KEGG   ENZYME: 3.2.2.5
Entry
EC 3.2.2.5                  Enzyme                                 
Name
NAD+ glycohydrolase;
NAD glycohydrolase;
nicotinamide adenine dinucleotide glycohydrolase;
beta-NAD+ glycohydrolase;
DPNase (ambiguous);
NAD hydrolase (ambiguous);
diphosphopyridine nucleosidase (ambiguous);
nicotinamide adenine dinucleotide nucleosidase (ambiguous);
NAD nucleosidase (ambiguous);
DPN hydrolase (ambiguous);
NADase (ambiguous);
nga (gene name);
NAD+ nucleosidase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
Sysname
NAD+ glycohydrolase
Reaction(IUBMB)
NAD+ + H2O = ADP-D-ribose + nicotinamide [RN:R00102]
Reaction(KEGG)
R00102
Substrate
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
ADP-D-ribose [CPD:C00301];
nicotinamide [CPD:C00153]
Comment
This enzyme catalyses the hydrolysis of NAD+, without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase). The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis. The enzyme from the venom of the snake Agkistrodon acutus also catalyses EC 3.6.1.5, apyrase [3].
History
EC 3.2.2.5 created 1961, modified 2013
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K18153  NAD+ glycohydrolase
K19980  ADP-ribosyltransferase 2 / NAD+ glycohydrolase
K28299  NAD(P)(+) glycohydrolase toxin Tse6
Genes
MMU11871(Art2a) 11872(Art2b)
MCAL110298813
MPAH110336159
RNO293152(Art2b)
MCOC116100665 116101301
ANU117693579 117695831
ASYL127664680 127664858 127664865
MUN110550800
CGE100750708 100751294 100771938 100772218 100772803
MAUA101824175 101839372 121134115 121144298
PROB127227991 127227992
PLEU114698648 114698743 114698744 114706661 119086245
MFOT126488848
NGI103748863 103749849
HGL106007650
CPOC100714269 100717061
CCAN109678990
NCAR124958806
MMMA107135550
ITI101967560 101976814
OPI101536559
TUP102487179
GVR103607714
BACU103000152
BMUS118899688
MYB102252898
MYD102773420
MMYO118664685 118664687
MLF102425244 102438022 102438936
MDT132240834 132242078
MYUM139017312 139017313 139018192
EFUS103293570
MNA107533657
DRO112315853
SHON119002660
AJM119042110
PDIC114498648 114500760
PHAS123805524 123816978
MMF118627508
PPAM129072723
RFQ117031024
PALE102895427
PGIG120590522
PVP105303689
RAY107517326
SARA101541382
ETF123522055
DNM111761064
CPLA122545933
FCD110841647
ECLGEC036_25880
ECLIECNIH5_12395
ECLZLI64_12510
ECLAECNIH3_12450
ECLCECR091_12385
EECEcWSU1_02673
ELGBH714_09110
EHUD5067_0009945
EQUOM418_12830
EDYF0320_12590
KORAWR26_10875
KOTEH164_09985
KOBHF650_12920
KINAB182_15040
MPHGMPHASIOC01_001702
EBCC2U52_25545
YPSYPTB3795
YPOBZ17_2790
YPIYpsIP31758_4019
YPBYPTS_3994
YPQDJ40_2600
YPUBZ21_3132
YPRBZ20_2299
YPCBZ23_3420
YPFBZ19_3283
YEEYE5303_15111
YALAT01_3152
SPESpro_3017
SOFNCTC11214_03782
ERJEJP617_B010
PAMPANA_2924
PEYEE896_11375 EE896_19530
PDISD8B20_02745 D8B20_19815
PALFK6R05_21685
PPHOCTZ24_16115
PAMTIAI47_11530
PGZC2E15_01190 C2E15_03645
MINTC7M51_00772(rhsA_2)
POJPtoMrB4_30350
PAEPA0093
PAEVN297_99
PAEIN296_99
PAUPA14_01140
PAGPLES_00941
PAFPAM18_0095
PNCNCGM2_0098
PAEBNCGM1900_0088
PDKPADK2_00485
PSGG655_00480
PRPM062_00480
PAEPPA1S_00505
PAERPA1R_gp0491 PA1R_gp3607
PAEMU769_00495
PAESSCV20265_0095
PAEUBN889_00141
PAECM802_99
PAEOM801_99
