KEGG   ENZYME: 1.13.11.34
Entry
EC 1.13.11.34               Enzyme                                 
Name
arachidonate 5-lipoxygenase;
leukotriene-A4 synthase;
Delta5-lipoxygenase;
5Delta-lipoxygenase;
arachidonic 5-lipoxygenase;
arachidonic acid 5-lipoxygenase;
C-5-lipoxygenase;
LTA synthase;
leukotriene A4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 5-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = leukotriene A4 + H2O (overall reaction) [RN:R08527];
(1a) arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595];
(1b) (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O [RN:R03058]
Reaction(KEGG)
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
Product
leukotriene A4 [CPD:C00909];
H2O [CPD:C00001];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
History
EC 1.13.11.34 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00461  arachidonate 5-lipoxygenase
Genes
HSA240(ALOX5)
PTR450428(ALOX5)
PPS100979027(ALOX5)
GGO101135686(ALOX5)
PON100460538(ALOX5)
NLE100584513(ALOX5)
MCC707926(ALOX5)
MCF102132853(ALOX5)
CSAB103215810(ALOX5)
CATY105576135(ALOX5)
PANU101004229(ALOX5)
TGE112632137(ALOX5)
RRO104678173(ALOX5)
RBB108522174(ALOX5)
TFN117082071(ALOX5)
PTEH111529801(ALOX5)
CJC100386217(ALOX5)
SBQ101031793(ALOX5)
CSYR103256562(ALOX5)
MMUR105860128 105860129
LCAT123650024(ALOX5)
OGA100952067(ALOX5)
MMU11689(Alox5)
MCAL110297094(Alox5)
MPAH110315917(Alox5)
RNO25290(Alox5)
MCOC116099451(Alox5)
MUN110563686 110563694
CGE100772492(Alox5)
MAUA101839970(Alox5)
PLEU114689650(Alox5)
MORG121438814(Alox5)
MFOT126505462
AAMP119807525(Alox5)
NGI103737907(Alox5)
HGL101700210(Alox5)
CPOC100718093(Alox5)
CCAN109700324(Alox5)
DORD106001013(Alox5)
DSP122122367(Alox5)
NCAR124975507 124985161 124985243 124985624
OCU100341714(ALOX5)
OPI101534185(ALOX5)
TUP102480526(ALOX5)
CFA477753(ALOX5)
CLUD112671999(ALOX5)
VVP112913415(ALOX5)
VLG121483983(ALOX5)
AML100476416(ALOX5)
UMR103668062(ALOX5)
UAH113243124(ALOX5)
UAR123800343(ALOX5)
ELK111144974
LLV125085017
MPUF101684572(ALOX5)
ORO101381769(ALOX5)
EJU114205241(ALOX5)
ZCA113923418(ALOX5)
MLX118023026(ALOX5)
NSU110589221(ALOX5)
FCA101097422(ALOX5)
PYU121036944(ALOX5)
PBG122492984(ALOX5)
LRUF124506966
PTG102973009(ALOX5)
PPAD109264579(ALOX5)
AJU106989649(ALOX5)
HHV120232804(ALOX5)
BTA404074(ALOX5)
BOM102270550(ALOX5)
BIU109553923(ALOX5)
BBUB102400249(ALOX5)
CHX102168425(ALOX5)
OAS101117390(ALOX5)
ODA120865494(ALOX5)
CCAD122446293(ALOX5)
SSC100156205(ALOX5)
CFR102507744(ALOX5)
CBAI105075631(ALOX5)
CDK105093424(ALOX5)
VPC102544906(ALOX5)
BACU103009115(ALOX5)
LVE103081267(ALOX5)
OOR101283796(ALOX5)
DLE111172567(ALOX5)
PCAD102987975(ALOX5) 114485528
PSIU116741371(ALOX5)
ECB100062042(ALOX5)
EPZ103553660(ALOX5)
EAI106846725(ALOX5)
MYB102249760(ALOX5)
MYD102754419(ALOX5)
MMYO118679341(ALOX5)
MLF102418693(ALOX5)
MNA107527950(ALOX5)
PKL118732103(ALOX5)
HAI109389501(ALOX5)
DRO112305481(ALOX5)
SHON118994142(ALOX5)
AJM119035943(ALOX5)
PDIC114496046(ALOX5)
PHAS123821021(ALOX5)
MMF118632052(ALOX5)
RFQ117036416(ALOX5)
PALE102898772(ALOX5)
PGIG120609662(ALOX5)
PVP105288958(ALOX5)
RAY107508911(ALOX5)
MJV108400689(ALOX5)
TOD119234526(ALOX5)
SARA101551293(ALOX5)
LAV100661336(ALOX5)
TMU101345496
DNM101433807(ALOX5)
MDO100013954(ALOX5)
GAS123236481(ALOX5)
SHR100932471(ALOX5)
PCW110213916(ALOX5)
OAA100077066(ALOX5)
GGA423769(ALOX5)
PCOC116238154(ALOX5)
MGP100542129(ALOX5)
CJO107315916(ALOX5)
NMEL110399270(ALOX5)
APLA101801930(ALOX5)
ACYG106049001(ALOX5)
AFUL116491605(ALOX5)
TGU100231888(ALOX5)
LSR110475663(ALOX5)
SCAN103813960(ALOX5)
PMOA120502228(ALOX5)
OTC121341694(ALOX5)
PRUF121350062(ALOX5)
GFR102035554(ALOX5)
