KEGG   ENZYME: 3.1.1.90
Entry
EC 3.1.1.90                 Enzyme                                 
Name
all-trans-retinyl ester 13-cis isomerohydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
all-trans-retinyl ester acylhydrolase, 13-cis-retinol-forming
Reaction(IUBMB)
an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid [RN:R09826]
Reaction(KEGG)
R09826
Substrate
all-trans-retinyl ester [CPD:C02075];
H2O [CPD:C00001]
Product
13-cis-retinol [CPD:C19962];
fatty acid [CPD:C00162]
Comment
All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 2.3.1.135, phosphatidylcholine---retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 3.1.1.64, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme.
History
EC 3.1.1.90 created 2011
Orthology
K20991  all-trans-retinyl ester 13-cis isomerohydrolase
Genes
DRE: 100002865(rpe65b)
Reference
1  [PMID:21235714]
  Authors
Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma JX
  Title
An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain.
  Journal
FEBS J 278:973-87 (2011)
DOI:10.1111/j.1742-4658.2011.08019.x
  Sequence
[dre:100002865]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.90
IUBMB Enzyme Nomenclature: 3.1.1.90
ExPASy - ENZYME nomenclature database: 3.1.1.90
BRENDA, the Enzyme Database: 3.1.1.90
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