Entry |
|
Name |
methylglutaconyl-CoA hydratase;
methylglutaconyl coenzyme A hydratase;
3-methylglutaconyl CoA hydratase;
methylglutaconase;
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase
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Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
|
Sysname |
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
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Reaction(IUBMB) |
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O [RN: R02085]
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Reaction(KEGG) |
|
Substrate |
(S)-3-hydroxy-3-methylglutaryl-CoA [CPD: C00356]
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Product |
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History |
EC 4.2.1.18 created 1961
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Pathway |
ec00280 | Valine, leucine and isoleucine degradation |
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Orthology |
K05607 | methylglutaconyl-CoA hydratase |
K13766 | methylglutaconyl-CoA hydratase |
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Genes |
PANU: | 101026404(AUH) 116268676 |
CJC: | 100395264(AUH) 100395767 |
MORG: | 121444487 121453331 |
NCAR: | 124965512 124989221 |
ORO: | 101371798 101372607(AUH) |
PBG: | 122475241(AUH) 122480665 |
PVIV: | 125150663(AUH) 125151635 |
LRUF: | 124507903 124527793 |
BTAX: | 128052404(AUH) 128066841 |
OOR: | 101282650(AUH) 101288536 |
DLE: | 111163642 111167650(AUH) |
PSIU: | 116755425(AUH) 116763609 |
NASI: | 112390843(AUH) 112401269 |
EPZ: | 103543917 103552518(AUH) |
DRO: | 112307258(AUH) 112309148 |
AJM: | 119047237 119060065(AUH) |
OMA: | 130265464(AUH) 130266672 |
CTIG: | 120317423 120318636(AUH) |
XLA: | 495229 734576(auh.S) |
MZE: | 101467889 101474898 112429671 112431933 |
ONL: | 100697484 100700973 102078228 |
OAU: | 116315832(auh) 120437804 120438486 |
PMEI: | 106911020 106912067 |
PSPA: | 121302193 121315703 |
ARUT: | 117400854 117409112 |
SKO: | 100373940 102807162 102807299 |
DSI: | Dsimw501_GD25824(Dsim_GD25824) |
BCOO: | 119066783 119068994 |
PPYR: | 116177613 116179652 |
CFEL: | 113364013 113364016 |
CBR: | CBG_23911(Cbr-ech-5) |
SPIS: | 111319094 111346928 |
CSAT: | 104718676 104723421 104731900 |
MINC: | 123210136 123210138 123210847 |
AHF: | 112695317 112722296 112747780 112800365 |
PCIN: | 129311857 129322144 |
PAVI: | 110756427 110756447 |
CMAX: | 111465075 111498438 |
CMOS: | 111431086 111453816 |
CPEP: | 111801090 111809612 |
PALZ: | 118039160 118062903 |
CANN: | 107868222 107876127 |
SSPL: | 121766779 121801554 |
CSIN: | 114262621 114262622 114274138 114281304 114312972 |
MING: | 122063390 122086970 |