FAB101813553(ALOX5)
PHI102112541(ALOX5)
PMAJ107207120(ALOX5)
CCAE111931122(ALOX5)
CCW104697933(ALOX5)
CBRC103624590(ALOX5)
ETL114054707(ALOX5)
ZAB102062876(ALOX5)
ACHL103800605(ALOX5)
FPG101914238(ALOX5)
FCH102053142(ALOX5)
CLV102085004(ALOX5)
EGZ104129027(ALOX5)
NNI104014074(ALOX5)
PLET104626025(ALOX5)
PCRI104029677(ALOX5)
ACUN113481652(ALOX5)
TALA104365651(ALOX5)
PADL103914082(ALOX5)
AFOR103897820(ALOX5)
ACHC115348416(ALOX5)
HALD104320512(ALOX5)
CCRI104162138(ALOX5)
CSTI104560045(ALOX5)
EHS104506301(ALOX5)
CMAC104486519(ALOX5)
MUI104535976(ALOX5)
FGA104076430(ALOX5)
GSTE104256524(ALOX5)
MNB103781231(ALOX5)
OHA104330385(ALOX5)
NNT104403581(ALOX5)
DPUB104297702(ALOX5)
ACAR104521858(ALOX5)
AVIT104276083(ALOX5)
AAM106497785(ALOX5)
AROW112963900(ALOX5)
NPD112957209(ALOX5)
TGT104577674(ALOX5)
DNE112990662(ALOX5)
SCAM104146056(ALOX5)
ASN102371605(ALOX5)
AMJ102568608(ALOX5)
CPOO109324293(ALOX5)
GGN109287144(ALOX5)
PSS102462244(ALOX5)
CMY102944803(ALOX5)
CPIC101932214(ALOX5)
TST117880642(ALOX5)
CABI116823588(ALOX5)
MRV120369164(ALOX5)
ACS100556313(alox5)
PVT110090785
SUND121927518(ALOX5)
PMUR107292379(ALOX5)
CTIG120300245(ALOX5)
TSR106553343(ALOX5)
PGUT117661247(ALOX5)
VKO123029661(ALOX5)
PMUA114601080(ALOX5)
ZVI118079372(ALOX5)
GJA107113129(ALOX5)
STOW125443871(ALOX5)
XLA108696220(alox5.L) 108697207(alox5.S)
XTR100036609(alox5)
NPR108800085(ALOX5)
RTEM120947174(ALOX5)
BBUF121004372(ALOX5)
BGAR122940049(ALOX5)
DRE567204(alox5a) 573013(alox5b.1) 724056(alox5b.2)
SRX107708393 107713771 107747471
SANH107671382 107677802 107678516 107684374 107690200
SGH107571808 107572920 107575181 107575442 107582511 107589586
CCAR109049814 109052610 109065335 109081069 109101776 109108493
CAUA113048375 113048377 113057166 113066049 113066078 113112941
PPRM120460470 120463765 120463775 120478382 120479775(alox5a) 120492594
MAMB125257158 125265844 125276632(alox5a) 125279367 125279782
IPU108263823(alox5a)
PHYP113546154(alox5)
SMEO124378204(alox5a)
TFD113639934(alox5a)
AMEX103035394(alox5)
EEE113587960(alox5)
TRU101066485 101077167(alox5) 101077844 115249685
TNGGSTEN00016500G001
LCO104930113(alox5)
NCC104946287(alox5)
CGOB115020076(alox5)
ELY117248563
EFO125903456(alox5a)
PLEP121954568 121954569
SLUC116054107(alox5a)
ECRA117960578(alox5a)
ESP116704939(alox5)
PFLV114572645(alox5)
GAT120820912(alox5a)
PPUG119213967(alox5a)
MSAM119916966(alox5a)
CUD121510776 121511083 121511143 121511190
ALAT119034095(alox5a)
MZE101482427(alox5)
ONL100693453(alox5)
OAU116316616(alox5a)
OLA101160835(alox5) 101165738
OML112162158(alox5a)
XMA102230376(alox5)
XCO114137934(alox5)
XHE116712547(alox5)
PRET103476884(alox5)
PFOR103147712(alox5)
PLAI106955189(alox5)
PMEI106907603(alox5)
GAF122843057(alox5a)
CVG107091526(alox5)
CTUL119788547(alox5a)
GMU124858722(alox5a)
NFU107375698(alox5)
KMR108243211
ALIM106529456(alox5)
NWH119418429(alox5a)
AOCE111564375(alox5)
MCEP125018433(alox5a)
CSEM103387317(alox5)
POV109631496(alox5)
SSEN122781462(alox5a)
HHIP117775306(alox5a)
HSP118118901(alox5a)
LCF108884347(alox5a)
SDU111235185(alox5)
SLAL111654678(alox5)
XGL120796514(alox5a)
HCQ109509924 109509925(alox5)
BPEC110164412(alox5)
MALB109961016(alox5)
BSPL114870428(alox5a)
SASA100194803(lox5) 106613187
STRU115153372 115193564
OTW112253187 112256283
OMY110502637 110532793
OGO124037261 124041114
ONE115113091 115134961
SALP111978799
SNH120017762 120045686
CCLU121553196 121583968
ELS105010608(alox5)
SFM108921027(alox5) 108937538
PKI111837191 111846223 111846232 111849566(alox5)
AANG118218047 118218049 118218050 118218460
LOC102697549(alox5)
PSPA121325182(alox5a)
ARUT117416027 117417615(alox5a)
LCM102353934(ALOX5)
