Entry
Name
peptide-aspartate beta-dioxygenase;
aspartate beta-hydroxylase;
aspartylpeptide beta-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN:
R04073 ]
Reaction(KEGG)
Substrate
peptide-L-aspartate;
2-oxoglutarate [CPD:
C00026 ];
O2 [CPD:
C00007 ]
Product
peptide-3-hydroxy-L-aspartate;
succinate [CPD:
C00042 ];
CO2 [CPD:
C00011 ]
Comment
Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
History
EC 1.14.11.16 created 1992
Orthology
K00476 aspartate beta-hydroxylase
Genes
CIMI : 108288419 108317225
CCAN : 109678257 109697332(Asph)
DORD : 105980430(Asph) 105980497
PLOP : 125341787 125341799 125360768(Asph)
VVP : 112932148 112932323(ASPH)
MLF : 102418625(ASPH) 102438511
MNA : 107526441 107526448(ASPH)
PHAS : 123833323(ASPH) 123833325
MDO : 100029689(ASPH) 103102349
AGEN : 126035803 126050521
FGA : 104075831(ASPH) 104080313
TGT : 104567035(ASPH) 104575587
CCAY : 125632489 125632493
CABI : 116818243(ASPH) 116823980
PMUR : 107294151 114923083
TSR : 106550102(ASPH) 106556479
PMUA : 114600572 114600573
ZVI : 118078745 118078746 118090397(ASPH)
XLA : 100137711(asph.L) 108695316
NPR : 108791345(ASPH) 108796606
RTEM : 120917056 120941029(ASPH)
SRX : 107714857 107729161 107730121 107731609 107731610
SANH : 107664966 107674369 107688512 107698672
SGH : 107559844(asph) 107561526 107584723 107602531
CCAR : 109051355 109056380 109056419 109086645 109086653 109106218
CAUA : 113045953 113051632 113106320(asph) 113117451
CGIB : 127961195 128017691
PTET : 122348539(unm_hu7910) 122349803
LROH : 127167840(unm_hu7910)
OMC : 131543532(unm_hu7910)
PPRM : 120480166(unm_hu7910)
RKG : 130106265(unm_hu7910)
MAMB : 125265879(unm_hu7910)
CERY : 137030130(unm_hu7910)
MASI : 127424201 127454087
TROS : 130550522(unm_hu7910) 130554111(asph)
TDW : 130433425(unm_hu7910)
MANU : 129452874(unm_hu7910)
IPU : 108267575(unm_hu7910)
IFU : 128609897(unm_hu7910)
SMEO : 124387087(unm_hu7910)
TFD : 113657448(unm_hu7910)
TVC : 132848477(unm_hu7910)
TRN : 134312244(unm_hu7910) 134334627(asph)
CMAO : 118825690(unm_hu7910)
CHAR : 105894731(unm_hu7910) 116224367
SPIL : 134066013(unm_hu7910)
TFS : 130513626 130539010(asph)
TNG : GSTEN00012782G001 GSTEN00012785G001
TBEN : 117495988(unm_hu7910)
GACU : 117544650(unm_hu7910)
EMAC : 134883879(unm_hu7910)
ELY : 117265014(unm_hu7910) 117272284
EFO : 125881517(unm_hu7910) 125901731(asph)
PLEP : 121951090(asph) 121960952
SLUC : 116036902 116040045 116043914(asph)
ECRA : 117938302 117954619(asph)
PFLV : 114548951 114565287
PPUG : 119198515(unm_hu7910) 119198516 119204275(asph)
AFB : 129110437(unm_hu7910)
CLUM : 117749504(unm_hu7910)
PSWI : 130197867(asph) 130206609 130206690
CANA : 137788543 137789055
CVE : 137874182(unm_hu7910)
MSAM : 119895086 119895394 119902612
SCHU : 122866446(unm_hu7910)
CUD : 121519823(asph) 121527265
SPUL : 138595718(unm_hu7910)
ALAT : 119009064(unm_hu7910) 119009090 119010859(asph)
MZE : 101470710 101480497 112432813 112433101
OAU : 116321936 116335722(unm_hu7910)
