KEGG ENZYME: 2.1.1.245

ENZYME: 2.1.1.245

Entry

EC 2.1.1.245                Enzyme

Name

5-methyltetrahydrosarcinapterin---corrinoid/iron-sulfur protein Co-methyltransferase;
cdhD (gene name);
cdhE (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase

Reaction(IUBMB)

a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin [RN:R10385]

Reaction(KEGG)

R10385

Substrate

[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrosarcinapterin [CPD:C18802]

Product

[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrosarcinapterin [CPD:C18799]

Comment

Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase, and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate.

History

EC 2.1.1.245 created 2012

Orthology

K00194

acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit delta

K00197

acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit gamma

Genes

DSF:

UWK_03161

DLM:	DPPLL_26580 DPPLL_26610

DAK:	DaAHT2_0824

DBK:	DGMP_17870 DGMP_17910

DDU:

GF1_14220

ECOM:

QTN59_00705(acsC)

EAJ:	Q3M24_13035(acsC)

EAQ:	LDFHOB_06865(acsC)

DOL:	Dole_3183 Dole_3186

DAL:	Dalk_0679 Dalk_0682

DAT:	HRM2_16650(cdhE) HRM2_16690(cdhD)

DTO:	TOL2_C11800(cdhE) TOL2_C11830(cdhD)

DOV:	DSCO28_59720 DSCO28_59750

DWD:	DSCW_28510 DSCW_28540

DALK:

DSCA_26700 DSCA_26730

DESB:

BuS5_02607

DVR:	Dvar_48440 Dvar_69800 Dvar_69830

DML:	Dmul_30830(cdhD) Dmul_30860(cdhE)

DLI:	dnl_32600(cdhE) dnl_32620(cdhD)

DMM:	dnm_013290(cdhD) dnm_013340(cdhE)

DEK:	DSLASN_16740 DSLASN_16770

DAO:	Desac_1965 Desac_1968

DTI:	Desti_0230 Desti_5164

SFU:	Sfum_2564 Sfum_2567

DAX:	FDQ92_06235 FDQ92_06250

DBR:	Deba_0239 Deba_0243

DMP:	FAK_42000 FAK_42030

TID:	Thein_2182

TOP:	TOPB45_0393

TCM:	HL41_07620

THET:

F1847_08570

CTHI:

THC_1763

TAV:	G4V39_01650

TMAI:

FVE67_00225

KST:	KSMBR1_1320(acsD) KSMBR1_1323(acsC_1)

BROC:

IPI25_11055 IPI25_11070

BPIT:

BPIT_02190 BPIT_02230

JET:	L3J17_07125 L3J17_07140

VAI:	BU251_04950 BU251_04965

TPI:	TREPR_3065 TREPR_3066

TAZ:	TREAZ_1645 TREAZ_1647

TYE:	THEYE_A1471 THEYE_A1472

TOB:	V4D31_06830 V4D31_06835(acsC)

TAUT:

V4D30_05215(acsC) V4D30_05220

DTP:	JZK55_05460 JZK55_05470

DHR:	LGS26_01910

CLJ:	CLJU_c37570 CLJU_c37580

CAH:	CAETHG_1610(acsC) CAETHG_1611(acsD)

CSQ:	CSCA_4548 CSCA_4549

CACE:

CACET_c10290(acsD) CACET_c10300(acsC)

CCK:	Ccar_18795 Ccar_18800

CFM:	BJL90_11120 BJL90_11125

CDRK:

B9W14_22260 B9W14_22265

CLOS:

DMR38_18730 DMR38_18735

RUM:	CK1_12650 CK1_12660

RGV:	NQ502_01490(acsC) NQ502_01495(acsD)

DSY:	DSY1648 DSY1651

DHD:	Dhaf_2793 Dhaf_2796

DDH:	Desde_2251 Desde_2254

DDL:	Desdi_1917 Desdi_1920

DMT:	DESME_07335 DESME_07350

DOR:	Desor_3269 Desor_3272

DAI:	Desaci_2970 Desaci_2973

DMI:	Desmer_2531 Desmer_2534

DED:	DHBDCA_p226(acsC) DHBDCA_p227(acsD)

DEC:	DCF50_p286(acsC) DCF50_p287(acsD)

DRS:	DEHRE_00715 DEHRE_00720

PTH:	PTH_1001(CdhE) PTH_1003(CdhD)

DAE:	Dtox_1272 Dtox_1275

DKU:	Desku_1488 Desku_1490

FWA:	DCMF_05845 DCMF_05860

AACX:

