KEGG ENZYME: 1.5.1.53

ENZYME: 1.5.1.53

Entry

EC 1.5.1.53                 Enzyme

Name

methylenetetrahydrofolate reductase (NADPH);
MTHFR (gene name);
methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase;
5,10-methylenetetrahydrofolate reductase (NADPH);
5,10-methylenetetrahydrofolic acid reductase (ambiguous);
5,10-CH2-H4folate reductase (ambiguous);
methylenetetrahydrofolate reductase (NADPH2);
5,10-methylenetetrahydrofolate reductase (ambiguous);
methylenetetrahydrofolate reductase (ambiguous);
N5,10-methylenetetrahydrofolate reductase (ambiguous);
5,10-methylenetetrahydropteroylglutamate reductase (ambiguous);
N5,N10-methylenetetrahydrofolate reductase (ambiguous);
methylenetetrahydrofolic acid reductase (ambiguous);
5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect);
5,10-methylenetetrahydrofolate reductase (FADH2) (ambiguous)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

5-methyltetrahydrofolate:NADP+ oxidoreductase

Reaction(IUBMB)

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+ [RN:R01224]

Reaction(KEGG)

R01224

Substrate

5-methyltetrahydrofolate [CPD:C00440];
NADP+ [CPD:C00006]

Product

5,10-methylenetetrahydrofolate [CPD:C00143];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

A flavoprotein (FAD). The enzyme from yeast and mammals catalyses a physiologically irreversible reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADPH as the electron donor. It plays an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. The enzyme contains an N-terminal catalytic domain and a C-terminal allosteric regulatory domain that binds S-adenosyl-L-methionine, which acts as an inhibitor. cf. EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).

History

EC 1.5.1.53 created 2021

Pathway

ec00670

One carbon pool by folate

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K25004

methylenetetrahydrofolate reductase (NADPH)

Genes

HSA:	4524(MTHFR)

PTR:	469800(MTHFR)

PPS:	100975693(MTHFR)

GGO:	101134157(MTHFR)

PON:	100454623(MTHFR)

PPYG:

129007712(MTHFR)

NLE:	105738058(MTHFR)

HMH:	116812932(MTHFR)

SSYN:

129471863(MTHFR)

MCC:	714840(MTHFR)

MCF:	102117536(MTHFR)

MTHB:

126953028

MNI:	105473166(MTHFR)

CSAB:

103225598(MTHFR)

CATY:

105580856(MTHFR)

PANU:

101019898(MTHFR)

TGE:	112616737(MTHFR)

MLEU:

105551372(MTHFR)

RRO:	104657549(MTHFR)

RBB:	108539360(MTHFR)

TFN:	117093311(MTHFR)

PTEH:

111526316(MTHFR)

CANG:

105507372(MTHFR)

CJC:	100391000(MTHFR)

SBQ:	101043467(MTHFR)

CIMI:

108286453(MTHFR)

ANAN:

105731778(MTHFR)

CSYR:

103266205(MTHFR)

MMUR:

105882714(MTHFR)

LCAT:

123634470(MTHFR)

PCOQ:

105824906(MTHFR)

OGA:	100960485(MTHFR)

MMU:	17769(Mthfr)

MCAL:

110293543(Mthfr)

MPAH:

110323320(Mthfr)

RNO:	362657(Mthfr)

MCOC:

116097006(Mthfr)

ANU:	117708999(Mthfr)

MUN:	110555748(Mthfr)

CGE:	100774930(Mthfr)

MAUA:

101832815(Mthfr)

PROB:

127213260(Mthfr)

PLEU:

114709673(Mthfr)

MORG:

121441775(Mthfr) 121447985

MFOT:

126508160

AAMP:

119817717(Mthfr)

NGI:	103747470(Mthfr)

HGL:	101719335(Mthfr)

CPOC:

100715703(Mthfr)

CCAN:

109697792(Mthfr)

DORD:

105997431(Mthfr)

DSP:	122121484(Mthfr)

PLOP:

125354578(Mthfr)

NCAR:

124983882

MMMA:

107155492(Mthfr)

OCU:

100352874

OPI:	101527929(MTHFR)

TUP:	102476978(MTHFR)

GVR:	103605195(MTHFR)

CFA:	478230(MTHFR)

CLUD:

112678116(MTHFR)

VVP:	112929750(MTHFR)

VLG:	121496764(MTHFR)

NPO:	129513898(MTHFR)

AML:	100469351(MTHFR)

UMR:	103666650(MTHFR)