OML : 112142277(unm_hu7910) 112144237(asph)
XHE : 116712096 116712098 116721209
PFOR : 103129444 103131754(asph)
PLAI : 106937679(asph) 106947909
PMEI : 106916021 106916023 106917814
GAF : 122824385 122840764(asph)
CVG : 107089110 107098908(asph) 107098913
CTUL : 119795166(asph) 119796944(unm_hu7910)
GMU : 124858096(unm_hu7910) 124869790
NFU : 107384363 107395322(asph)
KMR : 108250906(asph) 108251691(unm_hu7910)
ALIM : 106527660(asph) 106536003
NWH : 119426739(unm_hu7910)
AOCE : 111569010(asph) 111580824
EJA : 138212775(asph) 138215431(unm_hu7910)
BFRE : 138625762 138631098(asph)
MCEP : 124995579(unm_hu7910)
CSEM : 103377197 103396808(asph)
SSEN : 122768290 122777016(asph) 122780483
HHIP : 117753751(unm_hu7910) 117777773(asph)
HSP : 118098960(unm_hu7910) 118117376(asph)
PPLT : 128425439(unm_hu7910) 128425441 128454011
LCF : 108884981(unm_hu7910)
SDU : 111233829 111237396(asph)
SLAL : 111648389 111651459 111652358
XGL : 120789881(unm_hu7910) 120798551(asph)
SSCV : 125985655(unm_hu7910)
PEE : 133396703(unm_hu7910)
PTAO : 133469890(unm_hu7910)
MALB : 109971402 109972756
BSPL : 114844708(asph) 114853130(unm_hu7910)
SJO : 128369554(asph) 128382118 128382779(unm_hu7910)
SSCO : 133991249(asph) 133993965 134002038 134002045 134002056
SASA : 106568874 106579584 106590366 106599166
STRU : 115150347 115169866 115195553
OTW : 112227023 112227765 112232689 112260387
OMY : 110489730(unm_hu7910) 110508822 110530208(asph) 110535277
OGO : 123991364 124009277 124038966 124039608 124041947
ONE : 115103174 115104886 115130185
OKI : 109872019 109899309 109909819
OKE : 118361765 118370679(unm_hu7910) 118394581
OMM : 135517292 135517293 135522882
SALP : 111953589 111953870 111972783 111979344 112067901
SNH : 120020424 120027869 120051018 120051019 120056295
CCLU : 121549650 121569191
ELS : 105030616(asph) 105031615
SFM : 108929627(asph) 108937737
AANG : 118225427(unm_hu7910) 118233927
AROT : 135253555(unm_hu7910)
CCOG : 133126157(unm_hu7910)
PSPA : 121313375 121314303
ARUT : 117394552 117399998 117435698
PSEX : 120530250(unm_hu7910)
RTP : 109932114(unm_hu7910)
CPLA : 122549457(unm_hu7910)
HOC : 132810384(unm_hu7910)
LERI : 129696265(unm_hu7910)
DSI : Dsimw501_GD11159(Dsim_GD11159)
CQU : CpipJ_CPIJ002076 CpipJ_CPIJ002077
MPHA : 105829628 114253958
BROR : 134529422 134541854
CEL : CELE_K09A9.6(K09A9.6)
LSAX : 138956265 138980063
DPOL : 127847702 127847703
MAEA : 128206510 128206513
AAF : AURANDRAFT_61626 AURANDRAFT_64261
EHX : EMIHUDRAFT_216081 EMIHUDRAFT_426226
SQU : E4343_00015 E4343_24820
XPH : XppCFBP6546_04870(XppCFBP6546P_04870)
XBA : C7S18_09360 C7S18_20005
NAO : Y958_13705 Y958_27515
NCB : C0V82_08515 C0V82_22150
» show all
Taxonomy
Reference
Authors
Gronke RS, Welsch DJ, VanDusen WJ, Garsky VM, Sardana MK, Stern AM, Friedman PA.
Title
Partial purification and characterization of bovine liver aspartyl beta-hydroxylase.
Journal
J Biol Chem 265:8558-65 (1990)
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