KEGG   ENZYME: 4.1.2.59
Entry
EC 4.1.2.59                 Enzyme                                 
Name
dihydroneopterin phosphate aldolase;
H2NMP aldolase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
7,8-dihydroneopterin 3'-phosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
Reaction(IUBMB)
7,8-dihydroneopterin 3'-phosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde phosphate [RN:R11718]
Reaction(KEGG)
R11718
Substrate
7,8-dihydroneopterin 3'-phosphate [CPD:C05925]
Product
6-(hydroxymethyl)-7,8-dihydropterin [CPD:C01300];
glycolaldehyde phosphate [CPD:C21614]
Comment
The enzyme participates in methanopterin biosynthesis the archaeon Pyrococcus furiosus. The enzyme is specific for 7,8-dihydroneopterin 3'-phosphate. cf. EC 4.1.2.25, dihydroneopterin aldolase and EC 4.1.2.60, dihydroneopterin triphosphate aldolase.
History
EC 4.1.2.59 created 2017
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K22102  dihydroneopterin phosphate aldolase
Genes
PGFJ0G10_28675
PFUPF1278
PFIPFC_05605
PHOPH0634(PH0634)
PABPAB1445
PYNPNA2_1253
PYSPy04_1120
PYCTQ32_04640
TCHCHITON_0626
Reference
1  [PMID:22931285]
  Authors
de Crecy-Lagard V, Phillips G, Grochowski LL, El Yacoubi B, Jenney F, Adams MW, Murzin AG, White RH
  Title
Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate.
  Journal
ACS Chem Biol 7:1807-16 (2012)
DOI:10.1021/cb300342u
  Sequence
[pfu:PF1278]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.59
IUBMB Enzyme Nomenclature: 4.1.2.59
ExPASy - ENZYME nomenclature database: 4.1.2.59
BRENDA, the Enzyme Database: 4.1.2.59
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