Entry
Name
tryptophan 2,3-dioxygenase;
tryptophan pyrrolase (ambiguous);
tryptophanase;
tryptophan oxygenase;
tryptamine 2,3-dioxygenase;
tryptophan peroxidase;
indoleamine 2,3-dioxygenase (ambiguous);
indolamine 2,3-dioxygenase (ambiguous);
L-tryptophan pyrrolase;
TDO;
L-tryptophan 2,3-dioxygenase;
L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
L-tryptophan + O2 = N-formyl-L-kynurenine [RN:
R00678 ]
Reaction(KEGG)
Substrate
Product
N-formyl-L-kynurenine [CPD:
C02700 ]
Comment
A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC
1.13.11.52 , indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2].
History
EC 1.13.11.11 created 1961 as EC 1.11.1.4, deleted 1964, reinstated 1965 as EC 1.13.1.12, transferred 1972 to EC 1.13.11.11, modified 1989, modified 2006
Pathway
Orthology
K00453 tryptophan 2,3-dioxygenase
Genes
GVR : 103582154 103598559(TDO2)
ACHL : 103803251 103810312
DRE : 100008541(tdo2a) 334082(tdo2b)
SRX : 107715811 107718213 107723833 107740127
SANH : 107656502 107669055 107685956
SGH : 107551803 107562824 107567330 107573507
CCAR : 109051970 109094640 109096203
CAUA : 113055323 113082041 113099545 113113986 113114138
CGIB : 127971841 128022174 128027158
PTET : 122354662(tdo2b) 122357830(tdo2a)
LROH : 127172744(tdo2b) 127176203(tdo2a)
OMC : 131549571(tdo2b) 131553800(tdo2a)
PPRM : 120474313 120474314 120480232(tdo2b)
RKG : 130083563(tdo2b) 130095168(tdo2a)
MAMB : 125256977(tdo2b) 125259099(tdo2a)
CIDE : 127522920 127525663
CERY : 137016346(tdo2a) 137021017(tdo2b)
MASI : 127412918 127417981 127425913 127428096
TROS : 130563528(tdo2a) 130571373(tdo2b)
TDW : 130409898(tdo2b) 130437972(tdo2a)
MANU : 129422916(tdo2a) 129427989(tdo2b)
AMEX : 103028988(tdo2b) 103034668(tdo2a)
CMAO : 118807301(tdo2a) 118818769(tdo2b)
CHAR : 105896660(tdo2b) 105906188(tdo2a)
SLUC : 116052894 116052895
PPRL : 129360641 129360643
CVG : 107095810 107103256(tdo2)
SASA : 106604524(tdo2) 106611580
STRU : 115170736 115205110
OTW : 112221052(tdo2a) 112256334
OMY : 110488929(tdo2a) 110505124
OGO : 123993504 123993505 123993506 124010483
OKE : 118363592 118379565(tdo2a)
SALP : 111965833 111967580
SNH : 120048033(tdo2a) 120062247
CCLU : 121534593 121541483(tdo2a)
AANG : 118227143 118231307
CMK : 103187176 121849598 121851514
SPU : 115927664 589461 593764
LPIC : 129261084 129263136 129263137
DSI : Dsimw501_GD16993(Dsim_v)
DYA : Dyak_GE15897(Dyak_v)
AALB : 109428136 115256322
ATRA : 106136650 132904451
HHAL : 106684034(vermilion)
HAZT : 108674247 108674258 108681410
CSCU : 111629757 111629758
PMEO : 129591010 129596105
CEL : CELE_C28H8.11(tdo-2)
LGI : LOTGIDRAFT_171789 LOTGIDRAFT_202558
PVUL : 126830746 126830835
HRF : 124113219 124123567 124148468
HRJ : 124273671 124273678 124277558 124279445
CRG : 105317582 105327142 117680482 117690682
CANU : 128155586 128191861 128191862
