KEGG   ENZYME: 1.1.1.270
Entry
EC 1.1.1.270                Enzyme                                 

Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R12402]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 51478(HSD17B7) 79154(DHRS11)
PTR: 454598(DHRS11) 466046 747814(HSD17B7)
PPS: 100985156(HSD17B7) 100989828(DHRS11)
GGO: 101133645(DHRS11) 101137638(HSD17B7)
PON: 100446761(HSD17B7) 100450428(DHRS11)
NLE: 100580130(DHRS11) 100587120(HSD17B7)
MCC: 713823(DHRS11) 720399
MCF: 102127673(HSD17B7) 102133734(DHRS11)
CSAB: 103223654(HSD17B7) 103242795(DHRS11)
CATY: 105583369(DHRS11) 105589219(HSD17B7)
PANU: 101007886(DHRS11) 101019563(HSD17B7)
RRO: 104656967(HSD17B7) 104672997(DHRS11)
RBB: 108526295(DHRS11) 108535633
TFN: 117067355(DHRS11) 117074787(HSD17B7)
PTEH: 111525046(HSD17B7) 111537680(DHRS11)
CJC: 100410416(HSD17B7) 100415468(DHRS11)
SBQ: 101047238(HSD17B7) 101049784(DHRS11)
MMUR: 105873582(HSD17B7) 105879451(DHRS11)
MMU: 15490(Hsd17b7) 192970(Dhrs11)
MCAL: 110292934(Hsd17b7) 110304998(Dhrs11)
MPAH: 110322287(Hsd17b7) 110332326(Dhrs11)
RNO: 29540(Hsd17b7) 360583(Dhrs11)
MCOC: 116078372(Dhrs11) 116103156(Hsd17b7)
MUN: 110550630(Hsd17b7) 110555253(Dhrs11)
CGE: 100763193(Dhrs11) 100767580(Hsd17b7)
PLEU: 114689903(Hsd17b7) 114707715(Dhrs11)
NGI: 103732605(Dhrs11) 103746788(Hsd17b7)
HGL: 101704213(Dhrs11) 101712707(Hsd17b7)
CCAN: 109690973(Hsd17b7) 109691233(Dhrs11)
OCU: 100008778(HSD17B7) 100349261 100350282(DHRS11)
TUP: 102473205(HSD17B7) 102481007(DHRS11)
CFA: 491129(DHRS11) 609364(HSD17B7)
VVP: 112914306(HSD17B7) 112917964(DHRS11)
VLG: 121473558(DHRS11) 121501279(HSD17B7)
AML: 100477716(HSD17B7) 100483445(DHRS11)
UMR: 103658287(HSD17B7) 103667445(DHRS11)
UAH: 113268675(HSD17B7) 113268922(DHRS11)
ORO: 101368538(HSD17B7) 101372465(DHRS11)
MPUF: 101688526(DHRS11) 101689203(HSD17B7)
EJU: 114210516(HSD17B7) 114213877(DHRS11)
MLX: 118014038(HSD17B7) 118025129(DHRS11)
FCA: 101083482(HSD17B7) 101083724(DHRS11)
PTG: 102953856(DHRS11) 102968316(HSD17B7)
PPAD: 109251987(DHRS11) 109276652(HSD17B7)
AJU: 106980443(DHRS11) 106986761(HSD17B7)
HHV: 120241069(HSD17B7) 120248116(DHRS11)
BTA: 505212(HSD17B7) 510264(DHRS11)
BOM: 102266348(HSD17B7) 102267490(DHRS11)
BIU: 109574096(DHRS11) 109577890(HSD17B7)
BBUB: 102389083(HSD17B7) 102414485(DHRS11)
CHX: 102176160(DHRS11) 102179058(HSD17B7)
OAS: 101109465(DHRS11) 101110013(HSD17B7)
ODA: 120855521(HSD17B7) 120866412(DHRS11)
SSC: 100155418(HSD17B7) 100513307(DHRS11)
CFR: 102507556(DHRS11) 102512546(HSD17B7)
