KEGG   ENZYME: 3.4.21.41
Entry
EC 3.4.21.41                Enzyme                                 
Name
complement subcomponent C_overbar_1r_;
activated complement C1r;
C_overbar_1r_ esterase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Lys(or Arg)!Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42)
Comment
Activated from proenzyme C_overbar_1r_ in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family)
History
EC 3.4.21.41 created 1981
Orthology
K01330  complement component 1, r subcomponent
Genes
HSA715(C1R)
PTR466939(C1R)
PPS100991297(C1R)
GGO101148245(C1R)
PON100173855(C1R) 112135770
NLE100591142(C1R)
MCC722133 722144
MCF101866354 102135038
MTHB126930475 126930487
CSAB103218858(C1R)
CATY105583055(C1R)
PANU101009229 101009900(C1R)
RRO104681686
RBB108542014(C1R)
TFN117090591
PTEH111555907 113222928 113222932 113222937 113222938 113222939
CANG105519176(C1R)
CJC100386784(C1R)
SBQ101033061(C1R)
MMUR105869012(C1R)
LCAT123640083(C1R)
PCOQ105805061(C1R)
OGA100946113(C1R)
MMU50909(C1ra) 667277(C1rb)
MPAH110314999 110316472(C1r)
RNO312705(C1r)
MCOC116099565(C1r)
MUN110548593(C1r)
CGE100768476(C1r)
MAUA101837653(C1r)
PLEU114708807(C1r)
MORG121440981(C1r)
MFOT126514807
AAMP119807677(C1r)
NGI103727485(C1r)
HGL101717538(C1r)
CPOC100733374(C1r)
CCAN109682779(C1r)
DORD105991115(C1r)
DSP122097951(C1r)
NCAR124982534
OCU100342793
OPI101532973(C1R)
TUP102496021(C1R)
GVR103595775(C1R)
CFA477707(C1R)
CLUD112675377(C1R)
VVP112917317(C1R)
VLG121480339(C1R)
AML100472269(C1R)
UMR103656175(C1R)
UAH113257944(C1R)
UAR123781659(C1R)
ELK111159719
LLV125106219
MPUF101675669(C1R)
ORO101377329(C1R)
EJU114222545(C1R)
ZCA113922199(C1R)
MLX118025712(C1R)
NSU110579815(C1R)
LWW102737696(C1R)
FCA101088940 111561323(C1R)
PYU121022107(C1R)
PBG122472397(C1R)
LRUF124502378
PTG102972961(C1R)
PPAD109276088(C1R)
AJU106965334(C1R)
HHV120220469(C1R)
BTA511581(C1R)
BOM102264626(C1R) 102270366 102275017
BIU109558321 109558899 109558901(C1R)
BBUB102395781(C1R) 102412971 112584474
BBIS104992161(C1R)
CHX102188569 102188835(C1R)
OAS101107430(C1R)
ODA120858754(C1R)
CCAD122423663(C1R)
SSC445464(C1R)
CBAI105075582(C1R)
CDK105098187(C1R)
VPC102534527(C1R)
BACU103014234(C1R)
LVE103085319(C1R)
OOR101269650(C1R)
DLE111176709(C1R)
PCAD102987961(C1R)
PSIU116760464(C1R)
ECB100060297(C1R)
EPZ103563701(C1R)
EAI106847307(C1R)
MYB102255103(C1R)
MYD102754399(C1R)
MMYO118651308(C1R)
MLF102433529(C1R)
MNA107544003(C1R)
PKL118730584(C1R)
HAI109373632(C1R)
DRO112321892(C1R)
SHON119002277(C1R)
AJM119065713(C1R)
PDIC114513729(C1R)
PHAS123810702(C1R)
MMF118623285(C1R)
RFQ117029197(C1R)
PALE102897527(C1R)
PGIG120611679(C1R)
PVP105295937(C1R)
RAY107519842(C1R)
MJV108384823(C1R)
TOD119247045(C1RL)
SARA101547327(C1R)
LAV100658090(C1R)
TMU101359146
ETF101663421(C1R)
DNM101422209
MDO100016799(C1R) 100016836
GAS123250037(C1R)
SHR100925028(C1R)
PCW110213817(C1R) 110213855(C1RL)
OAA100090998(C1R)
GGA418295(C1R)
PCOC116239943(C1R)
MGP100549554(C1R)
CJO107318585(C1R)
NMEL110398250(C1R)
APLA101791982(C1R)
ACYG106047869(C1R)
AFUL116502151(C1R)
TGU100224962(C1R)
LSR110480854(C1R)
SCAN103812469(C1R)
PMOA120506470(C1R)
OTC121339350(C1R)
PRUF121351613(C1R)
GFR102043291(C1R)
FAB101809091(C1R)
PHI102111934(C1R)
PMAJ107207095(C1R)
CCAE111938131(C1R)
CCW104687137(C1R)
CBRC103614069(C1R)
ETL114058183(C1R)
ZAB102071226(C1R)
ACHL103799612(C1R)
FPG101920055(C1R)
FCH102054607(C1R)
CLV102093497(C1R)
EGZ104126607(C1R)
NNI104009783(C1R)
PLET104614540(C1R)
PCRI104024134(C1R)
PCAO104045747(C1R)
