(HADHA)
PMAJ107198787(HADHA)
CCAE111927468(HADHA)
CCW104683133(HADHA)
CBRC103623553(HADHA)
ETL114071979(HADHA)
ZAB102070146(HADHA)
ACHL103811379(HADHA)
FPG101918262(HADHA)
FCH102045684(HADHA)
CLV102093055(HADHA)
EGZ104130955(HADHA)
NNI104014780(HADHA)
PLET104614692(HADHA)
PCRI104034514(HADHA)
ACUN113478819(HADHA)
TALA104358376(HADHA)
PADL103923913(HADHA)
AFOR103895536(HADHA)
ACHC115351165(HADHA)
HALD104318448(HADHA)
CCRI104160439(HADHA)
CSTI104557761(HADHA)
CMAC104475950(HADHA)
MUI104542112(HADHA)
FGA104075821(HADHA)
GSTE104257198(HADHA)
MNB103775594(HADHA)
OHA104337467(HADHA)
NNT104406262(HADHA)
DPUB104304364(HADHA)
PGUU104461816(HADHA)
ACAR104524733(HADHA)
AVIT104280150(HADHA)
CVF104291167(HADHA)
AAM106499621(HADHA)
AROW112972947(HADHA)
NPD112956290(HADHA)
TGT104568022(HADHA)
DNE112989866(HADHA)
SCAM104140737(HADHA)
ASN102387874(HADHA)
AMJ102559143(HADHA)
CPOO109311569(HADHA)
GGN109300077(HADHA)
PSS102461507(HADHA)
CMY102938765(HADHA)
CPIC101942783(HADHA)
TST117875458(HADHA)
CABI116823900(HADHA)
MRV120400398(HADHA)
ACS100553746(hadha)
PVT110090547(HADHA)
SUND121922293(HADHA)
PBI103053277(HADHA)
PMUR107291031(HADHA) 107300505
CTIG120309141(HADHA)
TSR106541761(HADHA)
PGUT117667656(HADHA)
VKO123018734(HADHA)
PMUA114594987(HADHA)
ZVI118082904(HADHA)
GJA107113769(HADHA)
STOW125443944(HADHA)
XLA108717268(hadha.L) 444044(hadha.S)
XTR394832(hadha)
NPR108803249(HADHA)
RTEM120936094(HADHA)
BBUF120997121(HADHA)
BGAR122933725(HADHA)
DRE553401(hadhaa) 793834(hadhab)
SRX107721447 107741851 107752738
SANH107666258 107679805 107691000 107697212
SGH107550361 107593272 107594700 107600864
CCAR109061322 109113061 109113066
CAUA113060497 113075076 113117304
PPRM120460162(hadhaa) 120476495(hadhab)
MAMB125269353(hadhab) 125278517(hadhaa)
IPU100304971(hadhab) 108257474(hadhaa)
PHYP113529090 113538951
SMEO124400829(hadhaa)
TFD113658631(hadhaa) 113659508(hadhab)
AMEX103035446 103046024
EEE113586544 113586545 113591046(hadha)
TRU101073662(hadha)
TNGGSTEN00035720G001
LCO104929997(hadha)
NCC104942173(hadha)
CGOB115027323(hadha)
ELY117267492(hadhab) 117271127(hadhaa)
EFO125896959(hadhaa) 125901249(hadhab)
PLEP121953563(hadhab) 121955566(hadhaa)
SLUC116057562(hadhab) 116066337(hadhaa)
ECRA117935938(hadhab)
ESP116670345
PFLV114547202 114573387
GAT120833269(hadhab)
PPUG119227720(hadhab)
MSAM119910484(hadhab)
CUD121521089(hadhaa) 121526460(hadhab)
ALAT119005062(hadhab)
MZE101468911 101473024
ONL100703423 100704158
OAU116310316(hadhab) 116311176(hadhaa)
OLA101155646(hadha)
OML112146401(hadhab)
XMA102229661(hadha)
XCO114133804(hadha)
XHE116708744(hadha)
PRET103458382(hadha)
PFOR103148343(hadha)
PLAI106959504(hadha)
PMEI106927681(hadha)
GAF122845967(hadhab)
CVG107095825(hadha)
CTUL119788761 119792796
GMU124856057(hadhab)
NFU107392010(hadha)
KMR108239107(hadhab)
ALIM106529789(hadha)
NWH119427588(hadhab)
AOCE111569588 111589017
MCEP125023173(hadhab)
CSEM103380450(hadha)
POV109636387(hadha)
SSEN122783282(hadhab)
HHIP117756355(hadhab)
HSP118116643(hadhab)
LCF108874899(hadhab)
SDU111225708(hadha)
SLAL111673117(hadha)
XGL120795237(hadhab)
HCQ109528184 109528452
BPEC110156324 110175061
MALB109964597(hadha)
BSPL114848644(hadhab)
