KEGG   ENZYME: 2.1.1.258
Entry
EC 2.1.1.258                Enzyme                                 
Name
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase;
acsE (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate [RN:R02289]
Reaction(KEGG)
R02289;
(other) R10243
Substrate
[methyl-Co(III) corrinoid Fe-S protein];
tetrahydrofolate [CPD:C00101]
Product
[Co(I) corrinoid Fe-S protein];
5-methyltetrahydrofolate [CPD:C00440]
Comment
Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.
History
EC 2.1.1.258 created 2012
Pathway
ec00720  Other carbon fixation pathways
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15023  5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase
Genes
XOR: XOC_1783
XOZ: BE73_08365
ABRE: pbN1_19000
BVY: NCTC9239_01829(metH_2)
DSF: UWK_01140
DLM: DPPLL_26570
DAK: DaAHT2_1991 DaAHT2_2486
DBK: DGMP_17860
DDU: GF1_31690
ECOM: QTN59_15335
EAJ: Q3M24_07185
ELAX: KKHLCK_13260
EAQ: LDFHOB_03725 LDFHOB_04170
DOL: Dole_2576 Dole_2853 Dole_3182
DAL: Dalk_0683 Dalk_4619 Dalk_4910
DAT: HRM2_00520(metH1) HRM2_16640(metH3)
DTO: TOL2_C05310 TOL2_C11790(metH)
DOV: DSCO28_10640 DSCO28_24780 DSCO28_59710
DWD: DSCW_06570 DSCW_19000 DSCW_28550 DSCW_34490
DALK: DSCA_20770 DSCA_26740 DSCA_44750 DSCA_55930 DSCA_62150
DESB: BuS5_02606
DVR: Dvar_48610 Dvar_69840
DML: Dmul_15220 Dmul_30880(metH) Dmul_32250
DLI: dnl_12310 dnl_32590 dnl_60060
DMM: dnm_013350 dnm_058130
DEK: DSLASN_16780
DAO: Desac_0369 Desac_1969
DTI: Desti_0229 Desti_0441 Desti_0981 Desti_2096 Desti_2349 Desti_4769
SFU: Sfum_2563
DAX: FDQ92_06230
DBR: Deba_0238 Deba_1009 Deba_1649
DMP: FAK_22470 FAK_41990
TID: Thein_1435 Thein_2179
TCM: HL41_07615
THET: F1847_08565
CTHI: THC_1765
TAV: G4V39_01645 G4V39_10610
TMAI: FVE67_00220
OTE: Oter_4334
TTF: THTE_3701
KST: KSMBR1_1319(acsE)
BROC: IPI25_11050
BPIT: BPIT_02180
JET: L3J17_07120
PBU: L21SP3_00049(acsE)
PBP: STSP1_00914(metH_1)
ALUS: STSP2_01509(acsE)
VBL: L21SP4_02015(acsE_1) L21SP4_02433(acsE_2)
VAI: BU251_04945
TPI: TREPR_1556 TREPR_2898 TREPR_3064
SSM: Spirs_2845
TAZ: TREAZ_1644 TREAZ_1652
RAG: B739_0062
RAT: M949_0493
TYE: THEYE_A1473
TOB: V4D31_06825
TAUT: V4D30_05225
DTP: JZK55_05450 JZK55_20280
DHR: LGS26_01905
CLJ: CLJU_c07500(metH2) CLJU_c07550(metH3) CLJU_c20620(metH4) CLJU_c20690(metH5) CLJU_c37560(meTr)
CLB: Clo1100_0739
CAH: CAETHG_0145 CAETHG_1609(acsE) CAETHG_2843 CAETHG_2848
CSQ: CSCA_0288 CSCA_4550 CSCA_5050
CACE: CACET_c10310(acsE) CACET_c12990 CACET_c32510(metH2)
CCK: Ccar_13140 Ccar_15510 Ccar_18790
CFM: BJL90_01660 BJL90_02620 BJL90_11130 BJL90_20245
