KEGG ENZYME: 1.13.11.52

ENZYME: 1.13.11.52

Entry

EC 1.13.11.52               Enzyme

Name

indoleamine 2,3-dioxygenase;
IDO (ambiguous);
tryptophan pyrrolase (ambiguous);
D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

D-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)

Reaction(IUBMB)

(1) D-tryptophan + O2 = N-formyl-D-kynurenine [RN:R07362];
(2) L-tryptophan + O2 = N-formyl-L-kynurenine [RN:R00678]

Reaction(KEGG)

R00678 R07362;
(other) R02702 R02909 R03628

Substrate

D-tryptophan [CPD:C00525];
O2 [CPD:C00007];
L-tryptophan [CPD:C00078]

Product

N-formyl-D-kynurenine [CPD:C15605];
N-formyl-L-kynurenine [CPD:C02700]

Comment

A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase [1]. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver [2]. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].

History

EC 1.13.11.52 created 2006

Pathway

ec00380

Tryptophan metabolism

ec01100

Metabolic pathways

Orthology

K00463

indoleamine 2,3-dioxygenase

Genes

HSA:	169355(IDO2) 3620(IDO1)

PTR:	464134(IDO1) 472744(IDO2)

PPS:	100969906(IDO2) 100970596(IDO1)

GGO:	101131712(IDO1) 101134018(IDO2)

PON:	100435160(IDO2) 100436652(IDO1)

PPYG:

129042836(IDO2) 129042837(IDO1)

NLE:	100580631(IDO1) 100580956(IDO2)

HMH:	116461652(IDO1) 116461868(IDO2)

SSYN:

129491826(IDO1) 129491827(IDO2)

MCC:	574370(IDO1) 707424(IDO2)

MCF:	102126825(IDO1) 102129002(IDO2)

MTHB:

126961208 126961209

MNI:	105476547(IDO1) 105476549(IDO2)

CSAB:

103215667(IDO2) 103215668(IDO1)

CATY:

105590814(IDO1) 105590816(IDO2)

PANU:

101010384(IDO1) 101010746(IDO2)

TGE:	112630102(IDO1) 112630460(IDO2)

MLEU:

105535001(IDO2) 105535011(IDO1)

RRO:	104655209(IDO2) 104655211(IDO1)

RBB:	108537679(IDO2) 108537681(IDO1)

TFN:	117095206(IDO1) 117095225(IDO2)

PTEH:

111544106(IDO2) 111544107(IDO1)

CANG:

105525140(IDO1) 105525203(IDO2)

CJC:	100400216(IDO1) 100402049(IDO2)

SBQ:	101027731(IDO1) 101050312(IDO2)

CIMI:

108310239(IDO1) 108310249(IDO2)

ANAN:

105733495(IDO2) 105733580(IDO1)

CSYR:

103253231(IDO1) 103253232(IDO2)

MMUR:

105878169(IDO1) 105878170(IDO2)

LCAT:

123626627(IDO2) 123626628(IDO1)

PCOQ:

105820620(IDO2) 105820621(IDO1)

OGA:	100953210(IDO2) 100953516(IDO1)

MMU:	15930(Ido1) 209176(Ido2)

MCAL:

110300027(Ido2) 110300694(Ido1)

MPAH:

110337001(Ido1) 110337123(Ido2)

RNO:	66029(Ido1) 681319(Ido2)

MCOC:

116069031(Ido1) 116069032(Ido2)

ANU:	117721718(Ido2) 117721974(Ido1)

ASYL:

127668598(Ido1) 127668979(Ido2)

MUN:	110560029(Ido1) 132653594(Ido2)

CGE:	100754111(Ido2) 100754402(Ido1)

MAUA:

101838023(Ido2) 101839710(Ido1)

PROB:

127220347(Ido1) 127220354(Ido2)

PLEU:

114705753(Ido1) 114705759(Ido2)

MORG:

121462300(Ido2) 121462305(Ido1)

MFOT:

126504423 126504447

AAMP:

119812720(Ido2) 119813008(Ido1)

NGI:	103742351(Ido1)

HGL:	101723386(Ido2) 101723745(Ido1)

CPOC:

100727752(Ido2) 100728309(Ido1)

CCAN:

109698340(Ido1) 109698345(Ido2)

DORD:

105991692(Ido2) 106002559(Ido1)

DSP:	122107656(Ido1) 122107660(Ido2)

PLOP:

125339452(Ido2) 125339609(Ido1)

NCAR:

124983204 124983972

MMMA:

107159629(Ido2) 107159646(Ido1)

ITI:	101970717(Ido2) 101971000(Ido1)

OCU:	100357946 100358205

OPI:	101519630(IDO1) 101526429(IDO2)

TUP:	102485305(IDO2) 102494474(IDO1)

GVR:	103595156(IDO2) 103608867(IDO1)

CFA:	475574(IDO1) 482846(IDO2)

CLUD:

112653230(IDO1) 112653288(IDO2)

VVP:	112916145(IDO2) 112916272(IDO1)

VLG:	121489289(IDO2) 121489290(IDO1)