SASA106603767 106611334(ECHA)
STRU115162017 115172268
OTW112256902 112261537(hadhab)
OMY110497612(hadhab) 110505842
OGO124001829(hadhab) 124046680
ONE115138738 115145942
SALP112068050 112071018
SNH120023184 120060492
CCLU121539559(hadhab) 121544655
ELS105026863(hadha)
SFM108922328 108929107
PKI111851531(hadha) 111857967
AANG118230436(hadhaa)
LOC102683906(hadha)
PSPA121315588 121317462
ARUT117402708
LCM102350823(HADHA)
CMK103183149
RTP109910714(hadha)
BFO118404846
BBEL109480946
CIN100181980
SCLV120334615
SPU585357
APLC110978691
SKO100369576(HADHA)
DMEDmel_CG4389(Mtpalpha)
DER6541344
DSE6611826
DSIDsimw501_GD22351(Dsim_GD22351)
DYADyak_GE10479
DAN6504621
DSR110176800
DPO4816964
DPE6589537
DMN108161786
DWI6641563
DGR6561593
DMODmoj_GI17575
DAZ108610802
DNV108649592
DHE111603880
DVI6634031
CCAT101457240
BOD106622402
RZE108354841 108375603
MDE101889137
SCAC106091191
LCQ111679665
LSQ119607014
HIS119650780
AGAAgaP_AGAP007784
ACOZ120955422
AARA120899980
ASTE118513924
AAG5572923
AALB109401379 109432898
CQUCpipJ_CPIJ020263
CPII120413536
CNS116336882
BCOO119072832
AME410325
ACER107995032
ALAB122718199
BIM100741897
BBIF117206238
BVK117232959
BVAN117156743
BTER100642892
BPYO122572468
CCAL108623987
OBB114875921
MGEN117229783
NMEA116435158
CGIG122404552
SOC105201374
MPHA105837947
AEC105152057
ACEP105621618
PBAR105434016
VEM105567443
HST105189285
DQU106748121
CFO105254374
FEX115242387
LHU105673815
PGC109863893
OBO105279823
PCF106784609
PFUC122516683
VPS122627695
NVI100121740
CSOL105361087
TPRE106653983
MDL103579736
CGLO123273695
FAS105270145
DAM107036133
AGIF122860743
LHT122498904
CCIN107272281
TCA662336
DPA109535049
SOY115878734
ATD109603223
CSET123312294
AGB108909349
LDC111505103
NVL108558831
APLN108743158
PPYR116170876
OTU111424721
BMOR692820
BMAN114248364
MSEX115449399
DPLKGM_211087
BANY112051091
NIQ126781172
PMAC106719824
PPOT106099818
PXU106118328
PRAP110999633
ZCE119839977
HAW110371935
HZE124645632
TNL113493488
SLIU111352208
OFU114354510
PXY105387328
CFEL113372732
API100165657
DNX107168916
AGS114130103
RMD113555782
BTAB109036133
DCI103508490
CLEC106670657
HHAL106692538
NLU111051734
PHUPhum_PHUM238600
FOC113206808
TPAL117639258
ZNE110827146
CSEC111865385
FCD110854334
DPXDAPPUDRAFT_302417
DMK116935944 123477457
PVM113805029
PJA122242720
PCHN125039425
HAME121879971
PCLA123757303
HAZT108677383
EAF111710504
LSM121122786
PPOI119089474
ISCIscW_ISCW005458
DSV119465929
RSAN119372045
VDE111250076
VJA111259811
TUT107359547
DPTE113799485
DFR124495829
CSCU111616495
PTEP107437387 107437388
SDM118188550
CELCELE_C29F3.1(ech-1.1) CELE_T08B2.7(ech-1.2)
CBRCBG_12562
BMYBM_BM2467(Bm2467)
LOALOAG_09850
NAINECAME_01330
TSPTsp_08084 Tsp_09991
HROHELRODRAFT_194454
LGILOTGIDRAFT_112349
PCAN112574360
BGT106057657
GAE121374973
HRF124123593
HRJ124279900
CRG105342066
MMER123524417
OBI106883270
LAK106173898
OVIT265_08169
NVE5499345 5509237
EPA110254396
ATEN116304116
ADF107334024
AMIL114957985
PDAM113673361
SPIS111326946
DGT114535097
XEN124450357
HMG100197152
TADTRIADDRAFT_58079
AQU100631983
ATHAT3G06860(MFP2) AT4G29010(AIM1)
ALY9305530 9320679
CRB17878655 17890904
CSAT104717299 104721975 104728084 104730438 104744862 104764393