CDK: 105092702(HSD17B7) 105097850(DHRS11)
BACU: 103011691(DHRS11) 103014331(HSD17B7)
LVE: 103069867(DHRS11) 103084050(HSD17B7)
OOR: 101278328(DHRS11) 101286750(HSD17B7)
DLE: 111163734(DHRS11) 111169243(HSD17B7)
PCAD: 102984493(HSD17B7) 102995379(DHRS11)
ECB: 100059061(HSD17B7) 100071416(DHRS11)
EPZ: 103554456(DHRS11) 103559639(HSD17B7)
EAI: 106823694(HSD17B7) 106844689(DHRS11)
MYB: 102251181(HSD17B7) 102262752(DHRS11)
MYD: 102765268(DHRS11) 102767046(HSD17B7)
MMYO: 118671682(DHRS11) 118673077(HSD17B7)
MNA: 107530816(DHRS11) 107535110(HSD17B7)
HAI: 109379798(DHRS11) 109392309(HSD17B7)
DRO: 112298817(HSD17B7) 112316505(DHRS11)
SHON: 118979201(HSD17B7) 119003587(DHRS11)
AJM: 119052313(HSD17B7) 119062640(DHRS11)
MMF: 118633927(DHRS11) 118637572(HSD17B7)
PALE: 102892079(HSD17B7) 102894290(DHRS11)
RAY: 107510114(DHRS11)
MJV: 108383263(DHRS11) 108396655(HSD17B7)
TOD: 119231930(DHRS11) 119241348(HSD17B7)
LAV: 100676060 100676239(DHRS11) 100676343(HSD17B7)
MDO: 100016071(HSD17B7) 100618596(DHRS11)
SHR: 100926227(HSD17B7) 100933320(DHRS11)
PCW: 110209887(HSD17B7) 110212020(DHRS11)
OAA: 100077820(DHRS11) 114817513(HSD17B7)
GGA: 395172(DHRS11) 424367(HSD17B7)
PCOC: 116227942(DHRS11) 116230531(HSD17B7)
MGP: 100542399(DHRS11) 100542640(HSD17B7)
CJO: 107317140(HSD17B7) 107322636(DHRS11)
NMEL: 110402344(HSD17B7)
APLA: 101796287(DHRS11) 101799136(HSD17B7)
ACYG: 106041628(HSD17B7) 106046860(DHRS11)
TGU: 100222823(HSD17B7) 100230987(DHRS11)
LSR: 110467717(DHRS11) 110478897(HSD17B7)
SCAN: 103820184(DHRS11) 103824326(HSD17B7)
PMOA: 120497588(HSD17B7) 120507831(DHRS11)
GFR: 102031952(DHRS11) 102042580(HSD17B7)
FAB: 101806967(DHRS11) 101818521(HSD17B7)
PHI: 102107312(HSD17B7) 102113937(DHRS11)
PMAJ: 107198613(HSD17B7) 107213026(DHRS11)
CCAE: 111932684(HSD17B7) 111937859(DHRS11)
CCW: 104690988(DHRS11) 104695594(HSD17B7)
ETL: 114057489(DHRS11) 114067481(HSD17B7)
FPG: 101912846(DHRS11) 101919410(HSD17B7)
FCH: 102050282(DHRS11) 102059217(HSD17B7)
CLV: 102090168(DHRS11) 102097738(HSD17B7)
EGZ: 104121871(DHRS11) 104132130(HSD17B7)
NNI: 104010459(HSD17B7) 104016400(DHRS11)
ACUN: 113483111(HSD17B7) 113487258(DHRS11)
PADL: 103914076(HSD17B7) 103917037(DHRS11)
AAM: 106494687(DHRS11) 106499711(HSD17B7)
ASN: 102374189(HSD17B7) 112551119(DHRS11)
AMJ: 102561890(DHRS11) 102565865(HSD17B7)
CPOO: 109307069(HSD17B7) 109317147(DHRS11)
GGN: 109287068(HSD17B7) 109293262(DHRS11)
PSS: 102452802(DHRS11) 102461698(HSD17B7)
CMY: 102944731(HSD17B7) 102944881(DHRS11)
CPIC: 101936463(DHRS11) 101953232(HSD17B7)
