KEGG ORTHOLOGY: K01330

ORTHOLOGY: K01330

Entry

K01330                      KO

Symbol

C1R

Name

complement component 1, r subcomponent [EC:3.4.21.41]

Pathway

map04145

Phagosome

map04610

Complement and coagulation cascades

map05133

Pertussis

map05150

Staphylococcus aureus infection

map05171

Coronavirus disease - COVID-19

map05322

Systemic lupus erythematosus

Disease

H02240

Ehlers-Danlos syndrome periodontal type

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K01330  C1R; complement component 1, r subcomponent
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01330  C1R; complement component 1, r subcomponent
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01330  C1R; complement component 1, r subcomponent
  09171 Infectious disease: bacterial
   05133 Pertussis
    K01330  C1R; complement component 1, r subcomponent
   05150 Staphylococcus aureus infection
    K01330  C1R; complement component 1, r subcomponent
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K01330  C1R; complement component 1, r subcomponent
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01330  C1R; complement component 1, r subcomponent
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01330  C1R; complement component 1, r subcomponent
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.41  complement subcomponent C_overbar_1r_
     K01330  C1R; complement component 1, r subcomponent
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01330  C1R; complement component 1, r subcomponent
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Opsonins
    K01330  C1R; complement component 1, r subcomponent

Genes

HSA:

715(C1R)

PTR:	466939(C1R)

PPS:	100991297(C1R)

GGO:	101148245(C1R)

PON:	100173855(C1R) 112135770

PPYG:

129010370 129010371

NLE:	100591142(C1R)

HMH:	116472621(C1R)

SSYN:

129483447(C1R)

MCC:	722133 722144

MCF:	101866354 102135038

MTHB:

126930475 126930487

MNI:	105484220(C1R) 105484253

CSAB:

103218858(C1R)

CATY:

105583055(C1R)

PANU:

101009229 101009900(C1R)

MLEU:

105541822 105541845

RRO:

104681686

RBB:	108542014(C1R)

TFN:

117090591

PTEH:

111555907 113222928 113222932 113222937 113222938 113222939

CANG:

105519176(C1R)

CJC:	100386784(C1R)

SBQ:	101033061(C1R)

CIMI:

108295009(C1R)

ANAN:

105731189(C1R)

MMUR:

105869012(C1R)

LCAT:

123640083(C1R)

PCOQ:

105805061(C1R)

OGA:	100946113(C1R)

MMU:	50909(C1ra) 667277(C1rb)

MPAH:

110314999 110316472(C1r)

RNO:	312705(C1r)

MCOC:

116099565(C1r)

ANU:	117715497(C1r)

MUN:	110548593(C1r)

CGE:	100768476(C1r)

MAUA:

101837653(C1r)

PROB:

127239127(C1r)

PLEU:

114708807(C1r)

MORG:

121440981(C1r)

MFOT:

126514807

AAMP:

119807677(C1r)

NGI:	103727485(C1r)

HGL:	101717538(C1r)

CPOC:

100733374(C1r)

CCAN:

109682779(C1r)

DORD:

105991115(C1r)

DSP:	122097951(C1r)

NCAR:

124982534

MMMA:

107154925(C1r)

OCU:

100342793

OPI:	101532973(C1R)

TUP:	102496021(C1R)

GVR:	103595775(C1R)

CFA:	477707(C1R)

CLUD:

112675377(C1R)

VVP:	112917317(C1R)

VLG:	121480339(C1R)

NPO:	129503431(C1R)

AML:	100472269(C1R)

UMR:	103656175(C1R)

UAH:	113257944(C1R)

UAR:	123781659(C1R)

ELK:

111159719

LLV:

125106219

MPUF:

101675669(C1R)

MNP:	132019896(C1R)

MLK:	131838482(C1R)

NVS:	122891966(C1R)

ORO:	101377329(C1R)

EJU:	114222545(C1R)

ZCA:	113922199(C1R)

MLX:	118025712(C1R)

NSU:	110579815(C1R)

LWW:	102737696(C1R)

FCA:	101088940(C1R)

PYU:	121022107(C1R)

PCOO:

112867898(C1R)

PBG:	122472397(C1R)

PVIV:

125170354(C1R)

LRUF:

124502378

PTG:	102972961(C1R)

PPAD:

109276088(C1R)

PUC:

125918799

AJU:

106965334

HHV:	120220469(C1R)

BTA:	511581(C1R)

BOM:	102264626(C1R) 102270366 102275017

BIU:	109558321 109558899 109558901(C1R)

