KEGG   ENZYME: 1.14.11.48
Entry
EC 1.14.11.48               Enzyme                                 
Name
xanthine dioxygenase;
XanA;
alpha-ketoglutarate-dependent xanthine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
xanthine,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2 [RN:R10920]
Reaction(KEGG)
R10920
Substrate
xanthine [CPD:C00385];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
urate [CPD:C00366];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.
History
EC 1.14.11.48 created 2015
Orthology
K23516  xanthine dioxygenase
Genes
APRO: F751_4638
KLA: KLLA0_E04357g
KMX: KLMA_20520
LTH: KLTH0A03674g
ZRO: ZYRO0D16324g
TGB: HG536_0C04630
TDL: TDEL_0H02320(TDEL0H02320)
ZMK: HG535_0F03460
SLUD: SCDLUD_000378
DHA: DEHA2A01518g
PIC: PICST_34838
PGU: PGUG_04939
SPAA: SPAPADRAFT_60857
LEL: PVL30_001093
LBG: 92209650(LODBEIA_P44540)
CAL: CAALFM_C201540WA(CaO19.1461)
CTP: CTRG_01245
COT: CORT_0A13470
CDU: CD36_16390
CTEN: 18246643(PSN45_003365)
CLU: CLUG_03270
CLUS: A9F13_01g09218
CAUR: CJI96_0002396
ASAU: 88175028(PUMCH_003965)
PPA: PAS_chr3_0332
PKZ: C5L36_0E04300
BNN: FOA43_002239
BBRX: BRETT_005011
OPA: HPODL_02648
YLI: 2906404(YALI2_A00104g)
SLB: AWJ20_5294
NCR: NCU09738
NTE: NEUTE1DRAFT78605(NEUTE1DRAFT_78605)
SMP: 10803989(SMAC4_04772)
PAN: PODANSg7245
PBEL: QC761_602860(XAN1)
PPSD: QC762_602860(XAN1)
PPSP: QC763_602860(XAN1)
PPSA: QC764_602860(XAN1)
PGRI: PgNI_08720 PgNI_11652
TMN: UCRPA7_562 UCRPA7_8167 UCRPA7_8169
SSCK: SPSK_05310 SPSK_05319 SPSK_07553
FGR: FGSG_02692
FPU: FPSE_00399
FPOA: FPOAC1_002821(XAN1)
FVN: FVRRES_03136
FVR: FVEG_09012
FOX: FOXG_10360
NHE: NECHADRAFT_94403
FFC: NCS54_00820500
FKR: NCS57_00863700
FMU: J7337_005382(XAN1)
TRE: TRIREDRAFT_77767
TRR: M419DRAFT_35772
TATV: 25777460(TrAtP1_005004) 25783971(TrAtP1_002473)
TASP: 36607203(XAN1) 36613902(TrAFT101_000204)
AMUS: LMH87_008517
VAL: VDBG_04614
VDA: VDAG_04163
CFJ: CFIO01_07110 CFIO01_12421 CFIO01_12422
CLUP: CLUP02_14577 CLUP02_14578 CLUP02_15960
CHIG: CH63R_11300 CH63R_12258 CH63R_12321
CDET: 87942478(CDEST_05975) 87946051(CDEST_09548) 87947016(CDEST_10514)
SAPO: SAPIO_CDS0323
ELA: UCREL1_10403 UCREL1_10408 UCREL1_2937
PFY: PFICI_02622 PFICI_03917 PFICI_03927 PFICI_11089 PFICI_11090
SSL: SS1G_04722
BFU: BCIN_01g08370
PSCO: LY89DRAFT_455914 LY89DRAFT_461846 LY89DRAFT_579972 LY89DRAFT_679151 LY89DRAFT_683826 LY89DRAFT_712245
GLZ: GLAREA_11001
ANI: ANIA_10081
ACT: ACLA_066400
AOR: AO090001000152
ANG: An01g14680
AFV: AFLA_008496
ALUC: AKAW2_20050A
ACHE: ACHE_70909A
APUU: APUU_11553A
PCS: N7525_007948
PDP: PDIP_55050
POU: POX_b01952
TMF: EYB26_003731 EYB26_003733 EYB26_009981
TRG: TRUGW13939_04711 TRUGW13939_11977 TRUGW13939_11979
PTE: PTT_11857 PTT_11858
PTRR: 6346891(PtrM4_146170)
BZE: COCCADRAFT_32934 COCCADRAFT_9324
BSC: COCSADRAFT_81895
