KEGG   ENZYME: 2.3.1.85
Entry
EC 2.3.1.85                 Enzyme                                 
Name
fatty-acid synthase system;
FASN (gene name);
fatty-acid synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+ [RN:R05188]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain fatty acid [CPD:C00638];
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase system.
History
EC 2.3.1.85 created 1984, modified 2019
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K00665  fatty acid synthase, animal type
Genes
HSA2194(FASN)
PTR454986(FASN)
PPS100985873(FASN)
GGO101151060(FASN)
PON100456558(FASN)
NLE100596750 100597701(FASN)
MCC715708(FASN)
MCF102119674(FASN)
CSAB103243754(FASN)
CATY105588564(FASN)
PANU101013778(FASN)
TGE112609166(FASN)
RRO104654984(FASN)
RBB108525064 108534089(FASN)
TFN117066371(FASN)
PTEH111527639(FASN)
CJC100402953(FASN)
SBQ101045175(FASN)
CSYR103251321(FASN)
MMUR105878096(FASN)
LCAT123650731(FASN)
OGA100947008(FASN)
MMU14104(Fasn)
MCAL110305254(Fasn)
MPAH110332500(Fasn)
RNO50671(Fasn)
MCOC116079118(Fasn)
MUN110548829(Fasn)
CGE100689207(Fasn)
MAUA101833743(Fasn)
PLEU114703909(Fasn)
MORG121444071 121444583
AAMP119811347(Fasn)
NGI103730050(Fasn)
HGL101698314(Fasn)
CPOC100714828(Fasn)
CCAN109702407(Fasn)
DORD105998431(Fasn)
DSP122098339(Fasn)
NCAR124979686
OPI101535716
TUP102481635(FASN)
CFA483378(FASN)
CLUD112672967(FASN)
VVP112920917(FASN)
VLG121472961(FASN)
AML100468470(FASN)
UMR103666012(FASN)
UAH113244480(FASN)
UAR123777917(FASN)
ELK111160286
LLV125087726
MPUF101693535(FASN)
ORO101372296(FASN)
EJU114216135(FASN)
ZCA113939482(FASN)
MLX118024149(FASN)
FCA100270775(FASN)
PYU121018088(FASN)
PBG122485977(FASN)
PTG102956933(FASN)
PPAD109276748(FASN)
AJU106986313(FASN)
HHV120228300(FASN)
BTA281152(FASN)
BOM102278267(FASN)
BIU109573330(FASN)
BBUB102409414(FASN)
CHX100861286(FASN)
OAS100170327(FASN)
ODA120866858(FASN)
CCAD122438739(FASN)
SSC397561(FASN)
CFR102509439(FASN)
CBAI105065535(FASN)
CDK105102220(FASN)
VPC102531336(FASN)
BACU103017465
LVE103077747(FASN)
OOR101279575(FASN)
DLE111182671(FASN)
PCAD102976967(FASN)
PSIU116745034(FASN)
ECB100057311(FASN)
EPZ103551124(FASN)
EAI106846150(FASN)
MYB102251003(FASN)
MYD102761714(FASN)
MMYO118671637(FASN)
MNA107539079(FASN)
PKL118704582(FASN)
HAI109393056(FASN)
DRO112298725(FASN)
SHON119002394(FASN)
AJM119058629(FASN)
PDIC114502687(FASN)
PHAS123816716(FASN)
MMF118633964(FASN)
RFQ117013046(FASN)
PALE102887167(FASN)
PGIG120600316(FASN)
PVP105301128(FASN)
RAY107520266(FASN)
MJV108387187(FASN)
TOD119231088(FASN)
SARA101537514(FASN) 101539044
LAV100674176(FASN)
TMU101361851
DNM101426754
MDO100025176(FASN)
GAS123247142(FASN)
PCW110218312(FASN)
OAA100091954(FASN)
GGA396061(FASN)
PCOC116232578(FASN)
MGP100542651(FASN)
CJO107322058(FASN)
NMEL110407258(FASN)
APLA101796973(FASN)
ACYG106046771(FASN)
AFUL116496544(FASN)
TGU100226957(FASN)
LSR110472404(FASN)
SCAN103819722(FASN)
PMOA120505406(FASN)
OTC121338244(FASN)
PRUF121352757(FASN)
GFR102043163(FASN)
FAB101820764(FASN)
PHI102102393(FASN)
PMAJ107212310(FASN)
CCAE111937506(FASN)
CCW104698180(FASN)
CBRC103613078(FASN)
ETL114060364(FASN)
ZAB102069381(FASN)
FPG101924649(FASN)