EUSEUTSA_v10020152mg EUTSA_v10024533mg
BRP103834740 103849627 103853925 103859186 103861864 103870717
BNA106346097 106348746 106361183 106375554 106388929 106389027 106389792 106398246 106401486 106409243 106415581 111213653
BOE106295945 106303780 106304818 106312132 106327577 106335788
RSZ108813782 108822759 108841906 108848805 108856939 108862021
THJ104802693 104814713 104818910
CPAP110819879
CIT102609147 102623634
CICCICLE_v10004429mg CICLE_v10007590mg
PVY116116793 116135578 116135612
MINC123200342 123206803 123211856 123221025 123221562
TCC18587944 18588574 18588575 18603530 18613590
GRA105774094 105777302 105786587 105792895 105798859
GHI107891859 107896697 107901248 107916181 107930826 107932835 107932954 107939487 121206665 121230435
GAB108456773 108469496 108484106 108486224 108489585
DZI111279702 111283515 111284788 111284789 111292937 111299112
EGR104415161 104428598 104436741 104439158
GMX100170754 100777319 100780325 100798079 100813542
GSJ114368875 114393637 114394062 114418553 114420030
PVUPHAVU_003G096400g PHAVU_003G096500g PHAVU_004G164800g
VRA106766980 106768824 106773786
VAR108342169 108342180 108345899
VUN114175727 114175728 114182034
CCAJ109800067 109807955 109809413
APRC113846185 113867124
MTR11419352 11435682 25488097
CAM101492255 101492731 101509552
LJALj0g3v0340609.1(Lj0g3v0340609.1) Lj4g3v2310310.1(Lj4g3v2310310.1) Lj6g3v1465030.1(Lj6g3v1465030.1)
ADU107463971 107483586 107490282
AIP107636178 107638698 107644391
AHF112703784 112723093 112741727 112751218 112796415 112802129
LANG109330029 109340259 109343445 109358341
FVE101294002 101314365
RCN112184573 112198295
PPER18769834 18792635
PMUM103323034 103340979
PAVI110750295 110771278
PDUL117631689 117634291
MDM103400486 103403739 103418149 103452890
PXB103943676 103960685 103962984
ZJU107431819 107433153
MNT21384821 21386066 21386067 21390618
CSV101209359 101210295 101218899
CMO103497841 103497849 103497860
BHJ120067271 120067869 120079743
MCHA111009683 111009902 111024216
CMAX111493808 111494319 111494685 111499076
CMOS111436752 111436753 111450378 111460069
CPEP111778622 111779036 111798022 111805343 111806463 111806496
RCU8268345 8278749
JCU105637741 105643451
HBR110631424 110633034 110636151 110661083
MESC110603692 110611094 110611736
POP18101815 7475903 7476291
PEU105110534 105115105 105142449
PALZ118032861 118036960 118051653
JRE108986842 108987297 108987298 108994835 108997856
QSU112003821 112026503
QLO115975697 115994699
TWL119996085 120000391 120005871 120015532
VVI100244762 100245687
VRI117914103 117925260
SLY101248790 101252256 101258102 101259939 101261255 101263592
SPEN107007255 107007290 107023510 107026420 107027206 107027328 107028200
SOT102579434 102586729 102586890 102587081 102587367 102596014 102605537
SSTN125841791 125853782 125861844 125861910 125872449 125876862
CANN107839143 107841025 107850556 107855140 107879966
NTA107766180 107770112 107781819 107786400 107794207 107797268 107798726 107805198 107824491 107825779 107828149(NtMFP) 107831676
NSY104217699 104220198 104221368 104235287 104248918
NTO104091880 104098969 104102803 104114113 104115085
NAU109214987 109218338 109226540 109234185 109241281
