KEGG   ENZYME: 1.1.1.378
Entry
EC 1.1.1.378                Enzyme                                 
Name
L-rhamnose 1-dehydrogenase [NAD(P)+]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-rhamnose:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
L-rhamnose + NAD(P)+ = L-rhamnono-1,4-lactone + NAD(P)H + H+ [RN:R10788 R10995]
Reaction(KEGG)
R10788 R10995
Substrate
L-rhamnose [CPD:C00507];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
L-rhamnono-1,4-lactone [CPD:C02991];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which occurs in the bacteria Azotobacter vinelandii and Sphingomonas sp. SKA58, is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+ and EC 1.1.1.377, L-rhamnose 1-dehydrogenase (NADP+).
History
EC 1.1.1.378 created 2014
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18337  L-rhamnose 1-dehydrogenase
Genes
DHA: DEHA2E01100g
PIC: PICST_50944(DHG2)
PGU: PGUG_03591
CTEN: 18247188(DHG2)
CLU: CLUG_02926
CLUS: A9F13_18g00385
PPA: PAS_chr4_0338
BNN: FOA43_001971(DHG2)
OPA: HPODL_01987
SLB: AWJ20_4952(SPS19)
NCR: NCU09035
NTE: NEUTE1DRAFT102514(NEUTE1DRAFT_102514)
SMP: 10803051(SMAC4_05850)
PAN: PODANSg706
PBEL: QC761_400940
PPSD: QC762_400940
PPSP: QC763_400940
PPSA: QC764_400940
TTT: THITE_2111000
MTM: MYCTH_102290
CTHR: CTHT_0045640
MGR: MGG_08318
PPEI: PpBr36_02105
PGRI: PgNI_07905
TMN: UCRPA7_3732 UCRPA7_5029
SSCK: SPSK_02647
FGR: FGSG_09882
FPU: FPSE_10199
FPOA: FPOAC1_002961
FVN: FVRRES_03279
FVR: FVEG_02597
FOX: FOXG_05543
NHE: NECHADRAFT_37021 NECHADRAFT_41350
FFC: NCS54_00676000
FKR: NCS57_00469700 NCS57_00715800
FMU: J7337_005520
TRE: TRIREDRAFT_65588
TRR: M419DRAFT_36736
TATV: 25775150(TrAtP1_001151)
TASP: 36615895(DHG2)
MAJ: MAA_08254
MBRN: 26246537(DHG2)
PCHM: VFPPC_07453
CMT: CCM_06363
AMUS: LMH87_000967 LMH87_002840
PLJ: 28891680(PLICBS_010274)
PTKZ: JDV02_002154(DHG2)
VAL: VDBG_07058
VDA: VDAG_06700
CFJ: CFIO01_07064 CFIO01_09199
CLUP: CLUP02_17412
CHIG: CH63R_09431
CDET: 87949276(CDEST_12776) 87950630(CDEST_14130)
ELA: UCREL1_2272 UCREL1_7808
PFY: PFICI_03100 PFICI_06510 PFICI_13970
SSL: SS1G_10326
BFU: BCIN_14g04170
MBE: MBM_02654
PSCO: LY89DRAFT_684259 LY89DRAFT_707448
GLZ: GLAREA_03301
ANI: ANIA_01886 ANIA_04186
AFM: AFUA_7G04360
ACT: ACLA_006060
NFI: NFIA_025330
AOR: AO090005000123
ANG: An05g02050 An13g00930
AFV: AFLA_002906
ALUC: AKAW2_20117A(DHG2) AKAW2_81349A
ACHE: ACHE_31306A ACHE_40186A(DHG2)
APUU: APUU_21191A APUU_50081S APUU_60465A(DHG2) APUU_60792A
PCS: N7525_005303 N7525_006925
PDP: PDIP_82370
POU: POX_b03426
TMF: EYB26_005568
TRG: TRUGW13939_06749 TRUGW13939_09624
ABE: ARB_00929
TVE: TRV_00758
PNO: SNOG_14192(SNOG_14191)
PTE: PTT_09742
PTRR: 6342727(PtrM4_114020)
BZE: COCCADRAFT_36707
BSC: COCSADRAFT_40878
BOR: COCMIDRAFT_4863
AALT: CC77DRAFT_1054497
ARAB: EKO05_0003752
ZTR: MYCGRDRAFT_83548
PFJ: MYCFIDRAFT_39072
FFU: CLAFUR5_12021 CLAFUR5_13485
CBET: CB0940_06284 CB0940_11605
BCOM: BAUCODRAFT_64509
NPA: UCRNP2_3170
TML: GSTUM_00003021001 GSTUM_00009300001
CNE: CNB05760
CNB: CNBB0030
CNG: CNAG_04097
CGI: CGB_A0020C
CDEU: CNBG_5386
CDEP: 91085938(L203_101725)
KMG: 30165237(I203_108529)
KNE: 92177317(IAR55_000057)
TASA: A1Q1_01844
CCAC: CcaHIS019_0607430(DHG2)
PPL: POSPLDRAFT_87849
TVS: TRAVEDRAFT_159063
DSQ: DICSQDRAFT_131032
PCO: PHACADRAFT_247452
SHS: STEHIDRAFT_89569
HIR: HETIRDRAFT_456869
PSQ: PUNSTDRAFT_48714
ADL: AURDEDRAFT_80943
FME: FOMMEDRAFT_81776
GTR: GLOTRDRAFT_53059
RSX: RhiXN_00566
ABP: AGABI1DRAFT31987(AGABI1DRAFT_31987)