NPO:	129515878(IDO1) 129515880(IDO2)

AML:	100480334(IDO2) 100480587(IDO1)

UMR:	103677106(IDO2) 103677107(IDO1)

UAH:	113245545(IDO1) 113245547(IDO2)

UAR:	123780297(IDO2) 123780317(IDO1)

ELK:	111144562 111144619

LLV:	125092781 125092782

MPUF:

101672897(IDO1) 101674323(IDO2)

MNP:	132006340(IDO1) 132006468(IDO2)

MLK:	131820500(IDO1) 131820524(IDO2)

NVS:	122889868(IDO2) 122919260(IDO1)

ORO:	101369080(IDO2) 101376680(IDO1)

EJU:	114224793(IDO1) 114224848(IDO2)

ZCA:	113924539(IDO2) 113924540(IDO1)

MLX:	118009935(IDO2) 118009936(IDO1)

NSU:	110573100(IDO1) 110573101(IDO2)

LWW:	102727570 102741055(IDO1) 102741357(IDO2)

FCA:	101096722(IDO2) 101096977(IDO1)

PYU:	121015606(IDO1) 121039912(IDO2)

PCOO:

112858128(IDO2) 112858555(IDO1)

PBG:	122473238(IDO2) 122473243(IDO1)

PVIV:

125163938(IDO2) 125164352(IDO1)

LRUF:

124520306 124520989

LGF:	123588551(IDO2) 123588553(IDO1)

AJU:	106978365 106978398

PTG:	102959839(IDO2) 102969142(IDO1)

PPAD:

109262284(IDO2) 109262285(IDO1)

PUC:	125923290 125923291

PLEZ:

122217592(IDO2) 122217594(IDO1)

HHV:	120246074(IDO1) 120246083(IDO2)

BTA:	506281(IDO1) 513810(IDO2)

BOM:	102264395(IDO1) 102267516(IDO2)

BIU:	109553529(IDO1) 109553543(IDO2)

BBUB:

102397405(IDO1) 102397944(IDO2)

BBIS:

104993210(IDO1) 104993211(IDO2)

CHX:	102184119(IDO1) 102184590(IDO2)

OAS:	100196903(IDO1) 101120548(IDO2)

BTAX:

128068368(IDO1) 128068377(IDO2)

CSUM:

138078259(IDO2) 138078422(IDO1)

ODA:	120865678(IDO1) 120865680(IDO2)

CCAD:

122432568(IDO2) 122432572(IDO1)

MREE:

136176498(IDO1) 136176519(IDO2)

OVR:	110126570(IDO2) 110126581(IDO1)

MBEZ:

129549237(IDO1) 129549238(IDO2)

SSC:	100519341(IDO2) 100519877(IDO1)

CFR:	102518520(IDO2) 106729416(IDO1)

CBAI:

105071346(IDO1) 105071511(IDO2)

CDK:	105105464(IDO1) 105105465(IDO2)

VPC:	102544039(IDO2) 102544305(IDO1)

BACU:

102998882(IDO1) 102999165(IDO2)

BMUS:

118887739(IDO1) 118887787(IDO2)

LVE:	103068351(IDO2) 103068620(IDO1)

OOR:	101286688(IDO2) 101286954(IDO1)

LALB:

132512595(IDO2) 132512712(IDO1)

DLE:	111173537(IDO1) 111173538(IDO2)

PCAD:

102990011(IDO1) 102990290(IDO2)

PSIU:

116746627(IDO1) 116746850(IDO2)

NASI:

112413103(IDO1) 112413205(IDO2)

ECB:	100056686(IDO2) 106782641(IDO1)

EPZ:	103554295(IDO2) 103554296(IDO1)

EAI:	106828941(IDO1) 106828942(IDO2)

MYB:	102256119(IDO1) 102256420(IDO2)

MYD:	102755941(IDO2) 102756580(IDO1)

MMYO:

118651942(IDO1) 118652090(IDO2)

MLF:	102426253(IDO1) 102426572(IDO2)

MDT:	132228621(IDO2) 132228622(IDO1)

MYUM:

139004892(IDO1) 139004893(IDO2)

PKL:	118730235(IDO2) 118730629(IDO1)

EFUS:

103288165(IDO1) 103288287(IDO2)

MNA:	107523935(IDO2) 107523938(IDO1)

DRO:	112321513(IDO2) 112321553(IDO1)

SHON:

118993190(IDO1) 118993191(IDO2)

AJM:	119064992(IDO2) 119065052(IDO1)

PDIC:

114508403(IDO1) 114508713(IDO2)

PHAS:

123807675(IDO2) 123807694(IDO1)

MMF:	118623040(IDO1) 118623043(IDO2)

PPAM:

129064645(IDO1) 129064680(IDO2)

HAI:	109386258(IDO1) 109386283(IDO2)

RFQ:	117021796(IDO2) 117021797(IDO1)

PALE:

102878670(IDO2) 102896453(IDO1)

PGIG:

120595557(IDO1) 120595607(IDO2)

PVP:	105300415(IDO1) 105300983(IDO2)

RAY:	107501321(IDO1) 107501322(IDO2)