UAH:	113270501(MTHFR)

UAR:	123779081(MTHFR)

ELK:

111154700

LLV:

125096774

MPUF:

101694159(MTHFR)

MNP:	132001220(MTHFR)

MLK:	131810442(MTHFR)

NVS:	122899460(MTHFR)

ORO:	101367692(MTHFR)

EJU:	114213206(MTHFR)

ZCA:	113933704(MTHFR)

MLX:	118020001(MTHFR)

NSU:	110574669(MTHFR)

LWW:	102742884(MTHFR)

FCA:	101100576(MTHFR)

PYU:	121021216(MTHFR)

PCOO:

112871980(MTHFR)

PBG:	122479932(MTHFR)

PVIV:

125171998(MTHFR)

LRUF:

124514789

PTG:	102969340(MTHFR)

PPAD:

109274118(MTHFR)

PUC:

125913110

AJU:

106971872

HHV:	120233615(MTHFR)

BTA:	497032(MTHFR)

BOM:	102286710(MTHFR)

BIU:	109570335(MTHFR)

BBUB:

102395627(MTHFR)

BBIS:

104995835(MTHFR)

CHX:	102182523(MTHFR)

OAS:	101111645(MTHFR)

BTAX:

128061407(MTHFR)

ODA:	120880227(MTHFR)

CCAD:

122451796(MTHFR)

MBEZ:

129551542(MTHFR)

SSC:	397180(MTHFR)

CFR:	102505417(MTHFR)

CBAI:

105070965(MTHFR)

CDK:	105107034(MTHFR)

VPC:	102532634(MTHFR)

BACU:

102998853(MTHFR)

BMUS:

118905488(MTHFR)

LVE:	103079236(MTHFR)

OOR:	101287316(MTHFR)

DLE:	111187289(MTHFR)

PCAD:

102986652(MTHFR)

PSIU:

116748237(MTHFR)

NASI:

112402713(MTHFR)

ECB:	100050979(MTHFR)

EPZ:	103552183(MTHFR)

EAI:	106836668(MTHFR)

MYB:	102245334(MTHFR)

MYD:	102764267(MTHFR)

MMYO:

118675486(MTHFR)

MLF:	102437960(MTHFR)

MDT:	132231678(MTHFR)

PKL:	118732048(MTHFR)

EFUS:

103295330(MTHFR)

MNA:	107531557(MTHFR)

DRO:	112299114(MTHFR)

SHON:

118986343(MTHFR)

AJM:	119064129(MTHFR)

PDIC:

114496601(MTHFR)

PHAS:

123831738(MTHFR)

MMF:	118626195(MTHFR)

PPAM:

129075652(MTHFR)

HAI:	109381260(MTHFR)

RFQ:	117027712(MTHFR)

PALE:

102882062(MTHFR)

PGIG:

120585812(MTHFR)

PVP:	105294362(MTHFR)

RAY:	107513124(MTHFR)

MJV:	108385719(MTHFR)

TOD:	119236603(MTHFR)

SARA:

101554814(MTHFR)

SETR:

126011521(MTHFR)

LAV:	100661160(MTHFR)

TMU:

101359718

ETF:	101638069(MTHFR)

DNM:	101428504(MTHFR)

MDO:	100018128(MTHFR)

GAS:	123240311(MTHFR)

SHR:	100929400(MTHFR)

AFZ:

127555865

PCW:	110199057(MTHFR)

TVP:	118838870(MTHFR)

OAA:	100086119(MTHFR)

GGA:	419489(MTHFR)

PCOC:

116242702(MTHFR)

MGP:	100543073(MTHFR)

CJO:	107323372(MTHFR)

TPAI:

128084952(MTHFR)

LMUT:

125703509(MTHFR)

NMEL:

110408579(MTHFR)

APLA:

101805333(MTHFR)

ACYG:

106040241(MTHFR)

CATA:

118253386(MTHFR)

AFUL:

116497721(MTHFR)

TGU:	100220660(MTHFR)

LSR:	110479731(MTHFR)

SCAN:

103820847(MTHFR)

PMOA:

120496725(MTHFR)

OTC:	121343904(MTHFR)

PRUF:

121358379(MTHFR)

GFR:	102033068(MTHFR)

FAB:	101817361(MTHFR)

OMA:	130261721(MTHFR)

PHI:	102109675(MTHFR)

PMAJ:

107213633(MTHFR)

CCAE:

111938714(MTHFR)

CCW:	104693242(MTHFR)

