KEGG ENZYME: 3.4.21.108

ENZYME: 3.4.21.108

Entry

EC 3.4.21.108               Enzyme

Name

HtrA2 peptidase;
high temperature requirement protein A2;
HtrA2;
Omi stress-regulated endoprotease;
serine proteinase OMI;
HtrA2 protease;
OMI/HtrA2 protease;
HtrA2/Omi;
Omi/HtrA2

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues

Comment

This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment [4]. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP) [3]. Belongs in peptidase family S1C.

History

EC 3.4.21.108 created 2006

Orthology

K08669

HtrA serine peptidase 2

Genes

HSA:	27429(HTRA2)

PTR:	459339(HTRA2)

PPS:	100985283(HTRA2)

GGO:	101153780(HTRA2)

PON:	100461940(HTRA2)

PPYG:

129029966(HTRA2)

NLE:	100591213(HTRA2)

HMH:	116483898(HTRA2)

SSYN:

129461556(HTRA2)

MCC:	709938(HTRA2)

MCF:	102126403(HTRA2)

MTHB:

126933984

MNI:	105465308(HTRA2)

CSAB:

103220019(HTRA2)

CATY:

105596870(HTRA2)

PANU:

100999628(HTRA2)

TGE:	112637005(HTRA2)

MLEU:

105540209(HTRA2)

RRO:	104674825(HTRA2)

RBB:	108531686(HTRA2)

TFN:	117062068(HTRA2)

PTEH:

111523451(HTRA2)

CANG:

105514609(HTRA2)

CJC:	100385512(HTRA2)

SBQ:	101046884(HTRA2)

CIMI:

108289325(HTRA2)

ANAN:

105717145(HTRA2)

CSYR:

103251916(HTRA2)

MMUR:

105884574(HTRA2)

LCAT:

123637092(HTRA2)

PCOQ:

105821488(HTRA2)

OGA:	100965412(HTRA2)

MMU:	64704(Htra2)

MCAL:

110295867(Htra2)

MPAH:

110317283(Htra2)

RNO:	297376(Htra2)

MCOC:

116099123(Htra2)

ANU:	117715331(Htra2)

ASYL:

127678819(Htra2)

MUN:	110541049(Htra2)

CGE:	100760629(Htra2)

MAUA:

101833773(Htra2)

PROB:

127235774(Htra2)

PLEU:

114694427(Htra2)

MORG:

121439551(Htra2)

MFOT:

126515304

AAMP:

119806736(Htra2)

NGI:	103726986(Htra2)

HGL:	101725239(Htra2)

CPOC:

100734064(Htra2)

CCAN:

109692441(Htra2)

DORD:

105999574(Htra2)

DSP:	122125215(Htra2)

PLOP:

125356383(Htra2)

MMMA:

107154234(Htra2)

ITI:	101971420(Htra2)

OCU:

100338967

OPI:	101517086(HTRA2)

TUP:	102501824(HTRA2)

GVR:	103593845(HTRA2)

CFA:	475782(HTRA2)

CLUD:

112664260(HTRA2)

VVP:	112916707(HTRA2)

VLG:	121490681(HTRA2)

NPO:	129501268(HTRA2)

AML:	100471770(HTRA2)

UMR:	103671421(HTRA2)

UAH:	113243611(HTRA2)

UAR:	123786085(HTRA2)

ELK:

111148182

LLV:

125108306

MPUF:

101681959(HTRA2)

MNP:	132021422(HTRA2)

MLK:	131840338(HTRA2)

NVS:	122915023(HTRA2)

ORO:	101375505 101382419(HTRA2)

EJU:	114218893(HTRA2)

ZCA:	113936941(HTRA2)

MLX:	118007942(HTRA2)

NSU:	110588722(HTRA2)

LWW:	102732477(HTRA2)

FCA:	768259(HTRA2)

PYU:	121019218(HTRA2)

PCOO:

112869042(HTRA2)

PBG:	122497060(HTRA2)

PVIV:

125161606(HTRA2)

LRUF:

124502982

LGF:	123581006(HTRA2)

AJU:

106988577

PTG:	102968855(HTRA2)

PPAD:

109263345(HTRA2)

PUC:

125937141

PLEZ:

122216238(HTRA2)

HHV:	120237033(HTRA2)

BTA:	523039(HTRA2)

BOM:	102273081(HTRA2)

BIU:	109565903(HTRA2)

BBUB:

102389817(HTRA2)

BBIS:

104980877(HTRA2)

CHX:	102181963(HTRA2)

OAS:	101120228(HTRA2)

BTAX:

128055221(HTRA2)

CSUM:

138084138(HTRA2)

ODA:	120851251(HTRA2)

CCAD:

122441473(HTRA2)

MREE:

136164533(HTRA2)

OVR:	110138544(HTRA2)

MBEZ:

129538979(HTRA2)

SSC:	100512831(HTRA2)

CFR:	102522927(HTRA2)

CBAI:

105078073(HTRA2)

CDK:	105105950(HTRA2)

VPC:	102534828(HTRA2)

BACU:

103003966(HTRA2)

BMUS:

118905936(HTRA2)

LVE:	103086746(HTRA2)

OOR:	101276862(HTRA2)

LALB:

132531762(HTRA2)

DLE:	111169079(HTRA2)

PCAD:

102995172(HTRA2)

PSIU:

116764730(HTRA2)

NASI:

112413631(HTRA2)

ECB:	100053688(HTRA2)

EPZ:	103557683(HTRA2)

EAI:	106823864(HTRA2)

MYB:	102242360(HTRA2)

MYD:	102772576(HTRA2)

MMYO:

118668824(HTRA2)

MLF:	102430969(HTRA2)

MDT:	132213178(HTRA2)

MYUM:

139020030(HTRA2)

PKL:	118717574(HTRA2) 118726900

EFUS:

103291391(HTRA2)

MNA:	107529250(HTRA2)

DRO:	112303094(HTRA2)

SHON:

119000105(HTRA2)

AJM:	119038363(HTRA2)

PDIC:

114500921(HTRA2)

PHAS:

123811483(HTRA2)

MMF:	118630461(HTRA2)

PPAM:

129086785(HTRA2)

HAI:	109371208(HTRA2)

RFQ:	117033097(HTRA2)

PALE:

102890616(HTRA2)

PGIG:

120594570(HTRA2)

PVP:	105290726(HTRA2)

RAY:	107502930(HTRA2)

MJV:	108402276(HTRA2)

TOD:	119259102(HTRA2)

SARA:

101537740(HTRA2)

SFUM:

130025801(HTRA2)

SETR:

126024593(HTRA2)

LAV:	100659066(HTRA2)

TMU:

101344176

ETF:	101644287(HTRA2)

DNM:	101422887(HTRA2)

MDO:	100025882(HTRA2)

GAS:	123251237(HTRA2)

SHR:	100923981(HTRA2)

AFZ:

127541189

PCW:	110221089(HTRA2)

TVP:	118853046(HTRA2)

PBRV:

138148941(HTRA2)

OAA:	114811155(HTRA2)

TACU:

119927198(HTRA2)

GGA:	395990(HTRA2)

PCOC:

116225954(HTRA2)

MGP:	100538527(HTRA2)

CJO:	107306835(HTRA2)

TPAI:

128071993(HTRA2)

LMUT:

125692673(HTRA2)

NMEL:

110390926(HTRA2)

APLA:

101802615(HTRA2)

ACYG:

106043211(HTRA2)

CATA:

118260606(HTRA2)

AFUL:

116489251(HTRA2)

TGU:	115494796(HTRA2)

LSR:	110468691(HTRA2)

SCAN:

103823115(HTRA2)

PMOA:

120509181(HTRA2)

OTC:	121334999(HTRA2)

PRUF:

121364686(HTRA2)

ATRC:

139604662(HTRA2)

GFR:	102042326(HTRA2)

FAB:	101806812(HTRA2)

OMA:	130252080(HTRA2)

PHI:	102107154(HTRA2)

