KEGG ENZYME: 1.18.1.7

ENZYME: 1.18.1.7

Entry

EC 1.18.1.7                 Enzyme

Name

ferredoxin---NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific);
NADH-ferredoxin(NAP) reductase

Class

Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor

Sysname

ferredoxin:NAD(P)+ oxidoreductase

Reaction(IUBMB)

2 reduced [2Fe-2S] ferredoxin + NAD(P)+ + H+ = 2 oxidized [2Fe-2S] ferredoxin + NAD(P)H [RN:R05875 R12422]

Reaction(KEGG)

R05875 R12422

Substrate

reduced [2Fe-2S] ferredoxin [CPD:C22150];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H+ [CPD:C00080]

Product

oxidized [2Fe-2S] ferredoxin [CPD:C22151];
NADH [CPD:C00004];
NADPH [CPD:C00005]

Comment

The enzyme from the aerobic bacterium Ralstonia sp. U2 donates electrons to both EC 1.14.12.12, naphthalene 1,2-dioxygenase and EC 1.14.13.172, salicylate 5-hydroxylase [1]. The enzyme from Pseudomonas NCIB 9816 is specific for the ferredoxin associated with naphthalene dioxygenase; it contains FAD and a [2Fe-2S] cluster.

History

EC 1.18.1.7 created 2013

Orthology

K14581

naphthalene 1,2-dioxygenase ferredoxin reductase component

Genes

EBT:	EBL_c34260(ndoR)

KAS:	KATP_22580

KLU:	K7B04_17400

PPI:	ND053(nahAa)

PFK:	PFAS1_28600

PSC:	A458_06735

PSTU:

UIB01_22615

PBM:	CL52_14600

ALT:	ambt_18035

MMW:	Mmwyl1_2668

MME:	Marme_2403

MPC:	Mar181_2356

MPRI:

MP3633_2252

FCE:	JN531_005600

RSO:	RSc1091(nagAa)

RSE:

F504_1062

RPU:	CDC45_05600

RNC:	GO999_11015

RSL:	RPSI07_2300(ndoR)

RSN:	RSPO_c02273

RSM:	CMR15_20210(ndoR)

RSY:	RSUY_15130

RSG:	JK151_19130

RPJ:	N234_28700

RMN:	TK49_07925

CBW:	RR42_s2750

CCUP:

BKK81_31190

CUP:	BKK80_25160

CUU:	BKK79_30870

CCAX:

KZ686_18760

BMK:	DM80_1434(ndoR) DM80_1439(ndoR)

BUG:	BC1001_0575

BUQ:	AC233_10920

BPX:	BUPH_04465

BUZ:	AYM40_33160

BFN:	OI25_3043(ndoR)

PARB:

CJU94_38680

PTER:

C2L65_39085

PPAI:

E1956_38415

PPK:	U875_04290

PPNO:

DA70_21365

PPNM:

LV28_08955

PRB:	X636_05155

PPUL:

RO07_03185

PSPU:

NA29_24095

PAPI:

SG18_03375

PVE:	UC34_19340

POX:	MB84_24095

PFG:	AB870_06335

PNR:	AT302_02770

PFIB:

PI93_008705

PCOM:

NTU39_21100

PANN:

PanNE5_24090

PANX:

OYT13_19460

CABK:

NK8_60790

AXY:	AXYL_06582

AFA:	UZ73_08385

AFQ:

AFA_02200

AAQU:

D3M96_02175

PIG:	EGT29_02420 EGT29_23985

POL:

Bpro_0980

PNA:

Pnap_2489

AJS:

Ajs_3089

ACK:	C380_10005

ACIQ:

ACDW_45610

ACIV:

EXV95_08415

AAV:

Aave_0164

AAA:

Acav_0195

VPE:	Varpa_2932

VBO:	CKY39_17850

VAM:	C4F17_05700

VAZ:	H7F35_31275

VAV:	IG196_15120

HYY:	JNX00_12180

DIJ:	HND92_13260

LCH:

Lcho_0800

JAJ:	EKL02_16445

HEW:	HBDW_22650

MASY:

DPH57_09575

EHB:	E7V67_009695

UND:	UNDKW_4644

TIN:

Tint_1781

THI:

THI_2205

AZO:	azo2517(nagAa)

AOA:

dqs_2674

AZR:	CJ010_15890

SIX:	BSY16_5589

RHV:	BA939_22370

SHZ:

shn_02370

OAN:	Oant_3238 Oant_4051

OAH:	DR92_3251 DR92_4202

OCR:	HGK82_13400

OCL:	GTN27_14640

BOP:	AXW83_15000

STAR:

G3545_17180

MRD:	Mrad2831_0219

MNO:

Mnod_0136

MPHY:

MCBMB27_05204

METX:

A3862_01170

MOC:	BB934_42075

CDQ:	BOQ54_10960

HMC:	HYPMC_3092

AALA:

IGS74_00605

NOH:	G5V57_28305

RBM:

TEF_01260

PSF:

PSE_0864

PPHR:

APZ00_10945

LAP:	ACP90_27015

LABR:

CHH27_20650

LABT:

FIU93_04780(nagAa1)

LAGG:

B0E33_11075

SIW:	GH266_12635

PYE:	A6J80_03590

PARR:

EOJ32_06500

PKD:	F8A10_03980

SGI:	SGRAN_2805(thnY)

DVN:	HQ394_12615

TII:	DY252_20845

TMO:	TMO_2240(ndoR)

» show all

Reference

1 [PMID:11872705]

Authors

Zhou NY, Al-Dulayymi J, Baird MS, Williams PA

Title

Salicylate 5-hydroxylase from Ralstonia sp. strain U2: a monooxygenase with close relationships to and shared electron transport proteins with naphthalene dioxygenase.

Journal

J Bacteriol 184:1547-55 (2002)
DOI:10.1128/JB.184.6.1547-1555.2002

Sequence

[ag:AAD12606]

Reference

2 [PMID:2294092]

Authors

Haigler BE, Gibson DT

Title

Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816.

Journal

J Bacteriol 172:457-64 (1990)
DOI:10.1128/JB.172.1.457-464.1990