KEGG   ENZYME: 1.1.1.344
Entry
EC 1.1.1.344                Enzyme                                 
Name
dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+];
tal (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
dTDP-6-deoxy-beta-L-talose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-talose + NAD(P)+ = dTDP-4-dehydro-beta-L-rhamnose + NAD(P)H + H+ [RN:R02776 R10190]
Reaction(KEGG)
R02776 R10190
Substrate
dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme works equally well with NAD+ and NADP+.
History
EC 1.1.1.344 created 2013
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19652  dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
Genes
SXT: KPP03845_104259(tal_2)
MPRN: Q3V37_22695
Reference
1  [PMID:20667525]
  Authors
Karki S, Yoo HG, Kwon SY, Suh JW, Kwon HJ
  Title
Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose.
  Journal
Carbohydr Res 345:1958-62 (2010)
DOI:10.1016/j.carres.2010.07.004
  Sequence
[ag:ADO32602]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.344
IUBMB Enzyme Nomenclature: 1.1.1.344
ExPASy - ENZYME nomenclature database: 1.1.1.344
BRENDA, the Enzyme Database: 1.1.1.344
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