KEGG   ENZYME: 2.1.1.258
Entry
EC 2.1.1.258                Enzyme                                 
Name
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase;
acsE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate [RN:R02289]
Reaction(KEGG)
R02289;
(other) R10243
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrofolate [CPD:C00101]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrofolate [CPD:C00440]
Comment
Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.
History
EC 2.1.1.258 created 2012
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15023  5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase
Genes
XORXOC_1783
XOZBE73_08365
ABREpbN1_19000
DSFUWK_01140
DAKDaAHT2_1991 DaAHT2_2486
DBKDGMP_17860
DOLDole_2576 Dole_2853 Dole_3182
DMLDmul_15220 Dmul_30880(metH) Dmul_32250
DALDalk_0683 Dalk_4619 Dalk_4910
DATHRM2_00520(metH1) HRM2_16640(metH3)
DTOTOL2_C05310 TOL2_C11790(metH)
DOVDSCO28_10640 DSCO28_24780 DSCO28_59710
DWDDSCW_06570 DSCW_19000 DSCW_28550 DSCW_34490
DALKDSCA_20770 DSCA_26740 DSCA_44750 DSCA_55930 DSCA_62150
DLIdnl_12310 dnl_32590 dnl_60060
DMMdnm_013350 dnm_058130
DEKDSLASN_16780
DAODesac_0369 Desac_1969
DTIDesti_0229 Desti_0441 Desti_0981 Desti_2096 Desti_2349 Desti_4769
SFUSfum_2563
DAXFDQ92_06230
DBRDeba_0238 Deba_1009 Deba_1649
DHRLGS26_01905
BVYNCTC9239_01829(metH_2)
CLJCLJU_c07500(metH2) CLJU_c07550(metH3) CLJU_c20620(metH4) CLJU_c20690(metH5) CLJU_c37560(meTr)
CLBClo1100_0739
CAHCAETHG_0145 CAETHG_0153 CAETHG_1609 CAETHG_2843 CAETHG_2848
CSQCSCA_0288 CSCA_4550 CSCA_5050
CACECACET_c10310(acsE) CACET_c12990 CACET_c32510(metH2)
CCKCcar_13140 Ccar_15510 Ccar_18790
CFMBJL90_01660 BJL90_02620 BJL90_11130 BJL90_20245
CDRKB9W14_17025 B9W14_19560 B9W14_22255
CLOSDMR38_03585 DMR38_03610 DMR38_03630 DMR38_10555 DMR38_10590 DMR38_18725
AMTAmet_2027 Amet_2085 Amet_2092
GFEGferi_04565 Gferi_06320 Gferi_07815 Gferi_15430 Gferi_16345 Gferi_16365 Gferi_17595 Gferi_17730
PBIFKXZ80_13905
CCECcel_2473
CCELCCDG5_0495
RUMCK1_05540 CK1_12640 CK1_29210
ROBCK5_28650
BYLA4V09_05475 A4V09_19575
BHANCGC63_07955
BLAUDQQ01_01790 DQQ01_09710
BPROPMF13cell1_00337(acsE_1) PMF13cell1_01636(acsE_2) PMF13cell1_03817(acsE_3) PMF13cell1_04280(acsE_4)
BLABEYS05_14255 EYS05_16710
BLIQINP51_05970
CDFCD630_07270
PDCCDIF630_00843(acsE)
CDCCD196_0673
CDLCDR20291_0654
PDFCD630DERM_07270
CSTCLOST_1170
PSORRSJ16_15715
ROCHF520_08190 HF520_11265
TEMJW646_10890
TEBT8CH_0660
CALKHUE98_15605
DSYDSY0589 DSY1268 DSY1647 DSY2719 DSY4702 DSY4754 DSY4972
DHDDhaf_0540 Dhaf_0722 Dhaf_1108 Dhaf_1838 Dhaf_1896 Dhaf_2367 Dhaf_2568 Dhaf_2792 Dhaf_3883 Dhaf_4612 Dhaf_4640 Dhaf_4871
DDHDesde_2049 Desde_2250 Desde_3331 Desde_3948
DDLDesdi_1916 Desdi_2542 Desdi_2551 Desdi_3330
DMTDESME_07355
DORDesor_1138 Desor_1147 Desor_1650 Desor_2083 Desor_2369 Desor_2613 Desor_2716 Desor_2734 Desor_2799 Desor_2943 Desor_3268 Desor_3940 Desor_4150 Desor_4258 Desor_4397 Desor_5170
DAIDesaci_1203 Desaci_2790 Desaci_2831 Desaci_2969
DMIDesmer_1620 Desmer_2202 Desmer_2353 Desmer_2530 Desmer_3054 Desmer_3193 Desmer_3491
DEDDHBDCA_p1157 DHBDCA_p2017 DHBDCA_p225 DHBDCA_p232 DHBDCA_p2404