MJV:	108398102(IDO2) 108398103(IDO1)

TOD:	119256541 119256963(IDO1) 119256965(IDO2)

SARA:

101543020(IDO1) 101543560(IDO2) 101553130

SFUM:

130025999(IDO1) 130026164(IDO2) 130028821

SETR:

126006487(IDO2) 126007259(IDO1) 126022054

LAV:	100660395(IDO1) 100671377(IDO2)

TMU:	101343111 101348111

ETF:	101651677 101651988 101652302(IDO2)

DNM:	101427072(IDO2) 101435095(IDO1) 101447628

MDO:	100032999(IDO1) 100033003(IDO2)

GAS:	123234853(IDO2) 123234854(IDO1)

SHR:	100926615 100926876(IDO2) 105749589

AFZ:	127548253 127548254 127548255

PCW:	110203204(IDO1) 110203211(IDO2)

TVP:	118840861(IDO1) 118844896(IDO2)

PBRV:

138152100(IDO2) 138152101(IDO1)

OAA:	100085939(IDO2) 100086385(IDO1)

TACU:

119928289(IDO2) 119928918

GGA:	426785(IDO2)

PCOC:

116234567(IDO2)

MGP:	100548413(IDO2)

CJO:	107323723(IDO2)

TPAI:

128089983

LMUT:

125685304

NMEL:

110387039(IDO2)

APLA:

101791377(IDO2)

ACYG:

106044372(IDO2)

CATA:

118256059(IDO2)

AFUL:

116499488(IDO2)

TGU:	100219367(IDO2)

LSR:	110473378(IDO2)

SCAN:

103822691(IDO2)

PMOA:

120505687

OTC:

121346780

PRUF:

121359402

ATRC:

139603813

GFR:	102036837(IDO2)

FAB:	101810571(IDO2)

OMA:	130262076(IDO2)

PHI:	102102902(IDO2)

PMAJ:

107213849(IDO2)

CCAE:

111938853(IDO2)

CCW:	104694855(IDO2)

CBRC:

103614695(IDO2)

ACOE:

138121828

ETL:	114066491(IDO2)

ZAB:	102073086(IDO2)

ZLE:

135456910

ACHL:

103809592

SVG:	106862070(IDO2)

MMEA:

130586945(IDO2)

HRT:

120763981

SATI:

136372659

CCIC:

134054616

FPG:	101914440(IDO2)

FCH:	102055026(IDO2)

CCRI:

104165066

NNT:	104405069(IDO2)

SHAB:

115618415(IDO2)

ACUN:

113488059(IDO2)

TALA:

116959097(IDO2)

HALD:

104321310

HLE:

104828800

AGEN:

126051707

HHAR:

128150044

GCL:

127025238

CSTI:

104561280

LDI:

104346755

MNB:

103770321

DPUB:

104301272(IDO2)

PPUS:

135192385(IDO2)

BRHI:

104496623

EGZ:

104135315

NNI:	104016072(IDO2)

PCRI:

104023850

PADL:

103920552(IDO2)

AFOR:

103900537(IDO2)

GSTE:

104253536

CLV:	102086320(IDO2)

MUI:

104542255

PGUU:

104471341

PLET:

104625203

EHS:

104506818

CUCA:

104068583

TEO:

104377572

BREG:

104634789

OHA:	104333237(IDO2)

ACAR:

104531226

CPEA:

104384845

CVF:	104295637(IDO2)

RTD:

128900095

CRID:

134526562

AAM:

106487770

AROW:

112974197(IDO2)

NPD:	112953858(IDO2)

DNE:	112990465(IDO2)

SCAM:

104148768(IDO2)

ASN:	102376360(IDO2)

AMJ:

106739382

CPOO:

109317406(IDO2)

GGN:	109295535(IDO2)

PSS:	102453712(IDO2) 102455437

CMY:	102945834 102946062

CCAY:

125626412(IDO1) 125626414(IDO2)

DCC:	119848555(IDO2) 119848556(IDO1)

CPIC:

101943268 101943538

TST:	117873036 117873037

CABI:

116821428 116821432

MRV:	120399464 120399465

ACS:	100560005(ido2)

ASAO:

132782501(IDO2)

PVT:	110072158(IDO2)

SUND:

121933413

PBI:	103053378(IDO2)

PMUR:

107289243(IDO2)

CTIG:

120312874(IDO2)

TSR:

106557309

PGUT:

117658246(IDO2)

APRI:

131203950(IDO2)

PTEX:

113445787(IDO2)

NSS:

113427994

VKO:

123027126

PMUA:

114585055

PRAF:

128402585(IDO2)

ZVI:

118097138

HCG:

128334000

GJA:	107112976(IDO2)

STOW:

125425359(IDO2)

EMC:	129341838(IDO2)

XLA:	100037099(ido1.L)

XTR:	448488(ido1)

NPR:	108792467(IDO2)

RTEM:

120933077(IDO2)

BBUF:

120986163(IDO2)

BGAR:

122927394(IDO2)

PWL:

138265923

MUO:	115469301 115469714

GSH:	117362757 117362937

DRE:	571967(ido1)

