KEGG   ENZYME: 1.3.1.95
Entry
EC 1.3.1.95                 Enzyme                                 
Name
acrylyl-CoA reductase (NADH)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
propanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
propanoyl-CoA + NAD+ = acryloyl-CoA + NADH + H+ [RN:R10161]
Reaction(KEGG)
R10161
Substrate
propanoyl-CoA [CPD:C00100];
NAD+ [CPD:C00003]
Product
acryloyl-CoA [CPD:C00894];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC 1.3.1.84, acrylyl-CoA reductase (NADPH).
History
EC 1.3.1.95 created 2012
Pathway
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K20143  acrylyl-CoA reductase (NADH)
Genes
CCAA: KQH81_11430
CAPR: EQM14_13595
ARF: AR1Y2_3402
ACAC: EYQ97_00785
LGG: QJR73_02610
EHL: EHLA_1855
CPRO: CPRO_21630(acrC)
ANV: RBQ60_06035
AOE: Clos_0168
CDF: CD630_08030
PDC: CDIF630_00922(acrC)
CDC: CD196_0753
CDL: CDR20291_0734
PDF: CD630DERM_08030
TEM: JW646_01980
TGC: L0P85_06205
TMY: TEMA_03220(acrC)
TPET: TPHSE_14220(acrC)
PEB: O0R46_01435
MSEA: METESE_33210
FNF: BSQ88_04025
 » show all
Reference
1  [PMID:12603323]
  Authors
Hetzel M, Brock M, Selmer T, Pierik AJ, Golding BT, Buckel W
  Title
Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.
  Journal
Eur J Biochem 270:902-10 (2003)
DOI:10.1046/j.1432-1033.2003.03450.x
Reference
2  [PMID:22810300]
  Authors
Kandasamy V, Vaidyanathan H, Djurdjevic I, Jayamani E, Ramachandran KB, Buckel W, Jayaraman G, Ramalingam S
  Title
Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation.
  Journal
Appl Microbiol Biotechnol 97:1191-200 (2013)
DOI:10.1007/s00253-012-4274-y
  Sequence
[ag:AEM62998]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.95
IUBMB Enzyme Nomenclature: 1.3.1.95
ExPASy - ENZYME nomenclature database: 1.3.1.95
BRENDA, the Enzyme Database: 1.3.1.95
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