PMAJ:

107203523(HTRA2)

CCAE:

111929153(HTRA2)

CCW:	104690945(HTRA2)

CBRC:

103621144(HTRA2)

ACOE:

138110097(HTRA2)

ETL:	114068870(HTRA2)

ZAB:	102073494(HTRA2)

ZLE:	135447179(HTRA2)

SVG:	106853114(HTRA2)

MMEA:

130575443(HTRA2)

HRT:	120753458(HTRA2)

SATI:

136360317(HTRA2)

CCIC:

134044171(HTRA2)

FPG:	101914636(HTRA2)

FCH:	102050387(HTRA2)

CCRI:

104158899(HTRA2)

NNT:	104407518(HTRA2)

SHAB:

115603591(HTRA2)

ACUN:

113490506(HTRA2)

TALA:

104357118(HTRA2)

ACHC:

115338040(HTRA2)

HALD:

104323727

HLE:	104832327(HTRA2)

AGEN:

126034425

HHAR:

128139056(HTRA2)

GCL:

127015433

LDI:

104344932

DPUB:

104304160(HTRA2)

PPUS:

135178285(HTRA2)

EGZ:	104130002(HTRA2)

NNI:	104013943(HTRA2)

PCRI:

104033270(HTRA2)

PCAO:

104048057

PADL:

103922175(HTRA2)

AFOR:

103902152(HTRA2)

FGA:

104077444

GSTE:

104253882(HTRA2)

CLV:	102085893(HTRA2)

PLET:

104627978(HTRA2)

CUCA:

104056875(HTRA2)

BREG:

104631783(HTRA2)

OHA:	104327021(HTRA2)

CPEA:

104398131(HTRA2)

CVF:	104294205(HTRA2)

RTD:	128910329(HTRA2)

CRID:

134516077(HTRA2)

AAM:	106487415(HTRA2)

AROW:

112978200(HTRA2)

NPD:	112954033(HTRA2)

TGT:

104575976

DNE:	112995277(HTRA2)

SCAM:

104141829(HTRA2)

ASN:	102378167(HTRA2)

AMJ:	102573820(HTRA2)

CPOO:

109324453(HTRA2)

GGN:

109291026

PSS:	102456624(HTRA2)

CMY:	102937290(HTRA2)

CCAY:

125635208(HTRA2)

DCC:	119854643(HTRA2)

CPIC:

101936375(HTRA2)

TST:	117878397(HTRA2)

CABI:

116830477(HTRA2)

MRV:	120406783(HTRA2)

ACS:	100565079(htra2)

ASAO:

132777143(HTRA2)

PVT:	110079828(HTRA2)

SUND:

121931747(HTRA2)

PBI:	103059726(HTRA2)

PMUR:

107292494(HTRA2)

CTIG:

120303956(HTRA2)

TSR:	106538932(HTRA2)

PGUT:

117670678(HTRA2)

APRI:

131203309(HTRA2)

PTEX:

113447164(HTRA2)

NSS:	113417909(HTRA2)

VKO:	123022581(HTRA2)

PMUA:

114603783(HTRA2)

PRAF:

128420645(HTRA2)

ZVI:	118095517(HTRA2)

HCG:	128326349(HTRA2)

GJA:	107110467(HTRA2)

STOW:

125439669(HTRA2)

EMC:	129336917(HTRA2)

XLA:	108706463(htra2.S)

XTR:	100492982(htra2)

NPR:

108804097

RTEM:

120921526(HTRA2)

BBUF:

120990589(HTRA2)

BGAR:

122923779(HTRA2)

PWL:	138249339(HTRA2)

MUO:	115461203(HTRA2)

GSH:	117365207(HTRA2)

DRE:	100137109(htra2-14) 100149563 110438948 110438965 560917 797799 799791(htra2-7)

SRX:	107708385 107733689

SANH:

107678491 107690150

SGH:

107582530

CCAR:

109054998

CAUA:

113057043

CGIB:

127970236

PTET:

122356791

LROH:

127175604

OMC:

131552595

PPRM:

120479419

RKG:

130083068

MAMB:

125276591

CIDE:

127524653

CERY:

137020367

MASI:

127412466 127414229

TROS:

130559159

TDW:

130431847

MANU:

129416057

PDAB:

135787261

IPU:

108263241

IFU:

128605501

PHYP:

113539574(htra2)

SMEO:

124402477

TFD:

113639859

TVC:

132847203

CGAR:

128529474

NGRA:

132889346

TRN:

134315104

AMEX:

103043568

CMAO:

118810305

EEE:	113585783(htra2)

CHAR:

105899646

SPIL:

134067380

TRU:	101079124(htra2)

TFS:

130540195

TNG:	GSTEN00032214G001

LCO:

104921575

NCC:

104960364

TBEN:

117480412

CGOB:

115027100(htra2)

PGEO:

117467719

GACU:

117549823

EMAC:

134881437

ELY:

117266700

EFO:

125900377

PLEP:

121953346

SLUC:

116035658

ECRA:

117936052

ESP:	116669612(htra2)

PFLV:

114546640(htra2)

GAT:

120832623

PPUG:

119227317

AFB:

129103317

CLUM:

117751278

PSWI:

130201960

CANA:

137787614

CVE:

137884487

MSAM:

119903298

SCHU:

122861507

CUD:

121526039

SPUL:

138590864

LMIX:

132993663

ALAT:

119004606

ASTR:

137610890

MZE:

101482753

ONL:

100693638

OAU:

116334688

OLA:

101174474

OML:

112157885

CSAI:

133462012

XMA:	102226566(htra2)

XCO:	114134420(htra2)

XHE:	116708980 116708981

PRET:

103458895(htra2)

PFOR:

103144266

PLAI:

106963707

PMEI:

106918274

GAF:

122845789

PPRL:

129374773

CVG:

107087576

CTUL:

119784285

GMU:

124855804

NFU:

107392303

KMR:

108235278

ALIM:

106521377

NWH:

119427318

AOCE:

111578923

EJA:

138199946

BFRE:

138630547

MCEP:

125023264

CSEM:

103376892

POV:

109628063

SSEN:

122782664

SSOE:

131444463

HHIP:

117755592

HSP:

118116153

PPLT:

128451500

SMAU:

118286011

LCF:

108892481

SDU:

111225343

SLAL:

111651107(htra2)

XGL:

120795653

HCQ:	109522905(htra2)

SSCV:

125981385

SBIA:

133512933

PEE:

133412715

PTAO:

133487722

BPEC:

110155255(htra2)

ENY:

140371060

MALB:

109955094

BSPL:

114848171

SJO:

128375916

SSCO:

134000556

GMH:	115543981(htra2)

SASA:

106589831

STRU:

115201642

OTW:

112224672

OMY:

110499413

OGO:

124040381

OKI:

109888869

OKE:

118402736

OMM:

135523430

OCLA:

139376947

SALP:

111968136

SNH:

120029524

CCLU:

121547701 121552217

ELS:

105015851

OEP:

134026392

SFM:

108918851

PKI:

111845796

AANG:

118227649 118231742

AROT:

135254756 135259625

CCOG:

133131740

LOC:	102688355(htra2)

PSPA:

121315538 121331242

ARUT:

117409633 117420941

PSEX:

120527899

LCM:	102356234(HTRA2)

CMK:

103173274

CPLA:

122555148

LERI:

129695061

BFO:

118413391

BBEL:

109471472

SCLV:

120344804

SPU:	115918650 756975

LPIC:

129273579

AJJ:

139967423

APLC:

110973949

ARUN:

117294977

AAMU:

139941005

AFIL:

140151306

AJC:

117105771

SKO:

102807217

PFLL:

139120640

DME:	Dmel_CG8464(HtrA2)

DER:

6552632

DSE:

6606394

DSI:	Dsimw501_GD20417(Dsim_GD20417)

DYA:	Dyak_GE26447

DAN:

6500264

DSR:

110176513

DPO:

4801955

DPE:

6588623

DMN:

108157255

DWI:

6647029

DGR:

6568330

DMO:	Dmoj_GI24802

DAZ:

108620802

DNV:

108660102

DHE:

111601551

DVI:	6630732(HtrA2)

CCAT:

101457197

BOD:

106625313

BDR:

105229787

RZE:	108364219 108379064

AOQ:

129235390

ALUD:

128855100

TDA:	119678863 119683986

MDE:	101893592 131801165

SCAC:

106089054

LCQ:

111675035

LSQ:

119601498

CVJ:	135963559(HtrA2)

GFS:

119640149

ECOE:

129951948

CLON:

129614284

HIS:	119650663 119650665 119653370

AGA:

1272021

ACOZ:

120959623

AARA:

120905933

AMER:

121598464

ASTE:

118506942

AMAP:

126558041

AFUN:

125771053

AMOU:

128307094

AMRS:

128719781

AALI:

118459981

ACOS:

131269279

AAG:

5567933

AALB:

109414079 115256087

ASUA:

134205707

CQU:	CpipJ_CPIJ005160 CpipJ_CPIJ019291

CPII:

128092479

CNS:

116346677

BCOO:

119066862

LLL:

129787442

PPAP:

129798065 129799514

AME:

551969

ACER:

107997943

ALAB:

122713768

ADR:

102671434

AFLR:

100871743

BIM:

100747622

BBIF:

117208046

BVK:

117240222

BVAN:

117164541

BHUN:

126870252

BTER:

100651265

BAFF:

126924130

BPYO:

122576016

BPAS:

132912017

FVI:

122531742

CCAL:

108623857

OBB:

114872063

OLG:

117603623

MGEN:

117219609

NMEA:

116432289

CGIG:

122405263

SOC:

105199767

MPHA:

105830742

AEC:

105152625

ACEP:

105624355

PBAR:

105432441

VEM:

105564315

COBS:

139113270(Htra2)

TLN:	139809163(Htra2)

HST:

105188006

DQU:

106750279

CFO:

105256231

FEX:

115243091

PMEC:

138934741(Htra2)

LHU:	105672452(HtrA2)

PGC:

109861450

OBO:

105274742

PCF:

106791733

PFUC:

122518764

VPS:

122637894

VCRB:

124422666

VVE:

124946966

NVI:

100122950

CSOL:

105368312

TPRE:

106651887

LHT:	122509625 122509666

LBD:	127286547 127286589

MDL:

103578876

CGLO:

123274441

FAS:

105266736

DAM:

107040704

AGIF:

122854409

CINS:

118067425

VCAN:

122410180

CCIN:

107272031

DSM:

124415996

NPT:	124212779(HtrA2)

NFB:

124174641

NLO:

107221928

NVG:

124301517

AROA:

105689081

TCA:	657089 657173

TMOL:

138127030 138138716

DPA:

109538837

ESIM:

136411684(HtrA2)

EFOR:

136349235(HtrA2)

SOY:	115883491 115885849

AGRG:

126739416 126739657

ATD:	109603615 109605817

CSET:

123321414 123322973

HAXR:

123672726 123673423

AGB:	108909361 108914966

LDC:	111516164 111516878

DVV:	114341488 126885264

NVL:	108558222 108561986

APLN:

108736222 108744581

PPYR:

116173013 116174078 116174361

OTU:	111415963 111417190

BMOR:

100533207(htra2)

BMAN:

114248093 114248094

MSEX:

115453358

DPL:	KGM_208208 KGM_208209A

BANY:

112051830

MJU:

123877486

NIQ:

126778331

VCD:	124539738 124539739

MCIX:

123665162

PMAC:

106713982

PPOT:

106110637

PXU:

106116412

BPHI:

137925862

PRAP:

110994139

PBX:

123720862

PNAP:

125054904

ZCE:

119837952

CCRC:

123702726

LSIN:

126977177

AAGE:

121737846

HAW:

110379176

HZE:

124641857

TNL:	113495117 113495493

SLIU:

111356977

OFU:

114351337

ONU:

135083857

ATRA:

106129280

GMW:

113519587

PXY:

105386447

PGW:

126377264

LGLY:

125238300

CSTB:

134750693

CFEL:

113374458 113382759

CCRN:

123297754

BTAB:

109042751

DCI:

103513681

CLEC:

106670287

HHAL:

106679589(HtrA2)

NLU:

111049046

HVI:

124359809

MQU:

128986285

PHU:	Phum_PHUM529710

FOC:

113208860

TPAL:

117649824

ZNE:

110835296

CSEC:

111861347

SGRE:

126282288

BROR:

134539434

IEL:

124154102

HAMR:

139688230(HtrA2)

FCD:

110858213

DPZ:

124335797

AFRA:

136027111

PVM:	113804151(HtrA2)

PJA:

122256331

PCHN:

125046636

PMOO:

119575961 119591398

HAME:

121859542

PCLA:

123745529(HtrA2)

CQD:	128697462(HtrA2)

PTRU:

123513944

ESN:

126985038

MNZ:	135225265 135225266

MRJ:	136848121(HtrA2)

PORN:

139745728(HtrA2)

HAZT:

108668712

EAF:

111717466

LSM:	121124264(HtrA2)

TCF:

131890026

PPOI:

119112121

DSV:

119437453

RSAN:

119392517

RMP:

119160800

DPTE:

113798514

CSCU:

111623622

CVS:	136987301(HtrA2)

PTEP:

107446348

UDV:

129218019

SDM:

118186308

LPOL:

106469650

PMEO:

129599891 129599911

TSP:	Tsp_09197 Tsp_09212

HRO:	HELRODRAFT_82139

PCAN:

112565039

LSAX:

138981567

BGT:	106059316 106067187

GAE:

121384327

HRF:

124117397

HRJ:	124267384 124281929

HASI:

137265244

HCRA:

139452372

CRG:

105347711

CANU:

128181202

CVN:

111133695

OED:

125657589

MCAF:

127706096

OBI:

106876978

OSN:

115219868

LJP:

135466695

LAK:

106151169

SMM:	Smp_211260

SHX:	MS3_00005043(HTRA2_1)

OVI:	T265_06722

EGL:

EGR_02598

LLON:

135489469

NVE:

116617828

EPA:

110232501

ADF:

107348404

AMIL:

114963716

MCAZ:

138042976

MFOO:

138007281

PDAM:

113671173

SPIS:

111326210

DGT:

114516112

HMG:

101239153

HSY:

130644977

RES:	135692652 135695982

TAD:	TRIADDRAFT_58565

AQU:	100637088 105312877

ATH:	AT5G27660(DEG14)

ALY:	9308332 9325896

CRB:

17883659

CSAT:

104707036 104736749 104771198

EUS:	EUTSA_v10004245mg

BRP:

103874520

BNA:	106348679 106407376

BOE:

106306356

RSZ:	108854973 130495218

THJ:

104802800

CIT:

102608405

CIC:	CICLE_v10001167mg

PVY:

116111841

MINC:

123197839

TCC:	18600461 18600462

GRA:

105792510

GHI:

107894209

GAB:

108468039

HSYR:

120116213

DZI:

111293631

EGR:	104415569 104417702 104429273

RARG:

115743838 115743843

GSJ:

114398353

PVU:

137831682

VRA:

106775158

VAR:

108342259

MTR:

11430547

TPRA:

123890924

CAM:

101500419

PSAT:

127132374

VVO:

131610590

LJA:	130731173 130731177

ADU:

107492133

AIP:

107645908

AHF:	112695532 112758373

LANG:

109329681

QSA:	O6P43_007498

AANS:

126798376 126800810

PPER:

18772880

PMUM:

103344586

PAVI:

110759195

MDM:	103408538 103430468

PXB:

103965318

PCOX:

137722423 137745543

ZJU:

107411888

MNT:	21383913 21390093

CSV:

101212324

CMO:

103494739

BHJ:

120080204

MCHA:

111018849

CMAX:

111465556

CMOS:

111444435

CPEP:

111798791

RCU:

8287072

MEAN:

126675335

JCU:

105647513

HBR:

110659756

MESC:

110620825

POP:

7473270

PEU:

105125071

PALZ:

118060835

PNZ:

133669421

JRE:

109012743

CILL:

122316749

CAVE:

132171605 132171606

AGLU:

133851029

QSU:

112024241

QLO:	115979360 115979955 115980370

TWL:	120010734 120011045

VVI:

100264796

VRI:

117930880

CANN:

107863029

LBB:

132621797

NTA:	107774648 107790499

NSY:

104247943

NTO:

104112327

NAU:

109242764

INI:

109181984

ITR:

116006573

SIND:

105172372

OEU:

111386814

EGT:	105960795 105966285

SSPL:

121797426 121801255

SMIL:

130996914

SHIS:

125203927

APAN:

127261382

HAN:

110890458

ECAD:

122592869

LSV:

111884540

CCAV:

112505655

DCR:

108224612

CSIN:

114314077

AEW:

130794377

DLT:	127801994 127802077

BVG:

104890298

SOE:

110794681

CQI:

110736872

ATRI:

130796824

MOF:

131154235

NNU:

104609043

MING:

122082010

TSS:

122667510

PSOM:

113279085 113290163

OSA:

4350193

DOSA:

Os11g0246600

OBR:

102706235

OGL:

127753728

BDI:

100822885

ATS:

109732288

TDC:	119286577 119295187

TAES:

123086771 123091208 123096196

TUA:

125550711

LPER:

127293991 127293993

LRD:	124699588 124699771 124699772

SBI:

8057143

ZMA:

100277723

MFLO:

136481770

SITA:

101768487

SVS:

117866466

PVIR:

120643949 120686550

PHAI:

112872446

PAUA:

133887418 133900238

PDA:

103715494

EGU:

105051535

MUS:	103989835 135620438 135622746

ZOF:	122001036 122005320 122017557 122049217

DCT:

110101476

PEQ:

110033765

AOF:

109827286

MSIN:

131240293

ACAK:

137951870

ATR:

18448569

CJF:

131042466

SMO:	SELMODRAFT_164697 SELMODRAFT_185147

PPP:

112283886

CSL:	COCSUDRAFT_28277

CVR:	CHLNCDRAFT_18457

APRO:

F751_2338

CCP:	CHC_T00007659001

PIF:	PITG_03582

PSOJ:

PHYSODRAFT_537128

SPAR:

SPRG_10340

IDO:	I598_0941(htrA_1)

» show all

Reference

1 [PMID:12835328]

Authors

Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.

Title

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.

Journal

J Biol Chem 278:31469-72 (2003)
DOI:10.1074/jbc.C300240200

Reference

2 [PMID:10873535]

Authors

Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, Gray CW, Ward RV, Jenkins O, Creasy CL.

Title

Expression, purification, and functional analysis of the human serine protease HtrA2.

Journal

Protein Expr Purif 19:227-34 (2000)
DOI:10.1006/prep.2000.1240

Sequence

[hsa:27429]

Reference

3 [PMID:14512424]

Authors

Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J.

Title

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.

Journal

J Biol Chem 278:49417-27 (2003)
DOI:10.1074/jbc.M308659200

Sequence

[hsa:27429]

Reference

4 [PMID:10971580]

Authors

Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL

Title

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

Journal

Eur J Biochem 267:5699-710 (2000)
DOI:10.1046/j.1432-1327.2000.01589.x

Sequence

[hsa:27429] [mmu:64704]

Reference

5 [PMID:11967569]

Authors

Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y.

Title

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.

Journal

Nat Struct Biol 9:436-41 (2002)
DOI:10.1038/nsb795

Sequence

[hsa:27429]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.108

IUBMB Enzyme Nomenclature:

3.4.21.108

ExPASy - ENZYME nomenclature database:

3.4.21.108

BRENDA, the Enzyme Database:

3.4.21.108

LinkDB

DBGET integrated database retrieval system