SRX:	107710826 107718947

SANH:

107665200 107678376

SGH:	107553133 107575786

CCAR:

109050442 109082139

CAUA:

113039681 113106758

CGIB:

127962849 128018248

PTET:

122350763

LROH:

127169613 127169615

OMC:	131545248 131545889(ido1)

PPRM:

120481312(ido1)

RKG:	130082096(ido1)

MAMB:

125280376(ido1)

CIDE:

127517080

CERY:

137026654(ido1)

MASI:

127415469

TROS:

130567911(ido1)

TDW:	130406907 130407334

MANU:

129413756(ido1)

PDAB:

135729797(ido1)

IPU:	108261789 108265915(ido1)

IFU:	128607443 128607444

PHYP:

113533299

SMEO:

124399808(ido1)

TFD:	113646483(ido1)

TVC:	132853496(ido1)

CGAR:

128530512(ido1)

NGRA:

132892420(ido1)

TRN:	134318409(ido1)

AMEX:

103034408(ido1)

CMAO:

118813288(ido1)

EEE:

113578171

CHAR:

105902744(ido1) 105910904

SPIL:

134088566(ido1) 134101283

TRU:

101074760

TFS:	130526345(ido1)

TNG:	GSTEN00020439G001

LCO:	104929405 104931154

NCC:

104966201

TBEN:

117496919(ido1) 117499780

CGOB:

115013739 115020208

PGEO:

117452824(ido1) 117460173

GACU:

117560899 117561112(ido1)

EMAC:

134858405 134873878(ido1)

ELY:	117248703 117252223(ido1)

EFO:	125890312(ido1) 125903634

PLEP:

121944647(ido1) 121955034

SLUC:

116053927(ido1) 116055474

ECRA:

117944249(ido1) 117960787

ESP:	116690199 116705329

PFLV:

114556148 114562965 114572566

GAT:	120830916(ido1)

PPUG:

119224575(ido1)

AFB:	129101507(ido1)

CLUM:

117736511(ido1)

PSWI:

130196165(ido1)

CANA:

137779142(ido1) 137779789

CVE:	137867482(ido1) 137877368

MSAM:

119891997(ido1) 119917540

SCHU:

122876973(ido1) 122884667

CUD:	121509246(ido1) 121510772

SPUL:

138588796 138610688(ido1)

LMIX:

132974076(ido1) 132975423

ALAT:

119019532(ido1) 119033434

ASTR:

137592567 137592645 137592729 137604237

MZE:	101472607 101479436

ONL:	100702686 100706576

OAU:	116310246(ido1) 116322211

OLA:	101167965 101169805

OML:	112147981(ido1) 112161927

CSAI:

133450358(ido1) 133463681

XMA:	102229086 102236092

XCO:	114138571 114154044

XHE:	116713820 116729695

PRET:

103470503 103476765

PFOR:

103133561 103145719

PLAI:

106936396 106949737

PMEI:

106914144 106932858

GAF:	122827979(ido1) 122842685

PPRL:

129359800 129372209(ido1)

CVG:	107093575 107093869

CTUL:

119776059 119783931(ido1)

GMU:	124859383 124877638 124877910

NFU:	107375992 107393763

KMR:	108236475(ido1) 108242928

ALIM:

106532554

NWH:	119413466(ido1) 119419086

AOCE:

111566901 111578649(ido1)

EJA:	138192041(ido1)

BFRE:

138621623(ido1)

MCEP:

125011925(ido1) 125018475

CSEM:

103387655 103398229

POV:

109633673

SSEN:

122769196(ido1) 122781502

SSOE:

131464225(ido1) 131474228

HHIP:

117768409(ido1) 117775696

HSP:	118115278(ido1) 118119113

PPLT:

128438272(ido1) 128453844

SMAU:

118284113 118314580(ido1)

LCF:	108878793(ido1) 108897278

SDU:	111230009 111235291

SLAL:

111649548 111663420 111663848

XGL:	120796675 120804813(ido1)

HCQ:

109525131

SSCV:

125994380(ido1)

SBIA:

133499451(ido1)

PEE:	133400628(ido1)

PTAO:

133475030(ido1)

BPEC:

110169903

ENY:	140347290(ido1)

MALB:

109956908 109960434

BSPL:

114841969 114863162(ido1)

SJO:	128364091(ido1) 128372507

SSCO:

133979749(ido1) 133992318

GMH:	115545892 115559482

SASA:

106577031 106579858 106585586

STRU:

115164544 115193722 115200101

OTW:	112248460 112253538 112263992(ido1)

OMY:	110525639 110529307 110536009(ido1)

OGO:	124034340 124036279 124041233

ONE:	115111577 115135078 115140017

OKI:	109879368 109888797 109894902

OKE:	118358316 118369741 118393182

OMM:	135511053 135514127 135541345

OCLA:

139389581 139408352 139410889

SALP:

111951597 111957692 111975044

SNH:	120017416 120017668 120063219

CCLU:

121530873(ido1) 121553712 121584820

ELS:	105010594 105014035

OEP:	134011930(ido1) 134022765

SFM:	108922613 108929475

PKI:	111838843 111842017 111842059 111849886

AANG:

