KEGG ENZYME: 1.3.1.39

ENZYME: 1.3.1.39

Entry

EC 1.3.1.39                 Enzyme

Name

enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific);
acyl-ACP dehydrogenase;
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACp reductase;
enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific);
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific);
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific);
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (A-specific)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)

Reaction(IUBMB)

an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:R01404]

Reaction(KEGG)

R01404 > R04430 R04725 R04956 R04959 R04962 R04967 R04970

Substrate

acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006]

Product

trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC 2.3.1.85, fatty-acid synthase system. The mammalian enzyme is Re-specific with respect to NADP+. cf. EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH).

History

EC 1.3.1.39 created 1986, modified 2013, modified 2018

Reference

1 [PMID:4394955]

Authors

Dugan RE, Slakey LL, Porter JW.

Title

Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis.

Journal

J Biol Chem 245:6312-6 (1970)

Reference

2 [PMID:16215233]

Authors

Carlisle-Moore L, Gordon CR, Machutta CA, Miller WT, Tonge PJ

Title

Substrate recognition by the human fatty-acid synthase.

Journal

J Biol Chem 280:42612-8 (2005)
DOI:10.1074/jbc.M507082200

Other DBs

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