Entry
Name
peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase;
glycopeptide N-glycosidase;
glycopeptidase;
N-oligosaccharide glycopeptidase;
N-glycanase;
Jack-bean glycopeptidase;
PNGase A;
PNGase F
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase
Reaction(IUBMB)
Hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue [RN:
R08707 ]
Reaction(KEGG)
Comment
Does not act on (GlcNAc)Asn, because it requires the presence of more than two amino-acid residues in the substrate [cf. EC
3.5.1.26 , N4-(beta-N-acetylglucosaminyl)-L-asparaginase]. The plant enzyme was previously erroneously listed as EC
3.2.2.18 .
History
EC 3.5.1.52 created 1984, modified 1989 (EC 3.2.2.18 created 1984, incorporated 1989)
Orthology
K01456 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase
Genes
XLA : 108718927(ngly1.L) 733299(ngly1.S)
MUO : 115459116 115471838(NGLY1)
SANH : 107688325 107696895
SGH : 107579448 107593604(ngly1)
CCAR : 109066243 109066324(ngly1)
CAUA : 113062246 113120093
CGIB : 127935160 127978573
PTET : 122323357(ngly1) 122344761
MASI : 127421408 127424905
TROS : 130566700 130567004
MCEP : 125019462 125019463
DSI : Dsimw501_GD10391(Dsim_GD10391)
CBR : CBG_08042(Cbr-png-1)
SHX : MS3_00009515(NGLY1_1)
ATEN : 116290040 116298322
AMIL : 114967644 114967774
PDAM : 113673876 113673879
SPIS : 111323412 111323413
CSAT : 104724015 104760936
PAVI : 110759671 110759676
PDUL : 117630013 117632416
CPEP : 111784749 111798864
PEU : 105110806 105110807 105110809 105110816
CSIN : 114313061 114316662
PSOM : 113287156 113310535
TAES : 123044749 123052608 123188515
MFLO : 136542338 136550181
PVIR : 120661393 120688469
SMO : SELMODRAFT_402766 SELMODRAFT_402768 SELMODRAFT_402770 SELMODRAFT_402772 SELMODRAFT_87223
CGR : 2888806(GVI51_H05599)
NCS : NCAS_0C01930(NCAS0C01930)
NDI : NDAI_0E02650(NDAI0E02650)
TPF : TPHA_0A01280(TPHA0A01280)
TBL : TBLA_0H03830(TBLA0H03830)
TDL : TDEL_0A05180(TDEL0A05180)
KAF : KAFR_0E00750(KAFR0E00750)
KNG : KNAG_0A01780(KNAG0A01780)
LBG : 92209018(LODBEIA_P38220)
CAL : CAALFM_C206490WA(CaO19.26)
YLI : 2909617(YALI2_B00309g)
NTE : NEUTE1DRAFT126890(NEUTE1DRAFT_126890)
SMP : 10810128(SMAC4_01332)
FPU : FPSE_04348 FPSE_11510
FPOA : FPOAC1_000275(PNG1)
FOX : FOXG_01189 FOXG_19871
TATV : 25785646(TrAtP1_006638)
PLJ : 28892100(PLICBS_004225)
CDET : 87949081(CDEST_12581)
ELA : UCREL1_1534 UCREL1_791
BFU : BCIN_01g01080(Bcpng1)
PTRR : 6345711(PtrM4_039160)
ZTR : MYCGRDRAFT_102416 MYCGRDRAFT_14552
PFJ : MYCFIDRAFT_109817 MYCFIDRAFT_143453
KMG : 30162732(I203_101282)
KNE : 92179621(IAR55_002362)
CCAC : CcaHIS019_0212580(PNG1)
TVA : TVAG_2v0430880 TVAG_2v0662780 TVAG_2v0997870 TVAG_2v1001050
GTT : GUITHDRAFT_117383 GUITHDRAFT_138861 GUITHDRAFT_72606
» show all
Taxonomy
Reference
Authors
Plummer TH Jr, Tarentino AL.
Title
Facile cleavage of complex oligosaccharides from glycopeptides by almond emulsin peptide: N-glycosidase.
Journal
J Biol Chem 256:10243-6 (1981)
Reference
Authors
Takahashi N.
Title
Demonstration of a new amidase acting on glycopeptides.
Journal
Reference
Authors
Takahashi N, Nishibe H.
Title
Some characteristics of a new glycopeptidase acting on aspartylglycosylamine linkages.
Journal
Reference
Authors
Tarentino AL, Gomez CM, Plummer TH Jr.
Title
Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.52
ExPASy - ENZYME nomenclature database: 3.5.1.52
LinkDB
All DBs