Entry
Name
D-serine ammonia-lyase;
D-hydroxyaminoacid dehydratase;
D-serine dehydrase;
D-hydroxy amino acid dehydratase;
D-serine hydrolase;
D-serine dehydratase (deaminating);
D-serine deaminase;
D-serine hydro-lyase (deaminating)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
D-serine ammonia-lyase (pyruvate-forming)
Reaction(IUBMB)
D-serine = pyruvate + NH3 (overall reaction) [RN:
R00221 ];
(1a) D-serine = 2-aminoprop-2-enoate + H2O;
(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);
(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)
Reaction(KEGG)
Substrate
Product
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC
4.2.1.14 , D-serine dehydratase) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC
3.5.99.10 , 2-iminobutanoate/2-iminopropanoate deaminase. Also acts, slowly, on D-threonine.
History
EC 4.3.1.18 created 1961 as EC 4.2.1.14, transferred 2001 to EC 4.3.1.18
Pathway
ec00260 Glycine, serine and threonine metabolism
Orthology
Genes
CGIB : 127968199(zgc:162816)
PTET : 122353926(zgc:162816)
LROH : 127172754(zgc:162816)
OMC : 131549284(zgc:162816)
PPRM : 120480363(zgc:162816)
RKG : 130083576(zgc:162816)
MAMB : 125256568(zgc:162816)
CIDE : 127522631(zgc:162816)
CERY : 137021476(zgc:162816)
MASI : 127425915(zgc:162816)
TROS : 130571202(zgc:162816)
TDW : 130409948(zgc:162816)
MANU : 129427954(zgc:162816)
PDAB : 135718792(zgc:162816)
IPU : 108271324(zgc:162816)
IFU : 128613475(zgc:162816)
SMEO : 124390942(zgc:162816)
TFD : 113658924(zgc:162816)
TVC : 132850081(zgc:162816)
CGAR : 128543381(zgc:162816)
NGRA : 132899688(zgc:162816)
TRN : 134331591(zgc:162816)
AMEX : 103028050(zgc:162816)
CMAO : 118818925(zgc:162816)
CHAR : 105896624(zgc:162816)
SPIL : 134071115(zgc:162816)
TFS : 130539326(zgc:162816)
TBEN : 117489019(zgc:162816)
GACU : 117556591(zgc:162816)
EMAC : 134865626(zgc:162816)
ELY : 117271741(zgc:162816)
EFO : 125902255(zgc:162816)
PLEP : 121951629(zgc:162816)
SLUC : 116055105(zgc:162816)
GAT : 120816031(zgc:162816)
PPUG : 119209187(zgc:162816)
AFB : 129089091(zgc:162816)
CLUM : 117746301(zgc:162816)
PSWI : 130198448(zgc:162816)
CANA : 137782181(zgc:162816)
CVE : 137865854(zgc:162816)
MSAM : 119902465(zgc:162816)
SCHU : 122886614(zgc:162816)
CUD : 121520448(zgc:162816)
LMIX : 132978775(zgc:162816)
ALAT : 119011235(zgc:162816)
ASTR : 137612548(zgc:162816)
OAU : 116332945(zgc:162816)
OML : 112147860(zgc:162816)
CSAI : 133452138(zgc:162816)
GAF : 122840741(zgc:162816)
PPRL : 129361766(zgc:162816)
GMU : 124870055(zgc:162816)
KMR : 108238630(zgc:162816)
NWH : 119414387(zgc:162816)
