CYP82Y2 (gene name);
DRS (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
(S)-reticuline,[reduced NADPH---hemoprotein reductase]:oxygen 1,2-oxidoreductase
(S)-reticuline + [reduced NADPH---hemoprotein reductase] + O2 = 1,2-dehydroreticuline + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:
[reduced NADPH---hemoprotein reductase] [CPD:
[oxidized NADPH---hemoprotein reductase] [CPD:
A P-450 (heme-thiolate) cytochrome. The enzyme from Papaver rhoeas (field poppy) is specific for (S)-reticuline and does not act on the (R)-form. The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC
, 1,2-dehydroreticulinium reductase (NADPH), which catalyses the reduction of 1,2-dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline.
EC 184.108.40.206 created 2018
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
K22093 1,2-dehydroreticuline synthase/reductase
Hirata K, Poeaknapo C, Schmidt J, Zenk MH
1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway.
Winzer T, Kern M, King AJ, Larson TR, Teodor RI, Donninger SL, Li Y, Dowle AA, Cartwright J, Bates R, Ashford D, Thomas J, Walker C, Bowser TA, Graham IA
Plant science. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein.
Farrow SC, Hagel JM, Beaudoin GA, Burns DC, Facchini PJ
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy.
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