DEACI_2513 DEACI_2515

TJR:	TherJR_1159 TherJR_1160

DGI:	Desgi_2048 Desgi_2050

ELM:	ELI_3605 ELI_3606

EMT:	CPZ25_018690 CPZ25_018695

ELIM:

B2M23_08385 B2M23_08390

AWO:	Awo_c10710(acsD) Awo_c10720(acsC)

AWI:	CHL1_002705 CHL1_002706

ALKA:

J0B03_11250 J0B03_11255

CTHM:

CFE_1662 CFE_1664

ROB:	CK5_28660 CK5_28670

BYL:	A4V09_05465 A4V09_05470

BHAN:

CGC63_07960 CGC63_07965

BLAU:

DQQ01_09715 DQQ01_09720

BPRO:

PMF13cell1_04281(acsC) PMF13cell1_04282(acsD)

BLAB:

EYS05_16715 EYS05_16720

BLIQ:

INP51_05960 INP51_05965

BWX:	NQ550_13500(acsC) NQ550_13505(acsD)

BMAS:

LK422_06260 LK422_06265

BLAR:

LC508_02770 LC508_02775

BLUI:

Blut17040_19190(acsC) Blut17040_19200(acsD)

BCOC:

BLCOC_33090(acsC) BLCOC_33100(acsD)

BHV:	BLHYD_15420(acsD) BLHYD_15430(acsC)

QDO:	H9Q78_01460 H9Q78_01465

WHJ:	H9Q79_03160 H9Q79_03165

MFOR:

NQ534_19155(acsD) NQ534_19160(acsC)

AHAD:

FRZ06_02575 FRZ06_02590

AMT:	Amet_2025 Amet_2026

GFE:	Gferi_06325 Gferi_06330

PBIF:

KXZ80_13910 KXZ80_13915

PSOR:

RSJ16_15720 RSJ16_15725

CDF:	CD630_07250 CD630_07260

PDC:	CDIF630_00841(acsD) CDIF630_00842(acsC)

CDC:	CD196_0671 CD196_0672

CDL:	CDR20291_0652 CDR20291_0653

PDF:	CD630DERM_07250 CD630DERM_07260

ROC:	HF520_11270 HF520_11275

RIL:	CRIB_2161 CRIB_2162

RHOM:

FRIFI_2468 FRIFI_2469

TEM:	JW646_10880 JW646_10885

TGC:	L0P85_16875(acsC) L0P85_16880(acsD)

TMY:	TEMA_26070(acsC) TEMA_26080(acsD)

TPET:

TPHSE_37300(acsC) TPHSE_37310(acsD)

TEB:	T8CH_0658 T8CH_0659

THYR:

P4S50_13880(acsC) P4S50_13885(acsD)

IBR:	NQ514_13095(acsC) NQ514_13100(acsD)

CST:	CLOST_1168 CLOST_1169

DAU:	Daud_0112 Daud_0114 Daud_0872 Daud_0875

TKI:	TKV_c19840(acsC) TKV_c19850(acsD)

CHY:	CHY_1223(acsC) CHY_1226(acsD)

ADG:	Adeg_0337 Adeg_0340

TPZ:	Tph_c15140(acsD) Tph_c15160(acsC)

AAUT:

ACETAC_10545 ACETAC_10550

MTA:	Moth_1198 Moth_1201

MTHO:

MOTHE_c11740(acsD) MOTHE_c11770(acsC1)

MTHZ:

MOTHA_c12610(acsD) MOTHA_c12640(acsC1)

MHUI:

MHLNE_12650(acsD) MHLNE_12680(acsC)

DBC:	MFMK1_002339 MFMK1_002342

TEP:	TepRe1_0558 TepRe1_0559

TAE:	TepiRe1_0610(acsD) TepiRe1_0611(acsC)

BACG:

D2962_12365 D2962_12370

TOC:	Toce_0810 Toce_0811

NCD:	ACONDI_02972(acsC_2) ACONDI_02973(acsD)

AAR:	Acear_1300 Acear_1303

MANA:

MAMMFC1_00472(acsD) MAMMFC1_00475(acsC)

STED:

SPTER_13690(acsC) SPTER_13720(acsD)

SSPH:

SPSPH_013890(acsC) SPSPH_013920(acsD)

SOVA:

SOV_14260(acsC) SOV_14290(acsD)

SSID:

SPSIL_019330(acsC) SPSIL_019360(acsD)

SACV:

SPACI_019050(acsC_1) SPACI_019080(acsD_1) SPACI_034810(acsD_2) SPACI_034820(acsC_2)

CALK:

HUE98_15610 HUE98_15615

DET:	DET0665(acsC-1) DET0667(acsD-1) DET0699(acsC-2) DET0701(acsD-2)

