KEGG   ENZYME: 1.13.11.52
Entry
EC 1.13.11.52               Enzyme                                 
Name
indoleamine 2,3-dioxygenase;
IDO (ambiguous);
tryptophan pyrrolase (ambiguous);
D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
D-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
(1) D-tryptophan + O2 = N-formyl-D-kynurenine [RN:R07362];
(2) L-tryptophan + O2 = N-formyl-L-kynurenine [RN:R00678]
Reaction(KEGG)
R00678 R07362;
(other) R02702 R02909 R03628
Substrate
D-tryptophan [CPD:C00525];
O2 [CPD:C00007];
L-tryptophan [CPD:C00078]
Product
N-formyl-D-kynurenine [CPD:C15605];
N-formyl-L-kynurenine [CPD:C02700]
Comment
A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase [1]. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver [2]. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].
History
EC 1.13.11.52 created 2006
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00463  indoleamine 2,3-dioxygenase
Genes
HSA169355(IDO2) 3620(IDO1)
PTR464134(IDO1) 472744(IDO2)
PPS100969906(IDO2) 100970596(IDO1)
GGO101131712(IDO1) 101134018(IDO2)
PON100435160(IDO2) 100436652(IDO1)
NLE100580631(IDO1) 100580956(IDO2)
HMH116461652(IDO1) 116461868(IDO2)
MCC574370(IDO1) 707424(IDO2)
MCF102126825(IDO1) 102129002(IDO2)
MTHB126961208 126961209
MNI105476547(IDO1) 105476549(IDO2)
CSAB103215667(IDO2) 103215668(IDO1)
CATY105590814(IDO1) 105590816(IDO2)
PANU101010384(IDO1) 101010746(IDO2)
TGE112630102(IDO1) 112630460(IDO2)
MLEU105535001(IDO2) 105535011(IDO1)
RRO104655209(IDO2) 104655211(IDO1)
RBB108537679(IDO2) 108537681(IDO1)
TFN117095206(IDO1) 117095225(IDO2)
PTEH111544106(IDO2) 111544107(IDO1)
CANG105525140(IDO1) 105525203(IDO2)
CJC100400216(IDO1) 100402049(IDO2)
SBQ101027731(IDO1) 101050312(IDO2)
CIMI108310239(IDO1) 108310249(IDO2)
CSYR103253231(IDO1) 103253232(IDO2)
MMUR105878169(IDO1) 105878170(IDO2)
LCAT123626627(IDO2) 123626628(IDO1)
PCOQ105820620(IDO2) 105820621(IDO1)
OGA100953210(IDO2) 100953516(IDO1)
MMU15930(Ido1) 209176(Ido2)
MCAL110300027(Ido2) 110300694(Ido1)
MPAH110337001(Ido1) 110337123(Ido2)
RNO66029(Ido1) 681319(Ido2)
MCOC116069031(Ido1) 116069032(Ido2)
ANU117721718(Ido2) 117721974(Ido1)
MUN110560029(Ido1) 132653594(Ido2)
CGE100754111(Ido2) 100754402(Ido1)
MAUA101838023(Ido2) 101839710(Ido1)
PROB127220347(Ido1) 127220354(Ido2)
PLEU114705753(Ido1) 114705759(Ido2)
MORG121462300(Ido2) 121462305(Ido1)
MFOT126504423 126504447
AAMP119812720(Ido2) 119813008(Ido1)
NGI103742351(Ido1)
HGL101723386(Ido2) 101723745(Ido1)
CPOC100727752(Ido2) 100728309(Ido1)
CCAN109698340(Ido1) 109698345(Ido2)
DORD105991692(Ido2) 106002559(Ido1)
DSP122107656(Ido1) 122107660(Ido2)
