KEGG ENZYME: 1.5.1.16

ENZYME: 1.5.1.16

Entry

EC 1.5.1.16                 Enzyme

Name

D-lysopine dehydrogenase;
D-lysopine synthase;
lysopine dehydrogenase;
D(+)-lysopine dehydrogenase;
2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

Reaction(IUBMB)

N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O = L-lysine + pyruvate + NADPH + H+ [RN:R00452]

Reaction(KEGG)

R00452

Substrate

N2-(D-1-carboxyethyl)-L-lysine [CPD:C04020];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

L-lysine [CPD:C00047];
pyruvate [CPD:C00022];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

In the reverse reaction, a number of L-amino acids can act instead of L-lysine, and 2-oxobutanoate and, to a lesser extent, glyoxylate can act instead of pyruvate.

History

EC 1.5.1.16 created 1978

Pathway

ec00310

Lysine degradation

Reference

1 [PMID:21695]

Authors

Otten LA, Vreugdenhil D, Schilperoort RA.

Title

Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue.

Journal