DEH:	cbdbA651(acsC) cbdbA654(acsD)

DEB:	DehaBAV1_0634 DehaBAV1_0636

DEV:	DhcVS_603(cdhE) DhcVS_605(cdhD)

DEG:	DehalGT_0596 DehalGT_0598

DMC:	btf_621(acsC) btf_623(acsD)

DMD:	dcmb_667(acsC) dcmb_669(acsD)

DMG:	GY50_0590(cdhE) GY50_0592(cdhD)

DMX:	X792_03225 X792_03235

DMY:	X793_02970 X793_02980

DMZ:	X794_02720 X794_02730

DUC:	UCH007_05830(acsC) UCH007_05850(acsD)

DLY:	Dehly_0816 Dehly_0818

DEW:	DGWBC_1387

DFO:	Dform_00888(cdhE\|acsC) Dform_00913(cdhD\|acsD) Dform_00915(cdhE\|acsC)

DETH:

HX448_06195 HX448_06205

DLF:	V8247_08630 V8247_08640(acsC)

MJA:	MJ_0112 MJ_0113

MFE:	Mefer_0823 Mefer_0824

MVU:	Metvu_1052 Metvu_1053

MFS:	MFS40622_0985 MFS40622_0986

MIF:	Metin_1344 Metin_1345

MJH:	JH146_0755 JH146_0756

MESG:

MLAUSG7_0009(cdhD) MLAUSG7_0010(cdhE)

MESA:

MLASG1_1026(cdhE) MLASG1_1027(cdhD)

MIG:	Metig_1085 Metig_1086

MMP:	MMP0980(cdh) MMP0981(cdhD)

MMQ:	MmarC5_0800 MmarC5_0801

MMX:	MmarC6_1677 MmarC6_1678

MMZ:	MmarC7_0222 MmarC7_0223

MMD:	GYY_05725 GYY_05730

MMAK:

MMKA1_11360(cdhE) MMKA1_11370(cdhD)

MMAO:

MMOS7_10720(cdhE) MMOS7_10730(cdhD)

MMAD:

MMJJ_00100(acsD) MMJJ_00110(acsC)

MAE:	Maeo_0210 Maeo_0211

MVN:	Mevan_0306 Mevan_0307

MOK:	Metok_0141 Metok_0142

METF:

CFE53_01055(cdhD) CFE53_01060

MTH:	MTH_1712 MTH_1713

MMG:	MTBMA_c02910(cdhD) MTBMA_c02920(cdhE)

MWO:	MWSIV6_0253(cdhD) MWSIV6_0254(cdhE)

METC:

MTCT_1565 MTCT_1566

METE:

tca_01659(acsD) tca_01660(acsC_2)

METK:

FVF72_03100 FVF72_03105

MTHM:

FZP57_01145 FZP57_01150

METJ:

FZP68_06150 FZP68_06155

MARO:

MarbSA_08760 MarbSA_08770

MEL:	Metbo_0466 Metbo_0467

MEW:	MSWAN_1929 MSWAN_1930

METH:

MBMB1_1560(cdhE) MBMB1_1561(cdhD)

MFC:	BRM9_0796(cdhE) BRM9_0797(cdhD)

MFI:	DSM1535_0758(cdhE) DSM1535_0759(cdhD)

MCUB:

MCBB_1816(cdhE) MCBB_1817(cdhD)

MSUB:

BK009_06785 BK009_06790

METN:

BK008_02430 BK008_02435

METT:

CIT01_07290(cdhD) CIT01_07295

METO:

CIT02_10140(cdhD) CIT02_10145

MEME:

HYG87_07920 HYG87_07925

MFEG:

GCM10025860_00980 GCM10025860_00990

MEER:

NKF70_04615(acsC) NKF70_04620(cdhD)

MRID:

FGU46_07090 FGU46_07095

MFV:	Mfer_0522 Mfer_0523

MKA:	MK0722(cdhD) MK0723(cdhE)

AFU:	AF_0376 AF_0377

AFG:	AFULGI_00003760 AFULGI_00003770

AVE:	Arcve_1125 Arcve_1126

AST:	Asulf_02024 Asulf_02025

FPL:	Ferp_0735 Ferp_0736

GAC:	GACE_0354 GACE_0355

GAH:	GAH_01143 GAH_01144

MBA:	Mbar_A0199 Mbar_A0200 Mbar_A0429 Mbar_A0430

MBY:	MSBRM_0623 MSBRM_0624 MSBRM_2759 MSBRM_2760

MBW:	MSBRW_0571 MSBRW_0572 MSBRW_0796 MSBRW_0797

MBAR:

MSBR2_1755 MSBR2_1756 MSBR2_2717 MSBR2_2718

MBAK:

MSBR3_2710 MSBR3_2711 MSBR3_2950 MSBR3_2951

MAC:	MA_1011(cdhE) MA_1012(cdhD) MA_3864(cdhD) MA_3865(cdhE)

MMA:	MM_0688 MM_0689 MM_2084 MM_2085

MMAZ:

MmTuc01_2152 MmTuc01_2153

MMJ:	MSMAS_0625 MSMAS_0626 MSMAS_2600 MSMAS_2601

MMAC:

MSMAC_0627 MSMAC_0628 MSMAC_1818 MSMAC_1820

MVC:	MSVAZ_0990 MSVAZ_0991 MSVAZ_3012 MSVAZ_3013

MEK:	MSKOL_0962 MSKOL_0963 MSKOL_3024 MSKOL_3025

MLS:	MSLAZ_0644 MSLAZ_0645

METM:

MSMTP_0682 MSMTP_0683 MSMTP_0690 MSMTP_0691

MEF:	MSWH1_0791 MSWH1_0792

MEQ:	MSWHS_0843 MSWHS_0844

MSJ:	MSSAC_3459 MSSAC_3460 MSSAC_3601 MSSAC_3602 MSSAC_3603

MSZ:	MSSIH_2987 MSSIH_2988 MSSIH_3141 MSSIH_3142

MSW:	MSSIT_3045 MSSIT_3046 MSSIT_3213 MSSIT_3214

MTHR:

MSTHT_2335 MSTHT_2336

MTHE:

MSTHC_0944 MSTHC_0945

MHOR:

MSHOH_0734 MSHOH_0735 MSHOH_3264 MSHOH_3265

MFZ:	AOB57_003755(cdhD) AOB57_003760

MHAB:

RSJ42_01810(cdhD) RSJ42_01815(acsC) RSJ42_12480(cdhD) RSJ42_12485(acsC)

METW:

AAY43_05860 AAY43_05865

MBU:	Mbur_0862 Mbur_0863

MMET:

MCMEM_0994 MCMEM_0995

MELO:

J7W08_03320(cdhD) J7W08_03325

MMH:	Mmah_1170 Mmah_1171

MHAZ:

BHR79_07680 BHR79_07685

MPOT:

BKM01_03925 BKM01_03930

MEV:	Metev_0421 Metev_0422

MZH:	Mzhil_1132 Mzhil_1133

MPY:	Mpsy_2890 Mpsy_2891

MZI:	HWN40_08245(cdhD) HWN40_08250

MMAV:

RE476_02145(cdhD) RE476_02150(acsC)

MSEB:

RE474_12040(cdhD) RE474_12045(acsC)

MHZ:	Metho_0979 Metho_0980

MEHF:

MmiHf6_01240 MmiHf6_01250(acsC)

MEES:

MmiEs2_08410 MmiEs2_08420(acsC)

MTP:	Mthe_0287 Mthe_0288

MCJ:	MCON_1325(cdhE) MCON_1326(cdhD)

MHI:	Mhar_2322 Mhar_2323

MHU:	Mhun_0686 Mhun_0687

MRTJ:

KHC33_09845(cdhD) KHC33_09850

MBG:	BN140_2373(acsC) BN140_2374(acsD)

MEMA:

MMAB1_3159(acsC) MMAB1_3161

MCHK:

MchiMG62_09120 MchiMG62_09130

MRC:	R6Y96_05885 R6Y96_05890(acsC)

MFK:	E2N92_11680 E2N92_11685

MBN:	Mboo_1194 Mboo_1195 Mboo_1369 Mboo_1370

MFO:	Metfor_1454 Metfor_1455 Metfor_1717 Metfor_1718

MPL:	Mpal_0804 Mpal_0805

RCI:	LRC461(cdhD) LRC463(cdhE)

MELU:

MTLP_05390(cdhD) MTLP_05400

MER:	MMINT_19120 MMINT_19130

BARC:

AOA65_0450(cdhE1) AOA65_0451(cdhD)

BARB:

AOA66_1431(cdhD) AOA66_1432(cdhE1)

LOB:	NEF87_003955 NEF87_004234

» show all

Reference

1 [PMID:8550451]

Authors

Maupin-Furlow J, Ferry JG

Title

Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina thermophila.

Journal

J Bacteriol 178:340-6 (1996)
DOI:10.1128/JB.178.2.340-346.1996

Sequence

[ag:AAA93168 AAA93167]

Reference

2 [PMID:8626532]

Authors

Grahame DA, DeMoll E.

Title

Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri.

Journal

J Biol Chem 271:8352-8 (1996)
DOI:10.1074/jbc.271.14.8352