PLOP125339452(Ido2) 125339609(Ido1)
NCAR124983204 124983972
MMMA107159629(Ido2) 107159646(Ido1)
OCU100357946 100358205
OPI101519630(IDO1) 101526429(IDO2)
TUP102485305(IDO2) 102494474(IDO1)
GVR103595156(IDO2) 103608867(IDO1)
CFA475574(IDO1) 482846(IDO2)
CLUD112653230(IDO1) 112653288(IDO2)
VVP112916145(IDO2) 112916272(IDO1)
VLG121489289(IDO2) 121489290(IDO1)
NPO129515878(IDO1) 129515880(IDO2)
AML100480334(IDO2) 100480587(IDO1)
UMR103677106(IDO2) 103677107(IDO1)
UAH113245545(IDO1) 113245547(IDO2)
UAR123780297(IDO2) 123780317(IDO1)
ELK111144562 111144619
LLV125092781 125092782
MPUF101672897(IDO1) 101674323(IDO2)
MNP132006340(IDO1) 132006468(IDO2)
MLK131820500(IDO1) 131820524(IDO2)
NVS122889868(IDO2) 122919260(IDO1)
ORO101369080(IDO2) 101376680(IDO1)
EJU114224793(IDO1) 114224848(IDO2)
ZCA113924539(IDO2) 113924540(IDO1)
MLX118009935(IDO2) 118009936(IDO1)
NSU110573100(IDO1) 110573101(IDO2)
LWW102727570 102741055(IDO1) 102741357(IDO2)
FCA101096722(IDO2) 101096977(IDO1)
PYU121015606(IDO1) 121039912(IDO2)
PCOO112858128(IDO2) 112858555(IDO1)
PBG122473238(IDO2) 122473243(IDO1)
LRUF124520306 124520989
PTG102959839(IDO2) 102969142(IDO1)
PPAD109262284(IDO2) 109262285(IDO1)
PUC125923290 125923291
AJU106978365 106978398
HHV120246074(IDO1) 120246083(IDO2)
BTA506281(IDO1) 513810(IDO2)
BOM102264395(IDO1) 102267516(IDO2)
BIU109553529(IDO1) 109553543(IDO2)
BBUB102397405(IDO1) 102397944(IDO2)
BBIS104993210(IDO1) 104993211(IDO2)
CHX102184119(IDO1) 102184590(IDO2)
OAS100196903(IDO1) 101120548(IDO2)
BTAX128068368(IDO1) 128068377(IDO2)
ODA120865678(IDO1) 120865680(IDO2)
CCAD122432568(IDO2) 122432572(IDO1)
MBEZ129549237(IDO1) 129549238(IDO2)
SSC100519341(IDO2) 100519877(IDO1)
CFR102518520(IDO2) 106729416(IDO1)
CBAI105071346(IDO1) 105071511(IDO2)
CDK105105464(IDO1) 105105465(IDO2)
VPC102544039(IDO2) 102544305(IDO1)
BACU102998882(IDO1) 102999165(IDO2)
LVE103068351(IDO2) 103068620(IDO1)
OOR101286688(IDO2) 101286954(IDO1)
DLE111173537(IDO1) 111173538(IDO2)
PCAD102990011(IDO1) 102990290(IDO2)
PSIU116746627(IDO1) 116746850(IDO2)
NASI112413103(IDO1) 112413205(IDO2)
ECB100056686(IDO2) 106782641(IDO1)
EPZ103554295(IDO2) 103554296(IDO1)
EAI106828941(IDO1) 106828942(IDO2)
MYB102256119(IDO1) 102256420(IDO2)
MYD102755941(IDO2) 102756580(IDO1)
MMYO118651942(IDO1) 118652090(IDO2)
MLF102426253(IDO1) 102426572(IDO2)
PKL118730235(IDO2) 118730629(IDO1)
EFUS103288165(IDO1) 103288287(IDO2)
MNA107523935(IDO2) 107523938(IDO1)
DRO112321513(IDO2) 112321553(IDO1)
SHON118993190(IDO1) 118993191(IDO2)
AJM119064992(IDO2) 119065052(IDO1)
PDIC114508403(IDO1) 114508713(IDO2)
PHAS123807675(IDO2) 123807694(IDO1)
MMF118623040(IDO1) 118623043(IDO2)