FCH102046127(FASN)
CLV102086015(FASN)
EGZ104131108(FASN)
NNI104014322(FASN)
PLET104616609(FASN)
ACUN113486868(FASN)
TALA104367309(FASN)
PADL103917422(FASN)
ACHC115341214(FASN)
HALD104325214(FASN)
CCRI104159587(FASN)
CSTI104556898(FASN)
EHS104510883(FASN)
FGA104074865(FASN)
GSTE104260249(FASN)
LDI104353072(FASN)
MNB103774070
AAM106487141(FASN)
AROW112968647(FASN)
NPD112945330(FASN)
DNE112990989(FASN)
ASN102384493(FASN)
AMJ102571811(FASN)
CPOO109324496(FASN)
GGN109288220(FASN)
PSS102458578(FASN)
CMY102933656(FASN)
CPIC101942965(FASN)
TST117887805(FASN)
CABI116815831(FASN)
MRV120383358(FASN)
ACS100563002(fasn)
PVT110090820(FASN)
SUND121922081(FASN)
PBI103062560(FASN)
PMUR107288857(FASN)
TSR106542096(FASN)
PGUT117663060(FASN)
VKO123018129(FASN)
PMUA114589796(FASN)
ZVI118079765(FASN)
GJA107118129(FASN)
STOW125428348(FASN)
XLA108701000(fasn.L)
XTR100487052(fasn)
NPR108791330(FASN)
RTEM120918905(FASN)
BBUF121003318(FASN)
BGAR122940673(FASN)
DRE559001(fasn)
SRX107722180 107755500(fasn)
SANH107684061(fasn) 107702482
SGH107565779 107581585(fasn)
CCAR109053232 109084667
CAUA113055967 113064170 113111640
PPRM120474646(fasn)
MAMB125255972(fasn)
IPU108273998(fasn)
PHYP113527148(fasn)
SMEO124389005(fasn)
TFD113662599(fasn)
AMEX103030617(fasn)
EEE113568104(fasn)
TRU101069108
TNGGSTEN00010858G001
LCO104927028(fasn)
ELY117247560(fasn)
EFO125880982(fasn)
PLEP121958488(fasn)
SLUC116067519(fasn)
ECRA117937374(fasn)
PFLV114547830(fasn)
GAT120819753(fasn)
PPUG119213101(fasn)
MSAM119915567(fasn)
CUD121528907(fasn)
ALAT119009623(fasn)
MZE101485706(fasn)
ONL100534502(fasn)
OAU116330715(fasn)
OLA101171365(fasn)
OML112138867(fasn)
XMA102232393(fasn)
XCO114151265(fasn)
XHE116727337(fasn)
PRET103482177(fasn)
PFOR103142568(fasn)
PLAI106963309(fasn)
PMEI106927214(fasn)
GAF122823248(fasn)
CVG107087621(fasn)
CTUL119796109(fasn)
GMU124875110(fasn)
NFU107396699(fasn)
KMR108248335(fasn)
ALIM106530206(fasn)
NWH119424080(fasn)
AOCE111564925(fasn)
MCEP125022634(fasn)
CSEM103381833(fasn)
POV109642814
SSEN122759096(fasn)
HHIP117753191(fasn)
HSP118100276(fasn)
LCF108879490 108882087
SDU111237039(fasn)
SLAL111664335(fasn)
XGL120794114(fasn)
HCQ109513269(fasn)
BPEC110154166(fasn)
MALB109965115(fasn)
BSPL114845882(fasn)
SASA106589612 106610271
OTW112224492 121841053
OMY110499230 110502946
OGO124038588 124040220
ONE115113815 115144264(fasn)
SALP111978091 112080426
SNH120029534(fasn) 120045991
CCLU121547561(fasn) 121577692
ELS105021150(fasn)
SFM108939982(fasn)
PKI111849631(fasn)
AANG118221028(fasn)
LOC102685951(fasn)
PSPA121295320 121296635
ARUT117423032 117424309
LCM102352909(FASN)
CMK103175468(fasn)
RTP109913760 109914699(fasn)
CIN100181277
SPU105440011
SKO100369299 100369443 100370573 100374692 100376755 102807132
DMEDmel_CG17374(FASN3) Dmel_CG3523(FASN1) Dmel_CG3524(FASN2)
DER6541559 6542433 6543504
DSE116803584 6613200 6620584
DSIDsimw501_GD17693(Dsim_GD17693) Dsimw501_GD23206(Dsim_GD23206) Dsimw501_GD23207(Dsim_GD23207)
DYADyak_GE18209 Dyak_GE18210 Dyak_GE28239
DAN26514500 6497225 6497226
DSR110180482 110187237 110187238
DPO4817018 4817023 6897794
DPE6589179 6589180 6594365
DMN108154969 108162261 108162262