CMK103185827(alox5a)
RTP109921931(alox5)
BFO118407044 118407190 118410745 118416628 118419219 118419222 118423903 118424144
BBEL109463619 109467523 109473009 109474494 109474550 109474633 109476869 109478405 109478532 109479429 109480412 109481529 109483336 109486824 109487021 109487229 109487274 109487288
CIN100176198 100176411 100176744 100178151 100178342 100178563 100179479
SCLV120327656 120328067 120330915 120339739 120339931 120339932 120342283 120342991
SPU115918885 574670 575389 579368 583823 584481 584789 585142 591845 754628 763828 764400
APLC110975305 110975972 110976201 110977737 110977751
SKO100369676 100369827 102805620
TPAL117644657
PVM113804806
PCLA123760292
PTRU123516860
PPOI119091807 119096450
DSV119449406
RSAN119382445
RMP119178021
CSCU111636555 111636558
PTEP107442379
SDM118200660
HROHELRODRAFT_66521
LGILOTGIDRAFT_137999 LOTGIDRAFT_171808 LOTGIDRAFT_209217 LOTGIDRAFT_224684
PCAN112558951
BGT106067963 106069395
GAE121374655 121392860
HRF124111845 124113998 124114830 124115001 124115002 124123794 124143720
HRJ124254639 124259952 124261755 124261766 124285520
CRG105319481 105324873 105327235 105327236 105327296 105327652 105333405 105333406 105336201 117683956
MYI110457288 110457778 110458666 110458669 110458670 110458673 110458677 110458678
PMAX117322747 117324142 117324143 117329167 117329376 117329377 117329378 117329966
MMER123539768 123540524 123541320 123541567 123553096 123557731
OBI106867440 106867441 106867443 106873090 106873091 106873092
OSN115215746 115215749 115215753 115221275 115221688 115226898 115227054
LAK106150754 106166490 106170509 106178940
OVIT265_15039
NVE5499732 5504404 5514194 5514339
EPA110239121 110242596 110248339 110250751 110253407
ATEN116286796 116290323 116294452 116296880 116301055 116304961 116304967 116307613 116308077
ADF107327113 107341953 107341972 107345340 107350206 107352928
AMIL114958630 114959396 114968909 114970008 114971001
PDAM113664617 113665281 113666770 113675130 113675559 113675883 113682318 113683498 113685341
SPIS111321744 111326629 111326882 111326890 111328829 111341264
DGT114516532 114516794 114521367 114521368 114527546 114529580 114531948 114541102
XEN124433523 124439795 124443860 124444372 124444381 124444382 124450812 124454266
HMG100200947 100205450 100209770 100213618 100215649
TADTRIADDRAFT_50085 TRIADDRAFT_63720
AQU100635761
CCPCHC_T00008739001
MXAMXAN_1744
MSDMYSTI_02579
MFBMFUL124B02_14090
CCXCOCOR_02733(loxA)
MBDMEBOL_004947
 » show all
Reference
1  [PMID:2829172]
  Authors
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B
  Title
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 85:26-30 (1988)
DOI:10.1073/pnas.85.1.26
  Sequence
[hsa:240]
Reference
2  [PMID:3038871]
  Authors
Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao S, Yotsumoto H, Takaku F, Shimizu T.
  Title
Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers.
  Journal
J Biol Chem 262:10200-5 (1987)
Reference
3  [PMID:3012557]
  Authors
Shimizu T, Izumi T, Seyama Y, Tadokoro K, Radmark O, Samuelsson B.
  Title
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 83:4175-9 (1986)
DOI:10.1073/pnas.83.12.4175
Reference
4  [PMID:6322165]
  Authors
Shimizu T, Radmark O, Samuelsson B.
  Title
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
  Journal
Proc Natl Acad Sci U S A 81:689-93 (1984)
DOI:10.1073/pnas.81.3.689
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.34
IUBMB Enzyme Nomenclature: 1.13.11.34
ExPASy - ENZYME nomenclature database: 1.13.11.34
BRENDA, the Enzyme Database: 1.13.11.34
CAS: 80619-02-9
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