PPAM129064645(IDO1) 129064680(IDO2)
HAI109386258(IDO1) 109386283(IDO2)
RFQ117021796(IDO2) 117021797(IDO1)
PALE102878670(IDO2) 102896453(IDO1)
PGIG120595557(IDO1) 120595607(IDO2)
PVP105300415(IDO1) 105300983(IDO2)
RAY107501321(IDO1) 107501322(IDO2)
MJV108398102(IDO2) 108398103(IDO1)
TOD119256541 119256963(IDO1) 119256965(IDO2)
SARA101543020(IDO1) 101543560(IDO2) 101553130
LAV100660395(IDO1) 100671377(IDO2)
TMU101343111 101348111
ETF101651677 101651988 101652302(IDO2)
DNM101427072(IDO2) 101435095(IDO1) 101447628
MDO100032999(IDO1) 100033003(IDO2)
GAS123234853(IDO2) 123234854(IDO1)
SHR100926615 100926876(IDO2) 105749589
AFZ127548253 127548254 127548255
PCW110203204(IDO1) 110203211(IDO2)
OAA100085939(IDO2) 100086385(IDO1)
GGA426785(IDO2)
PCOC116234567(IDO2)
MGP100548413(IDO2)
CJO107323723(IDO2)
TPAI128089983
LMUT125685304
NMEL110387039(IDO2)
APLA101791377(IDO2)
ACYG106044372(IDO2)
CATA118256059(IDO2)
AFUL116499488(IDO2)
TGU100219367(IDO2)
LSR110473378(IDO2)
SCAN103822691(IDO2)
PMOA120505687
OTC121346780
PRUF121359402
GFR102036837(IDO2)
FAB101810571(IDO2)
OMA130262076(IDO2)
PHI102102902(IDO2)
PMAJ107213849(IDO2)
CCAE111938853(IDO2)
CCW104694855(IDO2)
CBRC103614695(IDO2)
ETL114066491(IDO2)
ZAB102073086(IDO2)
ACHL103809592
SVG106862070(IDO2)
MMEA130586945(IDO2)
HRT120763981
FPG101914440(IDO2)
FCH102055026(IDO2)
CLV102086320(IDO2)
EGZ104135315(IDO2)
NNI104016072(IDO2)
PCRI104023850
PLET104625203
EHS104506818
ACUN113488059(IDO2)
TALA116959097(IDO2)
PADL103920552(IDO2)
AFOR103900537(IDO2)
HALD104321310
HLE104828800
AGEN126051707
GCL127025238
CCRI104165066
CSTI104561280
MUI104542255
BREG104634789
GSTE104253536
LDI104346755
MNB103770321
OHA104333237(IDO2)
NNT104405069(IDO2)
SHAB115618415(IDO2)
DPUB104301272(IDO2)
PGUU104471341
ACAR104531226
CPEA104384845
CVF104295637(IDO2)
RTD128900095
CUCA104068583
TEO104377572
BRHI104496623
AAM106487770
AROW112974197(IDO2)
NPD112953858(IDO2)
DNE112990465(IDO2)
SCAM104148768(IDO2)
ASN102376360(IDO2)
AMJ106739382
CPOO109317406(IDO2)
GGN109295535(IDO2)
PSS102453712(IDO2) 102455437
CMY102945834 102946062
CCAY125626412(IDO1) 125626414(IDO2)
DCC119848555(IDO2) 119848556(IDO1)
CPIC101943268 101943538
TST117873036 117873037
CABI116821428 116821432
MRV120399464 120399465
ACS100560005(ido2)
ASAO132782501(IDO2)
PVT110072158(IDO2)
SUND121933413
PBI103053378(IDO2)
PMUR107289243(IDO2)
CTIG120312874(IDO2)
TSR106557309
PGUT117658246(IDO2)
APRI131203950(IDO2)
PTEX113445787(IDO2)
NSS113427994
VKO123027126
PMUA114585055
PRAF128402585(IDO2)
ZVI118097138
HCG128334000
GJA107112976(IDO2)
STOW125425359(IDO2)
EMC129341838(IDO2)
XLA100037099(ido1.L)
XTR448488(ido1)
NPR108792467(IDO2)
RTEM120933077(IDO2)
