KEGG   ENZYME: 1.14.13.114
Entry
EC 1.14.13.114              Enzyme                                 
Name
6-hydroxynicotinate 3-monooxygenase;
NicC;
6HNA monooxygenase;
HNA-3-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
Reaction(IUBMB)
6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 [RN:R08764]
Reaction(KEGG)
R08764
Substrate
6-hydroxynicotinate [CPD:C01020];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxypyridine [CPD:C01059];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.
History
EC 1.14.13.114 created 2010
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14974  6-hydroxynicotinate 3-monooxygenase
Genes
SMARSM39_1770
SMACSMDB11_1583
SMWSMWW4_v1c23250
SPESpro_2311
SRRSerAS9_2268
SRLSOD_c21410(nicC)
SRYM621_11730
SPLYQ5A_011865(nicC)
SRSSerAS12_2268
SRASerAS13_2269
SLQM495_11500
SERFL085_17120
SQUE4343_04635
SFJSAMEA4384070_2380
SOFNCTC11214_04489
SURIJ0X03_12370
SNEMNLX84_11775
SNEVOI978_19645
SGRISGBXF1_02347(nicC)
GQUAWC35_02980
PAOPat9b_5176
PPHOCTZ24_20565
TCIA7K98_12090
TPTYNCTC11468_02201
PPUPP_3944(nicC)
PPFPput_1893
PPGPputGB1_3579
PPWPputW619_2140
PPBPPUBIRD1_1864(nahG)
PPIYSA_08966
PPXT1E_5123
PPUTL483_21710
PPUNPP4_17780
PALDLU682_010745(nicC)
PFSPFLU_2799
PFBVO64_0126
PAZOAYR47_21615
PTOLI7845_13260
PFWPF1751_v1c24700
PFFPFLUOLIPICF724380
PFXA7318_11830
PSKU771_14855
PFZAV641_08725
PANRA7J50_2716
PSILPMA3_12565
PYMAK972_2674
PGGFX982_03128
PEZHWQ56_12830
PWYHU734_022655(nicC)
PTAENCTC10697_01683
PPEGKUA23_13465
PNBNK667_12120
PTAIICN73_23200(nicC)
PPAOK3169_11255
PSJYAA098_17785
AWUBEN71_18355
AGUAS4_40070
HAMHALO0543
HAXIHAALTHF_14260n
HSVHNO53_05755
HPROLMS44_20675
HASOB2G49_16085
HAMSNF683_09245
HVNEI420_01980
HNPSR894_18995
HTTHZS52_07555
HTXEKK97_06040
ALCAASALC70_00125(nicC)
ADIB5T_02296
MARSA8C75_16300
RPJN234_04315
REHH16_A0922(h16_A0922)
CNCCNE_1c08720
CUHBJN34_04895
REUReut_A2515
CTIRALTA_A0867
CBWRR42_s0168
CGDCR3_3010(nicC)
CCUPBKK81_07355
CUPBKK80_06655
CUUBKK79_05495
CPAUEHF44_27000
COXE0W60_14755
CCAMM5D45_06890
CCAXKZ686_20190
CUKKB879_04555
CNANA2G96_05360
BSAVWS86_30265
BCMBcenmc03_3483
BCHBcen2424_4042
BCJBCAM1146
BCENDM39_3876
BCEOI35_4992
BMJBMULJ_03963(nahG)
BMUBmul_4547
BMKDM80_3717
BMULNP80_4072
BCEDDM42_3945
BCEPAPZ15_32845
BCONNL30_06905
BSEMWJ12_25625
BPSLWS57_08400
BMECWJ16_24255
BSTGWT74_20840
BANNJFN94_22970
BARINLX30_32970
BGLbglu_2g20070
BGUKS03_3918
BGDbgla_1g12700
BGOBM43_2602
BGPBGL_1c11630
BPLAbpln_1g11150
BUMAXG89_36980
BUIAX768_15610
BURKDM992_20090
BFNOI25_6802
BCAIK788_0007378
PTERC2L65_30600
PMEGFNZ07_29050
PTROG5S35_31870