118212365 118237252(ido1)

AROT:

135239659 135261269(ido1)

CCOG:

133139870(ido1) 133142493

LOC:	102690450 102692732

PSPA:

121302180 121302245 121303059 121303061(ido1)

ARUT:

117397802 117397807 117962507 117971679

PSEX:

120539301 120539486(ido1)

LCM:	102364348(IDO2)

CMK:	103191437(ido1)

RTP:	109930715(ido1)

CPLA:

122543131(ido1)

HOC:	132836903(ido1)

LERI:

129713216(ido1)

PMRN:

116940531

LRJ:

133343387

BFO:

118431881

BBEL:

109475153

SPU:	100893352 577419 754565

LPIC:

129263163 129263694 129269297 129270335

AJJ:

139959467

APLC:

110980378 110980392

ARUN:

117292357 117292421

AAMU:

139943959 139944382

AFIL:

140163897 140164233 140164235 140164300

PFLL:

139150924 139150929 139150931 139150932

BCOO:

119070407

NAI:	NECAME_04865

LOA:	LOAG_17446

TSP:

Tsp_04838

LGI:	LOTGIDRAFT_168391 LOTGIDRAFT_168398 LOTGIDRAFT_236096

PVUL:

126810606 130010305

PCAN:

112556297

LSAX:

138958242

BGT:	106056257 106061361

GAE:	121380352 121381952

HRF:	124132381 124132382 124145837 124145838

HRJ:	124256228 124256245 124287374 124287429

HASI:

137261411 137261420 137294067 137294068 137294771

HCRA:

139442871 139443234 139462102 139462103

CRG:

105346105

CANU:

128168233

CVN:	111119760 111119789

OED:	125670615 125670616

MYI:	110441193 110450994 110450995 110450996 110461080

PMAX:

117329726 117329738 117329744 117329747 117338256

AIRR:

138323510 138323973 138323974 138324081 138324597

MCAF:

127707726

MMER:

123563434

RPHI:

132713844

DPOL:

127867275 127868168

MAEA:

128222394

OSN:

115223125

LJP:	135470330 135470968 135471675

LAK:	106161424 106162758 106162759 106162760 106162816 106176942 106176946 106182094

SMM:	Smp_133900

OVI:	T265_07231

EGL:

EGR_09710

LLON:

135487910

NVE:

5509616

EPA:	110240490 110250165 110250194

ATEN:

116304907

ADF:	107346918 107346919

AMIL:

114958243 114958245

MCAZ:

138058961

MFOO:

137970121

PDAM:

113684337

SPIS:

111334011

DGT:	114538136 114539262 114539439 114544431

XEN:	124448021 124448022

RES:

135690249

AQU:	105312930 105315377 105315605

CJF:	131075029 131075031 131875809

CRE:	CHLRE_17g710200v5 CHLRE_17g713700v5

MNG:

MNEG_4429

CVR:	CHLNCDRAFT_133396

SCE:	YJR078W(BNA2)

SEUB:

DI49_3089

SPAO:

SPAR_J02590

AGO:	AGOS_ACR188C

ERC:

Ecym_4655

LTH:	KLTH0C05412g

VPO:	Kpol_520p15

ZRO:	ZYRO0F13376g

TPF:	TPHA_0B01500(TPHA0B01500)

TGB:	HG536_0B04150

TDL:	TDEL_0C03080(TDEL0C03080)

ZMK:	HG535_0B05340

DHA:	DEHA2G12188g

PIC:	PICST_87443(BNA2)

PGU:	PGUG_04309

SPAA:

SPAPADRAFT_63090(BNA2)

LEL:	PVL30_004899(BNA2)

LBG:	92210589(LODBEIA_P53930)

CAL:	CAALFM_C500800CA(CaO19.583)

CTP:	CTRG_05778

COT:	CORT_0F00140

CDU:	CD36_51480

CTEN:

18249239(BNA2)

CLU:	CLUG_01155

CLUS:

A9F13_09g02178

CAUR:

CJI96_0003309

ASAU:

88173395(PUMCH_002330)

PPA:	PAS_chr1-4_0083

PKZ:	C5L36_0E04730

BNN:	FOA43_000797

BBRX:

BRETT_001222

OPA:	HPODL_01018

YLI:	2908695(YALI2_E00979g)

SLB:	AWJ20_653(BNA2)

NCR:	NCU01402 NCU05752 NCU09184

NTE:	NEUTE1DRAFT43213(NEUTE1DRAFT_43213) NEUTE1DRAFT76034(NEUTE1DRAFT_76034) NEUTE1DRAFT86563(NEUTE1DRAFT_86563)

SMP:	10801219(SMAC4_08377) 10801685(SMAC4_08990) 10810851(SMAC4_08948)

PAN:	PODANSg2504 PODANSg762 PODANSg7893

PBEL:

QC761_201070 QC761_401340(BNA2) QC761_700760

PPSD:

QC762_201070 QC762_401340(BNA2) QC762_700760

PPSP:

QC763_201070 QC763_401340(BNA2) QC763_700760

PPSA:

QC764_201070 QC764_401340(BNA2) QC764_700760

TTT:	THITE_2106420 THITE_2110987 THITE_2120385

MTM:	MYCTH_2300294 MYCTH_2303249 MYCTH_2307600

CTHR:

CTHT_0045730 CTHT_0051700 CTHT_0072620

RTHE:

98128693(VTJ83DRAFT_7248) 98129003(VTJ83DRAFT_7527)

MGR:	MGG_00755 MGG_13773 MGG_14348

PPEI:

PpBr36_05444 PpBr36_08387 PpBr36_10865

PGRI:

PgNI_02884 PgNI_08067 PgNI_08551

TMN:	UCRPA7_1826 UCRPA7_5970 UCRPA7_8045

SSCK:

SPSK_03376 SPSK_05234 SPSK_09104

FGR:	FGSG_02657 FGSG_04828 FGSG_09040

FPU:	FPSE_00364 FPSE_04050 FPSE_07323

FPOA:

FPOAC1_002785 FPOAC1_007667 FPOAC1_012709

FVN:	FVRRES_03100 FVRRES_08130 FVRRES_13909

FVR:	FVEG_03512 FVEG_06565 FVEG_09278

FOX:	FOXG_05659 FOXG_08978 FOXG_10631

NHE:	NECHADRAFT_70501 NECHADRAFT_70795 NECHADRAFT_85363

FFC:	NCS54_00852400 NCS54_00996000 NCS54_01207800

FKR:	NCS57_00896000 NCS57_00990300 NCS57_01198600

FMU:	J7337_003526 J7337_005128 J7337_009220

TRE:	TRIREDRAFT_123550 TRIREDRAFT_54260 TRIREDRAFT_64330

TRR:	M419DRAFT_103027 M419DRAFT_82203 M419DRAFT_84917

TATV:

25781760(TrAtP1_008959) 25784169(TrAtP1_003159) 25784846(TrAtP1_006780)

TASP:

36608505(TrAFT101_006002) 36608907(TrAFT101_006863) 36611727(TrAFT101_002497)

MAW:	19246780(BNA2) 19246933(J3458_005693) 19249775(J3458_002357)

MAJ:	MAA_00343 MAA_03016 MAA_05241

MBRN:

26237397(BNA2_0) 26241496(BNA2_1) 26243149(BNA2_2)

PCHM:

VFPPC_08814 VFPPC_09609 VFPPC_10339 VFPPC_11154 VFPPC_16145

CMT:	CCM_02833 CCM_03688 CCM_06695

AMUS:

LMH87_007130 LMH87_007825 LMH87_008562 LMH87_012010

PLJ:	28885236(PLICBS_006807) 28890649(PLICBS_004994) 28892308(PLICBS_009945) 28892972(PLICBS_003894)

PTKZ:

JDV02_001859(BNA2_1) JDV02_005489(BNA2_2) JDV02_006827 JDV02_008848

VAL:	VDBG_00295 VDBG_04314 VDBG_09667

VDA:	VDAG_05624 VDAG_08582 VDAG_10523

CFJ:	CFIO01_11397 CFIO01_12906 CFIO01_13114

CLUP:

CLUP02_10126 CLUP02_10625 CLUP02_17214

CHIG:

CH63R_06938 CH63R_09055 CH63R_09419

CDET:

87938641(CDEST_02138) 87948332(CDEST_11832) 87950243(CDEST_13743) 87950617(CDEST_14117)

SAPO:

SAPIO_CDS10590 SAPIO_CDS9355

ELA:	UCREL1_5860 UCREL1_7574 UCREL1_7759

PFY:	PFICI_02204 PFICI_03646 PFICI_06657 PFICI_14031

SSL:	SS1G_00858 SS1G_08222 SS1G_10307

BFU:	BCIN_12g01060 BCIN_14g01360 BCIN_14g04320

MBE:	MBM_00447 MBM_04791 MBM_09099

PSCO:

LY89DRAFT_46206 LY89DRAFT_704456 LY89DRAFT_732805

GLZ:	GLAREA_00603 GLAREA_03347 GLAREA_11411

ANI:	ANIA_01858 ANIA_02509 ANIA_09108

AFM:	AFUA_3G14250 AFUA_4G09830 AFUA_7G02010

ACT:	ACLA_041740 ACLA_049060 ACLA_065510

NFI:	NFIA_063050 NFIA_106220 NFIA_114740

AOR:	AO090003001248 AO090020000618 AO090038000578

ANG:	An04g07210 An09g04250 An12g00660

AFV:	AFLA_000425 AFLA_009061 AFLA_010029

ALUC:

AKAW2_30285A AKAW2_40495S AKAW2_81033S

ACHE:

ACHE_10703A ACHE_20065A ACHE_31323A ACHE_60068A ACHE_70219S ACHE_70687A

APUU:

APUU_21222A APUU_30231S APUU_31574S

PCS:	N7525_002475 N7525_005148 N7525_007796

PDP:	PDIP_24520 PDIP_25600 PDIP_56120

POU:	POX_b02054 POX_e06475 POX_g08572

TMF:	EYB26_000580 EYB26_006842 EYB26_009539

TRG:	TRUGW13939_02130 TRUGW13939_04063 TRUGW13939_11421

CIM:	CIMG_00126 CIMG_07803

CPW:	9692257(D8B26_005005) 9693381(D8B26_004143)

URE:	UREG_00231 UREG_02134

ABE:	ARB_03636 ARB_04584 ARB_05733

TVE:	TRV_00864 TRV_01957 TRV_04509

PBL:	PAAG_05853 PAAG_06866

PBN:	PADG_04329 PADG_06139

AJE:	HCAG_01148 HCAG_04432

BGH:	BDBG_04038 BDBG_06623

PNO:	SNOG_02815 SNOG_10574 SNOG_10794

PTE:	PTT_07650 PTT_08299 PTT_13994

PTRR:

6339971(PtrM4_024560) 6348088(PtrM4_086460) 6348156(PtrM4_085730)

BZE:	COCCADRAFT_1250 COCCADRAFT_97046

BSC:	COCSADRAFT_102379 COCSADRAFT_138733

BOR:	COCMIDRAFT_1657 COCMIDRAFT_95092

AALT:

CC77DRAFT_1023915 CC77DRAFT_123730

ADAC:

96083215(ACET3X_002893) 96083259(ACET3X_002937) 96088087(ACET3X_007765)

ARAB:

EKO05_0001381 EKO05_0007622 EKO05_0007878

ZTR:	MYCGRDRAFT_52885 MYCGRDRAFT_73635 MYCGRDRAFT_75056

PFJ:	MYCFIDRAFT_215476 MYCFIDRAFT_48024 MYCFIDRAFT_56678

FFU:	CLAFUR5_00304 CLAFUR5_06900 CLAFUR5_12265

CBET:

CB0940_00866 CB0940_06399 CB0940_09211 CB0940_11439

BCOM:

BAUCODRAFT_31662

NPA:	UCRNP2_2918 UCRNP2_4546 UCRNP2_9460

TML:	GSTUM_00005398001 GSTUM_00007145001

CNE:

CNC04830

CNB:

CNBC2350

CNG:	CNAG_02868

CGI:	CGB_C7140C

CDEU:

CNBG_3517

CDEP:

91089766(L203_105557)

KMG:	30167543(I203_106455)

KNE:	92178276(IAR55_001017)

TMS:	TREMEDRAFT_73719

TASA:

A1Q1_00029 A1Q1_00097

CCAC:

CcaHIS019_0104590(CcaverHIS019_0104590) CcaHIS019_0113040(CcaverHIS019_0113040)

PPL:	POSPLDRAFT_102140

TVS:	TRAVEDRAFT_118782 TRAVEDRAFT_168783

DSQ:	DICSQDRAFT_49513 DICSQDRAFT_66685

PCO:	PHACADRAFT_255856

SHS:	STEHIDRAFT_128669 STEHIDRAFT_49151 STEHIDRAFT_96831

HIR:	HETIRDRAFT_326738 HETIRDRAFT_417390 HETIRDRAFT_43434

PSQ:	PUNSTDRAFT_100537 PUNSTDRAFT_102652 PUNSTDRAFT_53490 PUNSTDRAFT_60614

ADL:	AURDEDRAFT_103636 AURDEDRAFT_168315

FME:	FOMMEDRAFT_164852 FOMMEDRAFT_29270

GTR:	GLOTRDRAFT_122534 GLOTRDRAFT_36830 GLOTRDRAFT_46282

RSX:	RhiXN_02473 RhiXN_02769 RhiXN_02832 RhiXN_04477

LBC:	LACBIDRAFT_157851 LACBIDRAFT_253793 LACBIDRAFT_253815 LACBIDRAFT_256000 LACBIDRAFT_257063 LACBIDRAFT_306113

CCI:	CC1G_01112 CC1G_02499 CC1G_12399

ABP:	AGABI1DRAFT107428(AGABI1DRAFT_107428) AGABI1DRAFT34575(AGABI1DRAFT_34575) AGABI1DRAFT60207(AGABI1DRAFT_60207) AGABI1DRAFT85862(AGABI1DRAFT_85862)

ABV:	AGABI2DRAFT135051(AGABI2DRAFT_135051) AGABI2DRAFT177539(AGABI2DRAFT_177539) AGABI2DRAFT177540(AGABI2DRAFT_177540) AGABI2DRAFT64740(AGABI2DRAFT_64740)

MPR:	MPER_05176 MPER_12716

MRR:	Moror_12110 Moror_5206 Moror_8344 Moror_9957 Moror_9958

E1B28_000370 E1B28_009296 E1B28_010883 E1B28_010889

SCM:	SCHCO_02608091(SCHCODRAFT_02608091) SCHCO_02640585(SCHCODRAFT_02640585) SCHCO_02643132(SCHCODRAFT_02643132) SCHCO_02673121(SCHCODRAFT_02673121)

CPUT:

CONPUDRAFT_135908 CONPUDRAFT_135912 CONPUDRAFT_48837

SLA:	SERLADRAFT_467213 SERLADRAFT_476036

WSE:	WALSEDRAFT_7644

UMA:	UMAG_03728

PFP:	PFL1_01140

SGRA:

EX895_001163 EX895_001261

PGR:	PGTG_06521 PGTG_09355

PTRC:

PtA15_16A61 PtA15_8A651

PSTR:

Pst134EA_015643 Pst134EA_015685 Pst134EA_028861 Pst134EA_031248

MLR:	MELLADRAFT_117589 MELLADRAFT_25201 MELLADRAFT_78815 MELLADRAFT_90083

RIE:	OCT59_010426 OCT59_010427 OCT59_017638

MBR:	MONBRDRAFT_31854

SRE:	PTSG_11822

TET:	TTHERM_00035520 TTHERM_00035530

EHX:	EMIHUDRAFT_213134

GTT:	GUITHDRAFT_149065

ASIP:

AQUSIP_11920

NOC:

Noc_1709

NHL:

Nhal_1432

OME:	OLMES_5389

MBRY:

B1812_07760

MROS:

EHO51_18230

MHEY:

H2LOC_020715

NGF:	FRF71_13670

SPAI:

FPZ24_13335

CIJ:	WG74_09600

SPHG:

AZE99_10335

SFLA:

SPHFLASMR4Y_00166

SPHY:

CHN51_12400

BMAA:

T8S45_04225

PALG:

HFP57_00940

PARJ:

J4G78_13540

AEP:	AMC99_01154

ALH:	G6N82_01105

ALTN:

LBX01_11200

AMX:	AM2010_904

PMAS:

NCF86_05485

ANH:	A6F65_01695

ADO:	A6F68_02366

TFV:	IDJ81_12080

ERY:	CP97_09975

QSO:	IRL76_05555

QAR:	K3148_12215

QPS:	K3166_06360

QXI:	K3162_01620

ELI:

ELI_06040

ERF:	FIU90_10105

ERYT:

KDC96_04900

ERYS:

LY632_08715

MAI:

MICA_2463

MAN:

A11S_2397

SACI:

Sinac_2518

GAU:	GAU_3278(indO)

GPH:	GEMMAAP_16770

NDE:

NIDE0784

NMV:	NITMOv2_0702

NIO:	NITINOP_1554

BMYO:

BG05_5592

EUZ:	DVS28_a0378

ASD:

AS9A_2778

SCB:	SCAB_15261

SGE:	DWG14_08250

SROI:

IAG44_01315

AAB:	A4R43_06715

AMYY:

YIM_20245

PVN:	A7sIIA15_02365

ABAM:

B1s21122_01565

NHI:	B1s21160_01375

NAB:	B1sIIB91_01285

LEPV:

J4558_02165

TER:

Tery_4014

NCN:	BZZ01_21155

FGI:	OP10G_1182

NSAL:

HWV07_19335

HRU:	Halru_2529

» show all

Reference

1 [PMID:6065097]

Authors

Yamamoto S, Hayaishi O.

Title

Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes.

Journal

J Biol Chem 242:5260-6 (1967)

Reference

2 [PMID:2428037]

Authors

Yasui H, Takai K, Yoshida R, Hayaishi O.

Title

Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients.

Journal

Proc Natl Acad Sci U S A 83:6622-6 (1986)
DOI:10.1073/pnas.83.17.6622

Sequence

[hsa:3620]

Reference

3 [PMID:2419335]

Authors

Takikawa O, Yoshida R, Kido R, Hayaishi O

Title

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

Journal

J Biol Chem 261:3648-53 (1986)

Sequence

[mmu:15930]

Reference

4 [PMID:194886]

Authors

Hirata F, Ohnishi T, Hayaishi O.

Title

Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex.

Journal

J Biol Chem 252:4637-42 (1977)

Reference

5 [PMID:10719243]

Authors

Dang Y, Dale WE, Brown OR

Title

Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway.

Journal

Free Radic Biol Med 28:615-24 (2000)
DOI:10.1016/S0891-5849(99)00272-5

Sequence

[rno:66029]

Reference

6 [PMID:12766158]

Authors

Littlejohn TK, Takikawa O, Truscott RJ, Walker MJ.

Title

Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase.

Journal

J Biol Chem 278:29525-31 (2003)
DOI:10.1074/jbc.M301700200

Sequence

[hsa:3620]

Reference

7 [PMID:10731095]

Authors

Thomas SR, Stocker R.

Title

Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway.

Journal

Redox Rep 4:199-220 (1999)
DOI:10.1179/135100099101534927

Reference

8 [PMID:2334706]

Authors

Sono M.

Title

Spectroscopic and equilibrium studies of ligand and organic substrate binding to indolamine 2,3-dioxygenase.

Journal

Biochemistry 29:1451-60 (1990)
DOI:10.1021/bi00458a016

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.52

IUBMB Enzyme Nomenclature:

1.13.11.52

ExPASy - ENZYME nomenclature database:

1.13.11.52

BRENDA, the Enzyme Database:

1.13.11.52

CAS:

9014-51-1

LinkDB

DBGET integrated database retrieval system