KEGG   ENZYME: 2.7.8.46
Entry
EC 2.7.8.46                 Enzyme                                 
Name
teichoic acid ribitol-phosphate primase;
Tar primase;
tarK (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-ribitol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitylphosphotransferase
Reaction(IUBMB)
CDP-ribitol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CMP + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11613 R12864]
Reaction(KEGG)
R11613 R12864(G)
Substrate
CDP-ribitol [CPD:C00789];
4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21464]
Product
CMP [CPD:C00055];
4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21503]
Comment
Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the first ribitol unit to the disaccharide linker of the teichoic acid.
History
EC 2.7.8.46 created 2017
Pathway
ec00552  Teichoic acid biosynthesis
Orthology
K21592  teichoic acid ribitol-phosphate primase
Genes
BSL: A7A1_1141
BSY: I653_17455
BSUS: Q433_19605
BSX: C663_3470(tarK)
BSS: BSUW23_17575(tarK)
BST: GYO_3935(tarK)
BIT: BIS30_07545
BHT: DIC78_13175
BMOJ: HC660_34690
BTEQ: G4P54_18380
BIQ: AN935_18035
BRY: M0696_18140
BJS: MY9_3632
BACY: QF06_16300
BGI: BGM20_12055
TAID: KS242_14080
VSS: PD280_09990
FEC: QNH15_21940
PRD: F7984_17515
BLEN: NCTC4824_03821(tarK)
BVJ: I5776_16310
HSPO: JGZ69_01900
FAF: OE104_14485
PUK: PU629_01930
ESI: Exig_0191
EAN: Eab7_0183(tarK)
EXU: ESP131_03405
EACE: KKI46_01225
EXI: A0126_00990
EXH: HNY42_02450
LCAR: BHS00_06055
CBV: U729_1136
ALKA: J0B03_04335 J0B03_04340
WCP: H9Q76_02900 H9Q76_02905
ETM: CE91St48_15330
TEM: JW646_10245
CIU: G4D55_18420
FIT: Fi14EGH31_11100(tagB)
AHAT: ADCFC_17170
RTS: CE91St31_00290
MEST: PTQ19_14615
LTN: KVY00_06745
 » show all
Reference
1  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
  Sequence
[bss:BSUW23_17575]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.46
IUBMB Enzyme Nomenclature: 2.7.8.46
ExPASy - ENZYME nomenclature database: 2.7.8.46
BRENDA, the Enzyme Database: 2.7.8.46
LinkDB

DBGET integrated database retrieval system