TST: 117867488(DHRS11) 117881449(HSD17B7)
CABI: 116824223(DHRS11) 116831149(HSD17B7)
ACS: 100556465(hsd17b7)
PVT: 110075560(DHRS11) 110081655(HSD17B7)
PBI: 103063132(HSD17B7) 103065679(DHRS11)
PMUR: 107294873(DHRS11) 107302880(HSD17B7)
TSR: 106539066(DHRS11)
PGUT: 117661207(HSD17B7) 117675673(DHRS11)
PMUA: 114585448(DHRS11) 114598525(HSD17B7)
ZVI: 118078620 118089365(HSD17B7) 118097242(DHRS11)
GJA: 107108933(DHRS11) 107121042(HSD17B7)
XLA: 108704561(dhrs11.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR: 496708(dhrs11) 548963(hsd17b7)
NPR: 108801354(HSD17B7)
DRE: 436969(dhrs11b.2) 768185(hsd17b7) 791578(dhrs11a) 791770(dhrs11b.1)
IPU: 108260417(dhrs11) 108271889(hsd17b7)
PHYP: 113531061(dhrs11) 113538418(hsd17b7)
EEE: 113570462(hsd17b7) 113577576(dhrs11)
NCC: 104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
ELY: 117253561(hsd17b7) 117260047 117268096(dhrs11a) 117271615
SLUC: 116045810 116048477 116058070(dhrs11a) 116063209(hsd17b7)
ECRA: 117942184 117950534(hsd17b7) 117954002 117955964(dhrs11a)
GAT: 120816127(hsd17b7) 120822622(dhrs11a)
MSAM: 119882883 119895317(dhrs11a) 119900960(hsd17b7) 119902362
OML: 112138999(dhrs11a) 112147206 112149002 112150931(hsd17b7)
POV: 109625649(hsd17b7) 109628284(dhrs11) 109644359
XGL: 120790306(hsd17b7) 120792442 120798840 120803065(dhrs11a)
BPEC: 110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109960466(dhrs11) 109966957
SFM: 108921710(dhrs11) 108935177(hsd17b7) 108938265
PKI: 111841069(hsd17b7) 111854721(dhrs11) 111859701
LOC: 102694052(dhrs11) 102696390(hsd17b7)
PSPA: 121308431(dhrs11a) 121327382
LCM: 102348492(HSD17B7) 102362545(DHRS11)
CMK: 103180036(hsd17b7) 103180635(dhrs11)
RTP: 109920236(dhrs11) 109925128(hsd17b7)
NMEA: 116424013
FEX: 115240720
PPYR: 116171680
PTEP: 107437425
SCE: YLR100W(ERG27)
ERC: Ecym_4279
KMX: KLMA_40163(ERG27)
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PIC: PICST_61325(ERG27)
CAL: CAALFM_CR01140CA(ERG27)
CDU: CD36_26140(ERG27)
SLB: AWJ20_1569(ERG27)
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SSCK: SPSK_07425
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
MBE: MBM_01041
ANI: AN5585.2
ANG: ANI_1_1880184(An04g05000)
ABE: ARB_02354
TVE: TRV_04668
PTE: PTT_11743
SPO: SPBC1709.07(erg27)
CNE: CND03020
CNB: CNBD3330
TASA: A1Q1_03186
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
MGL: MGL_2564
MRT: MRET_0524
 » show all
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5
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