DECDCF50_p1224 DCF50_p2029 DCF50_p2416 DCF50_p285 DCF50_p292
DRSDEHRE_00710 DEHRE_00745 DEHRE_03815 DEHRE_04045 DEHRE_06900
PTHPTH_1004(MetH)
DAEDtox_1276
DKUDesku_1487 Desku_2712
DAUDaud_0113 Daud_0876
FWADCMF_02510 DCMF_05840 DCMF_07395 DCMF_07885 DCMF_08110 DCMF_08795 DCMF_12955 DCMF_16370 DCMF_23120 DCMF_26780 DCMF_27825 DCMF_27850 DCMF_28165 DCMF_28355
AACXDEACI_2516 DEACI_4249
TJRTherJR_1161 TherJR_2629
DGIDesgi_0674 Desgi_2047 Desgi_3921
HCVFTV88_3024(metH)
ELMELI_0371 ELI_0487 ELI_0560 ELI_2005 ELI_3604 ELI_3713
EMTCPZ25_002655 CPZ25_011395 CPZ25_011950 CPZ25_015290 CPZ25_018700
ELIMB2M23_01055 B2M23_04840 B2M23_07880 B2M23_08395 B2M23_16860
AWOAwo_c05180(mttA1) Awo_c09210(mttA3) Awo_c10730(acsE) Awo_c15660(mttA4) Awo_c18280(mttA5) Awo_c22740 Awo_c23260(mttB19) Awo_c23750(mttA8)
ALKAJ0B03_02805 J0B03_03050 J0B03_10100 J0B03_11260 J0B03_11305
CTHMCFE_1661
TKITKV_c19830(acsE)
CHYCHY_1227(acsE)
MTAMoth_1197
MTHOMOTHE_c03140(acsE1) MOTHE_c11730(acsE2)
MTHZMOTHA_c12600(acsE2)
ADGAdeg_0341
TPZTph_c01810 Tph_c15130(acsE) Tph_c27600(metH3)
CSCCsac_0898
ATEAthe_0749
COBCOB47_0680
CHDCalhy_1941
COWCalow_0596
CLCCalla_0391
CKNCalkro_1902
MASMahau_1083
TEPTepRe1_0302 TepRe1_0560
TAETepiRe1_0337(acsE) TepiRe1_0612
TOCToce_0796 Toce_0812 Toce_1080
NCDACONDI_02974(acsE_5)
AARAcear_0930 Acear_0954 Acear_1056 Acear_1299
KMEH0A61_00825(acsE)
MANAMAMMFC1_00471(acsE_1) MAMMFC1_01778(acsE_2) MAMMFC1_02498(acsE_3)
STEDSPTER_03920(acsE_1) SPTER_09890(acsE_2) SPTER_13730(acsE_3) SPTER_28050(acsE_4) SPTER_30460(acsE_6)
DLYDehly_0819
DEWDGWBC_1388
OTEOter_4334
TTFTHTE_3701
KSTKSMBR1_1319(acsE)
BROCIPI25_11050
BPITBPIT_02180
JETL3J17_07120
PBUL21SP3_00049(acsE)
PBPSTSP1_00914(metH_1)
ALUSSTSP2_01509(acsE)
VBLL21SP4_02015(acsE_1) L21SP4_02433(acsE_2)
VAIBU251_04945
TAZTREAZ_1644 TREAZ_1652
TPITREPR_1556 TREPR_2898 TREPR_3064
SSMSpirs_2845
RAGB739_0062
RATM949_0493
TYETHEYE_A1473
DTPJZK55_05450 JZK55_20280
TIDThein_1435 Thein_2179
TCMHL41_07615
THETF1847_08565
CTHITHC_1765
TAVG4V39_01645 G4V39_10610
TMAIFVE67_00220
MERMMINT_00400
 » show all
Reference
1  [PMID:7928975]
  Authors
Roberts DL, Zhao S, Doukov T, Ragsdale SW
  Title
The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum.
  Journal
J Bacteriol 176:6127-30 (1994)
DOI:10.1128/JB.176.19.6127-6130.1994
  Sequence
[mta:Moth_1197]
Reference
2  [PMID:10997901]
  Authors
Doukov T, Seravalli J, Stezowski JJ, Ragsdale SW
  Title
Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
  Journal
Structure 8:817-30 (2000)
DOI:10.1016/S0969-2126(00)00172-6
  Sequence
[mta:Moth_1197]
Reference
3  [PMID:17172470]
  Authors
Doukov TI, Hemmi H, Drennan CL, Ragsdale SW
  Title
Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in  activation of methyl transfer by methyltransferases.
  Journal
J Biol Chem 282:6609-18 (2007)
DOI:10.1074/jbc.M609828200
  Sequence
[mta:Moth_1197]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.258
IUBMB Enzyme Nomenclature: 2.1.1.258
ExPASy - ENZYME nomenclature database: 2.1.1.258
BRENDA, the Enzyme Database: 2.1.1.258
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