CVN : 111122750 111123201 111124043 111125187 111125818
MCAF : 127716691 127721918 127722179
MAEA : 128226644 128226672
HSY : 130614543 130655303 130655401
TAD : TRIADDRAFT_25841 TRIADDRAFT_56158 TRIADDRAFT_56189
NGR : NAEGRDRAFT_81411(AM30)
SMAR : SM39_0472 SM39_2497
SERS : SERRSCBI_05160 SERRSCBI_14610
SRZ : AXX16_0442 AXX16_2253
SFJ : SAMEA4384070_3044(kynA)
SURI : J0X03_08815(kynA) J0X03_18380
SRHZ : FO014_09550 FO014_19190(kynA)
SNEM : NLX84_05395 NLX84_15245(kynA)
SSAR : SSARUM_001050 SSARUM_002932(kynA)
PRJ : NCTC6933_03365(kynA)
XPE : BJD13_10110 BJD13_14635
XPH : XppCFBP6546_09520(XppCFBP6546P_09520)
XHD : LMG31886_04950(kynA)
XDY : NYR95_02700 NYR95_07590
LLZ : LYB30171_02351(kynA)
DJI : CH75_00570 CH75_23650
PPRC : PFLCHA0_c07630(kynA)
PMUD : NCTC8068_00686(kynA)
PFW : PF1751_v1c46490(kynA)
PTRT : HU722_0024765(kynA)
SCAA : TUM17387_27830(kynA)
SALH : HMF8227_00854(tdo2)
MSZE : MSZNOR_1830(kynA) MSZNOR_3064
GAI : IMCC3135_26500(kynA)
HAAH : HALA3H3_910070(kynA)
MARS : A8C75_03625 A8C75_04880
RSO : RSc0758(kynA) RSp0694
RSE : F504_4017 F504_4525 F504_778
RPU : CDC45_03925(kynA) CDC45_21090
RNC : GO999_12775 GO999_17555
RSC : RCFBP_10281 RCFBP_20657
RSN : RSPO_c00322(kynA) RSPO_c02607
RSM : CMR15_30139 CMR15_mp10665
RSY : RSUY_03010 RSUY_09760
RPJ : N234_15865 N234_22310
REH : H16_A2816(tdo1) H16_B1418(tdo2)
CNC : CNE_1c27160(kynA) CNE_BB1p03190(tdo)
REU : Reut_A0807 Reut_C5980
COX : E0W60_03610 E0W60_23295(kynA)
CCAM : M5D45_12440(kynA) M5D45_20095
CUK : KB879_26030(kynA) KB879_34780
BMV : BMASAVP1_A0650(kynA)
BML : BMA10229_A2485(kynA)
BPL : BURPS1106A_0895(kynA)
BCEN : DM39_2663(kynA) DM39_4553(kynA)
BSTL : BBJ41_15910 BBJ41_32965
BGF : BC1003_2815 BC1003_4450
BUE : BRPE67_ACDS22260(kynA)
BPX : BUPH_03407 BUPH_06578(kynA)
PGP : CUJ91_14555(kynA) CUJ91_32450(kynA)
PDIO : PDMSB3_0612(kynA) PDMSB3_3634(kynA)
BTRM : SAMEA390648704096(kynA)
AXX : ERS451415_01660(kynA)
DEL : DelCs14_4517 DelCs14_4526
DTS : BI380_13385 BI380_13430
DHK : BO996_10055 BO996_10100
DLA : I6G47_13695(kynA) I6G47_13740(kynA)
VAP : Vapar_1447 Vapar_5416
VPD : VAPA_1c15400(kynA) VAPA_2c08870 VAPA_2c12060(kynA)
VBO : CKY39_21920 CKY39_25470(kynA)
VAZ : H7F35_00925 H7F35_20325(kynA)
VAV : IG196_08350 IG196_22430(kynA)
LIM : L103DPR2_00866(kynA)
LIH : L63ED372_01900(kynA)
SMIO : CATMQ487_42230(kynA)
TMJ : P0M04_01750(kynA) P0M04_18810(kynA)
URU : DSM104443_03925(kynA)
UPL : DSM104440_03482(kynA)
ECAA : J3R84_22935(kynA) J3R84_25745
RTR : RTCIAT899_PC06335(kynA)
RHR : CKA34_00915 CKA34_21550
BGQ : X265_17370(kynA) X265_37530(kynA)
BGZ : XH91_20010(kynA) XH91_36730(kynA)
BSEP : HAP48_0033955(kynA)
BCAN : BcanWSM471_18100(kynA)
BVY : NCTC9239_00284(kynA)
TSV : DSM104635_01426(kynA)
PHP : PhaeoP97_00968(kynA)
PPIC : PhaeoP14_00915(kynA)
SINL : DSM14862_01901(kynA)
SPSE : SULPSESMR1_00939(kynA)
