KEGG   ENZYME: 1.13.11.34
Entry
EC 1.13.11.34               Enzyme                                 

Name
arachidonate 5-lipoxygenase;
leukotriene-A4 synthase;
Delta5-lipoxygenase;
5Delta-lipoxygenase;
arachidonic 5-lipoxygenase;
arachidonic acid 5-lipoxygenase;
C-5-lipoxygenase;
LTA synthase;
leukotriene A4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 5-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = leukotriene A4 + H2O (overall reaction) [RN:R08527];
(1a) arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595];
(1b) (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O [RN:R03058]
Reaction(KEGG)
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
Product
leukotriene A4 [CPD:C00909];
H2O [CPD:C00001];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
History
EC 1.13.11.34 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00461  arachidonate 5-lipoxygenase
Genes
HSA: 240(ALOX5)
PTR: 450428(ALOX5)
PPS: 100979027(ALOX5)
GGO: 101135686(ALOX5)
PON: 100460538(ALOX5)
NLE: 100584513(ALOX5)
MCC: 707926(ALOX5)
MCF: 102132853(ALOX5)
CSAB: 103215810(ALOX5)
CATY: 105576135(ALOX5)
PANU: 101004229(ALOX5)
RRO: 104678173(ALOX5)
RBB: 108522174(ALOX5)
TFN: 117082071(ALOX5)
PTEH: 111529801(ALOX5)
CJC: 100386217(ALOX5)
SBQ: 101031793(ALOX5)
MMU: 11689(Alox5)
MCAL: 110297094(Alox5)
MPAH: 110315917(Alox5)
RNO: 25290(Alox5)
MCOC: 116099451(Alox5)
CGE: 100772492(Alox5)
PLEU: 114689650(Alox5)
NGI: 103737907(Alox5)
HGL: 101700210(Alox5)
CCAN: 109700324(Alox5)
OCU: 100341714(ALOX5)
OPI: 101534185(ALOX5)
TUP: 102480526(ALOX5)
CFA: 477753(ALOX5)
VVP: 112913415(ALOX5)
VLG: 121483983(ALOX5)
AML: 100476416(ALOX5)
UMR: 103668062(ALOX5)
UAH: 113243124(ALOX5)
ORO: 101381769(ALOX5)
ELK: 111144974
MPUF: 101684572(ALOX5)
EJU: 114205241(ALOX5)
MLX: 118023026(ALOX5)
FCA: 101097422(ALOX5)
PYU: 121036944(ALOX5)
PBG: 122492984(ALOX5)
PTG: 102973009(ALOX5)
PPAD: 109264579(ALOX5)
AJU: 106989649(ALOX5)
HHV: 120232804(ALOX5)
BTA: 404074(ALOX5)
BOM: 102270550(ALOX5)
BIU: 109553923(ALOX5)
BBUB: 102400249(ALOX5)
CHX: 102168425(ALOX5)
OAS: 101117390(ALOX5)
ODA: 120865494(ALOX5)
CCAD: 122446293(ALOX5)
SSC: 100156205(ALOX5)
CFR: 102507744(ALOX5)
CBAI: 105075631(ALOX5)
CDK: 105093424(ALOX5)
BACU: 103009115(ALOX5)
LVE: 103081267(ALOX5)
OOR: 101283796(ALOX5)
DLE: 111172567(ALOX5)
PCAD: 102987975(ALOX5) 114485528
ECB: 100062042(ALOX5)
EPZ: 103553660(ALOX5)
EAI: 106846725(ALOX5)
MYB: 102249760(ALOX5)
MYD: 102754419(ALOX5)
MMYO: 118679341(ALOX5)
MNA: 107527950(ALOX5)
PKL: 118732103(ALOX5)
HAI: 109389501(ALOX5)
DRO: 112305481(ALOX5)
SHON: 118994142(ALOX5)
AJM: 119035943(ALOX5)
MMF: 118632052(ALOX5)
PALE: 102898772(ALOX5)
PGIG: 120609662(ALOX5)
RAY: 107508911(ALOX5)
MJV: 108400689(ALOX5)
TOD: 119234526(ALOX5)
LAV: 100661336(ALOX5)
TMU: 101345496
MDO: 100013954(ALOX5)
SHR: 100932471(ALOX5)
PCW: 110213916(ALOX5)
OAA: 100077066(ALOX5)
GGA: 423769(ALOX5)
PCOC: 116238154(ALOX5)
MGP: 100542129(ALOX5)
CJO: 107315916(ALOX5)
NMEL: 110399270(ALOX5)
APLA: 101801930(ALOX5)
ACYG: 106049001(ALOX5)
TGU: 100231888(ALOX5)
LSR: 110475663(ALOX5)
SCAN: 103813960(ALOX5)
PMOA: 120502228(ALOX5)
OTC: 121341694(ALOX5)
PRUF: 121350062(ALOX5)
GFR: 102035554(ALOX5)
FAB: 101813553(ALOX5)
PHI: 102112541(ALOX5)
PMAJ: 107207120(ALOX5)
CCAE: 111931122(ALOX5)