BBUF120986163(IDO2)
BGAR122927394(IDO2)
MUO115469301 115469714
GSH117362757 117362937
DRE571967(ido1)
SRX107710826 107718947
SANH107665200 107678376
SGH107553133 107575786
CCAR109082139 109093681
CAUA113039681 113106758
CGIB127962849 128018248
PTET122350763
LROH127169613 127169615
OMC131545248 131545889(ido1)
PPRM120481312(ido1)
RKG130082096(ido1)
MAMB125280376(ido1)
CIDE127517080
MASI127415469
TROS130567911(ido1)
TDW130406907 130407334
MANU129413756(ido1)
IPU108261789 108265915(ido1)
IFU128607443 128607444
PHYP113533299
SMEO124399808(ido1)
TFD113646483(ido1)
TVC132853496(ido1)
AMEX103034408
CMAO118813288(ido1)
EEE113578171
CHAR105902744(ido1) 105910904
TRU101074760
TFS130526345(ido1)
TNGGSTEN00020439G001
LCO104929405 104931154
NCC104966201
TBEN117496919(ido1) 117499780
CGOB115013739 115020208
PGEO117452824(ido1) 117460173
GACU117560899 117561112(ido1)
EMAC134858405 134873878(ido1)
ELY117248703 117252223(ido1)
EFO125890312(ido1) 125903634
PLEP121944647(ido1) 121955034
SLUC116053927(ido1) 116055474
ECRA117944249(ido1) 117960787
ESP116690199 116705329
PFLV114556148 114562965 114572566
GAT120830916(ido1)
PPUG119224575(ido1)
AFB129101507(ido1)
CLUM117736511(ido1)
PSWI130196165(ido1)
MSAM119891997(ido1) 119917540
SCHU122876973(ido1) 122884667
CUD121509246(ido1) 121510772
ALAT119019532(ido1) 119033434
MZE101472607 101479436
ONL100702686 100706576
OAU116310246(ido1) 116322211
OLA101167965 101169805
OML112147981(ido1) 112161927
CSAI133450358(ido1) 133463681
XMA102229086 102236092
XCO114138571 114154044
XHE116713820 116729695
PRET103470503 103476765
PFOR103133561 103145719
PLAI106936396 106949737
PMEI106914144 106932858
GAF122827979(ido1) 122842685
PPRL129359800 129372209(ido1)
CVG107093575 107093869
CTUL119776059 119783931(ido1)
GMU124859383 124877638 124877910
NFU107375992 107393763
KMR108236475(ido1) 108242928
ALIM106532554
NWH119413466(ido1) 119419086
AOCE111566901 111578649
MCEP125011925(ido1) 125018475
CSEM103387655 103398229
POV109633673
SSEN122769196(ido1) 122781502
HHIP117768409(ido1) 117775696
HSP118115278(ido1) 118119113
SMAU118284113 118314580(ido1)
LCF108878793(ido1) 108897278
SDU111230009 111235291
SLAL111649548 111663420 111663848
XGL120796675 120804813(ido1)
HCQ109525131
SSCV125994380
SBIA133499451(ido1)
PEE133400628(ido1)
PTAO133475030(ido1)
BPEC110169903
MALB109956908 109960434
BSPL114841969 114863162(ido1)
SJO128364091(ido1) 128372507
SASA106577031 106579858 106585586
STRU115164544 115193722 115200101
OTW112248460 112253538 112263992(ido1)
OMY110525639 110529307 110536009(ido1)
OGO124034340 124036279 124041233
ONE115111577 115135078 115140017
OKI109879368 109888797 109894902