CBRC:

103616120(MTHFR)

ETL:	114056920(MTHFR)

ZAB:	102071430(MTHFR)

ZLE:	135456507(MTHFR)

ACHL:

103807228(MTHFR)

SVG:	106856415(MTHFR)

MMEA:

130583060(MTHFR)

HRT:	120762427(MTHFR)

SATI:

136370757(MTHFR)

FPG:	101920680(MTHFR)

FCH:	102053108(MTHFR)

CCRI:

104162212(MTHFR)

NNT:	104403185(MTHFR)

SHAB:

115617312(MTHFR)

ACUN:

113487781(MTHFR)

TALA:

104368439(MTHFR)

ACHC:

115343387(MTHFR)

HALD:

104317869(MTHFR)

HLE:	104837887(MTHFR)

AGEN:

126036762

GCL:

127024779

CSTI:

104554865(MTHFR)

LDI:	104347526(MTHFR)

MNB:	103776798(MTHFR)

DPUB:

104305839(MTHFR)

AVIT:

104269937(MTHFR)

BRHI:

104493380

EGZ:	104133086(MTHFR)

NNI:	104009002(MTHFR)

PCRI:

104028163(MTHFR)

PCAO:

104042256(MTHFR)

PADL:

103918045(MTHFR)

AFOR:

103907443(MTHFR)

FGA:	104079210(MTHFR)

GSTE:

104251132(MTHFR)

CLV:	102089900(MTHFR)

MUI:	104548100(MTHFR)

PGUU:

104465847(MTHFR)

PLET:

104624937(MTHFR)

EHS:	104503465(MTHFR)

CMAC:

104479122(MTHFR)

CUCA:

104060557(MTHFR)

TEO:	104378985(MTHFR)

BREG:

104633204(MTHFR)

OHA:	104332674(MTHFR)

ACAR:

104523067(MTHFR)

CPEA:

104395435(MTHFR)

CVF:	104290447(MTHFR)

RTD:	128918501(MTHFR)

AAM:	106482439(MTHFR)

AROW:

112970030(MTHFR)

NPD:	112959653(MTHFR)

TGT:	104577392(MTHFR)

DNE:	112980540(MTHFR)

SCAM:

104141860(MTHFR)

ASN:	102373612(MTHFR)

AMJ:	102573230(MTHFR)

CPOO:

109314267(MTHFR)

GGN:	109293666(MTHFR)

PSS:	102448267(MTHFR)

CMY:	102945698(MTHFR)

CCAY:

125624226(MTHFR)

DCC:	119845049(MTHFR)

CPIC:

101950023(MTHFR)

TST:	117867765(MTHFR)

CABI:

116821910(MTHFR)

MRV:	120387999(MTHFR)

ACS:	100554267(mthfr)

ASAO:

132764724(MTHFR)

PVT:	110073216(MTHFR)

SUND:

121936126(MTHFR)

PBI:	103051539(MTHFR)

PMUR:

107294169(MTHFR)

CTIG:

120313278(MTHFR)

TSR:

106553080

PGUT:

117659694(MTHFR)

APRI:

131187094(MTHFR)

PTEX:

113450046(MTHFR)

NSS:	113428245(MTHFR) 113428642

VKO:	123031059(MTHFR)

PMUA:

114602804 114602982

PRAF:

128419874(MTHFR)

ZVI:	118087419(MTHFR)

HCG:	128338595(MTHFR)

GJA:	107117727(MTHFR)

STOW:

125445948(MTHFR)

EMC:	129345036(MTHFR)

XLA:	108697556(mthfr.S) 379784(mthfr.L)

XTR:	100125082(mthfr)

NPR:	108799423(MTHFR)

RTEM:

120915514(MTHFR)

BBUF:

120999546(MTHFR)

BGAR:

122928824(MTHFR)

MUO:	115456800(MTHFR)

GSH:	117348775(MTHFR)

DRE:	567547(mthfr)

SRX:	107710792(mthfr) 107748978

SANH:

107687111 107691055

SGH:	107595790 107602465

CCAR:

109092734

CAUA:

113097248 113107832

CGIB:

127962931 128018193

PTET:

122350940(mthfr)

LROH:

127169447(mthfr)

OMC:	131546356(mthfr)

PPRM:

120490013(mthfr)

RKG:	130082031(mthfr)

MAMB:

125280298(mthfr)

CIDE:

127518047

CERY:

137027308(mthfr)

MASI:

127414475 127424732

TROS:

130549617(mthfr)