CDRK: B9W14_17025 B9W14_19560 B9W14_22255
CLOS: DMR38_03585 DMR38_03610 DMR38_03630 DMR38_10555 DMR38_10590 DMR38_18725
CCE: Ccel_2473
RUM: CK1_05540 CK1_12640 CK1_29210
RGV: NQ502_01485(acsE)
CCEL: CCDG5_0495
DSY: DSY0589 DSY1268 DSY1647 DSY2719 DSY4702 DSY4754 DSY4972
DHD: Dhaf_0540 Dhaf_0722 Dhaf_1108 Dhaf_1838 Dhaf_1896 Dhaf_2367 Dhaf_2568 Dhaf_2792 Dhaf_3883 Dhaf_4612 Dhaf_4640 Dhaf_4871
DDH: Desde_2049 Desde_2250 Desde_3331 Desde_3948
DDL: Desdi_1916 Desdi_2542 Desdi_2551 Desdi_3330
DMT: DESME_07355
DOR: Desor_1138 Desor_1147 Desor_1650 Desor_2083 Desor_2369 Desor_2613 Desor_2716 Desor_2734 Desor_2799 Desor_2943 Desor_3268 Desor_4150 Desor_4258 Desor_4397 Desor_5170
DAI: Desaci_2790 Desaci_2831 Desaci_2969
DMI: Desmer_1620 Desmer_2202 Desmer_2353 Desmer_2530 Desmer_3193 Desmer_3491
DED: DHBDCA_p1157 DHBDCA_p2017 DHBDCA_p225 DHBDCA_p232 DHBDCA_p2404
DEC: DCF50_p1224 DCF50_p2029 DCF50_p2416 DCF50_p285 DCF50_p292
DRS: DEHRE_00710 DEHRE_00745 DEHRE_03815 DEHRE_04045 DEHRE_06900
PTH: PTH_1004(MetH)
DAE: Dtox_1276
DKU: Desku_1487 Desku_2712
FWA: DCMF_02510 DCMF_05840 DCMF_07395 DCMF_07885 DCMF_08110 DCMF_08795 DCMF_12955 DCMF_16370 DCMF_23120 DCMF_26780 DCMF_27825 DCMF_27850 DCMF_28165 DCMF_28355
AACX: DEACI_2516 DEACI_4249
TJR: TherJR_1161 TherJR_2629
DGI: Desgi_0674 Desgi_2047 Desgi_3921
HCV: FTV88_3024(metH)
ELM: ELI_0487 ELI_0560 ELI_2005 ELI_3604 ELI_3713
EMT: CPZ25_002655 CPZ25_011395 CPZ25_015290 CPZ25_018700
ELIM: B2M23_01055 B2M23_07880 B2M23_08395 B2M23_16860
AWO: Awo_c05180(mttA1) Awo_c09210(mttA3) Awo_c10730(acsE) Awo_c15660(mttA4) Awo_c18280(mttA5) Awo_c22740 Awo_c23260(mttB19) Awo_c23750(mttA8)
AWI: CHL1_000721 CHL1_001163 CHL1_001288 CHL1_001470 CHL1_002433 CHL1_002704 CHL1_002854 CHL1_003243
ALKA: J0B03_02805 J0B03_03050 J0B03_10100 J0B03_11260 J0B03_11305
CTHM: CFE_1661
ROB: CK5_28650
BYL: A4V09_05475 A4V09_19575
BHAN: CGC63_07955
BLAU: DQQ01_01790 DQQ01_09710
BPRO: PMF13cell1_00337(acsE_1) PMF13cell1_01636(acsE_2) PMF13cell1_03817(acsE_3) PMF13cell1_04280(acsE_4)
BLAB: EYS05_14255 EYS05_16710
BLIQ: INP51_05970 INP51_07905
BWX: NQ550_13495(acsE) NQ550_21245
BMAS: LK422_06270 LK422_09505
BLAR: LC508_02780 LC508_16895 LC508_19345 LC508_27400
BLUI: Blut17040_19180(acsE) Blut17040_32640
BCOC: BLCOC_00750(acsE_1) BLCOC_27960(acsE_2) BLCOC_33080(acsE_3)
BHV: BLHYD_15440(acsE)
QDO: H9Q78_01455
WHJ: H9Q79_03170 H9Q79_06470 H9Q79_12860
MFOR: NQ534_07715 NQ534_19165(acsE)
AHAD: FRZ06_02595
AMT: Amet_2027 Amet_2085 Amet_2092
GFE: Gferi_04565 Gferi_06320 Gferi_07815 Gferi_15430 Gferi_16345 Gferi_16365 Gferi_17595 Gferi_17730