OKE118358316 118369741 118393182
SALP111951597 111957692 111975044
SNH120017416 120017668 120063219
CCLU121530873(ido1) 121553712 121584820
ELS105010594 105014035
SFM108922613 108929475
PKI111838843 111842017 111842059 111849886
AANG118212365 118237252(ido1)
LOC102690450 102692732
PSPA121302180 121302245 121303059 121303061(ido1)
ARUT117397802 117397807 117962507 117971679
PSEX120539301 120539486(ido1)
LCM102364348(IDO2)
CMK103191437(ido1)
CPLA122543131(ido1)
HOC132836903(ido1)
LERI129713216(ido1)
PMRN116940531
LRJ133343387
BFO118431881
BBEL109475153
SPU100893352 577419 754565
LPIC129263163 129263694 129269297 129270335
APLC110980378 110980392
BCOO119070407
NAINECAME_04865
LOALOAG_17446
LGILOTGIDRAFT_168391 LOTGIDRAFT_168398 LOTGIDRAFT_236096
PVUL126810606 130010305
PCAN112556297
BGT106056257 106061361
GAE121380352 121381952
HRF124132381 124132382 124145837 124145838
HRJ124256228 124256245 124287374 124287429
CRG105346105
CVN111119760 111119789
CANU128168233
OED125670615 125670616
MYI110441193 110450994 110450995 110450996 110461080
PMAX117329726 117329738 117329744 117329747 117338256
MCAF127707726
MMER123563434
RPHI132713844
DPOL127867275 127868168
OSN115223125
LAK106161424 106162758 106162759 106162760 106162816 106176942 106176946 106182094
SMMSmp_133900
OVIT265_07231
EGLEGR_09710
NVE5509616
EPA110240490 110250165 110250194
ATEN116304907
ADF107346918 107346919
AMIL114958243 114958245
PDAM113684337
SPIS111334011
DGT114538136 114539262 114539439 114544431
XEN124448021 124448022
AQU105312930 105315377 105315605
CRECHLRE_17g710200v5 CHLRE_17g713700v5
MNGMNEG_4429
CVRCHLNCDRAFT_133396
SCEYJR078W(BNA2)
SEUBDI49_3089
SPAOSPAR_J02590
AGOAGOS_ACR188C
ERCEcym_4655
LTHKLTH0C05412g
VPOKpol_520p15
ZROZYRO0F13376g
TPFTPHA_0B01500(TPHA0B01500)
TGBHG536_0B04150
TDLTDEL_0C03080(TDEL0C03080)
ZMKHG535_0B05340
PPAPAS_chr1-4_0083
DHADEHA2G12188g
PICPICST_87443(BNA2)
PGUPGUG_04309
SPAASPAPADRAFT_63090(BNA2)
LELPVL30_004899(BNA2)
CALCAALFM_C500800CA(CaO19.583)
CTPCTRG_05778
COTCORT_0F00140
CDUCD36_51480
CTENCANTEDRAFT_127423
YLIYALI0F26455g
CLUCLUG_01155
CLUSA9F13_09g02178
CAURCJI96_0003309
SLBAWJ20_653(BNA2)
PKZC5L36_0E04730
BNNFOA43_000797
BBRXBRETT_001222
OPAHPODL_01018
NCRNCU01402 NCU05752 NCU09184
NTENEUTE1DRAFT43213(NEUTE1DRAFT_43213) NEUTE1DRAFT76034(NEUTE1DRAFT_76034) NEUTE1DRAFT86563(NEUTE1DRAFT_86563)
SMPSMAC_08377 SMAC_08948 SMAC_08990
PANPODANSg2504 PODANSg762 PODANSg7893
PBELQC761_201070 QC761_401340(BNA2) QC761_700760
PPSDQC762_201070 QC762_401340(BNA2) QC762_700760
PPSPQC763_201070 QC763_401340(BNA2) QC763_700760
PPSAQC764_201070 QC764_401340(BNA2) QC764_700760