AHT : ANTHELSMS3_02499(kynA)
LALG : LentiSH36_02542(kynA)
AALK : LGT41_0011665(kynA)
SPHK : SKP52_06930(kynA) SKP52_13195
SFLA : SPHFLASMR4Y_03167(kynA)
ADO : A6F68_00230(kynA_1) A6F68_02653(kynA_2)
MSD : MYSTI_00707 MYSTI_08055
MYM : A176_006273 A176_007124
MFB : MFUL124B02_04030 MFUL124B02_42805
MYX : QEG98_04220 QEG98_41390
MLAN : JY572_23025 JY572_27095
MFU : LILAB_05135 LILAB_09350
MMAS : MYMAC_000746 MYMAC_007119
PPAK : JY651_35880 JY651_41525
SUR : STAUR_0311 STAUR_7558
MBD : MEBOL_003094 MEBOL_004157
CFUS : CYFUS_000945 CYFUS_009720
VIN : AKJ08_2010 AKJ08_2550
LLU : AKJ09_05749 AKJ09_09501
BFD : NCTC4823_00732(kynA)
BSJ : UP17_06330 UP17_19410
PBUT : DTO10_06325(kynA) DTO10_19020(kynA)
PFRI : L8956_06865(kynA) L8956_20040(kynA)
PERI : RE409_07220(kynA) RE409_22190(kynA)
SSTE : SAMEA4384403_0273(kynA)
MCAK : MCCS_15060(kynA_1) MCCS_15450(kynA_2)
NBR : O3I_014100 O3I_021175 O3I_022625
NTP : CRH09_08865 CRH09_29395
NOZ : DMB37_03175 DMB37_34435 DMB37_35930
NAH : F5544_15820 F5544_36435 F5544_39850
NWL : NWFMUON74_37030(kynA)
SANL : KZO11_19255 KZO11_29640
SHO : SHJGH_1088 SHJGH_5153
SMAL : SMALA_4103 SMALA_6631
SSOI : I1A49_24545 I1A49_36930
SBH : SBI_00212 SBI_05678(tdo)
SGU : SGLAU_04480 SGLAU_18190 SGLAU_31845
STRM : M444_18840 M444_37830
SAMB : SAM23877_0415 SAM23877_3972(kynA)
SCZ : ABE83_19655 ABE83_21395
SCX : AS200_22495 AS200_43170
STRF : ASR50_01450 ASR50_15515
SLE : sle_33790(sle_33790)
SPAV : Spa2297_02665 Spa2297_17600
SKY : D0C37_15430 D0C37_23895 D0C37_31660
SGM : GCM10017557_44920(kynA)
SPHW : NFX46_01260 NFX46_22100
SLS : SLINC_4600 SLINC_8373
SPLU : LK06_014565 LK06_031320
SSIA : A7J05_17210 A7J05_34390
SVU : B1H20_02185 B1H20_15625
SPUN : BFF78_09715 BFF78_15630 BFF78_20050
SALF : SMD44_04637 SMD44_06528
SLX : SLAV_20360(kynA1) SLAV_28375(kynA2)
SDX : C4B68_18580 C4B68_39090
SAST : CD934_16245 CD934_28980
SHAW : CEB94_01765 CEB94_22015
SGAL : CP966_11155 CP966_19605
SSPO : DDQ41_17075 DDQ41_25585
SPAD : DVK44_09650 DVK44_18310
SGF : HEP81_00328(TDO2) HEP81_03685
SCAV : CVT27_13225 CVT27_14935
SSUB : CP968_15775 CP968_16630
SFUG : CNQ36_01405 CNQ36_18640
STUI : GCM10017668_37510(kynA)
SHUN : DWB77_00177(kynA_1) DWB77_04140(kynA_2) DWB77_06816(kynA_3)
SCAL : I6J39_02310 I6J39_15640
SDD : D9753_16570 D9753_27330
SACT : DMT42_00425 DMT42_20905
SINE : KI385_12265 KI385_21875 KI385_25130
SRUG : F0345_01270 F0345_13275
SVIO : HWN34_16375 HWN34_22380 HWN34_29740
STUB : MMF93_00100 MMF93_17460
SSPN : LXH13_05105 LXH13_19705
SXT : KPP03845_103682(kynA)
STEE : F3L20_01130 F3L20_18840
SGK : PET44_17460 PET44_35060
SOV : QZH56_07075 QZH56_18865
SCHG : NRO40_00795 NRO40_15985
SMIB : SMIR_00245 SMIR_17000
MLV : CVS47_00181(kynA_1) CVS47_00300(kynA_2)
MSUW : GCM10025863_31170(kynA)
AMAU : DSM26151_27040(kynA)
AMAV : GCM10025877_12170(kynA)
