KEGG   ENZYME: 3.4.21.41
Entry
EC 3.4.21.41                Enzyme                                 
Name
complement subcomponent C_overbar_1r_;
activated complement C1r;
C_overbar_1r_ esterase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Lys(or Arg)!Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42)
Comment
Activated from proenzyme C_overbar_1r_ in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family)
History
EC 3.4.21.41 created 1981
Orthology
K01330  complement component 1, r subcomponent
Genes
HSA715(C1R)
PTR466939(C1R)
PPS100991297(C1R)
GGO101148245(C1R)
PON100173855(C1R) 112135770
PPYG129010370 129010371
NLE100591142(C1R)
HMH116472621(C1R)
SSYN129483447(C1R)
MCC722133 722144
MCF101866354 102135038
MTHB126930475 126930487
MNI105484220(C1R) 105484253
CSAB103218858(C1R)
CATY105583055(C1R)
PANU101009229 101009900(C1R)
MLEU105541822 105541845
RRO104681686
RBB108542014(C1R)
TFN117090591
PTEH111555907 113222928 113222932 113222937 113222938 113222939
CANG105519176(C1R)
CJC100386784(C1R)
SBQ101033061(C1R)
CIMI108295009(C1R)
ANAN105731189(C1R)
MMUR105869012(C1R)
LCAT123640083(C1R)
PCOQ105805061(C1R)
OGA100946113(C1R)
MMU50909(C1ra) 667277(C1rb)
MPAH110314999 110316472(C1r)
RNO312705(C1r)
MCOC116099565(C1r)
ANU117715497(C1r)
ASYL127679179(C1r)
MUN110548593(C1r)
CGE100768476(C1r)
MAUA101837653(C1r)
PROB127239127(C1r)
PLEU114708807(C1r)
MORG121440981(C1r)
MFOT126514807
AAMP119807677(C1r)
NGI103727485(C1r)
HGL101717538(C1r)
CPOC100733374(C1r)
CCAN109682779(C1r)
DORD105991115(C1r)
DSP122097951(C1r)
DMER138803661 138835339
NCAR124982534
MMMA107154925(C1r)
ITI101975447(C1r)
OCU100342793
OPI101532973(C1R)
TUP102496021(C1R)
GVR103595775(C1R)
CFA477707(C1R)
CLUD112675377(C1R)
VVP112917317(C1R)
VLG121480339(C1R)
NPO129503431(C1R)
AML100472269(C1R)
UMR103656175(C1R)
UAH113257944(C1R)
UAR123781659(C1R)
ELK111159719
LLV125106219
MPUF101675669(C1R)
MNP132019896(C1R)
MLK131838482(C1R)
NVS122891966(C1R)
ORO101377329(C1R)
EJU114222545(C1R)
ZCA113922199(C1R)
MLX118025712(C1R)
NSU110579815(C1R)
LWW102737696(C1R)
FCA101088940(C1R)
PYU121022107(C1R)
PCOO112867898(C1R)
PBG122472397(C1R)
PVIV125170354(C1R)
LRUF124502378
LGF123589932(C1R)
AJU106965334
PTG102972961(C1R)
PPAD109276088(C1R)
PUC125918799
PLEZ122224190(C1R)
HHV120220469(C1R)
BTA511581(C1R)
BOM102264626(C1R) 102270366
BIU109558321 109558899 109558901(C1R)
BBUB102395781(C1R) 102412971 112584474
BBIS104992161(C1R)
CHX102188569 102188835(C1R)
OAS101107430(C1R)
BTAX128047412
CSUM138077747(C1R)
ODA120858754(C1R)
CCAD122423663(C1R)
MREE136172616(C1R)
OVR110128128(C1R)
MBEZ129536899(C1R)
SSC445464(C1R)
CBAI105075582(C1R)
CDK105098187(C1R)
VPC102534527(C1R)
BACU103014234(C1R)
BMUS118902500(C1R)
LVE103085319(C1R)
OOR101269650(C1R)
LALB132529907(C1R)
GMF115841006(C1R)
DDP132433469(C1R)
DLE111176709(C1R)
PCAD102987961(C1R)
PSIU116760464(C1R)
PPHC136130355(C1R)
NASI112391673(C1R)
ECB100060297(C1R)
EPZ103563701(C1R)
EAI106847307(C1R)
MYB102255103(C1R)
MYD102754399(C1R)
MMYO118651308(C1R)
MLF102433529(C1R)
MDT132227228(C1R)
MYUM139007376(C1R)
PKL118730584(C1R)
EFUS103289041(C1R)
MNA107544003(C1R)
DRO112321892(C1R)
SHON119002277(C1R)
