Homo sapiens (human): 27429
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Entry
27429 CDS
T01001
Symbol
HTRA2, MGCA8, OMI, PARK13, PRSS25
Name
(RefSeq) HtrA serine peptidase 2
KO
K08669
HtrA serine peptidase 2 [EC:
3.4.21.108
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa05012
Parkinson disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06463
Parkinson disease
nt06466
Pathways of neurodegeneration
Element
N01048
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
Disease
H00057
Parkinson disease
H00754
3-Methylglutaconic aciduria
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
27429 (HTRA2)
04215 Apoptosis - multiple species
27429 (HTRA2)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
27429 (HTRA2)
05022 Pathways of neurodegeneration - multiple diseases
27429 (HTRA2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
27429 (HTRA2)
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
27429 (HTRA2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.108 HtrA2 peptidase
27429 (HTRA2)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S1: chymotrypsin family
27429 (HTRA2)
Chaperones and folding catalysts [BR:
hsa03110
]
Other chaperones and cochaperones
DegP / HtrA
27429 (HTRA2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Trypsin_2
Trypsin
PDZ_6
PDZ_2
PDZ
Peptidase_S46
GRASP55_65
PDZ_Tricorn
Motif
Other DBs
NCBI-GeneID:
27429
NCBI-ProteinID:
NP_037379
OMIM:
606441
HGNC:
14348
Ensembl:
ENSG00000115317
UniProt:
O43464
A0A384MDW9
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:74529405..74533556
Genome browser
AA seq
458 aa
AA seq
DB search
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
NT seq
1377 nt
NT seq
+upstream
nt +downstream
nt
atggctgcgccgagggcggggcggggtgcaggctggagccttcgggcatggcgggctttg
gggggcattcgctgggggaggagaccccgtttgacccctgacctccgggccctgctgacg
tcaggaacttctgacccccgggcccgagtgacttatgggacccccagtctctgggcccgg
ttgtctgttggggtcactgaaccccgagcatgcctgacgtctgggaccccgggtccccgg
gcacaactgactgcggtgaccccagataccaggacccgggaggcctcagagaactctgga
acccgttcgcgcgcgtggctggcggtggcgctgggcgctgggggggcagtgctgttgttg
ttgtggggcgggggtcggggtcctccggccgtcctcgccgccgtccctagcccgccgccc
gcttctccccggagtcagtacaacttcatcgcagatgtggtggagaagacagcacctgcc
gtggtctatatcgagatcctggaccggcaccctttcttgggccgcgaggtccctatctcg
aacggctcaggattcgtggtggctgccgatgggctcattgtcaccaacgcccatgtggtg
gctgatcggcgcagagtccgtgtgagactgctaagcggcgacacgtatgaggccgtggtc
acagctgtggatcccgtggcagacatcgcaacgctgaggattcagactaaggagcctctc
cccacgctgcctctgggacgctcagctgatgtccggcaaggggagtttgttgttgccatg
ggaagtccctttgcactgcagaacacgatcacatccggcattgttagctctgctcagcgt
ccagccagagacctgggactcccccaaaccaatgtggaatacattcaaactgatgcagct
attgattttggaaactctggaggtcccctggttaacctggatggggaggtgattggagtg
aacaccatgaaggtcacagctggaatctcctttgccatcccttctgatcgtcttcgagag
tttctgcatcgtggggaaaagaagaattcctcctccggaatcagtgggtcccagcggcgc
tacattggggtgatgatgctgaccctgagtcccagcatccttgctgaactacagcttcga
gaaccaagctttcccgatgttcagcatggtgtactcatccataaagtcatcctgggctcc
cctgcacaccgggctggtctgcggcctggtgatgtgattttggccattggggagcagatg
gtacaaaatgctgaagatgtttatgaagctgttcgaacccaatcccagttggcagtgcag
atccggcggggacgagaaacactgaccttatatgtgacccctgaggtcacagaatga
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