PSPUNA29_11655
PVEUC34_12655
PNRAT302_20380
CABASBC2_37460(nicC_1)
BUOBRPE64_DCDS10960
CABKNK8_47350
BPEBP1954
BPCBPTD_1926
BPERBN118_0960
BPEUQ425_15000
BPABPP2327
BBHBN112_1737
BBRBB1778
BBMBN115_1680
BBXBBS798_1679
BPTBpet1330
BAVBAV1532
BFZBAU07_16150
BGMCAL15_11485
BGVCAL12_01135
AXONH44784_051881
AXNAX27061_3325
AXXERS451415_03305
ADTAPT56_16390
AISBUW96_28760
ASWCVS48_09660
ACHBDVB37_25095
PUDG9Q38_13515
AMIMMIM_c31140
AFAUZ73_17625
AFQAFA_08350
AAQUD3M96_09555
AAMMFE795_07540
ODIODI_R3895
PIGEGT29_04520
PACRFXN63_06610
AAVAave_3927
AAAAcav_3824
DACDaci_1853
DELDelCs14_4785
DTSBI380_15385
DHKBO996_08775
DLAI6G47_15015
CTESO987_23175
CRJQMY55_00780
HSEHsero_1333
HSZACP92_06675
HEEhmeg3_19250
HFRG5S34_06890
MTIMDIR46_21185
XYKGT347_16855
XYGR9X41_15980
AZRCJ010_22095
MLNA9174_33985
RLGRleg_5073 Rleg_6042
RTRRTCIAT899_PC08600
RJGCCGE525_26735
RADCO657_35845
RIIFFM53_026860 FFM53_028495
RRGJ3P73_36835
RAWNE851_01780
RSULN2599_21380
RRHOPR018_21710
RTUPR017_19755
RBWRLCC275e_26420
SSUMQ9314_24300
BJUBJ6T_75310
BJPRN69_36540
BGZXH91_28015
BBETF8237_08375
BARHWN72_11515
BBANJ4G43_012690
BGKIC762_34445
BCOUIC761_28200
BXNI3J27_07370
BROSQUH67_14820
RBKE0H22_02830 E0H22_17990
TRBHB776_13840
XDIEZH22_19720
APRAG3A50_11390
HMCHYPMC_0199
RHZRHPLAN_26580 RHPLAN_36190 RHPLAN_38050
DEAFPZ08_21690
AUBLXB15_07215
PSINCAK95_14010 CAK95_28725
PPHRAPZ00_25395
SAGUCDO87_22405
MALUKU6B_06580
PYEA6J80_23230
FAPGR316_11020
NREBES08_14200
SNAPPQ455_05905
GOYGLS_c14190
GALA0U94_10335
GTIFXF46_02595
GSPIGS75_12390
GXLH845_1043
KEUS101446_01671
KSCCD178_02882(nicC_2)
APTAPA01_23790
APWAPA42C_23790
APFAPA03_23790
APUAPA07_23790
APGAPA12_23790
APQAPA22_23790
APXAPA26_23790
APZAPA32_23790
APKAPA386B_1213(nahG)
ASVWG31_11920
APOMCPF11_08760
ATOCIW82_09410
ACETDS739_11650
ROSCTJ15_00285
RMUCFOB66_01430
KHAIFJ82_11100
SRFLHU95_08710
NGUQN315_13995
ALIAZOLI_p20435(nahG)
AZMDM194_20095
AOZHUE56_08295
AZSE6C72_22665
HTQFRZ44_10610
HADHFRZ61_10290
PARHI5S86_12075
KISHUT16_21990
 » show all
Reference
1  [PMID:10091591]
  Authors
Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T
  Title
Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.
  Journal
Eur J Biochem 260:120-6 (1999)
DOI:10.1046/j.1432-1327.1999.00124.x
Reference
2  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3944]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.114
IUBMB Enzyme Nomenclature: 1.14.13.114
ExPASy - ENZYME nomenclature database: 1.14.13.114
BRENDA, the Enzyme Database: 1.14.13.114
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