REACTION: R03263
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Entry
R03263 Reaction
Definition
18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O
Equation
C01124
+
C00662
+
C00007
<=>
C01780
+
C00667
+ 2
C00001
Reaction class
RC00893
C01124_C01780
Enzyme
1.14.15.4
1.14.15.5
Pathway
rn00140
Steroid hormone biosynthesis
rn01100
Metabolic pathways
Module
M00108
C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Orthology
K07433
steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:
1.14.15.4
1.14.15.5
]
Reference
1 [PMID:
21598279
]
Authors
Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ.
Title
Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.
Journal
J Comput Chem 32:2441-8 (2011)
DOI:
10.1002/jcc.21827
Other DBs
RHEA:
50795
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