DWI6651198 6651818 6651866
DGR6561996 6561997 6570749 6570831 6571452 6571616
DMODmoj_GI10509 Dmoj_GI10520 Dmoj_GI23207
DAZ108610876 108610878 108621673
DNV108649396 115562427 115563001
DHE111598659 111603989 111604008
DVI6628103 6628141 6630926
CCAT101452110 101463409
BOD106622597 106623804
MDE101888614 101893120
SCAC106087025 106090589
LCQ111681404 111690930 111690931
LSQ119604430 119604500 119606902
HIS119651873 119659457
AGAAgaP_AGAP001899 AgaP_AGAP008468 AgaP_AGAP009176
ACOZ120953445 120957046 120957047 120957376
AARA120897655 120901692 120901693 120902683
ASTE118506620 118512534 118514284 118514285
AAG5568814 5570229 5573927 5573929 5573930 5573931
AALB109407207 109419595 109421176 109421178 109421326 109421327 109426323 109427809 109427811 115265184 115265185 115265533 115265534 115265569
CQUCpipJ_CPIJ003494 CpipJ_CPIJ003495 CpipJ_CPIJ005595 CpipJ_CPIJ008367
CPII120414303 120416311 120429905 120429917
CNS116337764 116340889 116344296 116344424 116348279 116348400 116348460 116349479 116351032 116351271 116352489
BCOO119066110 119067832 119071053 119077605 119077681 119078059 119078233 119078601 119082139
AME411959 412815
ACER107993563 108000565
ALAB122713456 122719538
BIM100742442 100742781
BBIF117207135 117216471
BVK117232671 117234004
BVAN117158763 117160845
BTER100644763 100652317
BPYO122570077 122571176
CCAL108621920 108628229 108628230 108628231 108629850
OBB114875399 114880134
MGEN117224267 117224750
NMEA116426715 116430914
CGIG122396376 122397043
SOC105196297 105197914 105198903 105199688 105200156 105202179 105202319 105202483 105202557 105202953 105202956 105203128 105205000 105205264 105208165
MPHA105831114 105836966 105839757 105840656
AEC105145358 105145528 105151862 105153178 105153179 105153181
ACEP105617602 105621803 105621939 105621944 105626385 105626590
PBAR105423444 105426819 105426871 105427550 105430349 105430537
VEM105556117 105556674 105558192 105558962 105561532 105561632 105563525 105563598 105564674 105566143 105567646 105570994
HST105180672 105182083 105182544 105185168 105185960 105186441 105186768 105187141 105187401 105188623 105191040 105191892 112588711 112589354 112590320 112590570
DQU106742303 106742577 106745715 106748386
CFO105247751 105247758 105248514 105249037 105249406 105250095 105250609 105251211 105254251 105254262 105256048 105256223 105256457 105256463 105256816 105257505 105258076 105259522 105259561 112637545 112637552 112637553 112637864 112638128 112638761 112639698 112639847
FEX115233254 115233345 115233533 115234497 115235366 115238468 115238469 115241467 115241706 115241716 115242725 115245677 115246003
LHU105667548 105667688 105667834 105668496 105668646 105668856 105669150 105670251 105670847 105672402 105673445 105673457 105674779 105675105 105676017 105676185 105676405 105676834 105678596 105679005 105679169 105679281 105679506 105679904 105680084 105680116
PGC109853513 109854413 109856138 109856394 109858510 109859046 109859048 109859110 109860414 109860910 109861364 109861672 109862058 109862386 109862585 109862656 109862685 109864161
OBO105276900 105277111 105278724 105278763 105279620 105285513 105286065 105287194 105287903 105288090
