KEGG   ENZYME: 1.14.15.5
Entry
EC 1.14.15.5                Enzyme                                 
Name
corticosterone 18-monooxygenase;
corticosterone 18-hydroxylase;
corticosterone methyl oxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
corticosterone,reduced-adrenodoxin:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
corticosterone + 2 reduced adrenodoxin + O2 + 2 H+ = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H2O [RN:R03262]
Reaction(KEGG)
R03262;
(other) R03263
Substrate
corticosterone [CPD:C02140];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
18-hydroxycorticosterone [CPD:C01124];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
History
EC 1.14.15.5 created 1972
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Genes
HSA: 1585(CYP11B2)
PTR: 745937(CYP11B2)
PPS: 100971238(CYP11B2)
GGO: 101142418
PON: 100461139
PPYG: 129042640
NLE: 115830633
SSYN: 129486882
MCC: 695914(CYP11B2)
MCF: 102137301(CYP11B2)
MTHB: 126961020 126961026
MNI: 105483796 105488428
CSAB: 103237547(CYP11B2)
CATY: 105581294
PANU: 101002842
MLEU: 105536288
RRO: 104679775
RBB: 108536550
TFN: 117078861
CANG: 105509012
CJC: 100415304(CYP11B2)
CIMI: 108291253(CYP11B1) 108291254(CYP11B2)
ANAN: 105728086(CYP11B2) 105728099(CYP11B1)
CSYR: 103276450
MMUR: 105867373 105867374
LCAT: 123644516 123644520
PCOQ: 105813307 105813360
OGA: 100948396 100958146
HGL: 101700701
CPOC: 100379213(Cyp11b2) 100727186
GVR: 103599088 103604864 103604866
 » show all
Reference
1  [PMID:4381410]
  Authors
Raman PB, Sharma DC, Dorfman RI.
  Title
Studies on aldosterone biosynthesis in vitro.
  Journal
Biochemistry 5:1795-804 (1966)
DOI:10.1021/bi00870a004
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.5
IUBMB Enzyme Nomenclature: 1.14.15.5
ExPASy - ENZYME nomenclature database: 1.14.15.5
BRENDA, the Enzyme Database: 1.14.15.5
CAS: 37256-75-0
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