BOR: COCMIDRAFT_8838 COCMIDRAFT_90268
AALT: CC77DRAFT_1029939 CC77DRAFT_1091742 CC77DRAFT_282647 CC77DRAFT_956058
ADAC: 96080526(ACET3X_000204) 96080527(ACET3X_000205) 96089950(ACET3X_009628)
ARAB: EKO05_0009821
PFJ: MYCFIDRAFT_132918 MYCFIDRAFT_191119 MYCFIDRAFT_204269 MYCFIDRAFT_210878 MYCFIDRAFT_4952
FFU: CLAFUR5_06013
BCOM: BAUCODRAFT_464815 BAUCODRAFT_70747
NPA: UCRNP2_604 UCRNP2_605 UCRNP2_67 UCRNP2_9547
SPO: 2539549(xan1)
SOM: SOMG_04881(xan1)
CNE: CNC06420
CNB: CNBC0790
CNG: CNAG_01542
CGI: CGB_C1100C
CDEU: CNBG_3894
CDEP: 91090203(L203_105995)
KMG: 30167376(I203_103065)
KNE: 92179844(IAR55_002586) 92181978(IAR55_004720) 92184438(IAR55_007180)
TMS: TREMEDRAFT_26085
TASA: A1Q1_00018
CCAC: CcaHIS019_0109030(CcaverHIS019_0109030)
TVS: TRAVEDRAFT_67834
DSQ: DICSQDRAFT_96760
PCO: PHACADRAFT_248632
SHS: STEHIDRAFT_101392 STEHIDRAFT_170594
PSQ: PUNSTDRAFT_117809
ADL: AURDEDRAFT_79471
FME: FOMMEDRAFT_143156 FOMMEDRAFT_23586
GTR: GLOTRDRAFT_102027 GLOTRDRAFT_134924
RSX: RhiXN_09780
LBC: LACBIDRAFT_181264 LACBIDRAFT_227808 LACBIDRAFT_242796 LACBIDRAFT_301478
CCI: CC1G_00598 CC1G_00658
ABP: AGABI1DRAFT67631(AGABI1DRAFT_67631)
ABV: AGABI2DRAFT196515(AGABI2DRAFT_196515)
PCUB: JR316_0000256 JR316_0000260 JR316_0012159
MPR: MPER_00967
MRR: Moror_11000 Moror_1739
MORE: E1B28_001800
SCM: SCHCO_02505277(SCHCODRAFT_02505277)
CPUT: CONPUDRAFT_79364 CONPUDRAFT_79365
SLA: SERLADRAFT_480389
WSE: WALSEDRAFT_31174
UMA: UMAG_03386
SGRA: EX895_005468
MSYM: MSY001_2908
PGR: PGTG_00897
PTRC: PtA15_17A261
PSTR: Pst134EA_030520
MLR: MELLADRAFT_71644
PIF: PITG_15878
PSOJ: PHYSODRAFT_491326
 » show all
Reference
1  [PMID:15948966]
  Authors
Cultrone A, Scazzocchio C, Rochet M, Montero-Moran G, Drevet C, Fernandez-Martin R
  Title
Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases.
  Journal
Mol Microbiol 57:276-90 (2005)
DOI:10.1111/j.1365-2958.2005.04686.x
  Sequence
[ani:ANIA_10081] [ncr:NCU09738] [spo:2539549]
Reference
2  [PMID:17429948]
  Authors
Montero-Moran GM, Li M, Rendon-Huerta E, Jourdan F, Lowe DJ, Stumpff-Kane AW, Feig M, Scazzocchio C, Hausinger RP
  Title
Purification and characterization of the FeII- and alpha-ketoglutarate-dependent  xanthine hydroxylase from Aspergillus nidulans.
  Journal
Biochemistry 46:5293-304 (2007)
DOI:10.1021/bi700065h
  Sequence
[ani:ANIA_10081]
Reference
3  [PMID:18036331]
  Authors
Li M, Muller TA, Fraser BA, Hausinger RP
  Title
Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans.
  Journal
Arch Biochem Biophys 470:44-53 (2008)
DOI:10.1016/j.abb.2007.11.002
  Sequence
[ani:ANIA_10081]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.48
IUBMB Enzyme Nomenclature: 1.14.11.48
ExPASy - ENZYME nomenclature database: 1.14.11.48
BRENDA, the Enzyme Database: 1.14.11.48
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