PCF106785473 106793071 106793252
PFUC122513549 122513550 122513696 122517792 122517837 122522081 122524428 122525851
VPS122627509 122627510 122628351 122628583 122629032 122629201 122633870 122634824
NVI100119597 100121447 100122083 100122099 100124027 100678737 103316303
CSOL105361728 105363109 105366359 105366362
TPRE106650713 106652998 106653506 106656993 106659131 106659766
MDL103577141 103577902 103577904
CGLO123261598 123261635 123261644
FAS105267945 105271484 105272765 105272766
DAM107038444 107038445 107038474 107038498 107038503 107047821
AGIF122850599 122854259 122856284 122856308 122856310 122858803 122858805 122858806
CCIN107264238 107266560
TCA103314884 658024 658944 659179 660113 660178 662899
DPA109541738 109542929 109542979 109544836
SOY115874547 115876592 115876924 115876927 115876930 115876931 115883152 115886869 115887549 115887569
ATD109594991 109596773 109597610 109597612 109597613 109606028 109608696
CSET123308581 123309761 123318444 123320890 123320891 123321139 123322789
AGB108904619 108907685 108907709 108909811 108910339 108911983 108913380 108914573 108915456 108915506 108915555 108915676 108917957
LDC111502191 111502521 111503529 111508240 111508890 111517530
NVL108557772 108557787 108558974 108560588 108565026 108567254 108568351
APLN108738620 108738636 108744646 108744885 112903898
PPYR116160978 116161073 116161396 116161505 116161688 116161905 116161906 116161916 116161945 116161975 116161982 116161983 116162162 116162361 116163445 116171981 116173285 116173286 116174065 116174198 116174377 116174560 116174561 116181966 116181967 116181975 116181979
OTU111416369 111417792 111418554 111423847 111428957 111428975 111428976 111428987
BMOR101740134 101742625 110385087 110385370 693037 693038
BMAN114240500 114242082 114242083 114242139 114243311 114247718 114247719 114248778 114248779 114251936 114252855
MSEX115441336 115444304 115444306 115450916 115450926 115450927 115451366
DPLKGM_206960A KGM_207082 KGM_212360
BANY112043408 112046001 112047759 112048406 112048408 112048427 112055250 112055255 112055352 112055693 112055695 112055697
PMAC106713011 106716463 106718579 106718893
PPOT106105818 106106067
PXU106114262 106114263 106117824 106117869 106120940
PRAP110997060 110997061 110999406 110999413 111001727 111002699
ZCE119828244 119834958 119835685 119835701 119835711 119835720 119835731
HAW110369798 110369799 110369828 110370851 110370854 110370856 110370859 110380738
HZE124634824 124639663
TNL113495949 113498344 113502875 113502960 113503009
SLIU111356608 111356850 111359194 111359981 111360101 111360159 111360201 111360202 111360472
OFU114351871 114351872 114352147 114352958 114354373 114361471
PXY105386886 105386888 105386889 105386890 105386891 105393935
API100158855 100158857 100159146 100160920 100162692 100163154 100164777 100166426 100166618 100167255 100570193 103308252 115033631
DNX107162347 107162355 107162370 107162813 107164658 107167281 107172899 107172901
AGS114121653 114121660 114121661 114121664 114121759 114121761 114121762 114122899 114125345 114129891