BBUB:

102395781(C1R) 102412971 112584474

BBIS:

104992161(C1R)

CHX:	102188569 102188835(C1R)

OAS:	101107430(C1R)

BTAX:

128047412

ODA:	120858754(C1R)

CCAD:

122423663(C1R)

MBEZ:

129536899(C1R)

SSC:	445464(C1R)

CBAI:

105075582(C1R)

CDK:	105098187(C1R)

VPC:	102534527(C1R)

BACU:

103014234(C1R)

BMUS:

118902500(C1R)

LVE:	103085319(C1R)

OOR:	101269650(C1R)

DLE:	111176709(C1R)

PCAD:

102987961(C1R)

PSIU:

116760464(C1R)

NASI:

112391673(C1R)

ECB:	100060297(C1R)

EPZ:	103563701(C1R)

EAI:	106847307(C1R)

MYB:	102255103(C1R)

MYD:	102754399(C1R)

MMYO:

118651308(C1R)

MLF:	102433529(C1R)

PKL:	118730584(C1R)

EFUS:

103289041(C1R)

MNA:	107544003(C1R)

DRO:	112321892(C1R)

SHON:

119002277(C1R)

AJM:	119065713(C1R)

PDIC:

114513729(C1R)

PHAS:

123810702(C1R)

MMF:	118623285(C1R)

PPAM:

129085044(C1R)

HAI:	109373632(C1R)

RFQ:	117029197(C1R)

PALE:

102897527(C1R)

PGIG:

120611679(C1R)

PVP:	105295937(C1R)

RAY:	107519842(C1R)

MJV:	108384823(C1R)

TOD:	119247045(C1R)

SARA:

101547327(C1R)

SETR:

126006532(C1R)

LAV:	100658090(C1R)

TMU:

101359146

ETF:	101663421(C1R)

DNM:

101422209

MDO:	100016799(C1R) 100016836

GAS:	123250037(C1R)

SHR:	100925028(C1R)

AFZ:

127564331

PCW:	110213817(C1R) 110213855(C1RL)

TVP:	118850391(C1R)

OAA:	100090998(C1R)

GGA:	418295(C1R)

PCOC:

116239943(C1R)

MGP:	100549554(C1R)

CJO:	107318585(C1R)

TPAI:

128089837(C1R)

LMUT:

125687115(C1R)

NMEL:

110398250(C1R)

APLA:

101791982(C1R)

ACYG:

106047869(C1R)

CATA:

118247765(C1R)

AFUL:

116502151(C1R)

TGU:	100224962(C1R)

LSR:	110480854(C1R)

SCAN:

103812469(C1R)

PMOA:

120506470(C1R)

OTC:	121339350(C1R)

PRUF:

121351613(C1R)

GFR:	102043291(C1R)

FAB:	101809091(C1R)

OMA:	130259803(C1R)

PHI:	102111934(C1R)

PMAJ:

107207095(C1R)

CCAE:

111938131(C1R)

CCW:	104687137(C1R)

CBRC:

103614069(C1R)

ETL:	114058183(C1R)

ZAB:	102071226(C1R)

ZLE:	135453116(C1R)

ACHL:

103799612(C1R)

SVG:	106857859(C1R)

MMEA:

130574812(C1R)

HRT:	120748560(C1R)

FPG:	101920055(C1R)

FCH:	102054607(C1R)

CLV:	102093497(C1R)

EGZ:	104126607(C1R)

NNI:	104009783(C1R)

PCRI:

104024134(C1R)

PLET:

104614540(C1R)

EHS:	104513641(C1R)

PCAO:

104045747(C1R)

ACUN:

113479831(C1R)

TALA:

104355628(C1R)

PADL:

103921890(C1R)

AFOR:

103905509(C1R)

ACHC:

115343834(C1R)

HALD:

104310508(C1R)

HLE:	104831870(C1R)

AGEN:

126048885

GCL:

127014751

CCRI:

104154776(C1R)

CSTI:

104557955(C1R)

CMAC:

104473298(C1R)

MUI:	104540488(C1R)

BREG:

104629344(C1R)

FGA:	104078998(C1R)

GSTE:

104257360(C1R)

LDI:	104346354(C1R)

MNB:	103770373(C1R)

OHA:	104327150(C1R)

NNT:	104399396(C1R)

SHAB:

115601494(C1R)

DPUB:

104299509

PGUU:

104463168(C1R)

ACAR:

104517824(C1R)

