KEGG ENZYME: 1.4.1.25

ENZYME: 1.4.1.25

Entry

EC 1.4.1.25                 Enzyme

Name

L-arginine dehydrogenase;
dauB (gene name);
anabolic L-arginine dehydrogenase

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-arginine:NAD(P)+ oxidoreductase (deaminating)

Reaction(IUBMB)

L-arginine + H2O + NAD(P)+ = 5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R11031 R11032]

Reaction(KEGG)

R11031 R11032

Substrate

L-arginine [CPD:C00062];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

5-guanidino-2-oxopentanoate [CPD:C03771];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.99.6, D-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine.

History

EC 1.4.1.25 created 2017

Pathway

ec00470

D-Amino acid metabolism

ec01100

Metabolic pathways

Orthology

K19744

L-arginine dehydrogenase

Genes

PANE:

P6287_14755

PPR:	PBPRB0030(PA3862)

PRE:	PCA10_11000

PAE:	PA3862(dauB)

PAEV:

N297_3988

PAEI:

N296_3988

PAU:	PA14_14020

PAG:	PLES_11121

PAF:	PAM18_1076

PNC:	NCGM2_5052

PAEB:

NCGM1900_1111

PDK:	PADK2_05005

PSG:	G655_05385

PRP:	M062_20420

PAER:

PA1R_gp1756

PAEM:

U769_05545

PAEL:

T223_05460

PAES:

SCV20265_1135

PAEU:

BN889_04293

PAEG:

AI22_28105

PAEC:

M802_3986

PAEO:

M801_3854

PAP:	PSPA7_1243

PFL:

PFL_1045

PPRC:

PFLCHA0_c10640

PPRO:

PPC_1082

PFE:	PSF113_4742

PFO:	Pfl01_0970

PFC:	PflA506_2228

PFB:

VO64_5502

PMAN:

OU5_2435

PTV:	AA957_03145

PKR:	AYO71_07590

PFW:	PF1751_v1c20450

PFF:	PFLUOLIPICF726490

PBA:	PSEBR_a4580

PBC:	CD58_24250

PPUU:

PputUW4_04461

PDR:	H681_19275

PSK:	U771_12280

PKC:

PKB_0989

PCH:	EY04_04570

PCZ:	PCL1606_50590

PCP:	JM49_25075

PCHP:

C4K32_1113

PALK:

PSAKL28_08840

PSEM:

TO66_05260

PFK:	PFAS1_16745

PSIL:

PMA3_04250

PUM:	HGP31_04845

PGY:	AWU82_19030 AWU82_29060

PATA:

JWU58_22700

PZE:	HU754_006325

PMOE:

HV782_005900

PPII:

QL104_05235

PTZ:	HU718_005960

PPRG:

HU725_013415

PCAS:

LOY40_17935

PIE:	HU724_005725

PGF:	J0G10_06125

PSII:

NF676_05395

PSOA:

PSm6_09800(dauB)

PLIS:

NN484_01440

PKV:	QYQ93_11715

PDEU:

QEP73_00730

PSDT:

NH234_05880

PSNS:

CI807_25255

PSRU:

CCX46_04940

PMY:

Pmen_3566

TACT:

SG35_020515

TVD:	SG34_008640

ORB:	IPMB12_01150

UBR:	RHO15_01130

BUR:	Bcep18194_A3938

BCM:	Bcenmc03_0820

BCH:	Bcen2424_0848

BCJ:

BCAL3157

BCEN:

DM39_657

BCEW:

DM40_1511

BCEO:

I35_0706

BAM:

Bamb_0723

BAC:	BamMC406_0740

BMJ:	BMULJ_00699

BMU:

Bmul_2539

BMK:

DM80_839

BMUL:

NP80_860

BCT:

GEM_2683

BCED:

DM42_982

BDL:

AK34_2328

BPYR:

ABD05_09845

BCON:

NL30_11560

BUG:	BC1001_3931

BYI:	BYI23_C013410

BUQ:	AC233_21940

BPH:

Bphy_3431

BGE:	BC1002_4530

BPX:	BUPH_00515

BPY:	Bphyt_2072

BUZ:	AYM40_32340

BFN:

OI25_6281

BUE:	BRPE67_CCDS13080

EAD:	OV14_b1239

EAH:	FA04_28125

EAW:	ACEP9W_29125

REL:	REMIM1_PC00033

ABAW:

D5400_18045

MOC:	BB934_32250

CAUL:

KCG34_07640

SMAG:

AN936_14040

SMAZ:

LH19_04515

SPJJ:

V6U71_04295

STRE:

GZL_01015

» show all

Reference

1 [PMID:19139398]

Authors

Li C, Lu CD

Title

Arginine racemization by coupled catabolic and anabolic dehydrogenases.

Journal

Proc Natl Acad Sci U S A 106:906-11 (2009)
DOI:10.1073/pnas.0808269106

Sequence

[pae:PA3862]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.1.25

IUBMB Enzyme Nomenclature:

1.4.1.25

ExPASy - ENZYME nomenclature database:

1.4.1.25

BRENDA, the Enzyme Database:

1.4.1.25

LinkDB

DBGET integrated database retrieval system