INI109148091 109175130 109178676 109178711 109179559 109191370
ITR115999262 116006198 116007123 116007124 116016572 116031040
SIND105156885 105162083 105165214
OEU111372764 111396583 111407897
EGT105952502 105961081 105962940 105966448
SSPL121747970 121751668 121769224 121771471 121798565 121804796
HAN110886914 110893751 110899786 110899789 110928562 110930717
ECAD122595274 122599142 122599397
LSV111883753 111892781 111895467 111908713
CCAV112500142 112500143 112501883 112504620
DCR108199406 108199516 108202825 108203297
CSIN114279320 114292590 114292755
BVG104902237 104906532
SOE110790033 110801261
CQI110690998 110707499 110707751 110735020
NNU104595160 104598910
MING122070826 122076058 122082607 122091877
TSS122656041 122658061 122671461
PSOM113300558 113303947 113303948 113317859 113337926 113338071 113348892
NCOL116261219 116262432
OSA4326503 4328997 4337848 4338541
DOSAOs01t0348600-01(Os01g0348600) Os02t0274100-01(Os02g0274100) Os05t0155000-01(Os05g0155000) Os05t0362100-01(Os05g0362100)
OBR102700056 102715892 102721898
BDI100826280 100827794 100842445
ATS109733511 109739968 109751016 109760663 109773312
TDC119266989 119267061 119274876 119276751 119279323 119315323 119325551 119326624 119340544 119367575
TAES123053285 123060164 123060238 123068651 123068742 123077174 123077243 123113610 123129514 123132309 123136357 123143868 123180564 123181767 123191683
TUA125514708 125515736 125528060 125530317 125542670 125542752
SBI110433383 8059103 8061917
ZMA100281695 100285945 103628476 103630229 103654691
SITA101757736 101758148 101774575 101777462
SVS117849540 117856473 117856696 117856783
PVIR120655368 120665743 120672320 120697632 120698970 120706866
PHAI112874622 112874630 112886630 112895946
PDA103696074 103703626 103715010 103721688 120106977 120107306
EGU105040837 105045176 105048300 105052538
MUS103969314 103978957 103991664 103995050
DCT110091912 110091914 110095175 110104403 110112426
PEQ110020962 110025557 110025559 110026758 110035965
AOF109824930 109831419 109831837 109848615
ATR18426634 18426635 18430263
SMOSELMODRAFT_168461 SELMODRAFT_176615 SELMODRAFT_176660 SELMODRAFT_439712
PPP112278701 112282516 112284966
CRECHLRE_16g695050v5
VCNVOLCADRAFT_74021
CSLCOCSUDRAFT_54823
CVRCHLNCDRAFT_59763
APROF751_2626
OLUOSTLU_49128
OTAOT_ostta03g04620
BPGBathy07g02240
MISMICPUN_94758
MPPMICPUCDRAFT_45151
CMECYME_CMR380C
GSLGasu_52740
CCPCHC_T00009349001
MBRMONBRDRAFT_10361
SREPTSG_07214
ACANACA1_128570
PTIPHATRDRAFT_35240
FCYFRACYDRAFT_183437(ECH_HADH2)
TPSTHAPSDRAFT_26365
AAFAURANDRAFT_69589
PIFPITG_06693
PSOJPHYSODRAFT_355849
SPARSPRG_06557
EHXEMIHUDRAFT_239062 EMIHUDRAFT_436024 EMIHUDRAFT_442209
GTTGUITHDRAFT_121132
 » show all
Reference
1  [PMID:7150615]
  Authors
El-Fakhri M, Middleton B
  Title
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
  Journal
Biochim Biophys Acta 713:270-9 (1982)
DOI:10.1016/0005-2760(82)90244-2
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.211
IUBMB Enzyme Nomenclature: 1.1.1.211
ExPASy - ENZYME nomenclature database: 1.1.1.211
BRENDA, the Enzyme Database: 1.1.1.211
CAS: 84177-52-6
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