KEGG   ENZYME: 2.1.1.245
Entry
EC 2.1.1.245                Enzyme                                 
Name
5-methyltetrahydrosarcinapterin---corrinoid/iron-sulfur protein Co-methyltransferase;
cdhD (gene name);
cdhE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin [RN:R10385]
Reaction(KEGG)
R10385
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrosarcinapterin [CPD:C18802]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrosarcinapterin [CPD:C18799]
Comment
Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase, and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate.
History
EC 2.1.1.245 created 2012
Orthology
K00194  acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit delta
K00197  acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit gamma
Genes
DSFUWK_03161
DAKDaAHT2_0824
DBKDGMP_17870 DGMP_17910
DOLDole_3183 Dole_3186
DMLDmul_30830(cdhD) Dmul_30860(cdhE)
DALDalk_0679 Dalk_0682
DATHRM2_16650(cdhE) HRM2_16690(cdhD)
DTOTOL2_C11800(cdhE) TOL2_C11830(cdhD)
DOVDSCO28_59720 DSCO28_59750
DWDDSCW_28510 DSCW_28540
DALKDSCA_26700 DSCA_26730
DLIdnl_32600(cdhE) dnl_32620(cdhD)
DMMdnm_013290(cdhD) dnm_013340(cdhE)
DEKDSLASN_16740 DSLASN_16770
DAODesac_1965 Desac_1968
DTIDesti_0230 Desti_5164
SFUSfum_2564 Sfum_2567
DAXFDQ92_06235 FDQ92_06250
DBRDeba_0239 Deba_0243
DHRLGS26_01910
CLJCLJU_c37570 CLJU_c37580
CAHCAETHG_1610(acsC) CAETHG_1611(acsD)
CSQCSCA_4548 CSCA_4549
CACECACET_c10290(acsD) CACET_c10300(acsC)
CCKCcar_18795 Ccar_18800
CFMBJL90_11120 BJL90_11125
CDRKB9W14_22260 B9W14_22265
CLOSDMR38_18730 DMR38_18735
AMTAmet_2025 Amet_2026
GFEGferi_06325 Gferi_06330
PBIFKXZ80_13910 KXZ80_13915
RUMCK1_12650 CK1_12660
ROBCK5_28660 CK5_28670
BYLA4V09_05465 A4V09_05470
BHANCGC63_07960 CGC63_07965
BLAUDQQ01_09715 DQQ01_09720
BPROPMF13cell1_04281(acsC) PMF13cell1_04282(acsD)
BLABEYS05_16715 EYS05_16720
BLIQINP51_05960 INP51_05965
QDOH9Q78_01460 H9Q78_01465
WHJH9Q79_03160 H9Q79_03165
MFORNQ534_19155(acsD) NQ534_19160(acsC)
CDFCD630_07250 CD630_07260
PDCCDIF630_00841(acsD) CDIF630_00842(acsC)
CDCCD196_0671 CD196_0672
CDLCDR20291_0652 CDR20291_0653
PDFCD630DERM_07250 CD630DERM_07260
CSTCLOST_1168 CLOST_1169
PSORRSJ16_15720 RSJ16_15725
ROCHF520_11270 HF520_11275
TEMJW646_10880 JW646_10885
TGCL0P85_16875(acsC) L0P85_16880(acsD)
TEBT8CH_0658 T8CH_0659
IBRNQ514_13095(acsC) NQ514_13100(acsD)
CALKHUE98_15610 HUE98_15615
DSYDSY1648 DSY1651
DHDDhaf_2793 Dhaf_2796
DDHDesde_2251 Desde_2254
DDLDesdi_1917 Desdi_1920
DMTDESME_07335 DESME_07350
DORDesor_3269 Desor_3272
DAIDesaci_2970 Desaci_2973
DMIDesmer_2531 Desmer_2534
DEDDHBDCA_p226(acsC) DHBDCA_p227(acsD)
DECDCF50_p286(acsC) DCF50_p287(acsD)
DRSDEHRE_00715 DEHRE_00720
PTHPTH_1001(CdhE) PTH_1003(CdhD)
DAEDtox_1272 Dtox_1275
DKUDesku_1488 Desku_1490
DAUDaud_0112 Daud_0114 Daud_0872 Daud_0875