TTTTHITE_2106420 THITE_2110987 THITE_2120385
MTMMYCTH_2300294 MYCTH_2303249 MYCTH_2307600
CTHRCTHT_0045730 CTHT_0051700 CTHT_0072620
MGRMGG_00755 MGG_13773 MGG_14348
PPEIPpBr36_05444 PpBr36_08387 PpBr36_10865
PGRIPgNI_02884 PgNI_08067 PgNI_08551
TMNUCRPA7_1826 UCRPA7_5970 UCRPA7_8045
SSCKSPSK_03376 SPSK_05234 SPSK_09104
FGRFGSG_02657 FGSG_04828 FGSG_09040
FPUFPSE_00364 FPSE_04050 FPSE_07323
FPOAFPOAC1_002785 FPOAC1_007667 FPOAC1_012709
FVNFVRRES_03100 FVRRES_08130 FVRRES_13909
FVRFVEG_03512 FVEG_06565 FVEG_09278
FOXFOXG_05659 FOXG_08978 FOXG_10631
NHENECHADRAFT_70501 NECHADRAFT_70795 NECHADRAFT_85363
FFCNCS54_00852400 NCS54_00996000 NCS54_01207800
FKRNCS57_00896000 NCS57_00990300 NCS57_01198600
FMUJ7337_003526 J7337_005128 J7337_009220
TRETRIREDRAFT_123550 TRIREDRAFT_54260 TRIREDRAFT_64330
TRRM419DRAFT_103027 M419DRAFT_82203 M419DRAFT_84917
MAWMAC_02469 MAC_02622 MAC_05464
MAJMAA_00343 MAA_03016 MAA_05241
PCHMVFPPC_08814 VFPPC_09609 VFPPC_10339 VFPPC_11154 VFPPC_16145
CMTCCM_02833 CCM_03688 CCM_06695
AMUSLMH87_007130 LMH87_007825 LMH87_008562 LMH87_012010
PLJVFPFJ_03105 VFPFJ_08527 VFPFJ_10191 VFPFJ_10856
PTKZJDV02_001859(BNA2_1) JDV02_005489(BNA2_2) JDV02_006827 JDV02_008848
VALVDBG_00295 VDBG_04314 VDBG_09667
VDAVDAG_05624 VDAG_08582 VDAG_10523
CFJCFIO01_11397 CFIO01_12906 CFIO01_13114
CLUPCLUP02_10126 CLUP02_10625 CLUP02_17214
CHIGCH63R_06938 CH63R_09055 CH63R_09419
SAPOSAPIO_CDS10590 SAPIO_CDS9355
ELAUCREL1_5860 UCREL1_7574 UCREL1_7759
PFYPFICI_02204 PFICI_03646 PFICI_06657 PFICI_14031
SSLSS1G_00858 SS1G_08222 SS1G_10307
BFUBCIN_12g01060 BCIN_14g01360 BCIN_14g04320
MBEMBM_00447 MBM_04791 MBM_09099
PSCOLY89DRAFT_46206 LY89DRAFT_704456 LY89DRAFT_732805
GLZGLAREA_00603 GLAREA_03347 GLAREA_11411
ANIANIA_01858 ANIA_02509 ANIA_09108
AFMAFUA_3G14250 AFUA_4G09830 AFUA_7G02010
ACTACLA_041740 ACLA_049060 ACLA_065510
NFINFIA_063050 NFIA_106220 NFIA_114740
AORAO090003001248 AO090020000618 AO090038000578
ANGAn04g07210 An09g04250 An12g00660
AFVAFLA_000425 AFLA_009061 AFLA_010029
ALUCAKAW2_30285A AKAW2_40495S AKAW2_81033S
ACHEACHE_10703A ACHE_20065A ACHE_31323A ACHE_60068A ACHE_70219S ACHE_70687A
APUUAPUU_21222A APUU_30231S APUU_31574S
PCSN7525_002475 N7525_005148 N7525_007796
PDPPDIP_24520 PDIP_25600 PDIP_56120
POUPOX_b02054 POX_e06475 POX_g08572
TMFEYB26_000580 EYB26_006842 EYB26_009539
TRGTRUGW13939_02130 TRUGW13939_04063 TRUGW13939_11421
CIMCIMG_00126 CIMG_07803
CPWCPC735_041970 CPC735_060120
UREUREG_00231 UREG_02134
PBLPAAG_05853 PAAG_06866
PBNPADG_04329 PADG_06139
ABEARB_03636 ARB_04584 ARB_05733
TVETRV_00864 TRV_01957 TRV_04509
AJEHCAG_01148 HCAG_04432
BGHBDBG_04038 BDBG_06623
PNOSNOG_02815 SNOG_10574 SNOG_10794
