| Entry |
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| Name |
6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] thioesterase
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| Class |
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
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| Sysname |
6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] hydrolase
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| Reaction(IUBMB) |
6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] + H2O = 6-hydroxymusizin + CO2 + [acyl-carrier protein] (overall reaction) [RN: R13624];
(1a) 6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] + H2O = 6-hydroxymusizin carboxylate + [acyl-carrier protein] [RN: R13622];
(1b) 6-hydroxymusizin carboxylate = 6-hydroxymusizin + CO2 (spontaneous) [RN: R13623]
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| Reaction(KEGG) |
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| Substrate |
6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] [CPD: C23121];
H2O [CPD: C00001];
6-hydroxymusizin carboxylate [CPD: C23124]
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| Product |
6-hydroxymusizin [CPD: C23125];
CO2 [CPD: C00011];
[acyl-carrier protein] [CPD: C00229];
6-hydroxymusizin carboxylate [CPD: C23124]
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| Comment |
Found in the mushrooms Calonarius odorifer and Calonarius rufo-olivaceus and the mould Chrysosporium merdarium.
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| History |
EC 3.1.2.35 created 2025
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| Orthology |
| K28740 | 6-hydroxymusizin-2-carbonyl-ACP/atrochrysone-2-carbonyl-ACP synthase/thioesterase |
| K28743 | 6-hydroxymusizin-2-carbonyl-[acyl-carrier protein] thioesterase |
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| Reference |
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| Authors |
Thiele W, Obermaier S, Muller M. |
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| Title |
A Fasciclin Protein Is Essential for Laccase-Mediated Selective Phenol Coupling in Sporandol Biosynthesis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lohr NA, Eisen F, Thiele W, Platz L, Motter J, Huttel W, Gressler M, Muller M, Hoffmeister D. |
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| Title |
Unprecedented Mushroom Polyketide Synthases Produce the Universal Anthraquinone Precursor. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lohr NA, Urban MC, Eisen F, Platz L, Huttel W, Gressler M, Muller M, Hoffmeister D. |
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| Title |
The Ketosynthase Domain Controls Chain Length in Mushroom Oligocyclic Polyketide Synthases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lohr NA, Rakhmanov M, Wurlitzer JM, Lackner G, Gressler M, Hoffmeister D. |
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| Title |
Basidiomycete non-reducing polyketide synthases function independently of SAT domains. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.2.35 |
| ExPASy - ENZYME nomenclature database: | 3.1.2.35 |
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| LinkDB |
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