PBIF: KXZ80_13905
PSOR: RSJ16_15715
CDF: CD630_07270
PDC: CDIF630_00843(acsE)
CDC: CD196_0673
CDL: CDR20291_0654
PDF: CD630DERM_07270
ROC: HF520_08190 HF520_11265
RIL: CRIB_2160
RHOM: FRIFI_2467
TEM: JW646_10890
TGC: L0P85_16870(acsE)
TMY: TEMA_10930(acsE_1) TEMA_26060(acsE)
TPET: TPHSE_37290(acsE)
TEB: T8CH_0660
THYR: P4S50_13875(acsE)
IBR: NQ514_12800 NQ514_13090(acsE)
CST: CLOST_1170
DAU: Daud_0113 Daud_0876
TKI: TKV_c19830(acsE)
CHY: CHY_1227(acsE)
ADG: Adeg_0341
TPZ: Tph_c15130(acsE) Tph_c27600(metH3)
AAUT: ACETAC_10540
MAS: Mahau_1083
MTA: Moth_1197
MTHO: MOTHE_c03140(acsE1) MOTHE_c11730(acsE2)
MTHZ: MOTHA_c12600(acsE2)
MHUI: MHLNE_12640(acsE_1)
DBC: MFMK1_002338
TEP: TepRe1_0302 TepRe1_0560
TAE: TepiRe1_0337(acsE) TepiRe1_0612
BACG: D2962_12360
TOC: Toce_0796 Toce_0812 Toce_1080
NCD: ACONDI_02974(acsE_5)
AAR: Acear_0930 Acear_0954 Acear_1056 Acear_1299
KME: H0A61_00825(acsE)
MANA: MAMMFC1_00471(acsE_1) MAMMFC1_01778(acsE_2) MAMMFC1_02498(acsE_3)
STED: SPTER_03920(acsE_1) SPTER_09890(acsE_2) SPTER_13730(acsE_3) SPTER_28050(acsE_4) SPTER_30460(acsE_6)
SSPH: SPSPH_000490(acsE_1) SPSPH_013930(acsE_4) SPSPH_036210(acsE_11)
SOVA: SOV_14300(acsE_2) SOV_36520(acsE_3)
SSID: SPSIL_019370(acsE_2) SPSIL_039940(acsE_6)
SACV: SPACI_019090(acsE_2)
CALK: HUE98_15605
CSC: Csac_0898
ATE: Athe_0749
COB: COB47_0680
CHD: Calhy_1941
COW: Calow_0596
CLC: Calla_0391
CKN: Calkro_1902
DLY: Dehly_0819
DEW: DGWBC_1388
DLF: V8247_08645
MER: MMINT_00400
 » show all
Reference
1  [PMID:7928975]
  Authors
Roberts DL, Zhao S, Doukov T, Ragsdale SW
  Title
The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum.
  Journal
J Bacteriol 176:6127-30 (1994)
DOI:10.1128/JB.176.19.6127-6130.1994
  Sequence
[mta:Moth_1197]
Reference
2  [PMID:10997901]
  Authors
Doukov T, Seravalli J, Stezowski JJ, Ragsdale SW
  Title
Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
  Journal
Structure 8:817-30 (2000)
DOI:10.1016/S0969-2126(00)00172-6
  Sequence
[mta:Moth_1197]
Reference
3  [PMID:17172470]
  Authors
Doukov TI, Hemmi H, Drennan CL, Ragsdale SW
  Title
Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in  activation of methyl transfer by methyltransferases.
  Journal
J Biol Chem 282:6609-18 (2007)
DOI:10.1074/jbc.M609828200
  Sequence
[mta:Moth_1197]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.258
IUBMB Enzyme Nomenclature: 2.1.1.258
ExPASy - ENZYME nomenclature database: 2.1.1.258
BRENDA, the Enzyme Database: 2.1.1.258
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