ACUN113479831(C1R)
TALA104355628(C1R)
PADL103921890(C1R)
AFOR103905509(C1R)
ACHC115343834(C1R)
HALD104310508(C1R)
HLE104831870(C1R)
AGEN126048885
GCL127014751
CCRI104154776(C1R)
CSTI104557955(C1R)
EHS104513641(C1R)
CMAC104473298(C1R)
MUI104540488(C1R)
FGA104078998(C1R)
GSTE104257360(C1R)
LDI104346354(C1R)
MNB103770373(C1R)
OHA104327150(C1R)
NNT104399396(C1R)
DPUB104299509
PGUU104463168(C1R)
ACAR104517824(C1R)
CPEA104389826(C1R)
AVIT104279031(C1R)
CVF104293353(C1R)
CUCA104064392(C1R)
TEO104374570(C1R)
BRHI104495691(C1R)
AAM106497213(C1R)
AROW112973021(C1R)
NPD112945581(C1R)
TGT104565656(C1R)
DNE112991081(C1R)
SCAM104150724(C1R)
ASN102373027(C1R)
AMJ102572656(C1R)
CPOO109319371(C1R)
GGN109304739(C1R)
PSS102453764(C1R)
CMY102947496(C1R)
CPIC101944886(C1R)
TST117875658 117885626(C1R)
CABI116821038(C1R)
MRV120370724 120401962(C1R)
ACS100558220(c1r)
PVT110084645(C1R)
SUND121923276(C1R)
PBI103064088(C1R)
PMUR107285781(C1R)
CTIG120306116(C1R)
TSR106553558(C1R)
PGUT117661833(C1R)
VKO123033201(C1R)
PMUA114587897(C1R)
ZVI118097746(C1R)
GJA107111991(C1R)
STOW125437124(C1R)
XLA735208(MGC130869.L)
XTR613057(c1r)
NPR108784393(C1R)
RTEM120946625(C1R)
BBUF121006020(C1R)
BGAR122940308(C1R)
SRX107724791
SANH107671893
CCAR109046276 109104854 109104862
CAUA113081689 113099594 113116767
PPRM120484622
MAMB125243106 125244203 125244204 125261884
IPU108263468 108268478
PHYP113525156
SMEO124383792 124385308 124385347
TFD113636687 113644645 113647727(c1r)
AMEX103038083 111193304
EEE113574789
TRU101072466 101072695 115250370 115250377
TNGGSTEN00015326G001
LCO104932556
NCC104941465
CGOB115005684 115005685
ELY117265787 117266086
EFO125893107 125893469
SLUC116049708(c1r) 116049783
ECRA117945870
ESP116690810
PFLV114557470
GAT120810412
PPUG119197338
MSAM119896348 119897429 119898276
CUD121514155
ALAT119005710 119006317 119006318
MZE101486209
ONL100706759 112848257
OAU116323786 116323875
OLA101173495
OML112143650
XMA102236233 102236483(c1r)
XCO114142160(c1r)
XHE116716604 116717757(c1r)
PRET103477999 103478000
PFOR103136820 103136821
PLAI106955749 106955750
PMEI106921354 106921355
GAF122831002 122831004
CVG107082193
CTUL119783157
GMU124864288
NFU107379532
KMR108235398
ALIM106529165
NWH119409704(c1s.2)
AOCE111586786
MCEP125015866
POV109633063 109633301
SSEN122774705
HHIP117776780(c1r)
HSP118113178
LCF108880662
SDU111230024
SLAL111669859
XGL120784069
HCQ109515279
MALB109966183
BSPL114842912 114843081
SASA106574204 106576275 106593033
STRU115176822 115187764
OTW112244109 112247622
OMY100136073(c1r) 110503568
OGO123997148 124006285
ONE115125022 115140749
SNH120048591 120048709 120048712
CCLU121542956 121586209
ELS105019078
SFM108924259
PKI111835375
AANG118230349
LOC102687602
PSPA121296018
ARUT117425903
PSEX120535736
LCM102354841(C1R)
 » show all
Reference
1  [PMID:6281620]
  Authors
Sim RB.
  Title
The human complement system serine proteases C1r and C1s and their proenzymes.
  Journal
Methods Enzymol 80 Pt C:26-42 (1981)
DOI:10.1016/s0076-6879(81)80006-7
Reference
2  [PMID:3021205]
  Authors
Leytus SP, Kurachi K, Sakariassen KS, Davie EW
  Title
Nucleotide sequence of the cDNA coding for human complement C1r.
  Journal
Biochemistry 25:4855-63 (1986)
DOI:10.1021/bi00365a020
  Sequence
[hsa:715]
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.41
IUBMB Enzyme Nomenclature: 3.4.21.41
ExPASy - ENZYME nomenclature database: 3.4.21.41
BRENDA, the Enzyme Database: 3.4.21.41
CAS: 80295-69-8
LinkDB

DBGET integrated database retrieval system