TDW:	130439745(mthfr)

MANU:

129414952(mthfr)

IPU:

108265037

IFU:	128607571(mthfr)

PHYP:

113533585(mthfr)

SMEO:

124399833(mthfr)

TFD:	113656298(mthfr)

TVC:	132853862(mthfr)

TRN:	134317787(mthfr)

AMEX:

103033176(mthfr)

CMAO:

118813595(mthfr)

EEE:	113578182(mthfr)

CHAR:

122131825(mthfr)

TRU:	101078210(mthfr)

TFS:	130530456(mthfr)

TNG:	GSTEN00004910G001

LCO:	104936586(mthfr)

NCC:

104955699

TBEN:

117481494(mthfr)

PGEO:

117449835(mthfr)

GACU:

117559267(mthfr)

EMAC:

134861515(mthfr)

ELY:	117258736(mthfr)

EFO:	125891990(mthfr)

PLEP:

121947149(mthfr)

SLUC:

116058866(mthfr)

ECRA:

117948295

ESP:	116691919(mthfr)

PFLV:

114558693(mthfr)

GAT:	120829205(mthfr)

PPUG:

119223711(mthfr)

AFB:	129099663(mthfr)

CLUM:

117733916(mthfr)

PSWI:

130199689(mthfr)

MSAM:

119904965(mthfr)

SCHU:

122883725(mthfr)

CUD:	121518041(mthfr)

ALAT:

119023563(mthfr)

MZE:	101481615(mthfr)

ONL:	100706052(mthfr)

OAU:	116326127(mthfr)

OLA:	101173920(mthfr)

OML:	112140866(mthfr)

CSAI:

133456301(mthfr)

XMA:	102216417(mthfr)

XCO:	114141964(mthfr)

XHE:	116724335(mthfr)

PRET:

103466998(mthfr)

PFOR:

103154252(mthfr)

PLAI:

106947843(mthfr)

PMEI:

106926580(mthfr)

GAF:	122832650 122833189

PPRL:

129371664(mthfr)

CVG:	107102655(mthfr)

CTUL:

119786289(mthfr)

GMU:	124872528(mthfr)

NFU:	107391521(mthfr)

KMR:	108249409(mthfr)

ALIM:

106529348(mthfr)

NWH:	119429280 119429296

AOCE:

111566112(mthfr)

MCEP:

125024165(mthfr)

CSEM:

103384826(mthfr)

POV:

109630958

SSEN:

122777158(mthfr)

HHIP:

117765126(mthfr)

HSP:	118110475(mthfr)

PPLT:

128443060(mthfr)

SMAU:

118316574(mthfr)

LCF:

108900502

SDU:	111233770(mthfr)

SLAL:

111658836(mthfr)

XGL:	120803549(mthfr)

HCQ:	109528734(mthfr)

SSCV:

125987776

SBIA:

133511920(mthfr)

PEE:	133408300(mthfr)

PTAO:

133486619(mthfr)

BPEC:

110165619(mthfr)

MALB:

109951049(mthfr)

SJO:	128357914(mthfr)

SASA:

106572128(mthfr)

STRU:

115166009 115168944

OTW:	112215984 112221595

OMY:	110491842 110532243

OGO:	124031907 124046174

ONE:	115102605 115132121

OKI:	109869406 109907962

OKE:	118360209 118361064

SALP:

111976745 112068446

SNH:	120059363 120060956

CCLU:

121538303 121545939

ELS:	105013771(mthfr)

SFM:	108924892(mthfr)

PKI:	111859074(mthfr)

AANG:

118207739(mthfr)

LOC:	102688415(mthfr)

PSPA:

121329149 121329216

ARUT:

117425554 117426084

PSEX:

120531063(mthfr)

LCM:	102358326(MTHFR)

CMK:	103181396(mthfr)

RTP:	109914604(mthfr)

CPLA:

122540329(mthfr)

HOC:	132833517(mthfr)

LERI:

129711556(mthfr)

PMRN:

116955583(MTHFR)

BFO:

118430292

BBEL:

109472626

CIN:

100180174

SCLV:

120326455

SPU:	115924565 589576

LPIC:

129276741

APLC:

110979147

ARUN:

117302263

AJC:

117106607

SKO:	100368141(MTHFR)

DME:	Dmel_CG7560(CG7560)

DER:

6544580

DSE:

6605265

DSI:	Dsimw501_GD14304(Dsim_GD14304)

DYA:	Dyak_GE21809

DAN:

6507885

DSR:

110181246

DPO:

4813819

DPE:

6598998

DMN:

108152200

DWI:

6638944

DGR:

6558496

DMO:	Dmoj_GI11604

DAZ:

108614675

DNV:

108652425

DHE:	111593115 111601129 115483195

DVI:

6623335

CCAT:

101460408

BOD:

106627885

BDR:

105222633

RZE:

108372277

AOQ:

129239387

TDA:

119666732

MDE:

101899703

SCAC:

106085892

LCQ:

111684318

LSQ:

119615005

GFS:

119637471

ECOE:

129947813

CLON:

129617411

AGA:

3290378

ACOZ:

120953025

AARA:

120896047

AMER:

121594601

ASTE:

118512205

AFUN:

125767824

AMOU:

128305657

AAG:

5569213

AALB:

109397828 109418971

ASUA:

134208706

CQU:	CpipJ_CPIJ000297

CPII:

120426570

AME:

100578936

ACER:

107992402 107998358

ALAB:

122721074

AFLR:

100869841

BIM:

100748829

BBIF:

117210096

BVK:

117241833

BVAN:

117156993

BTER:

100645686

BAFF:

126920923

BPYO:

122573640

BPAS:

132916135

CCAL:

108622149

OBB:

114872033

OLG:

117605681

MGEN:

117219788

NMEA:

116424754

CGIG:

122401806

SOC:

105204539

MPHA:

105829361

AEC:

105154491

ACEP:

105621269

PBAR:

105430772

VEM:

105563068

HST:

105185895

DQU:

106745791

CFO:

105256449

PGC:

109861296

OBO:

105277295

PCF:

106789672

PFUC:

122518885

VPS:

122634605

VCRB:

124430578

VVE:

124954327

NVI:

100117482

CSOL:

105360655

MDL:

103571235

FAS:

105270971

VCAN:

122418937

CCIN:

107270032

DPA:

109534565

LDC:

111506350

OTU:

111417540

BMAN:

114249102

DPL:	KGM_206647

PMAC:

106711396

ZCE:

119833059

AAGE:

121734945

HAW:

110376495

TNL:

113495626

ATRA:

106135737

GMW:

113512910

PXY:

105388246

LGLY:

125235397

BTAB:

109032747

NLU:

111045770

TPAL:

117653073

ZNE:

110838326

CSEC:

111867742

BROR:

134532156

IEL:

124163299

FCD:

110842614

DPX:	DAPPUDRAFT_301720

DMK:

116931209

DPZ:

124340499

PVM:

113812240

PJA:

122261979

PCHN:

125024515

PMOO:

119568400

HAME:

121871205

PCLA:

123760246

CQD:

128703779

PTRU:

123503654

ESN:

127002737

MNZ:

135210982

HAZT:

108681433

EAF:

111701357

TCF:

131884906

TUT:

107360415

DPTE:

113790060 113794623

DFR:	124489958 124493973

CSCU:

111641837

CVS:

136977030

LPOL:

106476448

PMEO:

129593250

CEL:	CELE_C06A8.1(mthf-1)

CBR:

CBG_12960

CRQ:	GCK72_005714

NAI:	NECAME_11843

BMY:	BM_BM1999(Bma-mthf-1)

LOA:	LOAG_08597

TSP:

Tsp_08753

HRO:	HELRODRAFT_111699

LGI:	LOTGIDRAFT_214878

PVUL:

126827707

PCAN:

112556142 112556236

BGT:

106068520

GAE:

121390023

HRF:

124132255

HRJ:

124273373

CRG:

105340188

CANU:

128189541

CVN:

111138100

OED:

125683372

MYI:

110460561

PMAX:

117344501

MCAF:

127720074

MMER:

123527799

RPHI:

132735169

DPOL:

127881221

MAEA:

128203507

OBI:

106882151

OSN:

115209099

LJP:

135475130

LAK:	106154846 106174355

LLON:

135496701

NVE:	5512577 5513626

EPA:	110252119 110252167

ATEN:

116304937 116305961

ADF:

107327049

AMIL:

114962073 114969824

PDAM:

113668139 113679154

SPIS:

111327128 111332195

DGT:	114528959 114537439

XEN:

124457394

HMG:

100207609

HSY:	130624954 130641462

RES:	135688551 135688553

TAD:	TRIADDRAFT_26971

AQU:

100636961

SCE:	YGL125W(MET13) YPL023C(MET12)

SEUB:

DI49_1849 DI49_5433

SPAO:

SPAR_G01230 SPAR_P02400

AGO:	AGOS_AAR170W AGOS_AFR457W

ERC:	Ecym_1400 Ecym_3063

KLA:	KLLA0_D12188g KLLA0_F09647g

KMX:	KLMA_20276(MET13) KLMA_60378(MET12)

LTH:	KLTH0E11022g KLTH0H06446g

VPO:	Kpol_1007p12 Kpol_223p6

ZRO:	ZYRO0A02838g ZYRO0E01870g

CGR:	2887607(MET13) 2889935(MET12)

NCS:	NCAS_0C02530(NCAS0C02530) NCAS_0D03140(NCAS0D03140)

NDI:	NDAI_0E03230(NDAI0E03230) NDAI_0I01770(NDAI0I01770)

TPF:	TPHA_0C01840(TPHA0C01840) TPHA_0J01830(TPHA0J01830)

TBL:	TBLA_0D02780(TBLA0D02780) TBLA_0F02520(TBLA0F02520)

TGB:	HG536_0H01660 HG536_0H03600

TDL:	TDEL_0B01620(TDEL0B01620) TDEL_0G03480(TDEL0G03480)

KAF:	KAFR_0A04630(KAFR0A04630) KAFR_0H01590(KAFR0H01590)

KNG:	KNAG_0A02370(KNAG0A02370) KNAG_0F02500(KNAG0F02500)

ZMK:	HG535_0B03260 HG535_0C01620

SLUD:

SCDLUD_000993 SCDLUD_001942

DHA:	DEHA2F08976g DEHA2G01254g

PIC:	PICST_71674 PICST_83803

PGU:	PGUG_01501 PGUG_04648

SPAA:

SPAPADRAFT_137530 SPAPADRAFT_51518

LEL:	PVL30_002085(MET13) PVL30_003470(MET12)

LBG:	92207516(LODBEIA_P23200) 92208703(LODBEIA_P35070)

CAL:	CAALFM_C210460CA(CaO19.5321) CAALFM_C302950CA(MET13)

CTP:	CTRG_02026 CTRG_02573

COT:	CORT_0B03880 CORT_0C03560

CDU:	CD36_24470 CD36_82930

CTEN:

18248645(MET13)

CLU:	CLUG_02387 CLUG_05125

CLUS:

A9F13_03g01133 A9F13_24g00066

CAUR:

CJI96_0001128 CJI96_0002275

PPA:	PAS_chr2-2_0145 PAS_chr2-2_0182

PKZ:	C5L36_0B07640 C5L36_0D03770

BNN:	FOA43_000536 FOA43_004528

BBRX:

BRETT_001890 BRETT_003148

OPA:	HPODL_00022 HPODL_02993

YLI:	2906737(YALI2_C00796g)

SLB:	AWJ20_3315(MET13) AWJ20_715(MET12)

NCR:	NCU07690 NCU09545

NTE:	NEUTE1DRAFT128536(NEUTE1DRAFT_128536) NEUTE1DRAFT57029(NEUTE1DRAFT_57029)

SMP:	10803567(SMAC4_06582) 10807485(SMAC4_00862)

PAN:	PODANSg7263 PODANSg8765

PBEL:

QC761_209160(MET12) QC761_602690(MET13)

PPSD:

QC762_209160(MET12) QC762_602690(MET13)

PPSP:

QC763_209160(MET12) QC763_602690(MET13)

PPSA:

QC764_209160(MET12) QC764_602690(MET13)

TTT:	THITE_2107143 THITE_2115191

MTM:	MYCTH_2300974 MYCTH_2314160

CTHR:

CTHT_0033700 CTHT_0065570

MGR:	MGG_01728 MGG_08171

PPEI:

PpBr36_01245 PpBr36_01602

PGRI:

PgNI_03394 PgNI_03764

TMN:	UCRPA7_3085 UCRPA7_6818

SSCK:

SPSK_03199 SPSK_05053

FGR:	FGSG_07127 FGSG_09572

FPU:	FPSE_04091 FPSE_05848

FPOA:

FPOAC1_010897 FPOAC1_012085

FVN:	FVRRES_11909 FVRRES_13154

FVR:	FVEG_04126 FVEG_08038

FOX:	FOXG_01673 FOXG_06273

NHE:	NECHADRAFT_32750 NECHADRAFT_71723

FFC:	NCS54_00273400 NCS54_01131900

FKR:	NCS57_00269200 NCS57_01122500

FMU:	J7337_002907 J7337_004132

TRE:	TRIREDRAFT_55055 TRIREDRAFT_81824

TRR:	M419DRAFT_104048 M419DRAFT_135784

TATV:

25783884(TrAtP1_001274) 25786594(TrAtP1_011116)

TASP:

36607500(TrAFT101_001202) 36613616(TrAFT101_008965)

MAW:	19244796(MET12_2) 19252082(MET13)

MAJ:	MAA_01221 MAA_07320

MBRN:

26239328(met9) 26241089(met11)

PCHM:

VFPPC_09868 VFPPC_13512

CMT:	CCM_04157 CCM_05621

AMUS:

LMH87_004379 LMH87_006725

PLJ:	28882876(PLICBS_001097) 28889940(PLICBS_008653)

PTKZ:

JDV02_005288(MET12) JDV02_007903(MET13)

VAL:	VDBG_00123 VDBG_00853

VDA:	VDAG_00463 VDAG_08410

CFJ:	CFIO01_02428 CFIO01_07029

CLUP:

CLUP02_08015 CLUP02_17462

CHIG:

CH63R_04201 CH63R_07780

SAPO:

SAPIO_CDS7226

ELA:	UCREL1_6847 UCREL1_9493

PFY:	PFICI_05432 PFICI_08066

SSL:	SS1G_02009 SS1G_09764

BFU:	BCIN_07g02820 BCIN_07g06360

MBE:	MBM_01665 MBM_08501

PSCO:

LY89DRAFT_718062 LY89DRAFT_769751

GLZ:	GLAREA_11463 GLAREA_12614

ANI:	ANIA_05883 ANIA_08215

AFM:	AFUA_2G11300 AFUA_5G03480

ACT:	ACLA_001700 ACLA_070260

NFI:	NFIA_038640 NFIA_086570

AOR:	AO090026000520 AO090102000557

ANG:	An02g03270 An09g05860

AFV:	AFLA_005756 AFLA_011983

ALUC:

AKAW2_21343A AKAW2_40591A

ACHE:

ACHE_40648S ACHE_50694S

APUU:

APUU_10896A APUU_60645S

PCS:	N7525_008123 N7525_009990

PDP:	PDIP_10790 PDIP_48850

POU:	POX_a00488 POX_e07132

TMF:	EYB26_003580 EYB26_004262

TRG:	TRUGW13939_07742 TRUGW13939_08425

CIM:	CIMG_06560 CIMG_08202

CPW:	CPC735_022180 CPC735_030300

URE:	UREG_02453 UREG_03880

ABE:	ARB_01328 ARB_06846

TVE:	TRV_05244 TRV_07376

PBL:	PAAG_03665 PAAG_04294

PBN:	PADG_03172 PADG_07528

AJE:	HCAG_00541 HCAG_07107

BGH:	BDBG_00602 BDBG_01364

PNO:	SNOG_10985(SNOG_10984) SNOG_12690

PTE:	PTT_09481 PTT_18113

PTRR:

6347814(PtrM4_127600) 6349625(PtrM4_070860)

BZE:	COCCADRAFT_87884 COCCADRAFT_96319

BSC:	COCSADRAFT_136346 COCSADRAFT_140784

BOR:	COCMIDRAFT_28378 COCMIDRAFT_4719

AALT:

CC77DRAFT_1092254 CC77DRAFT_958941

ARAB:

EKO05_0009890 EKO05_0011104

ZTR:	MYCGRDRAFT_109648 MYCGRDRAFT_75203

PFJ:	MYCFIDRAFT_49642 MYCFIDRAFT_81197

FFU:	CLAFUR5_07224 CLAFUR5_07965

CBET:

CB0940_04150 CB0940_09049

BCOM:

BAUCODRAFT_210105 BAUCODRAFT_237275

NPA:	UCRNP2_6300 UCRNP2_9800

TML:	GSTUM_00003351001 GSTUM_00010817001

SPO:	2542993(met9) 2543105(met11)

SOM:	SOMG_01808(met9) SOMG_02033(met11)

CNE:	CNA07390 CNL04820

CNB:	CNBA7210 CNBI2020

CNG:	CNAG_00760 CNAG_05140

CGI:	CGB_A8490W CGB_D2260W

CDEU:

CNBG_1170 CNBG_9485

CDEP:

91088023(L203_103813) 91089035(L203_104826)

KMG:	30163963(I203_103755) 30166533(I203_100747)

KNE:	92179109(IAR55_001850) 92181595(IAR55_004337)