AOCE : 111571317(zgc:162816)
MCEP : 125010498(zgc:162816)
SSEN : 122780323(zgc:162816)
SSOE : 131451750(zgc:162816)
HHIP : 117778954(zgc:162816)
HSP : 118117255(zgc:162816)
PPLT : 128454784(zgc:162816)
SMAU : 118311513(zgc:162816)
LCF : 108883901(zgc:162816)
XGL : 120798484(zgc:162816)
SSCV : 125984838(zgc:162816)
SBIA : 133510492(zgc:162816)
PEE : 133411506(zgc:162816)
PTAO : 133488414(zgc:162816)
BSPL : 114845155(zgc:162816)
SJO : 128368875(zgc:162816)
SSCO : 133990440(zgc:162816)
OTW : 112237220(zgc:162816)
OMY : 110530868(zgc:162816)
OKE : 127923874(zgc:162816)
OMM : 135508552(zgc:162816)
CCLU : 121535547(zgc:162816)
OEP : 134036161(zgc:162816)
AANG : 118222602(zgc:162816)
AROT : 135250811(zgc:162816)
CCOG : 133124350(zgc:162816)
PSPA : 121323108(zgc:162816)
ARUT : 117414223(zgc:162816)
PSEX : 120531433(zgc:162816)
RTP : 109914798(zgc:162816)
CPLA : 122548958(zgc:162816)
HOC : 132815478(zgc:162816)
LERI : 129714857(zgc:162816)
HASI : 137298231 137298232
AIRR : 138310131 138310420 138314112
LTH : KLTH0A07986g KLTH0E03102g
CGR : 2887038(GVI51_D01705)
NCS : NCAS_0B05450(NCAS0B05450)
NDI : NDAI_0B02730(NDAI0B02730)
KNG : KNAG_0G01380(KNAG0G01380)
PIC : PICST_35359 PICST_63574
CTEN : 18246413(PSN45_002892)
ASAU : 88174350(PUMCH_003286)
YLI : 2910167(YALI2_D00812g)
SLB : AWJ20_34(DSD1) AWJ20_4453(DSD1)
SMP : 10803645(SMAC4_05804)
FGR : FGSG_02308 FGSG_12139
FPU : FPSE_01951 FPSE_03819
FVR : FVEG_09063 FVEG_13203
FOX : FOXG_10900 FOXG_15739 FOXG_20295
NHE : NECHADRAFT_100868 NECHADRAFT_37272 NECHADRAFT_56564
MAW : 19249077(J3458_000788)
PLJ : 28884669(PLICBS_005892)
VAL : VDBG_07613 VDBG_08911
VDA : VDAG_06573 VDAG_09334
CFJ : CFIO01_00084 CFIO01_05050
CDET : 87943607(CDEST_07104)
SAPO : SAPIO_CDS0207 SAPIO_CDS5469
PFY : PFICI_06923 PFICI_10804
BFU : BCIN_05g04050(Bcdsd1)
PSCO : LY89DRAFT_605405 LY89DRAFT_645282
NFI : NFIA_029690 NFIA_102480
ANG : An14g01470 An14g01500
PCS : N7525_002686 N7525_006917 N7525_010248
CPW : 9695586(D8B26_005934)
SPO : 2542996(SPOM_SPAC1039.06)
CDEP : 91087094(L203_102883)
KMG : 30166035(I203_103915)
KNE : 92183594(IAR55_006336)
CCAC : CcaHIS019_0104530(CcaverHIS019_0104530)
ABP : AGABI1DRAFT66972(AGABI1DRAFT_66972)
ABV : AGABI2DRAFT197270(AGABI2DRAFT_197270)
SCM : SCHCO_02631982(SCHCODRAFT_02631982)
ECOO : ECRM13514_3190(dsdA)
ECOH : ECRM13516_3053(dsdA)
ECW : EcE24377A_2652(dsdA)
ECT : ECIAI39_2509(dsdA) ECIAI39_4221(dsdA)
EOC : CE10_2743(dsdA1) CE10_4258(dsdA2)
ECI : UTI89_C2697(dsdA) UTI89_C4955
EDJ : ECDH1ME8569_2305(dsdA)
ELU : UM146_04770 UM146_21995
ECOI : ECOPMV1_02570(dsdA)