AJM119065713(C1R)
PDIC114513729(C1R)
PHAS123810702(C1R)
MMF118623285(C1R)
PPAM129085044(C1R)
HAI109373632(C1R)
RFQ117029197(C1R)
PALE102897527(C1R)
PGIG120611679(C1R)
PVP105295937(C1R)
RAY107519842(C1R)
MJV108384823(C1R)
TOD119247045(C1R)
SARA101547327(C1R)
SFUM130016172(C1R)
SETR126006532(C1R)
LAV100658090(C1R)
TMU101359146
ETF101663421(C1R)
DNM101422209
MDO100016799(C1R) 100016836
GAS123250037(C1R)
SHR100925028(C1R)
AFZ127564331
PCW110213817(C1R) 110213855(C1RL)
TVP118850391(C1R)
PBRV138171965(C1R)
MLAO141493330(C1R)
OAA100090998(C1R)
TACU119946556(C1R)
GGA418295(C1R)
PCOC116239943(C1R)
MGP100549554(C1R)
CJO107318585(C1R)
TPAI128089837(C1R)
LMUT125687115(C1R)
NMEL110398250(C1R)
APLA101791982(C1R)
ACYG106047869(C1R)
CATA118247765(C1R)
AFUL116502151(C1R)
TGU100224962(C1R)
LSR110480854(C1R)
SCAN103812469(C1R)
PMOA120506470(C1R)
OTC121339350(C1R)
PRUF121351613(C1R)
ATRC139592805(C1R)
GFR102043291(C1R)
FAB101809091(C1R)
OMA130259803(C1R)
PHI102111934(C1R)
PMAJ107207095(C1R)
CCAE111938131(C1R)
CCW104687137(C1R)
CBRC103614069(C1R)
ACOE138111861(C1R)
ETL114058183(C1R)
ZAB102071226(C1R)
ZLE135453116(C1R)
ACHL103799612(C1R)
SVG106857859(C1R)
MMEA130574812(C1R)
HRT120748560(C1R)
SATI136375536(C1R)
CCIC134041110(C1R)
FPG101920055(C1R)
FCH102054607(C1R)
CCRI104154776(C1R)
NNT104399396(C1R)
SHAB115601494(C1R)
ACUN113479831(C1R)
TALA104355628(C1R)
ACHC115343834(C1R)
HALD104310508(C1R)
HLE104831870(C1R)
AGEN126048885
HHAR128145208(C1R)
GCL127014751
CSTI104557955(C1R)
LDI104346354(C1R)
MNB103770373(C1R)
DPUB104299509
PPUS135182079
AVIT104279031(C1R)
BRHI104495691(C1R)
EGZ104126607(C1R)
NNI104009783(C1R)
PCRI104024134(C1R)
PCAO104045747(C1R)
PADL103921890(C1R)
AFOR103905509(C1R)
FGA104078998(C1R)
GSTE104257360(C1R)
CBOY140659664(C1R)
CLV102093497(C1R)
CNIC135990186(C1R)
MUI104540488(C1R)
PGUU104463168(C1R)
PLET104614540(C1R)
EHS104513641(C1R)
CMAC104473298(C1R)
CUCA104064392(C1R)
TEO104374570(C1R)
BREG104629344(C1R)
OHA104327150(C1R)
ACAR104517824(C1R)
CPEA104389826(C1R)
CVF104293353(C1R)
RTD128902147(C1R)
CRID134524172(C1R)
AAM106497213(C1R)
AROW112973021(C1R)
NPD112945581(C1R)
TGT104565656(C1R)
DNE112991081(C1R)
SCAM104150724(C1R)
ASN102373027(C1R)
AMJ102572656(C1R)
CPOO109319371(C1R)
GGN109304739(C1R)
PSS102453764(C1R)
CMY102947496(C1R)
CCAY125622857(C1R)
DCC119859690(C1R)
CPIC101944886(C1R)
TST117875658 117885626(C1R)
CABI116821038(C1R)
MRV120370724 120401962(C1R)
ACS100558220(c1r)
ASAO132767515(C1R)
PVT110084645(C1R)
SUND121923276(C1R)
PBI103064088(C1R)
PMUR107285781(C1R)
CTIG120306116(C1R)
TSR106553558(C1R)
PGUT117661833(C1R)
PCAE139313060(C1R)
APRI131192335(C1R)
PTEX113444430(C1R)
NSS113417165(C1R)
VKO123033201(C1R)
PMUA114587897(C1R)
PRAF128404588(C1R)
ZVI118097746(C1R)
HCG128342813(C1R)
GJA107111991(C1R)
STOW125437124(C1R)
EMC129345475(C1R)
XLA735208(MGC130869.L)
XTR613057(c1r)
NPR108784393(C1R)
RTEM120946625(C1R)
ACAT141105548
BBUF121006020(C1R)
BGAR122940308(C1R)
DTC141056252
PWL138247200 138303696(C1R)
MUO115457678(C1R)
GSH117350686(C1R)
SRX107724791
SANH107671893
SGH107552796
CCAR109046276 109104854 109104862
CAUA113081689 113099594 113116767
CGIB127974752 128030585
PTET122360198