FWADCMF_05845 DCMF_05860
AACXDEACI_2513 DEACI_2515
TJRTherJR_1159 TherJR_1160
DGIDesgi_2048 Desgi_2050
ELMELI_3605 ELI_3606
EMTCPZ25_018690 CPZ25_018695
ELIMB2M23_08385 B2M23_08390
AWOAwo_c10710(acsD) Awo_c10720(acsC)
AWICHL1_002705 CHL1_002706
ALKAJ0B03_11250 J0B03_11255
CTHMCFE_1662 CFE_1664
TKITKV_c19840(acsC) TKV_c19850(acsD)
CHYCHY_1223(acsC) CHY_1226(acsD)
MTAMoth_1198 Moth_1201
MTHOMOTHE_c11740(acsD) MOTHE_c11770(acsC1)
MTHZMOTHA_c12610(acsD) MOTHA_c12640(acsC1)
ADGAdeg_0337 Adeg_0340
TPZTph_c15140(acsD) Tph_c15160(acsC)
TEPTepRe1_0558 TepRe1_0559
TAETepiRe1_0610(acsD) TepiRe1_0611(acsC)
TOCToce_0810 Toce_0811
NCDACONDI_02972(acsC_2) ACONDI_02973(acsD)
AARAcear_1300 Acear_1303
MANAMAMMFC1_00472(acsD) MAMMFC1_00475(acsC)
STEDSPTER_13690(acsC) SPTER_13720(acsD)
DETDET0665(acsC-1) DET0667(acsD-1) DET0699(acsC-2) DET0701(acsD-2)
DEHcbdbA651(acsC) cbdbA654(acsD)
DEBDehaBAV1_0634 DehaBAV1_0636
DEVDhcVS_603(cdhE) DhcVS_605(cdhD)
DEGDehalGT_0596 DehalGT_0598
DMCbtf_621(acsC) btf_623(acsD)
DMDdcmb_667(acsC) dcmb_669(acsD)
DMGGY50_0590(cdhE) GY50_0592(cdhD)
DMXX792_03225 X792_03235
DMYX793_02970 X793_02980
DMZX794_02720 X794_02730
DUCUCH007_05830(acsC) UCH007_05850(acsD)
DLYDehly_0816 Dehly_0818
DEWDGWBC_1387
DFODform_00888(cdhE|acsC) Dform_00913(cdhD|acsD) Dform_00915(cdhE|acsC)
DETHHX448_06195 HX448_06205
KSTKSMBR1_1320(acsD) KSMBR1_1323(acsC_1)
BROCIPI25_11055 IPI25_11070
BPITBPIT_02190 BPIT_02230
JETL3J17_07125 L3J17_07140
VAIBU251_04950 BU251_04965
TPITREPR_3065 TREPR_3066
TAZTREAZ_1645 TREAZ_1647
TYETHEYE_A1471 THEYE_A1472
DTPJZK55_05460 JZK55_05470
TIDThein_2182
TOPTOPB45_0393
TCMHL41_07620
THETF1847_08570
CTHITHC_1763
TAVG4V39_01650
TMAIFVE67_00225
MJAMJ_0112 MJ_0113
MFEMefer_0823 Mefer_0824
MVUMetvu_1052 Metvu_1053
MFSMFS40622_0985 MFS40622_0986
MIFMetin_1344 Metin_1345
MJHJH146_0755 JH146_0756
MESGMLAUSG7_0009(cdhD) MLAUSG7_0010(cdhE)
MESAMLASG1_1026(cdhE) MLASG1_1027(cdhD)
MIGMetig_1085 Metig_1086
MMPMMP0980(cdh) MMP0981(cdhD)
MMQMmarC5_0800 MmarC5_0801
MMXMmarC6_1677 MmarC6_1678
MMZMmarC7_0222 MmarC7_0223
MMDGYY_05725 GYY_05730
MMAKMMKA1_11360(cdhE) MMKA1_11370(cdhD)
MMAOMMOS7_10720(cdhE) MMOS7_10730(cdhD)
MMADMMJJ_00100(acsD) MMJJ_00110(acsC)
MAEMaeo_0210 Maeo_0211
MVNMevan_0306 Mevan_0307
MOKMetok_0141 Metok_0142
METFCFE53_01055(cdhD) CFE53_01060
MTHMTH_1712 MTH_1713
MMGMTBMA_c02910(cdhD) MTBMA_c02920(cdhE)
MWOMWSIV6_0253(cdhD) MWSIV6_0254(cdhE)
METCMTCT_1565 MTCT_1566
METEtca_01659(acsD) tca_01660(acsC_2)
METKFVF72_03100 FVF72_03105
MTHMFZP57_01145 FZP57_01150
METJFZP68_06150 FZP68_06155
MAROMarbSA_08760 MarbSA_08770
MELMetbo_0466 Metbo_0467
MEWMSWAN_1929 MSWAN_1930
METHMBMB1_1560(cdhE) MBMB1_1561(cdhD)
MFCBRM9_0796(cdhE) BRM9_0797(cdhD)
MFIDSM1535_0758(cdhE) DSM1535_0759(cdhD)
MCUBMCBB_1816(cdhE) MCBB_1817(cdhD)
