| Entry |
|
| Name |
6,7-dihydropteridine reductase;
6,7-dihydropteridine:NAD(P)H oxidoreductase;
DHPR;
NAD(P)H:6,7-dihydropteridine oxidoreductase;
NADH-dihydropteridine reductase;
NADPH-dihydropteridine reductase;
NADPH-specific dihydropteridine reductase;
dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase;
dihydropteridine reductase;
dihydropteridine reductase (NADH);
5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase
|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
|
| Sysname |
5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase
|
| Reaction(IUBMB) |
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+ [RN: R07354 R07355]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase.
|
| History |
EC 1.5.1.34 created 1972 as EC 1.6.99.7, modified 1981 (EC 1.6.99.10 created 1978, incorporated 1981), transferred 2003 to EC 1.5.1.34
|
| Pathway |
|
| Orthology |
| K00357 | dihydropteridine reductase |
| K10679 | nitroreductase / dihydropteridine reductase |
|
| Genes |
| CCAD: | 122428268(QDPR) 122435698 |
| EFUS: | 103294526(QDPR) 103298127 |
| SFUM: | 130038531(QDPR) 130038882 |
| PMUA: | 114604230 114604587 |
| XLA: | 734473(qdpr.L) 734869(qdpr.S) |
| DRE: | 563255(qdprb.4) 566323(qdpra) 791448(qdprb.1) |
| SRX: | 107741111 107750446 107756464 |
| SANH: | 107680669 107694980 107702409 |
| CCAR: | 109054887 109074892(qdpra) 109102481 |
| CAUA: | 113091110 113093304 113107586 113114044 |
| CGIB: | 127957283 127971166 128027560 |
| PTET: | 122348482(qdprb.1) 122357202 |
| LROH: | 127172198(qdprb.1) 127176544(qdpra) |
| OMC: | 131540847(qdprb.1) 131552891(qdpra) |
| PPRM: | 120461105(qdpra) 120494227(qdprb.1) |
| RKG: | 130089568(qdprb.1) 130089738(qdpra) |
| MAMB: | 125259125(qdpra) 125272654(qdprb.1) |
| CIDE: | 127494116 127495109 |
| CERY: | 137022160(qdpra) 137032647(qdprb.1) |
| MASI: | 127413054 127418335 127443653 |
| TROS: | 130552768(qdprb.1) 130563352(qdpra) |
| TDW: | 130409004(qdprb.1) 130438432(qdpra) |
| MANU: | 129422557(qdpra) 129444630(qdprb.1) |
| PDAB: | 135736012(qdprb.1) 135759868(qdpra) |
| IPU: | 100528213(qdprb.1) 108269199(qdpra) |
| IFU: | 128604252(qdprb.1) 128611911(qdpra) |
| PHYP: | 113542680 113544431 |
| SMEO: | 124381319(qdprb.1) 124386531(qdpra) |
| TFD: | 113647774(qdpra) 113660718(qdprb.1) |
| TVC: | 132841879(qdprb.1) 132855939(qdpra) |
| CGAR: | 128508857(qdprb.1) 128531964(qdpra) |
| NGRA: | 132883202(qdprb.1) 132890045(qdpra) |
| TRN: | 134319460(qdpra) 134326365(qdprb.1) |
| AMEX: | 103021866(qdpra) 103041363(qdprb.1) |
| CMAO: | 118807017(qdpra) 118816589(qdprb1) |
| EEE: | 113570776 113587698(qdpr) |
| CHAR: | 105908429(qdprb.1) 105908699 |
| SPIL: | 134065663(qdprb.1) 134095642(qdpra) |
| ASAD: | 121682274 121710308(qdprb.1) |
| PPRL: | 129360424 129360739 |
| SASA: | 100196358(dhpr) 106604536 106611553 |
| STRU: | 115168999 115170554 115205098 |
| OTW: | 112220650(qdpra) 112221627 112256348 |
| OMY: | 110488941 110491900 110505140 |
| OGO: | 123994116 124010377 124046152 |
| ONE: | 115102633 115129560 115130825 |
| OKI: | 109864996 109869162 109905290 |
| OKE: | 118360181 118363601 118379721 |
| OMM: | 135526511 135528556 135546029 |
| OCLA: | 139366011 139368356 139391250 |
| SALP: | 111965842 111967589 111976925 |
| SNH: | 120048024 120060974 120062242 |
| SFON: | 129827980 129858246(qdpra) 129860476 |
| CCLU: | 121535483 121541316 121545926 |
| ELS: | 105007585(qdpr) 105026033 |
| OEP: | 134032204(qdpra) 134034001 |
| AANG: | 118226813 118231344 |
| AROT: | 135254565 135259817 |
| CCOG: | 133130309 133135321 |
| PSPA: | 121324430 121329860 |