PTEPTT_07650 PTT_08299 PTT_13994
BZECOCCADRAFT_1250 COCCADRAFT_97046
BSCCOCSADRAFT_102379 COCSADRAFT_138733
BORCOCMIDRAFT_1657 COCMIDRAFT_95092
AALTCC77DRAFT_1023915 CC77DRAFT_123730
ARABEKO05_0001381 EKO05_0007622 EKO05_0007878
ZTRMYCGRDRAFT_52885 MYCGRDRAFT_73635 MYCGRDRAFT_75056
PFJMYCFIDRAFT_215476 MYCFIDRAFT_48024 MYCFIDRAFT_56678
FFUCLAFUR5_00304 CLAFUR5_06900 CLAFUR5_12265
CBETCB0940_00866 CB0940_06399 CB0940_09211 CB0940_11439
BCOMBAUCODRAFT_31662
NPAUCRNP2_2918 UCRNP2_4546 UCRNP2_9460
TMLGSTUM_00005398001 GSTUM_00007145001
CNECNC04830
CNBCNBC2350
CNGCNAG_02868
CGICGB_C7140C
CDEUCNBG_3517
TMSTREMEDRAFT_73719
TASAA1Q1_00029 A1Q1_00097
CCACCcaHIS019_0104590(CcaverHIS019_0104590) CcaHIS019_0113040(CcaverHIS019_0113040)
PPLPOSPLDRAFT_102140
TVSTRAVEDRAFT_118782 TRAVEDRAFT_168783
DSQDICSQDRAFT_49513 DICSQDRAFT_66685
PCOPHACADRAFT_255856
SHSSTEHIDRAFT_128669 STEHIDRAFT_49151 STEHIDRAFT_96831
HIRHETIRDRAFT_326738 HETIRDRAFT_417390 HETIRDRAFT_43434
PSQPUNSTDRAFT_100537 PUNSTDRAFT_102652 PUNSTDRAFT_53490 PUNSTDRAFT_60614
ADLAURDEDRAFT_103636 AURDEDRAFT_168315
FMEFOMMEDRAFT_164852 FOMMEDRAFT_29270
GTRGLOTRDRAFT_122534 GLOTRDRAFT_36830 GLOTRDRAFT_46282
RSXRhiXN_02473 RhiXN_02769 RhiXN_02832 RhiXN_04477
LBCLACBIDRAFT_157851 LACBIDRAFT_253793 LACBIDRAFT_253815 LACBIDRAFT_256000 LACBIDRAFT_257063 LACBIDRAFT_306113
CCICC1G_01112 CC1G_02499 CC1G_12399
ABPAGABI1DRAFT107428(AGABI1DRAFT_107428) AGABI1DRAFT34575(AGABI1DRAFT_34575) AGABI1DRAFT60207(AGABI1DRAFT_60207) AGABI1DRAFT85862(AGABI1DRAFT_85862)
ABVAGABI2DRAFT135051(AGABI2DRAFT_135051) AGABI2DRAFT177539(AGABI2DRAFT_177539) AGABI2DRAFT177540(AGABI2DRAFT_177540) AGABI2DRAFT64740(AGABI2DRAFT_64740)
MPRMPER_05176 MPER_12716
MRRMoror_12110 Moror_5206 Moror_8344 Moror_9957 Moror_9958
MOREE1B28_000370 E1B28_009296 E1B28_010883 E1B28_010889
SCMSCHCO_02608091(SCHCODRAFT_02608091) SCHCO_02640585(SCHCODRAFT_02640585) SCHCO_02643132(SCHCODRAFT_02643132) SCHCO_02673121(SCHCODRAFT_02673121)
CPUTCONPUDRAFT_135908 CONPUDRAFT_135912 CONPUDRAFT_48837
SLASERLADRAFT_467213 SERLADRAFT_476036
WSEWALSEDRAFT_7644
UMAUMAG_03728
PFPPFL1_01140
SGRAEX895_001163 EX895_001261
PGRPGTG_06521 PGTG_09355
PTRCPtA15_16A61 PtA15_8A651
PSTRPst134EA_015643 Pst134EA_015685 Pst134EA_028861 Pst134EA_031248
MLRMELLADRAFT_117589 MELLADRAFT_25201 MELLADRAFT_78815 MELLADRAFT_90083
MBRMONBRDRAFT_31854
SREPTSG_11822
TETTTHERM_00035520 TTHERM_00035530
SMINv1.2.032345.t1(symbB.v1.2.032345.t1)
EHXEMIHUDRAFT_213134
GTTGUITHDRAFT_149065
ASIPAQUSIP_11920
NOCNoc_1709
NHLNhal_1432
OMEOLMES_5389
MBRYB1812_07760
MROSEHO51_18230
MHEYH2LOC_020715
NGFFRF71_13670
SPAIFPZ24_13335
CIJWG74_09600