ARH : AHiyo8_13930 AHiyo8_62210
ACIT : HPK19_06520(kynA) HPK19_15320
AAGI : NCTC2676_1_02691(kynA)
PSNI : NIBR502771_18510(kynA)
GCR : GcLGCM259_0518(kynA)
SGRG : L0C25_13910 L0C25_18475
KQI : F1D05_02795 F1D05_27905
KRI : OX958_14100 OX958_28515
THAO : NI17_001980 NI17_008285
ACIR : OG979_02775 OG979_37520
NGN : LCN96_07000 LCN96_23450 LCN96_24280
NFS : OIE67_14510 OIE67_15275 OIE67_21275
AMYY : YIM_25130(kynA1) YIM_40065(kynA2)
AORI : SD37_09870 SD37_32385
AROO : NQK81_14155 NQK81_30250
ARHD : VSH64_10050 VSH64_24210 VSH64_30285
SSYI : EKG83_01460 EKG83_10720 EKG83_25925 EKG83_27620 EKG83_30860
AHM : TL08_18530 TL08_25750
AHG : AHOG_16430(kynA1) AHOG_26665(kynA2)
UME : RM788_03255 RM788_26715
MIL : ML5_3351 ML5_4182 ML5_4271
MICB : MicB006_3976 MicB006_5620
MICH : FJK98_18625 FJK98_26160
MCAB : HXZ27_19945 HXZ27_25065
MSAG : GCM10017556_12300(kynA) GCM10017556_57060(kynA)
VMA : VAB18032_21825 VAB18032_28776
MCRA : ID554_21645 ID554_27165
VER : HUT12_16630 HUT12_26085
MCAY : PVK37_23300 PVK37_31475
ACTR : Asp14428_67440(kynA)
PRY : Prubr_27940(kynA_1) Prubr_59190(kynA_2)
CATI : CS0771_01330(kynA_1) CS0771_04150(kynA_2)
NHY : JQS43_06585 JQS43_21025
CAI : Caci_1080 Caci_3508 Caci_7896
BALA : DSM104299_02258(kynA)
SBAE : DSM104329_00862(kynA)
LEPV : J4558_14695 J4558_16800
KBS : EPA93_13970 EPA93_29220
GFO : GFO_1393(tdo2) GFO_3168
ZGA : ZOBELLIA_1440(tdoA2) ZOBELLIA_300(tdoA1)
PHG : KCTC32516_00508(kynA)
FOR : FORMB_08890 FORMB_15390
AALG : AREALGSMS7_00203 AREALGSMS7_00986
KOS : KORDIASMS9_00868(kynA) KORDIASMS9_00874(kynA)
KAN : IMCC3317_31350(kynA_1) IMCC3317_31410(kynA_2)
ALTI : ALE3EI_0533 ALE3EI_0788
MRS : Murru_1114 Murru_2636
SPON : HME9304_01261(tdo2)
FTE : Fluta_1677 Fluta_3189
FLU : CHH17_13465 CHH17_18715
OHO : Oweho_2749 Oweho_3471
PTAN : CRYO30217_00114(kynA)
» show all
Taxonomy
Reference
Authors
Uchida K, Shimizu T, Makino R, Sakaguchi K, Iizuka T, Ishimura Y, Nozawa T, Hatano M.
Title
Magnetic and natural circular dichroism of L-tryptophan 2,3-dioxygenases and indoleamine 2,3-dioxygenase. I. Spectra of ferric and ferrous high spin forms.
Journal
J Biol Chem 258:2519-25 (1983)
Reference
Authors
Ren S, Liu H, Licad E, Correia MA.
Title
Expression of rat liver tryptophan 2,3-dioxygenase in Escherichia coli: structural and functional characterization of the purified enzyme.
Journal
Reference
Authors
Leeds JM, Brown PJ, McGeehan GM, Brown FK, Wiseman JS.
Title
Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase.
Journal
J Biol Chem 268:17781-6 (1993)
Reference
Authors
Dang Y, Dale WE, Brown OR
Title
Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway.
Journal
Reference
Authors
Littlejohn TK, Takikawa O, Truscott RJ, Walker MJ.
Title
Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase.
Journal
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