RMD113550201 113550202 113551735 113551933 113551934 113552284 113552745 113554502 113554570 113554723 113555001 113560874 113561322
BTAB109030324 109030326 109030328 109030331 109030398 109030399 109030416 109030430 109030431 109030434 109033165 109034371 109034713 109035771 109037047 109040649 109043544
DCI103508526 113465291
CLEC106661142 106663460 106664590 106667274 106667275
HHAL106683409 106687012 106687027 106689658 106690460 106690461
NLU111045930 111046194 111052494 111062415
PHUPhum_PHUM080440 Phum_PHUM448390 Phum_PHUM565830
FOC113202264 113202279 113206111 113207792 113208063 113210546 113210547 113210548 113210549 113210550 113213144 113213185 113213186 113214773 113217410
TPAL117639322 117642648 117643551 117647203 117647484 117650852 117651001
ZNE110830700 110834624 110834625 110836042 110837190 110841318
CSEC111862485 111868235 111869163 111872264 111872433 111874236 111874303
FCD110848499 110859129
PVM113815940
PJA122253228
PCHN125033471
HAME121856236
PCLA123773166
PTRU123510032
PPOI119113587
ISCIscW_ISCW009053
DSV119444321 119444325 119444367 119444470 119445413 119445414 119453329 119453373 119453374 119454055 119454056 119454112 119454113 119454267 119454364
RSAN119390905 119391816 119391817 119391856 119391859 119391860 119398657 119398658 119398705 119398707 119398708 119398960 119398989 119398992 119399780 119400146
RMP119179026 119179100 119179104 119179201 119179258 119179504 119179527 119185144
VDE111251023 111251929
VJA111268914 111268918
TUT107359791 107360391 107361055 107361744 107361815 107366193 107368728 107369476 107370796 107371424
DPTE113788529 113789596 113790804 113792212 113794834
DFR124494631 124494962 124496635 124497991 124499044
CSCU111635849
PTEP107439709 107441937 107447920 107451272 107454900 122272360
SDM118187786 118187796 118199791
CELCELE_F32H2.5(fasn-1)
CBRCBG_12408(Cbr-fasn-1)
BMYBM_BM3778(Bm3778)
LOALOAG_17873
TSPTsp_06638
HROHELRODRAFT_99033
LGILOTGIDRAFT_235996
PCAN112557139
BGT106063187
GAE121378992 121387861
HRF124117938 124131515
HRJ124276718 124282414
CRG105318687 105334039 105338805
MYI110448576 110453408 110453914
PMAX117332675 117336733 117338653
MMER123528595 123530400 123554103 123564054
OBI106874238
OSN115218869
LAK106159135 106163103 106172289
EPA110240069
ATEN116299530
ADF107350794
AMIL114969596
PDAM113669115
SPIS111339547
TADTRIADDRAFT_31339 TRIADDRAFT_34034 TRIADDRAFT_34041
CSLCOCSUDRAFT_42572 COCSUDRAFT_44339 COCSUDRAFT_47508 COCSUDRAFT_49000 COCSUDRAFT_58178 COCSUDRAFT_58179 COCSUDRAFT_58181
GTRGLOTRDRAFT_123623(pks6)
MRRMoror_3083 Moror_3093
MGLMGL_1024
MRTMRET_3131
MSYMMSY001_2608
 » show all
Reference
1  [PMID:457689]
  Authors
Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM.
  Title
Physicochemical studies of the rat liver and adipose fatty acid synthetases.
  Journal
J Biol Chem 254:7418-26 (1979)
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu Rev Biochem 52:537-79 (1983)
DOI:10.1146/annurev.bi.52.070183.002541
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.85
IUBMB Enzyme Nomenclature: 2.3.1.85
ExPASy - ENZYME nomenclature database: 2.3.1.85
BRENDA, the Enzyme Database: 2.3.1.85
CAS: 9045-77-6
LinkDB

DBGET integrated database retrieval system