| ARUT: | 117408521 117421346 |
| DSI: | Dsimw501_GD14155(Dsim_GD14155) |
| AALB: | 109414165 115257206 |
| CCAL: | 108624553 108630550 |
| ATD: | 109595462 109595472 109596444 |
| APLN: | 108737056 108739792 |
| PPYR: | 116178586 116179195 |
| HAW: | 110371270 110371272 110372467 135117666 |
| HZE: | 124638382 124638506 124645134 |
| CFEL: | 113367035 113368365 113372084 |
| DCI: | 103508335 103521770 103521771 |
| HHAL: | 106678260 106678261 106678265 |
| DPX: | DAPPUDRAFT_127519 DAPPUDRAFT_66856 |
| PPOI: | 119089493 119090621 |
| CEL: | CELE_T03F6.1(qdpr-1) |
| CBR: | CBG_07035(Cbr-qdpr-1) |
| BMY: | BM_BM5513(Bma-qdpr-1) |
| BARL: | 143293463 143300407 |
| DPOL: | 127841791 127841792 |
| LMA: | LMJF_34_4330(QDPR-1) LMJF_34_4360(QDPR-2) LMJF_34_4390(QDPR-3) LMJF_34_4420(QDPR-4) LMJF_34_4450(QDPR-5) LMJF_34_4480(QDPR-6) LMJF_34_4510(QDPR-7) |
| LPAN: | LPMP_204110(QDPR-1) |
| LOI: | 92357164(LSCM4_01167) |
| LEIS: | 94177699(GH5_02156) |
| LENR: | 94169016(CUR178_01738) |
| LEIN: | 94185510(JIQ42_01774) |
| PHET: | 94288122(JKF63_02002) |
| ECD: | ECDH10B_0536(nfnB) ECDH10B_0644(nfnB) |
| ECOO: | ECRM13514_0596(nfnB) |
| ECOH: | ECRM13516_0540(nfnB) |
| ECW: | EcE24377A_0596(nfnB) |
| EDJ: | ECDH1ME8569_0546(nfsB) |
| ECOI: | ECOPMV1_00594(nfnB) |
| ENHK: | EnteroDNA1_03852(nfnB) |
| REE: | electrica_03749(nfnB) |
| RTG: | NCTC13098_05509(nfnB) |
| CLAP: | NCTC11466_01575(nfnB) |
| KIE: | NCTC12125_02404(nfnB) |
| AHN: | NCTC12129_02673(nfnB) |
| PSHI: | SAMEA2665130_0741(nfnB) |
| MPHG: | MPHASIOC01_001267(nfsB) |
| TPTY: | NCTC11468_01824(nfnB) |
| PHEI: | NCTC12003_02655(nfnB) |
| ADP: | NCTC12871_01555(nfnB) |
| VPL: | SA104470976_03405(nfnB) |
| PTY: | JWV26_11690 JWV26_11795(nfsB) JWV26_23505(nfsB) |
| MCUN: | NCTC10297_01498(nfnB) |
| SCAA: | TUM17387_30250(nfnB) |
| PSEN: | PNC201_12715(nfnB1) |
| FTG: | FTU_0284(nfnB1) FTU_0367(nfnB2) |
| CDIZ: | CEDIAZO_00159(nfsB) |
| TMJ: | P0M04_12420(nfsB) P0M04_15825(nfsB) |
| SUTT: | SUTMEG_18260(nfnB_1) SUTMEG_18270(nfnB_2) |
| SUTK: | FG381_10485 FG381_10490 |
| SWS: | I6J16_01460 I6J16_01465 |
| DAJ: | VX159_01130(nfsB) VX159_05990(nfsB) |
| FPHO: | SHINM1_022610(nfnB) |
| SFLA: | SPHFLASMR4Y_01191(nfsB) |
| FUA: | LVD17_00095(nfsB) LVD17_28360(nfsB) |
| FFA: | FFWV33_04075 FFWV33_04140 |
| LACW: | FG167_13660(nfsB) FG167_13685(nfsB) |
| ZGA: | ZOBELLIA_4249(nfnB2) ZOBELLIA_4474(nfnB1) |
| PUN: | NQP51_02095(nfsB) NQP51_02165(nfsB) NQP51_02210(nfsB) |
| POLQ: | JOP69_03165(nfsB) JOP69_03225(nfsB) JOP69_03265(nfsB) JOP69_03335(nfsB) |
| KAN: | IMCC3317_15860(nfsB) |
| PSYN: | E9099_16335 E9099_16380(nfsB) |
| EXI: | A0126_07630 A0126_17910 |
» show all
|
| Reference |
1 |
| Authors |
Harano T. |
| Title |
New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin. |
| Journal |
Insect Biochem 2:385-399 (1972) |
| Reference |
|
| Authors |
Hasegawa H. |
| Title |
Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH. |
| Journal |
|
| Reference |
3 |
| Authors |
Kaufman S. |
| Title |
Phenylalanine hydroxylase. |
| Journal |
Methods Enzymol 5:809-816 (1962) |
| Reference |
|
| Authors |
Lind KE. |
| Title |
Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines. |
| Journal |
|
| Reference |
|
| Authors |
Nakanishi N, Hasegawa H, Watabe S. |
| Title |
A new enzyme, NADPH-dihydropteridine reductase in bovine liver. |
| Journal |
|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.1.34 |
| ExPASy - ENZYME nomenclature database: | 1.5.1.34 |
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| LinkDB |
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