ABV: AGABI2DRAFT182285(AGABI2DRAFT_182285)
MPR: MPER_11191
MRR: Moror_17215
MORE: E1B28_000966
SCM: SCHCO_02610587(SCHCODRAFT_02610587)
CPUT: CONPUDRAFT_86700
SLA: SERLADRAFT_467003
UMA: UMAG_11693
PFP: PFL1_03743
SGRA: EX895_004391
PFN: HZ99_04550
PTV: AA957_01200
PAZO: AYR47_21440
PFX: A7318_11935
PYM: AK972_2741
PEZ: HWQ56_16160
PTRT: HU722_0013875
AVN: Avin_09160
AVL: AvCA_09160
AVD: AvCA6_09160
ABER: BSR55_00550
HEL: HELO_4213(rhaD)
HHU: AR456_20000
HBH: E4T21_09965
HHAO: QWG60_05015
COBB: H2O77_06785
COBD: U0O11_06430
SALN: SALB1_2836
AMAH: DLM_0709
AQS: DKK66_01665
BCM: Bcenmc03_6233
BCH: Bcen2424_6635
BAM: Bamb_3400
BAC: BamMC406_1208
BPYR: ABD05_31635
BSEM: WJ12_16075
BUG: BC1001_3863
BGF: BC1003_5545
BYI: BYI23_B007530
BUE: BRPE67_BCDS10610
BUQ: AC233_21650
BGP: BGL_2c06950(fabG4)
BPLA: bpln_2g07800
BUM: AXG89_17635
BUI: AX768_27415
BURK: DM992_37155
BXE: Bxe_B1031
BXB: DR64_6352
BPH: Bphy_3467
BGE: BC1002_4237
BPX: BUPH_00437
BPY: Bphyt_5688
BFN: OI25_6825
BCAI: K788_0008513
PSPW: BJG93_25610
PARA: BTO02_31830
PARB: CJU94_23860
PHS: C2L64_22530
PTER: C2L65_25100
PGP: CUJ91_21880
PCJ: CUJ87_23065
PTS: CUJ90_29530
PMEG: FNZ07_09785
PTRO: G5S35_23015
PGIS: I6I06_24295
PACP: FAZ97_21155
PACS: FAZ98_17345
PEW: KZJ38_34630
PDIO: PDMSB3_2081.1(rhaD)
PBRY: NDK50_27200
PSAA: QEN71_12635
PKF: RW095_19230
PHUN: U0042_07615
PLAD: PPGU16_41630
CABA: SBC2_60260
BUO: BRPE64_BCDS05710
CABK: NK8_34400
TVL: FAZ95_33600
TCAR: U0034_23330
VPD: VAPA_2c00520
MESP: C1M53_17345
RPOD: E0E05_15250
CSE: Cseg_1768 Cseg_2740
CFH: C1707_14155
BSB: Bresu_2867
BRD: JL11_06990
BRG: A4249_07690
BREV: E7T10_08375
BND: KWG56_07380
BFQ: JX001_09280
BRES: E4341_07345
AEX: Astex_2133
ASTI: Q1W73_03000
ASTD: ATDW_19930
PTP: RCA23_c23450(fabG4)
HBA: Hbal_2755
STAX: MC45_07230 MC45_07285
SPHI: TS85_02230
SSAN: NX02_22785
SNJ: A7E77_11680
SMY: BJP26_16645
SPAN: AWL63_05960
SKR: BRX40_01540
SPLM: BXU08_17995
SPHC: CVN68_10795
SARI: H5J25_00325
SSUA: FPZ54_00310
SBIN: SBA_ch1_06520
SCAB: LZK98_19645
SNOS: K8P63_02120
SSAG: KV697_00800
SABI: PBT88_17560
SPHR: BSY17_3168
SYA: A6768_21720
SPYG: YGS_C1P2522
SPAG: sphantq_01941(fabG_2)
BLAS: BSY18_1707
BFW: B5J99_17915
SSAA: RPR59_02250
SPHS: ETR14_07025
ALTN: LBX01_05115
TFV: IDJ81_03365
ABG: Asbog_01342
ROS: CTJ15_21290
NAO: Y958_05065
NCB: C0V82_24320
PPSC: EHS13_31275
PBK: Back11_16610(fabG_2)
CHEB: HH215_02220 HH215_18270
COHL: J4772_13335 J4772_23225
PMAD: BAY61_19440
ATL: Athai_30200
ASER: Asera_44360
SACI: Sinac_3785
CPOL: WJU16_05740
CHIM: CK934_14605
RCG: N7E81_02085
TAC: Ta0747
TVO: TVG0436799(TVG0436799)
FAC: FACI_IFERC01G0497
 » show all
Reference
1  [PMID:18505728]
  Authors
Watanabe S, Saimura M, Makino K
  Title
Eukaryotic and bacterial gene clusters related to an alternative pathway of nonphosphorylated L-rhamnose metabolism.
  Journal
J Biol Chem 283:20372-82 (2008)
DOI:10.1074/jbc.M801065200
  Sequence
[pic:PICST_50944] [dha:DEHA2E01100g] [avn:Avin_09160]
Reference
2  [PMID:19187228]
  Authors
Watanabe S, Makino K
  Title
Novel modified version of nonphosphorylated sugar metabolism--an alternative L-rhamnose pathway of Sphingomonas sp.
  Journal
FEBS J 276:1554-67 (2009)
DOI:10.1111/j.1742-4658.2009.06885.x
  Sequence
[ag:EAT09360]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.378
IUBMB Enzyme Nomenclature: 1.1.1.378
ExPASy - ENZYME nomenclature database: 1.1.1.378
BRENDA, the Enzyme Database: 1.1.1.378
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