SPHGAZE99_10335
SFLASPHFLASMR4Y_00166
SPHYCHN51_12400
BMAAT8S45_04225
PALGHFP57_00940
PARJJ4G78_13540
AEPAMC99_01154
ALHG6N82_01105
AMXAM2010_904
PMASNCF86_05485
ANHA6F65_01695
ADOA6F68_02366
TFVIDJ81_12080
ERYCP97_09975
QSOIRL76_05555
QARK3148_12215
ELIELI_06040
ERFFIU90_10105
MAIMICA_2463
MANA11S_2397
BMYOBG05_5592
EUZDVS28_a0378
ASDAS9A_2778
SCBSCAB_15261
SGEDWG14_08250
SROIIAG44_01315
AABA4R43_06715
AMYYYIM_20245
PVNA7sIIA15_02365
ABAMB1s21122_01565
NHIB1s21160_01375
NABB1sIIB91_01285
TERTery_4014
NCNBZZ01_21155
FGIOP10G_1182
SACISinac_2518
GAUGAU_3278(indO)
GPHGEMMAAP_16770
NDENIDE0784
NMVNITMOv2_0702
NIONITINOP_1554
NSALHWV07_19335
HRUHalru_2529
 » show all
Reference
1  [PMID:6065097]
  Authors
Yamamoto S, Hayaishi O.
  Title
Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes.
  Journal
J Biol Chem 242:5260-6 (1967)
Reference
2  [PMID:2428037]
  Authors
Yasui H, Takai K, Yoshida R, Hayaishi O.
  Title
Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients.
  Journal
Proc Natl Acad Sci U S A 83:6622-6 (1986)
DOI:10.1073/pnas.83.17.6622
  Sequence
[hsa:3620]
Reference
3  [PMID:2419335]
  Authors
Takikawa O, Yoshida R, Kido R, Hayaishi O
  Title
Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.
  Journal
J Biol Chem 261:3648-53 (1986)
  Sequence
[mmu:15930]
Reference
4  [PMID:194886]
  Authors
Hirata F, Ohnishi T, Hayaishi O.
  Title
Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex.
  Journal
J Biol Chem 252:4637-42 (1977)
Reference
5  [PMID:10719243]
  Authors
Dang Y, Dale WE, Brown OR
  Title
Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway.
  Journal
Free Radic Biol Med 28:615-24 (2000)
DOI:10.1016/S0891-5849(99)00272-5
  Sequence
[rno:66029]
Reference
6  [PMID:12766158]
  Authors
Littlejohn TK, Takikawa O, Truscott RJ, Walker MJ.
  Title
Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase.
  Journal
J Biol Chem 278:29525-31 (2003)
DOI:10.1074/jbc.M301700200
  Sequence
[hsa:3620]
Reference
7  [PMID:10731095]
  Authors
Thomas SR, Stocker R.
  Title
Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway.
  Journal
Redox Rep 4:199-220 (1999)
DOI:10.1179/135100099101534927
Reference
8  [PMID:2334706]
  Authors
Sono M.
  Title
Spectroscopic and equilibrium studies of ligand and organic substrate binding to indolamine 2,3-dioxygenase.
  Journal
Biochemistry 29:1451-60 (1990)
DOI:10.1021/bi00458a016
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.52
IUBMB Enzyme Nomenclature: 1.13.11.52
ExPASy - ENZYME nomenclature database: 1.13.11.52
BRENDA, the Enzyme Database: 1.13.11.52
CAS: 9014-51-1
LinkDB

DBGET integrated database retrieval system