LROH127178333
OMC131521205
PPRM120484622
RKG130090828
MAMB125243106 125244203 125244204 125261884
CIDE127497059
CERY137026936 137034040
TROS130557520(c1s.2)
TDW130433447
MANU129448198
PDAB135727514 135727515
IPU108263468 108268478
IFU128611049 128617257
PHYP113525156
SMEO124383792 124385308 124385347
TFD113636687 113644645 113647727(c1r)
TVC132845842 132846292 132846295
CGAR128519708(c1r) 128519918 128519919 128519989
NGRA132885810(c1r)
TRN134310856
AMEX103038083
CMAO118820639
EEE113574789
CHAR105913006
TRU101072466 101072695 115250370 115250377
TFS130532929(c1r) 130532941
TNGGSTEN00015326G001
LCO104932556
NCC104941465
TBEN117494735
CGOB115005684 115005685
PGEO117461504(c1s.2)
GACU117548019
EMAC134861243
ELY117265787 117266086
EFO125893107 125893469
SLUC116049708(c1r) 116049783
ECRA117945870
ESP116690810
PFLV114557470
GAT120810412
PPUG119197338
AFB129109306
CLUM117745441
CANA137781149(c1s.2)
CVE137891040(c1s.2)
MSAM119896348 119897429 119898276
SCHU122881292
CUD121514155
SPUL138584189(c1s.2)
LMIX132983185
ALAT119005710 119006317 119006318
ASTR137601476(c1s.2)
MZE101486209
ONL100706759 112848257
OAU116323786 116323875
OLA101173495
OML112143650
CSAI133434838 133434854
XMA102236233 102236483(c1r)
XCO114142160(c1r)
XHE116716604 116717757(c1r)
PRET103477999 103478000
PFOR103136820 103136821
PLAI106955749 106955750
PMEI106921354 106921355
GAF122831002 122831004
PPRL129371499
CVG107082193
CTUL119783157
GMU124864288
NFU107379532
KMR108235398
ALIM106529165
NWH119409704(c1s.2)
AOCE111586786
EJA138194068(c1r)
BFRE138619211(c1s.2)
MCEP125015866
POV109633063 109633301
SSEN122774705
SSOE131471288
HHIP117776780(c1r)
HSP118113178
PPLT128449247
SMAU118314842
LCF108880662
SDU111230024
SLAL111669859
XGL120784069
HCQ109515279
SBIA133500699(c1s.2)
PEE133401934(c1s.2)
PTAO133479696(c1s.2)
ENY140374574(c1s.2)
MALB109966183
BSPL114842912 114843081
SSCO133983904
GMH115553827
SASA106574204 106576275 106593033
STRU115176822 115187764
OTW112244109 112247622
OMY100136073(c1r) 110503568
OGO123997148 124006285
ONE115125022 115140749
OKI109900582 109906229 109906258
OKE118373948
OMM135520583 135521899 135523017
OCLA139389498 139422151 139422171
SNH120048591 120048709 120048712
CCLU121542956 121586209
ELS105019078
OEP134023962(c1s.2)
SFM108924259
PKI111835375
AANG118230349
AROT135241000(c1r)
CCOG133124690
LOC102687602
PSPA121296018
ARUT117425903
PSEX120535736
LCM102354841(C1R)
LERI129710472
 » show all
Reference
1  [PMID:6281620]
  Authors
Sim RB.
  Title
The human complement system serine proteases C1r and C1s and their proenzymes.
  Journal
Methods Enzymol 80 Pt C:26-42 (1981)
DOI:10.1016/s0076-6879(81)80006-7
Reference
2  [PMID:3021205]
  Authors
Leytus SP, Kurachi K, Sakariassen KS, Davie EW
  Title
Nucleotide sequence of the cDNA coding for human complement C1r.
  Journal
Biochemistry 25:4855-63 (1986)
DOI:10.1021/bi00365a020
  Sequence
[hsa:715]
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.41
IUBMB Enzyme Nomenclature: 3.4.21.41
ExPASy - ENZYME nomenclature database: 3.4.21.41
BRENDA, the Enzyme Database: 3.4.21.41
CAS: 80295-69-8
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