SECHB18_07420
PAPPSPA7_0167
PPAAB7D75_00515
PPUPP_3103
PPGPputGB1_2758
PPTPPS_2829
PPUNPP4_24620 PP4_24640
PPUDDW66_3085
PMONX969_13520
PMOTX970_13165
PPJRK21_01838 RK21_01841
PALDLU682_015075
PSYRN018_23610 N018_25180 N018_25200
PSPPSPPH_2282 PSPPH_2819 PSPPH_5068
PSAVPSA3335_01220 PSA3335_24770
PAMGBKM19_028855
PFUVNLK61_13865
PFLPFL_6209
PPRCPFLCHA0_c61700
PPROPPC_6163
PCGAXG94_14815
PMEDE3Z27_27855
PSOSPOS17_6171
PVKEPZ47_29230
PEZHWQ56_04915
PBZGN234_18820 GN234_18830
PSEPC4K39_0174 C4K39_3563
PPIIQL104_00930 QL104_19260
PVWHU752_000430
PALVKSS97_00365
PTWTUM18999_29980
PASILG197_19740
PSOAPSm6_52880
PTAIICN73_20160
PSJYAA098_13375
PSKUKUIN1_23370
PSIVLZ023_33890
MMAIsS8_2269 sS8_3581
RSORSc3426
RSEF504_3474
RSCRCFBP_10026
RSLRPSI07_0020
RSNRSPO_c00018
BTEIWS51_08385
BSTLBBJ41_25115
BARINLX30_14130
BGFBC1003_5766
PMEGFNZ07_27120
TCARU0034_07425 U0034_10385
CARELT85_3876
CPRACPter91_2340
MASSCR152_05325
MASYDPH57_04905 DPH57_04925
MANCIV454_05125 IV454_11395
MASZC9I28_17075
MPLIE1742_04375
TCTPX653_05700
TMJP0M04_28865
EHBE7V67_014940
POQKZX46_03685 KZX46_18530
PMEAKTC28_14930 KTC28_19450
SPYSPy_0165(nga)
SPZM5005_Spy0139(nga)
SPYMM1GAS476_0178(nga)
SPYAA20_0190(nga)
SPMspyM18_0163(nga)
SPGSpyM3_0128(nga)
SPSSPs0130
SPHMGAS10270_Spy0141(nga)
SPIMGAS10750_Spy0145(nga)
SPJMGAS2096_Spy0146(nga)
SPKMGAS9429_Spy0141(nga)
SPFSpyM50134(nga)
SPAM6_Spy0186
SPBM28_Spy0137(nga)
STGMGAS15252_0175(nga)
STXMGAS1882_0175(nga)
SOZSpy49_0144(nga)
STZSPYALAB49_000178
SPYHL897_00945
SPYOSTAB901_00975
SEUSEQ_0311
SDSSDEG_2029(nga)
SDGSDE12394_10265
SDAGGS_1869(nga)
SDCSDSE_2125(nga)
SDQSDSE167_2131(nga)
SCAINCTC12191_01452
 » show all
Reference
1  [PMID:4322210]
  Authors
Fehrenbach FJ
  Title
[Purification and crystallization of NAD glycohydrolase of C streptococci].
  Journal
Eur J Biochem 18:94-102 (1971)
DOI:10.1111/j.1432-1033.1971.tb01219.x
Reference
2  [PMID:236282]
  Authors
Grushoff PS, Shany S, Bernheimer AW
  Title
Purification and properties of streptococcal nicotinamide adenine dinucleotide glycohydrolase.
  Journal
J Bacteriol 122:599-605 (1975)
DOI:10.1128/JB.122.2.599-605.1975
Reference
3  [PMID:18952139]
  Authors
Zhang L, Xu X, Luo Z, Shen D, Wu H
  Title
Identification of an unusual AT(D)Pase-like activity in multifunctional NAD glycohydrolase from the venom of Agkistrodon acutus.
  Journal
Biochimie 91:240-51 (2009)
DOI:10.1016/j.biochi.2008.09.003
Reference
4  [PMID:20018886]
  Authors
Ghosh J, Anderson PJ, Chandrasekaran S, Caparon MG
  Title
Characterization of Streptococcus pyogenes beta-NAD+ glycohydrolase: re-evaluation of enzymatic properties associated with pathogenesis.
  Journal
J Biol Chem 285:5683-94 (2010)
DOI:10.1074/jbc.M109.070300
Reference
5  [PMID:21300288]
  Authors
Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T
  Title
Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.
  Journal
Structure 19:192-202 (2011)
DOI:10.1016/j.str.2010.12.013
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.5
IUBMB Enzyme Nomenclature: 3.2.2.5
ExPASy - ENZYME nomenclature database: 3.2.2.5
BRENDA, the Enzyme Database: 3.2.2.5
CAS: 9025-46-1
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