PSOM: | 113297143 113302534 |
TAES: | 123137747 123144979 |
MFLO: | 136462259 136477869 |
PVIR: | 120656670 120711377 |
SMO: | SELMODRAFT_125455 SELMODRAFT_232742 |
CSL: | COCSUDRAFT_6243 COCSUDRAFT_67198 |
YLI: | 2908832(YALI2_E00675g) |
NTE: | NEUTE1DRAFT85151(NEUTE1DRAFT_85151) |
SMP: | 10803136(SMAC4_05937) |
FPU: | FPSE_04239 FPSE_08118 |
FVN: | FVRRES_00079 FVRRES_09675 |
FVR: | FVEG_04720 FVEG_14162 |
FKR: | NCS57_00338400 NCS57_00582300 |
TATV: | 25784033(TrAtP1_008349) |
TASP: | 36610074(TrAFT101_003047) |
MAW: | 19251743(J3458_018890) |
PLJ: | 28884307(PLICBS_005571) |
PTRR: | 6344481(PtrM4_046880) |
CDEP: | 91087814(L203_103603) |
KMG: | 30166176(I203_104059) |
KNE: | 92178979(IAR55_001720) |
CCAC: | CcaHIS019_0701240(CcaverHIS019_0701240) |
SHS: | STEHIDRAFT_76830 STEHIDRAFT_93579 |
RSX: | RhiXN_01538 RhiXN_03861 |
LBC: | LACBIDRAFT_245955(ECH-4) |
ABP: | AGABI1DRAFT113260(AGABI1DRAFT_113260) |
ABV: | AGABI2DRAFT192096(AGABI2DRAFT_192096) |
MRR: | Moror_16857 Moror_8108 |
MORE: | E1B28_004150 E1B28_004818 |
SCM: | SCHCO_01085193(SCHCODRAFT_01085193) SCHCO_02623103(SCHCODRAFT_02623103) |
UMA: | UMAG_01433 UMAG_01935 |
SGRA: | EX895_001894 EX895_004025 |
LMAT: | 92510943(LSCM1_00793) |
LOI: | 92357211(LSCM4_01215) |
XPH: | XppCFBP6546_20065(XppCFBP6546P_20065) |
XHD: | LMG31886_24520(paaF) |
VPB: | VPBB_A0562 VPBB_A1030 |
VPK: | M636_02295 M636_05020 |
VPF: | M634_20915 M634_23465 |
VPH: | VPUCM_20551 VPUCM_21027 |
VEX: | VEA_000379 VEA_001541 |
VDB: | AL552_00110 AL552_05975 |
VNA: | PN96_19030 PN96_21485 |
VEJ: | VEJY3_18531 VEJY3_20636 |
VNL: | D3H41_17140 D3H41_19530 |
VJP: | NP165_14490 NP165_19160 |
PAEB: | NCGM1900_4474(gnyH) |
PAEU: | BN889_02191(liuC_1) |
PMOL: | CLJ08_03600 CLJ08_20730 |
PMOS: | O165_003885 O165_005040 |
PMUD: | NCTC8068_03122(liuC) |
PFW: | PF1751_v1c33250(liuC) |
PSEC: | CCOS191_3463 CCOS191_3736 |
PSET: | THL1_3225 THL1_5569 |
PTAE: | NCTC10697_03140(menB) |
HPEG: | EAO82_08955 EAO82_13390 |
KAK: | Kalk_02230 Kalk_08100 |
ABB: | ABBFA_02090(echA8_3) |
SCAA: | TUM17387_13400(liuC) |
TVD: | SG34_003880 SG34_011670 |
PSEN: | PNC201_09585(echA2) |
SALH: | HMF8227_01311(liuC) |
MYA: | MORIYA_0479 MORIYA_2637(liuC) |
ZAL: | AZF00_01805 AZF00_04100 |
MICT: | FIU95_01600(paaF1) FIU95_11465(echA1) |
HJA: | BST95_14340 BST95_19140 |
LLG: | 44548918_02056(echA8_3) |
LJR: | NCTC11533_00708(echA8_1) |
LCJ: | NCTC11976_01877(menB) |
LWA: | SAMEA4504053_2020(echA8_3) |
LSS: | NCTC12082_02856(echA8_2) |
LADL: | NCTC12735_01378(echA8_2) |
GAI: | IMCC3135_26610(echA8_4) |
ALCA: | ASALC70_04374(paaF_2) |
AEL: | NCTC12917_01920(caiD_1) |
VFF: | VITFI_CDS1588 VITFI_CDS2822 VITFI_CDS3430 |