CPEA:

104389826(C1R)

AVIT:

104279031(C1R)

CVF:	104293353(C1R)

RTD:	128902147(C1R)

CUCA:

104064392(C1R)

TEO:	104374570(C1R)

BRHI:

104495691(C1R)

AAM:	106497213(C1R)

AROW:

112973021(C1R)

NPD:	112945581(C1R)

TGT:	104565656(C1R)

DNE:	112991081(C1R)

SCAM:

104150724(C1R)

ASN:	102373027(C1R)

AMJ:	102572656(C1R)

CPOO:

109319371(C1R)

GGN:	109304739(C1R)

PSS:	102453764(C1R)

CMY:	102947496(C1R)

CCAY:

125622857(C1R)

DCC:	119859690(C1R)

CPIC:

101944886(C1R)

TST:	117875658 117885626(C1R)

CABI:

116821038(C1R)

MRV:	120370724 120401962(C1R)

ACS:	100558220(c1r)

ASAO:

132767515(C1R)

PVT:	110084645(C1R)

SUND:

121923276(C1R)

PBI:	103064088(C1R)

PMUR:

107285781(C1R)

CTIG:

120306116(C1R)

TSR:	106553558(C1R)

PGUT:

117661833(C1R)

APRI:

131192335(C1R)

PTEX:

113444430(C1R)

NSS:	113417165(C1R)

VKO:	123033201(C1R)

PMUA:

114587897(C1R)

PRAF:

128404588(C1R)

ZVI:	118097746(C1R)

HCG:	128342813(C1R)

GJA:	107111991(C1R)

STOW:

125437124(C1R)

EMC:	129345475(C1R)

XLA:	735208(MGC130869.L)

XTR:	613057(c1r)

NPR:	108784393(C1R)

RTEM:

120946625(C1R)

BBUF:

121006020(C1R)

BGAR:

122940308(C1R)

MUO:	115457678(C1R)

GSH:	117350686(C1R)

SRX:

107724791

SANH:

107671893

SGH:

107552796

CCAR:

109046276 109104854 109104862

CAUA:

113081689 113099594 113116767

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

125243106 125244203 125244204 125261884

CIDE:

127497059

TROS:

130557520(c1s.2)

TDW:

130433447

MANU:

129448198

IPU:	108263468 108268478

IFU:	128611049 128617257

PHYP:

113525156

SMEO:

124383792 124385308 124385347

TFD:	113636687 113644645 113647727(c1r)

TVC:	132845842 132846292 132846295

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:	101072466 101072695 115250370 115250377

TFS:	130532929(c1r) 130532941

TNG:	GSTEN00015326G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117265787 117266086

EFO:	125893107 125893469

SLUC:

116049708(c1r) 116049783

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

MSAM:

119896348 119897429 119898276

SCHU:

122881292

CUD:

121514155

ALAT:

119005710 119006317 119006318

MZE:

101486209

ONL:	100706759 112848257

OAU:	116323786 116323875

OLA:

101173495

OML:

112143650

CSAI:

133434838 133434854

XMA:	102236233 102236483(c1r)

XCO:	114142160(c1r)

XHE:	116716604 116717757(c1r)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122831002 122831004

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:	119409704(c1s.2)

AOCE:

111586786

MCEP:

125015866

POV:	109633063 109633301

SSEN:

122774705

HHIP:

117776780(c1r)

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SBIA:

133500699(c1s.2)

PEE:	133401934(c1s.2)

PTAO:

133479696(c1s.2)

MALB:

109966183

BSPL:

114842912 114843081

SASA:

106574204 106576275 106593033

STRU:

115176822 115187764

OTW:	112244109 112247622

OMY:	100136073(c1r) 110503568

OGO:	123997148 124006285

ONE:	115125022 115140749

OKI:	109900582 109906229 109906258

OKE:

118373948

SNH:	120048591 120048709 120048712

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:	102354841(C1R)

LERI:

129710472

» show all

Reference

PMID:3021205

Authors

Leytus SP, Kurachi K, Sakariassen KS, Davie EW

Title

Nucleotide sequence of the cDNA coding for human complement C1r.

Journal

Biochemistry 25:4855-63 (1986)
DOI:10.1021/bi00365a020

Sequence

[hsa:715]

Reference

PMID:14748705

Authors

Sim RB, Tsiftsoglou SA

Title

Proteases of the complement system.

Journal

Biochem Soc Trans 32:21-7 (2004)
DOI:10.1042/bst0320021

LinkDB

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