KEGG   ORTHOLOGY: K22093
Entry
K22093                      KO                                     
Symbol
REPI
Name
1,2-dehydroreticuline synthase/reductase [EC:1.14.19.54 1.5.1.27]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00944  Morphine biosynthesis, (S)-reticuline => morphine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K22093  REPI; 1,2-dehydroreticuline synthase/reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.27  1,2-dehydroreticulinium reductase (NADPH)
     K22093  REPI; 1,2-dehydroreticuline synthase/reductase
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.54  1,2-dehydroreticuline synthase
     K22093  REPI; 1,2-dehydroreticuline synthase/reductase
Other DBs
RN: R03833 R04695
Genes
PSOM: 113322712
AG: AKO60175(REPI)
Reference
  Authors
Farrow SC, Hagel JM, Beaudoin GA, Burns DC, Facchini PJ
  Title
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy.
  Journal
Nat Chem Biol 11:728-32 (2015)
DOI:10.1038/nchembio.1879
  Sequence
LinkDB

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