MSUBBK009_06785 BK009_06790
METNBK008_02430 BK008_02435
METTCIT01_07290(cdhD) CIT01_07295
METOCIT02_10140(cdhD) CIT02_10145
MEMEHYG87_07920 HYG87_07925
MFVMfer_0522 Mfer_0523
MKAMK0722(cdhD) MK0723(cdhE)
AFUAF_0376 AF_0377
AFGAFULGI_00003760 AFULGI_00003770
AVEArcve_1125 Arcve_1126
ASTAsulf_02024 Asulf_02025
FPLFerp_0735 Ferp_0736
GACGACE_0354 GACE_0355
GAHGAH_01143 GAH_01144
MBAMbar_A0199 Mbar_A0200 Mbar_A0429 Mbar_A0430
MBYMSBRM_0623 MSBRM_0624 MSBRM_2759 MSBRM_2760
MBWMSBRW_0571 MSBRW_0572 MSBRW_0796 MSBRW_0797
MBARMSBR2_1755 MSBR2_1756 MSBR2_2717 MSBR2_2718
MBAKMSBR3_2710 MSBR3_2711 MSBR3_2950 MSBR3_2951
MACMA_1011(cdhE) MA_1012(cdhD) MA_3864(cdhD) MA_3865(cdhE)
MMAMM_0688 MM_0689 MM_2084 MM_2085
MMAZMmTuc01_2152 MmTuc01_2153
MMJMSMAS_0625 MSMAS_0626 MSMAS_2600 MSMAS_2601
MMACMSMAC_0627 MSMAC_0628 MSMAC_1818 MSMAC_1820
MVCMSVAZ_0990 MSVAZ_0991 MSVAZ_3012 MSVAZ_3013
MEKMSKOL_0962 MSKOL_0963 MSKOL_3024 MSKOL_3025
MLSMSLAZ_0644 MSLAZ_0645
METMMSMTP_0682 MSMTP_0683 MSMTP_0690 MSMTP_0691
MEFMSWH1_0791 MSWH1_0792
MEQMSWHS_0843 MSWHS_0844
MSJMSSAC_3459 MSSAC_3460 MSSAC_3601 MSSAC_3602 MSSAC_3603
MSZMSSIH_2987 MSSIH_2988 MSSIH_3141 MSSIH_3142
MSWMSSIT_3045 MSSIT_3046 MSSIT_3213 MSSIT_3214
MTHRMSTHT_2335 MSTHT_2336
MTHEMSTHC_0944 MSTHC_0945
MHORMSHOH_0734 MSHOH_0735 MSHOH_3264 MSHOH_3265
MFZAOB57_003755(cdhD) AOB57_003760
MBUMbur_0862 Mbur_0863
MMETMCMEM_0994 MCMEM_0995
MELOJ7W08_03320(cdhD) J7W08_03325
MMHMmah_1170 Mmah_1171
MHAZBHR79_07680 BHR79_07685
MEVMetev_0421 Metev_0422
MZHMzhil_1132 Mzhil_1133
MPYMpsy_2890 Mpsy_2891
MZIHWN40_08245(cdhD) HWN40_08250
MHZMetho_0979 Metho_0980
MTPMthe_0287 Mthe_0288
MCJMCON_1325(cdhE) MCON_1326(cdhD)
MHIMhar_2322 Mhar_2323
MHUMhun_0686 Mhun_0687
MRTJKHC33_09845(cdhD) KHC33_09850
MBGBN140_2373(acsC) BN140_2374(acsD)
MEMAMMAB1_3159(acsC) MMAB1_3161
MCHKMchiMG62_09120 MchiMG62_09130
MBNMboo_1194 Mboo_1195 Mboo_1369 Mboo_1370
MFOMetfor_1454 Metfor_1455 Metfor_1717 Metfor_1718
MPLMpal_0804 Mpal_0805
RCILRC461(cdhD) LRC463(cdhE)
MELUMTLP_05390(cdhD) MTLP_05400
MERMMINT_19120 MMINT_19130
BARCAOA65_0450(cdhE1) AOA65_0451(cdhD)
BARBAOA66_1431(cdhD) AOA66_1432(cdhE1)
 » show all
Reference
1  [PMID:8550451]
  Authors
Maupin-Furlow J, Ferry JG
  Title
Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina thermophila.
  Journal
J Bacteriol 178:340-6 (1996)
DOI:10.1128/JB.178.2.340-346.1996
  Sequence
Reference
2  [PMID:8626532]
  Authors
Grahame DA, DeMoll E.
  Title
Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri.
  Journal
J Biol Chem 271:8352-8 (1996)
DOI:10.1074/jbc.271.14.8352
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.245
IUBMB Enzyme Nomenclature: 2.1.1.245
ExPASy - ENZYME nomenclature database: 2.1.1.245
BRENDA, the Enzyme Database: 2.1.1.245
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