CCAH: | DWG20_10695 DWG20_14155 |
CVC: | BKX93_19595 BKX93_22010 |
CHRO: | CXB49_13535 CXB49_15670 |
CHRI: | DK842_14210 DK842_16025 |
CHRB: | DK843_19780 DK843_21555 |
CRZ: | D1345_05280 D1345_15850 |
CHRM: | FYK34_02055 FYK34_03915 |
CHAE: | CH06BL_11370 CH06BL_11960 |
VOX: | LCH97_00925 LCH97_02360 |
AQL: | BXU06_01515 BXU06_05680 BXU06_09290 |
RPJ: | N234_00685 N234_35735 |
REH: | H16_A0179(h16_A0179) |
BVI: | Bcep1808_3493 Bcep1808_5067 |
BUR: | Bcep18194_B0425 Bcep18194_B1319 |
BCM: | Bcenmc03_5034 Bcenmc03_5776 |
BCH: | Bcen2424_4528 Bcen2424_5238 |
BCEN: | DM39_5407 DM39_6119 |
BCEW: | DM40_3094 DM40_4540 |
BAC: | BamMC406_4421 BamMC406_5119 |
BMJ: | BMULJ_04378(paaG) BMULJ_05048(paaG) |
BMUL: | NP80_4488 NP80_5076 |
BCED: | DM42_5550 DM42_6239 |
BCEP: | APZ15_22660 APZ15_30460 |
BPYR: | ABD05_23435 ABD05_27345 |
BCON: | NL30_03630 NL30_15980 |
BDF: | WI26_21655 WI26_24975 |
BLAT: | WK25_25140 WK25_28050 |
BTEI: | WS51_06150 WS51_09145 |
BSEM: | WJ12_28455 WJ12_32195 |
BPSL: | WS57_01960 WS57_05455 |
BMEC: | WJ16_27305 WJ16_30685 |
BSTG: | WT74_27645 WT74_31030 |
BSTL: | BBJ41_21905 BBJ41_26090 |
BANN: | JFN94_16390 JFN94_26535 |
BARI: | NLX30_24980 NLX30_29595 |
BAEN: | L3V59_22425 L3V59_26975 |
BUQ: | AC233_22255 AC233_32485 |
BUM: | AXG89_06595 AXG89_13795 AXG89_15955 |
BUI: | AX768_07670 AX768_25740 |
BURK: | DM992_23735 DM992_32065 |
BXB: | DR64_5138 DR64_6283 DR64_7561 |
BCAI: | K788_0004245 K788_0004599 |
PARA: | BTO02_31960 BTO02_31980 |
PHS: | C2L64_22460 C2L64_41605 |
PTER: | C2L65_25505 C2L65_38595 |
PGP: | CUJ91_21275 CUJ91_25015 |
PPAI: | E1956_26140 E1956_41920 |
PLG: | NCTC10937_02511(fcbB1) |
AXX: | ERS451415_02191(echA8_5) |
BOZ: | DBV39_09325 DBV39_18940 |
RLH: | MIZ03_2341 MIZ03_4546 |
ACIP: | CBP36_09610 CBP36_16235 |
ACIS: | CBP35_02685 CBP35_09320 |
AANT: | HUK68_16925 HUK68_20615 |
CENP: | M9799_06405 M9799_18235 |
ADN: | Alide_2883 Alide_3799 |
ADK: | Alide2_1633 Alide2_4145 |
LIM: | L103DPR2_00023(menB) |
LIH: | L63ED372_03184(menB) |
HYR: | BSY239_2722 BSY239_3618 |
HPSE: | HPF_12900(echA9) HPF_21045(paaF4) |
HTN: | KI616_03940 KI616_12840 |
SAQA: | OMP39_12475 OMP39_14395 |
METP: | C1M51_06615 C1M51_13605 |
RDP: | RD2015_4344 RD2015_4473 |
ROI: | N4261_23155 N4261_24480 |
KIA: | G8A07_23945 G8A07_25010 |
PKT: | AT984_15690 AT984_16130 |
PAQA: | K9V56_008400 K9V56_020520 |
PAIS: | PFX98_03295 PFX98_04355 |
SNN: | EWH46_00470 EWH46_09890 |
JAJ: | EKL02_00480 EKL02_06190 |
HSE: | Hsero_0823 Hsero_3076(caiD) |
TMJ: | P0M04_09485 P0M04_30570 |
THI: | THI_0465 THI_3270 THI_3562 |
OTR: | OTERR_01880(liuC) OTERR_30280(liuC) |
QAU: | KI612_00390 KI612_07155 |
TMZ: | Tmz1t_0750 Tmz1t_1507 |