TMS:	TREMEDRAFT_38541 TREMEDRAFT_43239

TASA:

A1Q1_00789 A1Q1_04951

CCAC:

CcaHIS019_0509060(MET13) CcaHIS019_0510340(MET12)

TVS:	TRAVEDRAFT_164884 TRAVEDRAFT_28907

DSQ:	DICSQDRAFT_134054 DICSQDRAFT_177540

PCO:	PHACADRAFT_208793 PHACADRAFT_264540

SHS:	STEHIDRAFT_157081 STEHIDRAFT_75044

HIR:	HETIRDRAFT_445887 HETIRDRAFT_471420

PSQ:	PUNSTDRAFT_113018 PUNSTDRAFT_53586

ADL:	AURDEDRAFT_106360 AURDEDRAFT_142206

FME:	FOMMEDRAFT_100481 FOMMEDRAFT_88181

GTR:	GLOTRDRAFT_105411 GLOTRDRAFT_71781

RSX:	RhiXN_02363 RhiXN_05214

LBC:	LACBIDRAFT_182479 LACBIDRAFT_244474

CCI:	CC1G_00920 CC1G_01198

ABP:	AGABI1DRAFT111963(AGABI1DRAFT_111963) AGABI1DRAFT68194(AGABI1DRAFT_68194)

ABV:	AGABI2DRAFT193205(AGABI2DRAFT_193205) AGABI2DRAFT216007(AGABI2DRAFT_216007)

PCUB:

JR316_0003599 JR316_0008028

MRR:	Moror_1385 Moror_17235

E1B28_007686 E1B28_009106

SCM:	SCHCO_01284456(SCHCODRAFT_01284456) SCHCO_02607875(SCHCODRAFT_02607875)

CPUT:

CONPUDRAFT_117110 CONPUDRAFT_59824

SLA:	SERLADRAFT_363249

WSE:	WALSEDRAFT_37442 WALSEDRAFT_66783

WIC:	J056_001516 J056_004424

UMA:	UMAG_04612 UMAG_06065

PFP:	PFL1_01460 PFL1_02036

SGRA:

EX895_002182 EX895_003548

MGL:	MGL_3526 MGL_3786

MRT:	MRET_0589 MRET_0910

MSYM:

MSY001_1846 MSY001_2971

PGR:	PGTG_02893 PGTG_15769

PTRC:

PtA15_14A138 PtA15_17A7

PSTR:

Pst134EA_025877 Pst134EA_030187

MLR:	MELLADRAFT_42930 MELLADRAFT_45803

RIE:	OCT59_003347 OCT59_018836

» show all

Reference

1 [PMID:13817476]

Authors

DONALDSON KO, KERESZTESY JC.

Title

Naturally occurring forms of folic acid. I. "Prefolic A": preparation of concentrate and enzymatic conversion to citrovorum factor.

Journal

J Biol Chem 234:3235-40 (1959)

Reference

2 [PMID:4399897]

Authors

Kutzbach C, Stokstad EL.

Title

Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.

Journal

Biochim Biophys Acta 250:459-77 (1971)
DOI:10.1016/0005-2744(71)90247-6

Reference

3 [PMID:6975779]

Authors

Daubner SC, Matthews RG.

Title

Purification and properties of methylenetetrahydrofolate reductase from pig liver.

Journal

J Biol Chem 257:140-5 (1982)

Reference

4 [PMID:2383427]

Authors

Zhou J, Kang SS, Wong PW, Fournier B, Rozen R.

Title

Purification and characterization of methylenetetrahydrofolate reductase from human cadaver liver.

Journal

Biochem Med Metab Biol 43:234-42 (1990)
DOI:10.1016/0885-4505(90)90029-z

Reference

5 [PMID:11729203]

Authors

Roje S, Chan SY, Kaplan F, Raymond RK, Horne DW, Appling DR, Hanson AD.

Title

Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo.

Journal

J Biol Chem 277:4056-61 (2002)
DOI:10.1074/jbc.M110651200

Reference

6 [PMID:29891918]

Authors

Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW.

Title

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.

Journal

Nat Commun 9:2261 (2018)
DOI:10.1038/s41467-018-04735-2

Sequence

[hsa:4524] [sce:YPL023C]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.53

IUBMB Enzyme Nomenclature:

1.5.1.53

ExPASy - ENZYME nomenclature database:

1.5.1.53

BRENDA, the Enzyme Database:

1.5.1.53

CAS:	71822-25-8

LinkDB

DBGET integrated database retrieval system