CCW: 104697933(ALOX5)
ETL: 114054707(ALOX5)
FPG: 101914238(ALOX5)
FCH: 102053142(ALOX5)
CLV: 102085004(ALOX5)
EGZ: 104129027(ALOX5)
NNI: 104014074(ALOX5)
ACUN: 113481652(ALOX5)
PADL: 103914082(ALOX5)
AAM: 106497785(ALOX5)
AROW: 112963900(ALOX5)
NPD: 112957209(ALOX5)
DNE: 112990662(ALOX5)
ASN: 102371605(ALOX5)
AMJ: 102568608(ALOX5)
CPOO: 109324293(ALOX5)
GGN: 109287144(ALOX5)
PSS: 102462244(ALOX5)
CMY: 102944803(ALOX5)
CPIC: 101932214(ALOX5)
TST: 117880642(ALOX5)
CABI: 116823588(ALOX5)
ACS: 100556313(alox5)
PVT: 110090785
PMUR: 107292379(ALOX5)
TSR: 106553343(ALOX5)
PGUT: 117661247(ALOX5)
PMUA: 114601080(ALOX5)
ZVI: 118079372(ALOX5)
GJA: 107113129(ALOX5)
XLA: 108696220(alox5.L) 108697207(alox5.S)
XTR: 100036609(alox5)
NPR: 108800085(ALOX5)
DRE: 567204(alox5a) 573013(alox5b.1) 724056(alox5b.2)
IPU: 108263823(alox5)
PHYP: 113546154(alox5)
AMEX: 103035394(alox5)
EEE: 113587960(alox5)
LCO: 104930113(alox5)
NCC: 104946287(alox5)
CGOB: 115020076(alox5)
ELY: 117248563
SLUC: 116054107(alox5a)
ECRA: 117960578(alox5a)
PFLV: 114572645(alox5)
GAT: 120820912(alox5a)
PPUG: 119213967(alox5a)
MSAM: 119916966(alox5a)
MZE: 101482427(alox5)
ONL: 100693453(alox5)
OAU: 116316616(alox5a)
OLA: 101160835(alox5) 101165738
OML: 112162158(alox5a)
XMA: 102230376(alox5)
XCO: 114137934(alox5)
XHE: 116712547(alox5)
PRET: 103476884(alox5)
CVG: 107091526(alox5)
CTUL: 119788547(alox5a)
NFU: 107375698(alox5)
KMR: 108243211
ALIM: 106529456(alox5)
AOCE: 111564375(alox5)
CSEM: 103387317(alox5)
POV: 109631496(alox5)
LCF: 108884347(alox5)
SDU: 111235185(alox5)
SLAL: 111654678(alox5)
XGL: 120796514(alox5a)
HCQ: 109509924 109509925(alox5)
BPEC: 110164412(alox5)
MALB: 109961016(alox5)
SASA: 100194803(lox5) 106613187
SALP: 111978799
ELS: 105010608(alox5)
SFM: 108921027(alox5) 108937538
LOC: 102697549(alox5)
PSPA: 121325182(alox5a)
ARUT: 117416027 117417615(alox5a)
LCM: 102353934(ALOX5)
CMK: 103185827(alox5a)
RTP: 109921931(alox5)
PFUC: 122522695
FAS: 105272890
DAM: 107042086
PVM: 113804806
DSV: 119449406
RSAN: 119382445
RMP: 119178021
PTEP: 107442379
SDM: 118200660
PCAN: 112558951
AQU: 100635761
MXA: MXAN_1744
CCX: COCOR_02733(loxA)
 » show all
Reference
1  [PMID:2829172]
  Authors
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B
  Title
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 85:26-30 (1988)
DOI:10.1073/pnas.85.1.26
  Sequence
[hsa:240]
Reference
2  [PMID:3038871]
  Authors
Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao S, Yotsumoto H, Takaku F, Shimizu T.
  Title
Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers.
  Journal
J Biol Chem 262:10200-5 (1987)
Reference
3  [PMID:3012557]
  Authors
Shimizu T, Izumi T, Seyama Y, Tadokoro K, Radmark O, Samuelsson B.
  Title
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 83:4175-9 (1986)
DOI:10.1073/pnas.83.12.4175
Reference
4  [PMID:6322165]
  Authors
Shimizu T, Radmark O, Samuelsson B.
  Title
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
  Journal
Proc Natl Acad Sci U S A 81:689-93 (1984)
DOI:10.1073/pnas.81.3.689
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.34
IUBMB Enzyme Nomenclature: 1.13.11.34
ExPASy - ENZYME nomenclature database: 1.13.11.34
BRENDA, the Enzyme Database: 1.13.11.34
CAS: 80619-02-9
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