KEGG   ENZYME: 5.4.99.40
Entry
EC 5.4.99.40                Enzyme                                 
Name
alpha-amyrin synthase;
2,3-oxidosqualene alpha-amyrin cyclase;
mixed amyrin synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-amyrin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin [RN:R06471]
Reaction(KEGG)
R06471
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
alpha-amyrin [CPD:C08615]
Comment
A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase).
History
EC 5.4.99.40 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15815  lupeol synthase 2
K20658  alpha/beta-amyrin synthase
K21928  delta/alpha/beta-amyrin synthase
Genes
ATH: AT1G78960(LUP2)
CRB: 17894179 17894180
EUS: EUTSA_v10018166mg EUTSA_v10022563mg
BRP: 103830506 103832374
BNA: 106354658
TPRA: 123885848
CAM: 101509140
PSAT: 127076375 127076377
VVO: 131616260 131616262 131623342 131623344
PDUL: 117620888
SLY: 100529100(TTS2)
SOT: 102591877
SSTN: 125852109
 » show all
Reference
1  [PMID:10848960]
  Authors
Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y
  Title
Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase.
  Journal
Eur J Biochem 267:3453-60 (2000)
DOI:10.1046/j.1432-1327.2000.01357.x
  Sequence
[ag:BAA97559]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.40
IUBMB Enzyme Nomenclature: 5.4.99.40
ExPASy - ENZYME nomenclature database: 5.4.99.40
BRENDA, the Enzyme Database: 5.4.99.40
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