KEGG ENZYME: 3.5.1.14

ENZYME: 3.5.1.14

Entry

EC 3.5.1.14                 Enzyme

Name

N-acyl-aliphatic-L-amino acid amidohydrolase;
aminoacylase 1;
aminoacylase I;
dehydropeptidase II;
histozyme;
hippuricase;
benzamidase;
acylase I;
hippurase;
amido acid deacylase;
L-aminoacylase;
acylase;
aminoacylase;
L-amino-acid acylase;
alpha-N-acylaminoacid hydrolase;
long acyl amidoacylase;
short acyl amidoacylase;
ACY1 (gene name);
N-acyl-L-amino-acid amidohydrolase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

N-acyl-aliphatic-L-amino acid amidohydrolase (carboxylate-forming)

Reaction(IUBMB)

(1) an N-acyl-aliphatic-L-amino acid + H2O = an aliphatic L-amino acid + a carboxylate [RN:R01263];
(2) an N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate [RN:R10553]

Reaction(KEGG)

R01263 > R00669;
R10553

Substrate

N-acyl-aliphatic-L-amino acid;
H2O [CPD:C00001];
N-acetyl-L-cysteine-S-conjugate

Product

aliphatic L-amino acid;
carboxylate [CPD:C00060];
L-cysteine-S-conjugate [CPD:C02882];
acetate [CPD:C00033]

Comment

Contains Zn2+. The enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It acts on mercapturic acids (S-conjugates of N-acetyl-L-cysteine) and neutral aliphatic N-acyl-alpha-amino acids. Some bacterial aminoacylases demonstrate substrate specificity of both EC 3.5.1.14 and EC 3.5.1.114. cf. EC 3.5.1.15, aspartoacylase and EC 3.5.1.114, N-acyl-aromatic-L-amino acid amidohydrolase.

History

EC 3.5.1.14 created 1965, modified 2013

Pathway

ec00220

Arginine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K14677

aminoacylase

Genes

HSA:	100526760(ABHD14A-ACY1) 95(ACY1)

PTR:	460414(ACY1)

PPS:	100989711(ACY1)

GGO:	129532583(ACY1)

PON:	100171519(ACY1)

PPYG:

129034121(ACY1)

NLE:

100603023

HMH:	116473414(ACY1)

SSYN:

129480735(ACY1)

MCC:	100425407 698851

MCF:	101867505 135969729

MTHB:

126948694 126948695

MNI:	105480529(ACY1)

CSAB:

103227712(ACY1)

CATY:

105574295(ACY1)

PANU:

101019806

TGE:

112619217

MLEU:

105544025(ACY1)

RRO:	104663721 115898588

TFN:	117082568(ACY1)

PTEH:

111528789 113219581 113223178 113223179

CANG:

105523844(ACY1)

CJC:	100386117(ACY1)

SBQ:	101027476(ACY1)

CIMI:

108316190(ACY1)

ANAN:

105722879

CSYR:

103260142(ACY1)

MMUR:

105875031(ACY1)

LCAT:

123623208

PCOQ:

105820431(ACY1)

OGA:	100943762(ACY1)

MMU:	109652(Acy1)

MCAL:

110301037(Acy1)

MPAH:

110327471

RNO:	300981(Acy1)

MCOC:

116072453(Acy1)

ANU:

117693324

MUN:	110550172(Acy1)

CGE:

100765707

MAUA:

101822669(Acy1)

PROB:

127237243(Acy1)

PLEU:

114710963(Acy1)

MORG:

121464220(Acy1)

MFOT:

126499781

AAMP:

119809889

NGI:	103747435(Acy1)

HGL:	101696409(Acy1)

CPOC:

100714326

CCAN:

109685975(Acy1)

DORD:

105994617(Acy1)

DSP:

122095742

PLOP:

125342698(Acy1)

NCAR:

124992349

MMMA:

107143421(Acy1)

OCU:

100344479

OPI:

101520640

TUP:	102503256(ACY1)

GVR:	103600712(ACY1)

CFA:

476602

CLUD:

112665866(ACY1)

VVP:

112910690

VLG:	121494440(ACY1)

NPO:	129521779(ACY1)

AML:

100479661

UMR:

103675074

UAH:	113256935(ACY1)

UAR:

123798716

ELK:

111143997

LLV:

125079256

MPUF:

101678773(ACY1)

MNP:	132011379(ACY1)

MLK:	131823989(ACY1)

NVS:

122909371

ORO:	101372032(ACY1)

EJU:

114225067

ZCA:

113917280

MLX:

118006024

NSU:

110584947

LWW:

102727895

PYU:

121025148

PCOO:

112852541

PBG:

122487287

PVIV:

125156506(ACY1)

LRUF:

124524344

PTG:	102948715(ACY1)

PPAD:

109247881

PUC:

125929428

AJU:

106987018

HHV:

120239411

BTA:	768058(ACY1)

BOM:	102274671(ACY1)

BIU:	109576040(ACY1)

BBUB:

102408788(ACY1)

BBIS:

104997150(ACY1)

CHX:	102173979(ACY1)

OAS:	101113801(ACY1)

BTAX:

128070654(ACY1)

ODA:	120868339(ACY1)

CCAD:

122424698(ACY1)

MBEZ:

129547889(ACY1)

SSC:	396930(ACY1)

CFR:

102512036

CBAI:

105080194(ACY1)

CDK:	105093821(ACY1)

VPC:

102529518

BACU:

103005903(ACY1)

BMUS:

118903160

LVE:	103082569(ACY1)

OOR:	101286870(ACY1)

DLE:	111174327(ACY1)

PCAD:

102982112 112064954

PSIU:

116762264(ACY1)

NASI:

112400560(ACY1)

ECB:	100060631(ACY1)

EPZ:	103546483(ACY1)

EAI:

106821753

MYB:	102263075(ACY1)

MYD:	102753333(ACY1)

MMYO:

118668420(ACY1)

MLF:	102430285(ACY1)

MDT:	132215797(ACY1)

PKL:

118715612

EFUS:

103298353(ACY1)

MNA:	107540194(ACY1)

DRO:

112309817

SHON:

118989417(ACY1)

AJM:

119036616

PDIC:

114502048(ACY1)

PHAS:

123830600(ACY1)

MMF:	118633130(ACY1)

PPAM:

129087554(ACY1)

HAI:	109375828(ACY1)

RFQ:	117036570(ACY1)

PALE:

102885238(ACY1)

PGIG:

120582410(ACY1)

PVP:	105295124(ACY1)

RAY:	107504158(ACY1)

MJV:	108388575 118967731(ACY1)

TOD:	119260910(ACY1)

SARA:

101552481(ACY1)

SETR:

126013572(ACY1)

LAV:

100663232

TMU:

101349746

ETF:	101642516(ACY1)

DNM:

101412378

MDO:	100031141(ACY1)

GAS:

123246081

SHR:	100934680(ACY1)

AFZ:

127554144

PCW:	110217043(ACY1)

TVP:	118831380 118831529

OAA:

100075293

GGA:	100858836(ACY1)

PCOC:

116241064

MGP:	100550404(ACY1)

CJO:

107319637

TPAI:

128078465(ACY1)

LMUT:

125698692(ACY1)

NMEL:

110405016(ACY1)

APLA:

101803141

ACYG:

106042853(ACY1)

CATA:

118248046(ACY1)

AFUL:

116492932

TGU:

100219242

LSR:

110472111

SCAN:

103824272

PMOA:

120495689

OTC:

121347401

PRUF:

121351117

GFR:	102033439(ACY1)

FAB:	101809806(ACY1)

OMA:	130258277(ACY1)

PHI:	102107169(ACY1)

PMAJ:

107210075

CCAE:

111935148(ACY1)

CCW:

104683245

CBRC:

103614277

ETL:

114058684

ZAB:

102066246

ZLE:	135453130(ACY1)

ACHL:

103807037(ACY1)

SVG:	106849184(ACY1)

MMEA:

130578572(ACY1)

HRT:	120758179(ACY1)

SATI:

136366013(ACY1)

FPG:	101918277(ACY1)

FCH:

102057393

CCRI:

104159570(ACY1)

NNT:	104412883(ACY1)

SHAB:

115614129(ACY1)

ACUN:

113484690(ACY1)

TALA:

104361246

ACHC:

115353853(ACY1)

HLE:	104835131(ACY1)

AGEN:

126049948

GCL:

127021404

CSTI:

104554008(ACY1)

LDI:	104346085(ACY1)

MNB:	103779811(ACY1)

DPUB:

104305438(ACY1)

AVIT:

104275163(ACY1)

BRHI:

104499392(ACY1)

EGZ:	104126741(ACY1)

NNI:	104008693(ACY1)

PCRI:

104024502(ACY1)

PCAO:

104042580(ACY1)

PADL:

103915051(ACY1)

AFOR:

103895237

FGA:	104079901(ACY1)

CLV:

102085226

MUI:	104537283(ACY1)

PGUU:

104468238(ACY1)

PLET:

104622468(ACY1)

CMAC:

104477695(ACY1)

CUCA:

104066707(ACY1)

TEO:	104383738(ACY1)

BREG:

104633629(ACY1)

OHA:	104336647(ACY1)

CPEA:

104387133(ACY1)

CVF:	104291962(ACY1)

RTD:	128915763(ACY1)

AAM:	106487065(ACY1)

AROW:

112968833(ACY1)

NPD:

112953100

TGT:

104576641

DNE:

112986955

ASN:	102369149(ACY1)

AMJ:	102566953(ACY1)

GGN:	109292714(ACY1)

PSS:	102455304(ACY1)

CMY:	102938259(ACY1)

CCAY:

125639885(ACY1)

DCC:	119859309(ACY1)

CPIC:

101950834(ACY1)

TST:	117880489(ACY1)

CABI:

116831336(ACY1)

MRV:	120409215(ACY1)

ACS:	100567123(acy1)

ASAO:

132769163(ACY1)

PVT:	110084475(ACY1)

SUND:

121920958(ACY1)

PBI:	103050622(ACY1)

PMUR:

107291116(ACY1)

CTIG:

120307654(ACY1)

TSR:	106557154(ACY1)

PGUT:

117678529(ACY1)

APRI:

131192020(ACY1)

PTEX:

113453651(ACY1)

NSS:	113415727(ACY1)

VKO:	123034292(ACY1)

PMUA:

114591568(ACY1)

PRAF:

128408186(ACY1)

ZVI:	118080610(ACY1)

HCG:	128346941(ACY1)

GJA:	107115931(ACY1)

STOW:

125429604(ACY1)

EMC:	129328990(ACY1)

XLA:	399011(acy1.2.L) 446741(acy1.1.S)

XTR:	101735201 496883(acy1.1)

NPR:

108793445

RTEM:

120944933(ACY1)

BBUF:

120978633

BGAR:

122943534(ACY1)

MUO:	115471917(ACY1)

GSH:	117351172(ACY1)

DRE:	100001620 103909643 393970(acy1)

SRX:	107747934 107752189

SANH:

107655273 107698043

SGH:	107550684 107575257

CCAR:

109047323

CAUA:

113039794(acy1) 113040498

CGIB:

127987355 127987361

PTET:

122334024(acy1)

LROH:

127153337(acy1)

OMC:	131531179(acy1)

PPRM:

120468729(acy1)

RKG:

130101981

MAMB:

125255195

CIDE:

127521970

CERY:

137029012(acy1)

MASI:

127438712

TROS:

130549214

MANU:

129453712

IPU:

108254950

IFU:

128624907

PHYP:

113539457(acy1)

SMEO:

124402449

TFD:

113637038

TVC:

132837803

TRN:

134301785

AMEX:

103031539

CMAO:

118799443

EEE:	113583811(acy1)

CHAR:

105903408

TRU:	101072726(acy1)

TFS:

130524157

TNG:	GSTEN00027408G001

LCO:	104931347(acy1)

NCC:	104967510(acy1)

TBEN:

117489886

CGOB:

115008844(acy1)

PGEO:

117447235

GACU:

117548236

EMAC:

134883458

ELY:

117256181

EFO:

125894269

PLEP:

121961092

SLUC:

116041589

ECRA:

117943525

ESP:	116687883(acy1)

PFLV:

114554745(acy1)

GAT:

120835815

PPUG:

119229954

AFB:

129105509

CLUM:

117731034

PSWI:

130208804

MSAM:

119885960

SCHU:

122861439

CUD:

121507518

ALAT:

119021735

MZE:	101471948(acy1)

ONL:	100694810(acy1)

OAU:

116313668

OLA:	101160548(acy1)

OML:

112145289

CSAI:

133448561

XMA:	102227096(acy1)

XCO:	114135714(acy1)

XHE:

116710200

PRET:

103464610(acy1)

PFOR:

103137960(acy1)

PLAI:

106962485(acy1)

PMEI:

106914943(acy1)

GAF:

122834516

PPRL:

129357121

CVG:	107102904(acy1)

CTUL:

119779981

GMU:

124856080

NFU:	107385138(acy1)

KMR:

108247369

ALIM:

106516071(acy1)

NWH:

119412469

AOCE:

111563222(acy1)

MCEP:

125007271

CSEM:

103385797(acy1)

POV:	109638451(acy1)

SSEN:

122768796

HHIP:

117761139

HSP:

118104836

PPLT:

128454389

SMAU:

118309321

LCF:

108889386

SDU:	111222940(acy1)

SLAL:

111660709(acy1)

XGL:

120783183

HCQ:	109522261(acy1)

SSCV:

125977114

SBIA:

133508041

PEE:

133408646

PTAO:

133483961

BPEC:

110168627(acy1)

MALB:

109952383(acy1)

BSPL:

114856169

SJO:

128355591

SASA:

100194932(acy1)

STRU:

115208237(acy1)

OTW:

112214706

OMY:

110494017

OGO:

124003713

ONE:	115142734(acy1)

OKI:	109892549(acy1)

OKE:

118389045

SALP:

112070374(acy1)

SNH:

120063802

CCLU:

121575493

ELS:	105028113(acy1)

SFM:	108933832(acy1)

PKI:	111860026(acy1)

AANG:

118211860

LOC:	102696507(acy1)

PSPA:

121329388

ARUT:

117411779 117971353

LCM:	102363836(ACY1)

CMK:

103176752

RTP:

109923199

CPLA:

122559125

HOC:

132822418

LERI:

129704611

PMRN:

116949455(ACY1)

LRJ:	133342526 133342542

BFO:

118416611

BBEL:

109467122

CIN:	100177060 100185588

SCLV:

120330375 120334015 120343054 120343197 120343198

SPU:	115918107 577570 578000

LPIC:

129256910 129257153

APLC:

110984341

ARUN:

117307330

AJC:

117125279

SKO:	100377599 102801074

DME:	Dmel_CG17109(CG17109) Dmel_CG17110(CG17110) Dmel_CG6465(CG6465) Dmel_CG6726(CG6726) Dmel_CG6733(CG6733) Dmel_CG6738(CG6738)

DER:	6551980 6554750 6554751 6554781 6554782

DSE:	6606940 6606941 6607531 6607532 6607533 6607534

DSI:	Dsimw501_GD20716(Dsim_GD20716) Dsimw501_GD20717(Dsim_GD20717) Dsimw501_GD20996(Dsim_GD20996) Dsimw501_GD20998(Dsim_GD20998) Dsimw501_GD20999(Dsim_GD20999) Dsimw501_GD21000(Dsim_GD21000) Dsimw501_GD21001(Dsim_GD21001)

DYA:	Dyak_GE10351 Dyak_GE10352 Dyak_GE10353 Dyak_GE10354 Dyak_GE10355 Dyak_GE24682 Dyak_GE24683

DAN:	6499765 6499766 6499767 6499768 6500302

DSR:	110191004 110191006 110191023 110191242 110191243 110191244 110191245 110191246 110191359

DPO:	4800580 4800581 6896822 6896999 6897000

DPE:	6588033 6588046 6595081 6595082 6595083

DMN:	108156815 108156816 108156818 108157010 108157011

DWI:	6649841 6649842 6650512 6650513 6650514 6650624

DGR:	6567872 6567873 6567874 6570878

DMO:	Dmoj_GI18128 Dmoj_GI23017 Dmoj_GI23018 Dmoj_GI23019 Dmoj_GI23020

DAZ:	108611518 108621151 108621152 108621153

DNV:	108659996 108659997 108659998 108659999 115564591

DHE:	111599611 111599613 111599614 111599619 111600558

DVI:	6627508 6630824 6630825 6630956

CCAT:

101455350 101455522 101455689 101455990

BOD:	106615864 106615890

BDR:	105229765 125778319

RZE:	108364405 108374913 108374915 108380894

AOQ:	129238566 129238567 129238568

TDA:	119666856 119670594 119670595

MDE:	101897431 101900051 101900512

SCAC:

106087402 106087411

LCQ:	111680294 111680298 111680303 111680317

LSQ:	119599679 119599683 119599685 119599698 119599699

GFS:	119639265 119640368

ECOE:

129941881 129944221 129947902

CLON:

129618702

HIS:	119658058 119658059

AGA:

1272425

ACOZ:

120955387

AARA:

120905887

AMER:

121593645

ASTE:

118507841

AFUN:

125762823

AMOU:

128306304

AALI:

118463646

AAG:

5574529

AALB:

109397278 109405345 109423208 115254536 115255644

ASUA:

134205197 134207962

CQU:	CpipJ_CPIJ009804 CpipJ_CPIJ013669 CpipJ_CPIJ013670 CpipJ_CPIJ013671

CPII:

120421076 120426017 120426018 120426019

CNS:	116341916 116341917 116341918 116341944 116341995 116342029 116342070 116342071 116342180 116342182 116344725

BCOO:

119069079 119070819 119072255 119073796 119075842 119076770 119077330 119078571 119080728 119080735 119083576 119084316

AME:

408969

ACER:

107993607

ALAB:

122717031

ADR:

102673709

AFLR:

100872009

BIM:

100746427

BBIF:

117216864

BVK:

117236511

BVAN:

117154557

BTER:

100645222

BAFF:

126925617

BPYO:

122576424

BPAS:

132914823

FVI:

122538205

CCAL:

108622570

OBB:

114876678

OLG:

117606634

MGEN:

117220922

NMEA:

116425841

SOC:

105207857

MPHA:

105839002

AEC:

105154436

ACEP:

105621043

PBAR:

105428375

VEM:	105569472 105569473

HST:	105183201 105183202 105191364

DQU:	106745603 106746890

CFO:	105252213 105254159 109610062

FEX:

115238716

LHU:

105669821

PGC:

109860040

OBO:

105276644

PCF:

106788996

PFUC:

122514608

VPS:

122634166

VCRB:

124430832

VVE:

124954480

NVI:

100114283

CSOL:

105359781

TPRE:

106658196

LHT:	122499798 122500776 122500917 122500939 122500940 122500941 122500943 122506344

LBD:	127277279 127278935 127282715 127282716 127285998 127288582 127288977 127288978 127288979 127288986 127289053 127290433

MDL:

103571230

CGLO:

123260466

FAS:

105263208

DAM:

107039965

AGIF:

122848000 122848393 122848968

CINS:

118074271

VCAN:

122418867

CCIN:

107270550

DSM:

124409209

NPT:

124217669

NFB:

124179534

NLO:

107225667

NVG:

124303988

AROA:

105687047

TCA:	657516 657592 657672

DPA:

109540108

SOY:

115874963

AGRG:

126742497

ATD:	109594510 109595479

CSET:

123312943 123313320

AGB:

108908583

LDC:

111502633

DVV:

114336237

NVL:	108556952 108564069 108564074

APLN:

108734169

PPYR:

116161901 116161911 116162037 116162500 116164352 116168720 116169314 116175360 116175491 116175909 116175910 116176242 116176638 116176772 116176794 116181156

OTU:

111421048

BMOR:

101742389 101742637 101745900 101746001 101746161 101746807

BMAN:

114246094 114246984 114248662 114253609

MSEX:

115441320 115447653 115449340 115449346 115454371

DPL:	KGM_205806 KGM_209240A KGM_213685

BANY:

112044749 112058061

MJU:	123869910 123870177

NIQ:	126771134 126772371

VCD:	124531763 124531862 124543706

MCIX:

123655546 123655584 123658639

PMAC:

106711796 106714707 106714708 106714888 106714916 106715066 106717664 106719537 106721337

PPOT:

106101948 106101949 106101950 106101952 106101987 106101992 106101996 106102026 106102027 106102053 106102439 106105700 106106778

PXU:	106122141 106123568 106123576 106125456 106126068 106126077 106126088 106127847 106127864

PRAP:

110993247 110994002 110999680

PBX:	123713244 123720140

PNAP:

125052354 125057936

ZCE:	119833720 119834323 119834473

CCRC:

123693699 123693779 123696839

LSIN:

126965367 126971791 126974460

AAGE:

121727966 121733896 121735888

HAW:	110370673 110370749 110374988 110376077 110384378

HZE:	124629670 124629751 124630081 124630713 124634023

TNL:	113497189 113497408 113497610 113502487 113505804

SLIU:

111348059 111348062 111348257 111348608 111349579 111357777

OFU:	114354272 114358927 114359563 114364278

ATRA:

106132269 106132445 106137352 106141831

GMW:	113511706 113512513 113512548 113514921 113517147

PXY:	105381157 105384203 105392298 105396706

PGW:	126367057 126368043 126368044 126368045 126368051 126368308 126368311 126371283

LGLY:

125226640 125229621 125229746

CFEL:

113374111 113374886 113382507 113382642

CCRN:

123292169 123293871 123296947 123299799 123299800 123302933

API:	100162258 100165297 100169089

DNX:	107171543 107171544

AGS:	114123475 114123476 114123487

RMD:	113548242 113551944 113556514

ACOO:

126838107 126842707 126843825 126843826

DVT:

126900288

BTAB:

109043553

DCI:

103513711

CLEC:

106670786

HHAL:

106692067 106692624 106692625 106692629 106692630

NLU:

111057758

HVI:	124363400 124365598 124367718 124371492

MQU:	128988880 128989894 128994589 129003966

PHU:	Phum_PHUM047660

FOC:

113214887

TPAL:

117645802

ZNE:

110832721

CSEC:

111861965 111875594

SGRE:

126278226 126278227 126298104

BROR:

134533870

IEL:

124156606

FCD:	110845065 110846477 110846510 110849901 110853823 110863528

DPX:	DAPPUDRAFT_48442

DMK:

116924907

DPZ:

124315722

PVM:	113810372 113813709

PJA:	122247043 122260464

PCHN:

125044986 125044988

PMOO:

119582562

HAME:

121854745 121854791 121859454 121859456

PCLA:

123745691 123762308

CQD:	128697092 128697156 128697288

PTRU:

123508561 123514320

ESN:	126983771 126985009 126992876

MNZ:

135224403

HAZT:

108681027

EAF:

111703871

LSM:

121117383

TCF:	131883757 131884507

PPOI:

119090565

CEL:	CELE_C06A6.4(C06A6.4) CELE_C10C5.3(C10C5.3) CELE_C10C5.4(C10C5.4) CELE_C10C5.5(C10C5.5)

CBR:	CBG_17687 CBG_24539

CRQ:	GCK72_013418 GCK72_014832

NAI:	NECAME_02060 NECAME_15660

BMY:	BM_BM17575(Bm17575)

LOA:	LOAG_18850

TSP:

Tsp_07914

HRO:	HELRODRAFT_62927

LGI:	LOTGIDRAFT_197114 LOTGIDRAFT_222505

PVUL:

126827264 126827266

PCAN:

112571574

BGT:	106052797 106052798

GAE:	121368078 121392474

HRF:

124133831

HRJ:	124289903 124289905

CRG:	105336810 117682059

CANU:

128159489 128159490 128159517

CVN:

111108137

OED:

130048341

MYI:

110443347

PMAX:

117330611

MCAF:

127710566

MMER:

123529625

RPHI:

132715745 132748102

DPOL:

127881175 127881176

MAEA:

128217962 128217993

OBI:

106878078

OSN:	115217582 115231172

LJP:	135474682 135474751

LAK:	106151703 106160986

SMM:	Smp_019630

SHX:	MS3_00003253(ACY1)

OVI:	T265_08174 T265_14495

EGL:

EGR_04365

LLON:

135491406

ADF:

107353293

AMIL:

114947117

PDAM:

113673272

SPIS:

111322407

RES:

135686400

TAD:	TRIADDRAFT_50344

AQU:

100634447

ATH:	AT1G44180 AT1G44820 AT4G38220(AQI)

ALY:	9304911 9315618 9317463 9330044 9330057

CRB:	17880285 17887806 17897659 17899585

CSAT:

104716103 104716105 104719897 104729133 104742184 104757947 104777562 104777586 104781947 104786010 109124733

EUS:	EUTSA_v10011489mg EUTSA_v10012140mg EUTSA_v10016717mg EUTSA_v10025205mg

BRP:	103827501 103828110 103847925

BNA:	106350679 106350870 106404689 106433265 106434002 106435544 106438617 125578932

BOE:	106300828 106303509 106309201 106335773

RSZ:	108813541 108836566 108842805 108846190 108849891 108854796 130508417

THJ:	104817223 104824731

CPAP:

110816746 110821496

CIT:	102611318 102622833

CIC:	CICLE_v10028440mg

PVY:	116110645 116119343 116132915

MINC:

123203623 123206126 123213983

TCC:	18592308 18608383

GRA:	105779666 105782851 105786149 105795027

GHI:	107894009 107898901 107901663 107907642 107907691 107908978 107920439 107922227 107942367 107944751 107953104 107963849 121215950 121229426

GAB:	108457661 108460705 108464322 108474591

HSYR:

120126330 120139849 120144638 120149714 120178718 120207583

DZI:	111282920 111315623

EGR:	104419053 104450949

GMX:	100783172 100817383

GSJ:	114382181 114403160

PVU:	PHAVU_003G001200g PHAVU_008G164800g

VRA:	106753643 106765126

VAR:	108335972 108338118

VUN:	114173929 114194525

VUM:	124839895 124848349

CCAJ:

109815996 109817938

APRC:

113846844 113868729 113868802

MTR:	11420656 11429277 11437031

TPRA:

123907384 123921897

CAM:

101489624

PSAT:

127074689 127081578 127098003 127098004 127118910

VVO:	131595736 131595737 131625183 131625184 131649548

ADU:	107470122 107485079

AIP:	107622734 107639661

AHF:	112715589 112743741 112797111

LANG:

109356547 109360836

PCIN:

129300097 129311135

QSA:	O6P43_019738 O6P43_026181 O6P43_032259 O6P43_032262

FVE:	101297614 101306972

RCN:	112172056 112173713 112184277

PPER:

18767701 18792444

PMUM:

103319947 103334632

PAVI:

110753256 110754679

PDUL:

117616560 117638599

MDM:	103440917 103440951 103445495

MSYL:

126585235 126602568 126621347

PXB:	103932870 103936000 103949509

ZJU:	107426535 107435996 132805413

MNT:	21386492 21396903 21403086

CSAV:

115697073 115702853 115702854

CSV:

101213747

CMO:	103490443 103493924

BHJ:	120069053 120071486

MCHA:

111011275 111011881

CMAX:

111469806 111487760

CMOS:

111451263 111464784

CPEP:

111794899 111811272

RCU:	8274101 8285377

MEAN:

126664979 126674772 126677123

JCU:

105638915

HBR:	110638919 110665147

MESC:

110608766 110610477 110610478

POP:	18098169 7463166 7463357

PEU:	105108297 105127919 105136990

PALZ:

118032276 118038880 118040921 118040930

JRE:	108988347 108997411

CILL:

122310713 122311297 122313061

CAVE:

132168997 132185770 132188072

QSU:	112003024 112032954

QLO:	115960364 115968776 115969487 115969489

TWL:	119981547 120010875

VVI:	100257526 100260562

VRI:	117907410 117911867

SLY:	101248259 543751

SPEN:

107005038 107027000

SOT:	102590216 102593106

SSTN:

125843613 125870979

SDUL:

129885239 129902507

CANN:

107840659 107868075

LBB:	132599410 132627020

NTA:	107768780 107774716 107817856(NtACY) 107828516

NSY:	104224953 104242920

NTO:	104103369 104112374

NAU:	109207749 109239313

INI:	109148830 109170791

ITR:	116011328 116015563 116016317 116031944 116032546

SIND:

105159481 105172986

OEU:

111393386

EGT:	105953697 105954674 105973033

SSPL:

121741959 121745000 121758150

SMIL:

131009403 131024158

SHIS:

125190531 125223199

APAN:

127246434 127265325

HAN:	110864297 110917191

ECAD:

122579155 122584840 122601374 122609499

LSV:	111896192 111896194

CCAV:

112501938 112527698

DCR:	108197289 108221895 108224269

CSIN:

114267349 114278969

RVL:	131307543 131307839

AEW:	130772830 130784649 130786648

BVG:	104904088 104904089 104904090 104904092 104906914

SOE:	110786634 110786638 110786639 110795036

CQI:	110682012 110682044 110682076 110718685 110718687 110718689 110718702 110718954 110725346

ATRI:

130804387 130805217 130825588

MOF:	131156355 131161641

NNU:	104606852 104608485

MING:

122073972 122073974 122075255 122084700

TSS:	122659862 122662214 122662713 122662714 122662715 122662798 122662799

PSOM:

113283129 113287071 113289662 113299177 113299187

OSA:	4340457 4346012

OBR:	102711640 102713551

OGL:	127776211 127782403

BDI:	100826836 100839108

ATS:	109742087 109779347

TDC:	119328664 119329542 119336964 119337630

TAES:

123148906 123151271 123157518 123159172 123165396 123170358

TUA:	125520020 125527886 125528985

LPER:

127316802 127317768

LRD:	124685226 124698285

SBI:	8055167 8077344

ZMA:	100282205 100283955

MFLO:

136472718 136472835 136526869

SITA:

101779195 101785165

SVS:	117852436 117860640

PVIR:

120669764 120678342 120704629 120712824

PHAI:

112888652 112897073

PDA:	103697173 103705188 120105761

EGU:	105052838 105060929

MUS:	103976998 103989500

ZOF:	122020297 122023985 122042119 122046646

DCT:	110099803 110100754 110101417

PEQ:	110026318 110031913 110034827

AOF:	109841919 109846270

MSIN:

131219346 131242509

NCOL:

116257676 116257722

ATR:	18425845 18435830 18439756

SMO:	SELMODRAFT_120255 SELMODRAFT_406809

PPP:	112284932 112295617

CME:	CYME_CMA011C

GSL:	Gasu_22570

CCP:	CHC_T00000215001

CHIG:

CH63R_12110

RIE:	OCT59_004365

MBR:	MONBRDRAFT_32786

SRE:	PTSG_01855

DDI:	DDB_G0270562(acy1)

DPP:	DICPUDRAFT_53427

DFA:	DFA_03140(acy1)

ACAN:

ACA1_156080

PTI:	PHATRDRAFT_15083

FCY:	FRACYDRAFT_181231

TPS:	THAPSDRAFT_15114

PIF:	PITG_00028 PITG_00029 PITG_02852

PSOJ:

PHYSODRAFT_344735 PHYSODRAFT_349947 PHYSODRAFT_358729

SPAR:

SPRG_01415

NGR:	NAEGRDRAFT_77264 NAEGRDRAFT_81120

» show all

Reference

1 [PMID:14927637]

Authors

BIRNBAUM SM, LEVINTOW L, KINGSLEY RB, GREENSTEIN JP.

Title

Specificity of amino acid acylases.

Journal

J Biol Chem 194:455-70 (1952)

Reference

2 [PMID:13061423]

Authors

FONES WS, LEE M.

Title

Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase.

Journal

J Biol Chem 201:847-56 (1953)

Reference

3 [PMID:3355856]

Authors

Henseling J, Rohm KH

Title

Aminoacylase I from hog kidney: anion effects and the pH dependence of kinetic parameters.

Journal

Biochim Biophys Acta 959:370-7 (1988)
DOI:10.1016/0005-2760(88)90211-1

Reference

4 [PMID:2318199]

Authors

Heese D, Berger S, Rohm KH

Title

Nuclear magnetic relaxation studies of the role of the metal ion in Mn2(+)-substituted aminoacylase I.

Journal

Eur J Biochem 188:175-80 (1990)
DOI:10.1111/j.1432-1033.1990.tb15385.x

Reference

5 [PMID:7662111]

Authors

Palm GJ, Rohm KH

Title

Aminoacylase I from porcine kidney: identification and characterization of two major protein domains.

Journal

J Protein Chem 14:233-40 (1995)
DOI:10.1007/bf01886764

Reference

6 [PMID:9671543]

Authors

Uttamsingh V, Keller DA, Anders MW

Title

Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines.

Journal

Chem Res Toxicol 11:800-9 (1998)
DOI:10.1021/tx980018b

Reference

7 [PMID:10727768]

Authors

Lindner H, Hopfner S, Tafler-Naumann M, Miko M, Konrad L, Rohm KH

Title

The distribution of aminoacylase I among mammalian species and localization of the enzyme in porcine kidney.

Journal

Biochimie 82:129-37 (2000)
DOI:10.1016/S0300-9084(00)00191-7

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.14

IUBMB Enzyme Nomenclature:

3.5.1.14

ExPASy - ENZYME nomenclature database:

3.5.1.14

BRENDA, the Enzyme Database:

3.5.1.14

CAS:

9012-37-7

LinkDB

DBGET integrated database retrieval system