THK: | CCZ27_16560 CCZ27_17925 |
THAG: | CKCBHOJB_01109(echA8_3) CKCBHOJB_03194(echA8_5) |
SMEL: | SM2011_b21126(eccH2) |
BMZ: | BM28_A0014 BM28_A0015 |
BMG: | BM590_A0014 BM590_A0015 |
BMW: | BMNI_I0014 BMNI_I0015 |
HMC: | HYPMC_0165 HYPMC_3379 |
AUB: | LXB15_06075 LXB15_15395 |
BVY: | NCTC9239_02137(menB_2) |
TSV: | DSM104635_01415(fadB_1) |
RFU: | ROLI_009430(echA8_1) |
MALG: | MALG_02368 MALG_03725 |
SUAM: | BOO69_06565 BOO69_21805 |
SPSE: | SULPSESMR1_01874(echA8) SULPSESMR1_04095(echA8) |
RMM: | ROSMUCSMR3_00239(echA8) |
RID: | RIdsm_01864(echA6) RIdsm_02343(echA8_5) RIdsm_05449(echA8_11) |
SAGU: | CDO87_18825 CDO87_24025 |
PMAU: | CP157_01592(echA8_1) |
DAA: | AKL17_2327 AKL17_3p0025 AKL17_4453 |
LVS: | LOKVESSMR4R_01809(menB) |
SHUM: | STHU_34510 STHU_44410 |
SVC: | STVA_17150 STVA_46170 |
STEL: | STAQ_04620 STAQ_09850 |
MGY: | MGMSRv2__0137 MGMSRv2__0407 |
MGRY: | MSR1_01480(menB) MSR1_18070(paaF_1) |
MAGX: | XM1_2265 XM1_4685(caiD) XM1_4764 |
MAGN: | WV31_02465 WV31_02750 |
NACI: | NUH88_04235 NUH88_20495 |
THAR: | T8K17_00340 T8K17_23185 |
CCRO: | CMC5_030050 CMC5_031710(paaG) |
BSTO: | C0V70_02635 C0V70_08250 |
DOR: | Desor_1410 Desor_4204 |
MAUU: | NCTC10437_01633(pksH) |
GYU: | FE374_03285 FE374_10695 |
PSEQ: | AD006_13665 AD006_29180 |
PECQ: | AD017_21485 AD017_29570 |
KUT: | JJ691_57590(paaG_10) |
ACTU: | Actkin_01419(menB_1) |
MICH: | FJK98_20505 FJK98_25690 |
MSAG: | GCM10017556_11160(paaG) GCM10017556_56990(eccH2) |
MENO: | Jiend_42170(paaG_4) |
MCAY: | PVK37_24940 PVK37_30960 |
ACTR: | Asp14428_30460(paaG_2) |
PLK: | CIK06_17605 CIK06_22030 |
PFLA: | Pflav_057770(paaG_2) |
ASER: | Asera_60790(paaG_2) |
CATI: | CS0771_00460(paaG_1) |
DACT: | KZZ52_44000 KZZ52_53000 |
MFF: | MFFC18_09960(echA8) MFFC18_45470(caiD) |
ROL: | CA51_12710(echA8_1) CA51_36910(echA8_2) |
RUV: | EC9_19580(echA8_1) EC9_38230(echA8_2) |
RCF: | Poly24_12450(paaF) Poly24_37060(echA8) |
LCRE: | Pla8534_27960(echA8_1) |
SMAM: | Mal15_56620(echA8_2) |
AMUC: | Pan181_40270(echA8) |
AGV: | OJF2_15620(paaF) OJF2_40820(echA8) |
ABAC: | LuPra_04311(paaF_1) |
SDJ: | NCTC13534_05627(menB) |
» show all
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Reference |
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Authors |
HILZ H, KNAPPE J, RINGELMANN E, LYNEN F. |
Title |
[Methylglutaconase, a new hydrase participating in the metabolism of various carboxylic acids.] |
Journal |
Biochem Z 329:476-89 (1958) |
Other DBs |
ExplorEnz - The Enzyme Database: | 4.2.1.18 |
ExPASy - ENZYME nomenclature database: | 4.2.1.18 |
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LinkDB |
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