REE : electrica_00017(dsdA)
RTG : NCTC13098_00025(dsdA)
KIE : NCTC12125_03815(dsdA)
AHN : NCTC12129_00668(dsdA)
METY : MRY16398_00240(dsdA)
SMW : SMWW4_v1c24950(dsdA)
SFJ : SAMEA4384070_2560(dsdA)
SOF : NCTC11214_04358(dsdA)
TPTY : NCTC11468_03504(dsdA)
PHEI : NCTC12003_03480(dsdA)
LRI : NCTC12151_03480(dsdA)
VCE : Vch1786_II0563(dsdA)
VRO : BSZ04_01270 BSZ04_14080
VIB : VspSTUT11_18160(dsdA)
VIS : VspSTUT16_19000(dsdA)
PAEB : NCGM1900_2918(dsdA)
PSES : PSCI_3625(dsdA) PSCI_4492
PTAE : NCTC10697_04306(dsdA)
PTAI : ICN73_16820 ICN73_21875
AVZ : HWI77_07445 HWI77_17420
AEL : NCTC12917_02967(dsdA)
NZO : SAMEA4504057_0435(dsdA)
BMV : BMASAVP1_1576 BMASAVP1_1577
BMAZ : BM44_3321 BM44_3322
BMAL : DM55_3361 DM55_3362
BMAE : DM78_4296 DM78_4297
BMAQ : DM76_4059 DM76_4060
BMAF : DM51_4107 DM51_4108
BMAB : BM45_4159 BM45_4160
BPM : BURPS1710b_A1220(dsdA)
BPL : BURPS1106A_A2856(dsdA)
BPD : BURPS668_A2980(dsdA)
BPZ : BP1026B_II2277(dsdA)
PLG : NCTC10937_03056(dsdA)
BTRM : SAMEA390648701980(dsdA)
CTEZ : CT3_06360(dsdA_1) CT3_33110(dsdA_2)
DLS : P4826_04530 P4826_10490(dsdA)
REP : IE4803_CH02015(dsdA)
REI : IE4771_CH02098(dsdA)
RPHA : AMC79_CH02133(dsdA)
SPSE : SULPSESMR1_04058(dsdA)
BAZ : BAMTA208_12175(dsdA)
BBY : CY96_08105 CY96_29240
BFX : BC359_08930 BC359_18755
LFU : HR49_09170 HR49_15410
LAGR : FJQ98_09335 FJQ98_15085
PASA : BAOM_1311(dsdA) BAOM_2635(dsdA)
RUE : DT065_02580 DT065_07335
SALE : EPH95_02065 EPH95_07835
SCIB : HUG20_09565 HUG20_10810 HUG20_14680
SCIA : HUG15_12005 HUG15_17470
NCM : QNK12_02895 QNK12_16745
SSTE : SAMEA4384403_0448(dsdA)
PBJ : VN24_07190 VN24_22460
SOB : CSE16_06425 CSE16_07965
SPSU : NCTC13786_01036(dsdA)
SPOC : NCTC10925_00178(dsdA)
LHIL : G8J22_02653(dsdA_1) G8J22_02654(dsdA_2)
LHB : D1010_05525 D1010_09815
CRN : CAR_c14010(dsdA1) CAR_c21500(dsdA2)
DPM : FNV33_03465 FNV33_07335
CLO : HMPREF0868_0667(dsdA)
CSCI : HDCHBGLK_02457(dsdA)
CHYL : CE91St63_11200(dsdA)
ETM : CE91St48_34330(dsdA)
EAC : EAL2_808p01140(dsdA)
GCR : GcLGCM259_2662(dsdA)
DCO : SAMEA4475696_1531(dsdA)
PPC : HMPREF9154_0768(dsdA)
BROO : brsh051_21070(dsdA)
» show all
Taxonomy
Reference
Authors
Dupourque D, Newton WA, Snell EE.
Title
Purification and properties of D-serine dehydrase from Escherichia coli.
Journal
J Biol Chem 241:1233-8 (1966)
Reference
Authors
METZLER DE, SNELL EE.
Title
Deamination of serine. II. D-Serine dehydrase, a vitamin B6 enzyme from Escherichia coli.
Journal
J Biol Chem 198:363-73 (1952)
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.18
ExPASy - ENZYME nomenclature database: 4.3.1.18
LinkDB
All DBs